Fabian Fröhlich
@frohlichlab.com
Dynamics of Living Systems (https://www.frohlichlab.com) group leader @thecrick.bsky.social Understanding signalling & cell state dynamics through mathematical modelling and machine learning.
Reposted by Fabian Fröhlich
[so AI may be bad but probably no worse than your average pundit and definitely not as bad as WSJ 😆] 3/n
November 22, 2025 at 5:59 PM
[so AI may be bad but probably no worse than your average pundit and definitely not as bad as WSJ 😆] 3/n
Reposted by Fabian Fröhlich
I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes
November 21, 2025 at 1:14 PM
I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes
Reposted by Fabian Fröhlich
I think almost all scientific projects should be planned carefully. And I think an app can dramatically improve that. So I wrote an app for that (free for now, if you can fund this let me know). I tested it quite a bit (>8000 users in beta so far). try it: planyourscience.com
November 20, 2025 at 3:33 PM
I think almost all scientific projects should be planned carefully. And I think an app can dramatically improve that. So I wrote an app for that (free for now, if you can fund this let me know). I tested it quite a bit (>8000 users in beta so far). try it: planyourscience.com
Reposted by Fabian Fröhlich
This is wild - an open challenge on 'virtual cell' perturbation prediction falls on its face due to flawed metrics:
gmdbioinformatics.substack.com/p/arc-virtua...
Benchmarking is important. It's also difficult. It's not just an engineering challenge. Figuring out what "good performance"...
⬇️
gmdbioinformatics.substack.com/p/arc-virtua...
Benchmarking is important. It's also difficult. It's not just an engineering challenge. Figuring out what "good performance"...
⬇️
November 19, 2025 at 2:42 PM
This is wild - an open challenge on 'virtual cell' perturbation prediction falls on its face due to flawed metrics:
gmdbioinformatics.substack.com/p/arc-virtua...
Benchmarking is important. It's also difficult. It's not just an engineering challenge. Figuring out what "good performance"...
⬇️
gmdbioinformatics.substack.com/p/arc-virtua...
Benchmarking is important. It's also difficult. It's not just an engineering challenge. Figuring out what "good performance"...
⬇️
Reposted by Fabian Fröhlich
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
November 18, 2025 at 11:03 PM
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
Reposted by Fabian Fröhlich
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Reposted by Fabian Fröhlich
New essay out today by me and @acjsissons.bsky.social - ‘Getting Britain out of the hole: a plan for the economy’. You can read the whole thing here getting-out-of-the-hole.uk
A chart mega-thread follows 🧵
A chart mega-thread follows 🧵
Getting Britain out of the hole
A plan for the UK economy
getting-out-of-the-hole.uk
November 17, 2025 at 8:00 AM
New essay out today by me and @acjsissons.bsky.social - ‘Getting Britain out of the hole: a plan for the economy’. You can read the whole thing here getting-out-of-the-hole.uk
A chart mega-thread follows 🧵
A chart mega-thread follows 🧵
To the consumers of LLM tools and of their outputs: Is it really that hard to see that ideation/conception and implementation are distinct skills in writing (of text and code), and that while LLMs are strong at implementation, they continue to fall short on ideation?
November 15, 2025 at 5:17 PM
To the consumers of LLM tools and of their outputs: Is it really that hard to see that ideation/conception and implementation are distinct skills in writing (of text and code), and that while LLMs are strong at implementation, they continue to fall short on ideation?
Reposted by Fabian Fröhlich
Enthusiastic about connectomics and X-rays?
Several positions in our group at Crick for postdocs and senior scientists (permanent!).
DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today!
Please share!
Several positions in our group at Crick for postdocs and senior scientists (permanent!).
DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today!
Please share!
November 14, 2025 at 3:22 PM
Enthusiastic about connectomics and X-rays?
Several positions in our group at Crick for postdocs and senior scientists (permanent!).
DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today!
Please share!
Several positions in our group at Crick for postdocs and senior scientists (permanent!).
DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today!
Please share!
Reposted by Fabian Fröhlich
Switzerland is joining Horizon Europe!
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
November 10, 2025 at 2:58 PM
Switzerland is joining Horizon Europe!
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
We are uniting two research powerhouses.
For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more.
Today is a good day for science, and for our EU-Switzerland partnership.
Reposted by Fabian Fröhlich
Haha, this from the New Yorker is getting passed around the math dork community. I did a comic about this kind of thought a few years ago: www.smbc-comics.com/comic/commut...
November 7, 2025 at 5:26 PM
Haha, this from the New Yorker is getting passed around the math dork community. I did a comic about this kind of thought a few years ago: www.smbc-comics.com/comic/commut...
Reposted by Fabian Fröhlich
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 6, 2025 at 2:32 PM
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Reposted by Fabian Fröhlich
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
October 27, 2025 at 2:07 PM
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Reposted by Fabian Fröhlich
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
October 27, 2025 at 8:50 AM
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Fabian Fröhlich
Skeetorial on our BRAF preprint!
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer
The RAF/MEK/ERK signaling cascade regulates cell proliferation and differentiation and is frequently dysregulated in cancer. Approximately 90% of RAF-mutant cancers harbour mutations in B-type of Rapi...
tinyurl.com
October 14, 2025 at 8:17 AM
Skeetorial on our BRAF preprint!
