Rémi Fronzes
@fronzeslab.bsky.social
🔬 CNRS Research Director, Bordeaux
| Structural biologist & microbiologist
🚴♂️ Cyclist (mostly Velotaf) & runner (just for fun)
⛰️ Mountain & nature lover
🎓 UCL/Birkbeck & Institut Pasteur alumnus
🔬 fronzeslab.cnrs.fr
#cryoEM #cryoET #microsky
| Structural biologist & microbiologist
🚴♂️ Cyclist (mostly Velotaf) & runner (just for fun)
⛰️ Mountain & nature lover
🎓 UCL/Birkbeck & Institut Pasteur alumnus
🔬 fronzeslab.cnrs.fr
#cryoEM #cryoET #microsky
Pinned
A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system
Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.
www.science.org
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
Reposted by Rémi Fronzes
How does linguistic bias reinforce privilege in science? #AppEnvMicro Editor in Chief @microgem.bsky.social offers insights and discusses how reviewers can identify it to support a more equitable review process. Read the article: asm.social/2Hp #COPE #PublicationIntegrity
Linguistic Bias and the Science Lost in Translation | ASM.org
Explore how linguistic bias subtly reinforces privilege in science by constraining scientific dissemination.
asm.social
November 21, 2025 at 7:48 PM
How does linguistic bias reinforce privilege in science? #AppEnvMicro Editor in Chief @microgem.bsky.social offers insights and discusses how reviewers can identify it to support a more equitable review process. Read the article: asm.social/2Hp #COPE #PublicationIntegrity
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system
Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.
www.science.org
November 21, 2025 at 7:05 PM
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
Sounds like a good excuse when arriving late to work
November 21, 2025 at 5:52 PM
Sounds like a good excuse when arriving late to work
Reposted by Rémi Fronzes
Know the difference.
November 19, 2025 at 10:08 PM
Know the difference.
Reposted by Rémi Fronzes
Fixation artifacts will haunt us forever until we get real about them.
Fix or Freeze? Spectral Differences Arising from Tissue Preparation in Chemical Imaging https://www.biorxiv.org/content/10.1101/2025.11.19.689284v1
November 19, 2025 at 8:50 PM
Fixation artifacts will haunt us forever until we get real about them.
Congrats Eloïse !
Honored to receive the FEBS Booster Funds 2025.
My sincere thanks to FEBS for this recognition and their support of early-career researchers.
This funding will greatly help advance my work.
Congratulations as well to all fellow 2025 awardees.
My sincere thanks to FEBS for this recognition and their support of early-career researchers.
This funding will greatly help advance my work.
Congratulations as well to all fellow 2025 awardees.
November 18, 2025 at 8:07 PM
Congrats Eloïse !
Reposted by Rémi Fronzes
New online! The type VI secretion system and associated effector proteins
The type VI secretion system and associated effector proteins
Nature Reviews Microbiology, Published online: 14 November 2025; doi:10.1038/s41579-025-01256-wIn this Review, Basler and colleagues examine the type VI secretion system (T6SS), focusing on the diversity of antibacterial T6SS effectors and the evolutionary forces that shape them. They explain how effectors diversify and highlight interbacterial antagonism as a key driver of this process.
www.nature.com
November 14, 2025 at 9:29 PM
New online! The type VI secretion system and associated effector proteins
Great review that pinpoints many critical gaps in the field! The PS "paradigm" needs to be tested/confirmed properly in cellulo in native conditions. Not easy.
November 14, 2025 at 11:36 AM
Great review that pinpoints many critical gaps in the field! The PS "paradigm" needs to be tested/confirmed properly in cellulo in native conditions. Not easy.
Reposted by Rémi Fronzes
Fucking magnates, how do they work
November 10, 2025 at 10:32 PM
Fucking magnates, how do they work
NMR spectroscopists according to the President of the USA (and let's be honest, according to everyone else) 😁
a young boy in a plaid shirt is holding a wand in his hand
ALT: a young boy in a plaid shirt is holding a wand in his hand
media.tenor.com
November 10, 2025 at 10:27 PM
NMR spectroscopists according to the President of the USA (and let's be honest, according to everyone else) 😁
"nobody knows what magnets are" DJT
a man with long curly hair and a mustache is wearing a pink unicorn shirt .
ALT: a man with long curly hair and a mustache is wearing a pink unicorn shirt .
media.tenor.com
November 10, 2025 at 9:56 PM
"nobody knows what magnets are" DJT
Reposted by Rémi Fronzes
Reposted by Rémi Fronzes
I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA!
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
November 9, 2025 at 6:43 PM
I am seeing a lot of posts about Rosalind Franklin that themselves ignore her publication record on DNA!
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
In fact Franklin and Gosling's paper, including the famous Photograph #51, was published, along with Wilkins's paper, back-to-back with the Watson and Crick paper in Nature in 1953.
I learned a lot from reading the posts over the last 2 days. I was struck by how much we are influenced by scientific mythology, some of it rooted in what we learned as far back as high school.
November 8, 2025 at 11:19 PM
I learned a lot from reading the posts over the last 2 days. I was struck by how much we are influenced by scientific mythology, some of it rooted in what we learned as far back as high school.
Just read the full letter. Wow !
« But the point of science is what is discovered, not how it was discovered or by whom. It is the results which need to be brought home to the public. »
F. Crick.
« But the point of science is what is discovered, not how it was discovered or by whom. It is the results which need to be brought home to the public. »
F. Crick.
November 8, 2025 at 11:10 PM
Just read the full letter. Wow !
« But the point of science is what is discovered, not how it was discovered or by whom. It is the results which need to be brought home to the public. »
F. Crick.
« But the point of science is what is discovered, not how it was discovered or by whom. It is the results which need to be brought home to the public. »
F. Crick.
I recommend reading this thread from F. Crick’s granddaughter.
Apparently even the scene at the Eagle pub, where we all went as scientific pilgrims, is not true?
Just mythology
Apparently even the scene at the Eagle pub, where we all went as scientific pilgrims, is not true?
Just mythology
"If you publish your book now, in the teeth of my opposition, history will condemn you”
“the tone used to describe Rosalind's work in the Epilogue
is perfectly reasonable,
but contrasts ludicrously with
the descriptions of her
in the text itself.”
-Francis Crick
Letter criticizing Watson’s book 🧪
“the tone used to describe Rosalind's work in the Epilogue
is perfectly reasonable,
but contrasts ludicrously with
the descriptions of her
in the text itself.”
-Francis Crick
Letter criticizing Watson’s book 🧪
November 8, 2025 at 10:47 PM
I recommend reading this thread from F. Crick’s granddaughter.
Apparently even the scene at the Eagle pub, where we all went as scientific pilgrims, is not true?
Just mythology
Apparently even the scene at the Eagle pub, where we all went as scientific pilgrims, is not true?
Just mythology
You know what? I did not read “The Double Helix.”
I was converted to molecular biology by the books from Monod and Jacob, real decent and courageous men in addition to being exceptional scientists. For me, one cannot go without the other!!
I was converted to molecular biology by the books from Monod and Jacob, real decent and courageous men in addition to being exceptional scientists. For me, one cannot go without the other!!
November 8, 2025 at 9:32 PM
You know what? I did not read “The Double Helix.”
I was converted to molecular biology by the books from Monod and Jacob, real decent and courageous men in addition to being exceptional scientists. For me, one cannot go without the other!!
I was converted to molecular biology by the books from Monod and Jacob, real decent and courageous men in addition to being exceptional scientists. For me, one cannot go without the other!!
Some still praise James Watson despite his racism. Same with colleagues who won’t condemn Elon Musk’s politics, hiding behind “scientists shouldn’t mix science and politics.”
November 8, 2025 at 12:36 PM
Some still praise James Watson despite his racism. Same with colleagues who won’t condemn Elon Musk’s politics, hiding behind “scientists shouldn’t mix science and politics.”
X
Thinking about Rosalind (and Maurice)
Thinking about Rosalind (and Maurice)
November 7, 2025 at 8:04 PM
X
Thinking about Rosalind (and Maurice)
Thinking about Rosalind (and Maurice)
Not sure to miss him…
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
www.nytimes.com
November 7, 2025 at 7:47 PM
Not sure to miss him…
Reposted by Rémi Fronzes
Many thanks to the folks at the San Diego Supercomputer Center for highlighting our project!
SDSC-housed Protein Data Bank Brings Molecules Up to Size
Molecules — the unseen architects that form everything from the DNA in your cells to the planets in distant galaxies, crafting the very fabric of reality while remaining too small for the human eye to glimpse. But thanks to the Protein Data Bank we can now “see” these hidden wonders.
today.ucsd.edu
November 6, 2025 at 8:44 PM
Many thanks to the folks at the San Diego Supercomputer Center for highlighting our project!
Reposted by Rémi Fronzes
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
November 6, 2025 at 3:51 PM
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
panic mode activated.
Deadline @erc.europa.eu Synergy grant deadline <24h !
Deadline @erc.europa.eu Synergy grant deadline <24h !
November 4, 2025 at 5:48 PM
panic mode activated.
Deadline @erc.europa.eu Synergy grant deadline <24h !
Deadline @erc.europa.eu Synergy grant deadline <24h !
Reposted by Rémi Fronzes
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
October 29, 2025 at 5:11 PM
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...