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
tinyurl.com/asymmBRAF
The RAS->RAF->MEK->ERK cascade carries mutations in most human cancers. Interestingly, although we have three RAF paralogues (A, B and C), it is the BRAF that is predominantly mutated in cancer patients. (1/10)
Reposted by Fabian Fröhlich
We just posted an impact story on policies at HHMI, Gates & Astera promoting #OpenAccess #OpenScience #OpenData. Powerful signals to other funders to accelerate discovery in science. Well done @madubs.bsky.social @openaccessmaven.bsky.social @pracheeac.bsky.social! sparcopen.org/impact-story...
Funders Roll Out Next Gen Open Policies - SPARC
sparcopen.org
October 10, 2025 at 3:43 PM
We just posted an impact story on policies at HHMI, Gates & Astera promoting #OpenAccess #OpenScience #OpenData. Powerful signals to other funders to accelerate discovery in science. Well done @madubs.bsky.social @openaccessmaven.bsky.social @pracheeac.bsky.social! sparcopen.org/impact-story...
Reposted by Fabian Fröhlich
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Opening my lab @crick.ac.uk two years ago has been a privilege, a delight and ultimately the most transformative experience of my sciencific career. Discovery science without boundaries, inspiring colleagues and infinite possibilities. Come join us!
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:56 PM
Opening my lab @crick.ac.uk two years ago has been a privilege, a delight and ultimately the most transformative experience of my sciencific career. Discovery science without boundaries, inspiring colleagues and infinite possibilities. Come join us!
Reposted by Fabian Fröhlich
Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme.
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
PhD students
Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.
www.crick.ac.uk
October 2, 2025 at 12:53 PM
Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme.
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
Apply by 05 November 2025
www.crick.ac.uk/careers-and-...
Reposted by Fabian Fröhlich
Omg nature is so weird and amazing
Many sea stars begin life as young fairy-like creature (called a brachiolaria) that float through the open ocean. Eventually, a small star forms within them (here in yellow). The fairy-like brachiolaria sinks under the star’s weight, and the star pops out!
🎥@the_story_of_a_biologist (on Insta)
🎥@the_story_of_a_biologist (on Insta)
October 9, 2025 at 8:30 AM
Omg nature is so weird and amazing
Reposted by Fabian Fröhlich
🚀 New talk!
"Automated ML-guided lead optimization: surpassing human-level performance at protein engineering"
▶️ www.youtube.com/watch?v=mEhB...
✨🧪 This was a talk I gave at the recent AIxBIO conference in Cambridge UK. A 10-minute pitch for what we do at Cradle!
"Automated ML-guided lead optimization: surpassing human-level performance at protein engineering"
▶️ www.youtube.com/watch?v=mEhB...
✨🧪 This was a talk I gave at the recent AIxBIO conference in Cambridge UK. A 10-minute pitch for what we do at Cradle!
Automated ML-guided lead optimization: surpassing human-level performance at protein engineering
YouTube video by Patrick Kidger
www.youtube.com
October 7, 2025 at 1:26 PM
🚀 New talk!
"Automated ML-guided lead optimization: surpassing human-level performance at protein engineering"
▶️ www.youtube.com/watch?v=mEhB...
✨🧪 This was a talk I gave at the recent AIxBIO conference in Cambridge UK. A 10-minute pitch for what we do at Cradle!
"Automated ML-guided lead optimization: surpassing human-level performance at protein engineering"
▶️ www.youtube.com/watch?v=mEhB...
✨🧪 This was a talk I gave at the recent AIxBIO conference in Cambridge UK. A 10-minute pitch for what we do at Cradle!
🌊 Signals intertwine,
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
Fröhlich Lab | Scientific Machine Learning for Signal Transduction
www.crick.ac.uk
October 7, 2025 at 1:44 PM
🌊 Signals intertwine,
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
🔬 cells tell hidden stories,
🤖✨ SciML maps their future.
Come do a PhD with us www.crick.ac.uk/careers-stud...
Reposted by Fabian Fröhlich
Applications are now open for the @cruk-cityoflondon.bsky.social Black Leaders in Cancer PhD Programme.
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
October 2, 2025 at 3:01 PM
Applications are now open for the @cruk-cityoflondon.bsky.social Black Leaders in Cancer PhD Programme.
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
If you are interested in our project ‘Reprogramming Plasticity in Colorectal Cancer’ feel free to get in touch!
www.colcc.ac.uk/2026-blic-ph...
Reposted by Fabian Fröhlich
First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer https://www.biorxiv.org/content/10.1101/2025.09.26.678760v1
September 28, 2025 at 10:33 AM
First work on kinases from my lab! Working on this project, I often remembered the late Cyrus Chothia who said that if the data doesn’t fit a beautiful model, maybe it’s not the model, maybe you just need more data. :)
Reposted by Fabian Fröhlich
🚨New Preprint🚨
How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness?
We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇
www.biorxiv.org/content/10.1...
How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness?
We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 22, 2025 at 10:35 AM
🚨New Preprint🚨
How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness?
We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇
www.biorxiv.org/content/10.1...
How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness?
We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇
www.biorxiv.org/content/10.1...