Félix Ramos-León
@felixrl.bsky.social
Postdoctoral fellow at NIH studying cell biology of coccoid bacteria.
Views my own.
He/him/Él 🏳️🌈
Views my own.
He/him/Él 🏳️🌈
Pinned
Félix Ramos-León
@felixrl.bsky.social
· Oct 28
PcdA promotes orthogonal division plane selection in Staphylococcus aureus
Nature Microbiology - PcdA interacts with DivIVA and FtsZ, promoting Z-ring formation and division plane selection in Staphylococcus aureus, which increases virulence in mice and reduces...
rdcu.be
Excited to share that our paper is now out in Nature Microbiology @natureportfolio.bsky.social! We characterize a positive mechanism for Z ring placement in S. aureus governed by the proteins PcdA/DivIVA, and its implication during infection in a mouse model #Microsky
rdcu.be/dYmdC
rdcu.be/dYmdC
Reposted by Félix Ramos-León
‘Chromosomal Topological Domain Formation Modulates Transcription and the Coupling of Neighboring Genes in Escherichia coli‘ by Drs. Nico Yehya, Christopher Bohrer, and collaborators, is now available on bioRxiv. Check it out! doi: doi.org/10.1101/2025...
Chromosomal Topological Domain Formation Modulates Transcription and the Coupling of Neighboring Genes in Escherichia coli
Chromosomal topology and transcription are tightly coupled, yet the quantitative impact of topological constraints on transcription, supercoiling, and the potential coupling between neighboring genes ...
doi.org
November 25, 2025 at 2:04 PM
‘Chromosomal Topological Domain Formation Modulates Transcription and the Coupling of Neighboring Genes in Escherichia coli‘ by Drs. Nico Yehya, Christopher Bohrer, and collaborators, is now available on bioRxiv. Check it out! doi: doi.org/10.1101/2025...
Reposted by Félix Ramos-León
Really cool paper from @vincentdebakker.bsky.social @jonbakerlab.bsky.social now published @natcomms.nature.com #MicroSky www.nature.com/articles/s41...
Multi-omics profiling reveals atypical sugar utilization and a key membrane composition regulator in Streptococcus pneumoniae - Nature Communications
The pathogen Streptococcus pneumoniae can adapt to diverse microenvironments in the human body. Here, De Bakker et al. study these adaptation responses, showing unusual sugar utilization and identifyi...
www.nature.com
November 25, 2025 at 1:44 PM
Really cool paper from @vincentdebakker.bsky.social @jonbakerlab.bsky.social now published @natcomms.nature.com #MicroSky www.nature.com/articles/s41...
Reposted by Félix Ramos-León
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis
Ulcerative colitis (UC) is a severe inflammatory bowel disease affecting millions of people worldwide, but the factors driving the condition are poorly understood. In tissue samples from individuals w...
scim.ag
November 24, 2025 at 10:00 PM
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
Reposted by Félix Ramos-León
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
November 24, 2025 at 8:20 PM
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
Reposted by Félix Ramos-León
Very happy to share our work on lipopolysaccharide assembly by the Lpt complex, published today in @natcomms.nature.com
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex - Nature Communications
The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors characterize the LPS translocon...
doi.org
November 24, 2025 at 3:22 PM
Very happy to share our work on lipopolysaccharide assembly by the Lpt complex, published today in @natcomms.nature.com
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Reposted by Félix Ramos-León
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
November 20, 2025 at 10:16 AM
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
Reposted by Félix Ramos-León
The University at Albany Biomedical Sciences Department is hiring at the Assistant Professor level. We are looking for researchers at the intersection of infectious disease and artificial intelligence:
albany.interviewexchange.com/jobofferdeta...
#infectiousdisease #artificialintelligence
albany.interviewexchange.com/jobofferdeta...
#infectiousdisease #artificialintelligence
albany.interviewexchange.com
November 18, 2025 at 10:45 PM
The University at Albany Biomedical Sciences Department is hiring at the Assistant Professor level. We are looking for researchers at the intersection of infectious disease and artificial intelligence:
albany.interviewexchange.com/jobofferdeta...
#infectiousdisease #artificialintelligence
albany.interviewexchange.com/jobofferdeta...
#infectiousdisease #artificialintelligence
Reposted by Félix Ramos-León
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
November 17, 2025 at 8:27 PM
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
Reposted by Félix Ramos-León
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
November 17, 2025 at 6:17 PM
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
Reposted by Félix Ramos-León
We're hiring! My dept. is looking for a candidate with a research program focusing on plant systems. All areas of molecular and cellular biology research will be considered. Not sure if you'd fit? Reach out to me. Please share! #microsky
November 17, 2025 at 6:18 PM
We're hiring! My dept. is looking for a candidate with a research program focusing on plant systems. All areas of molecular and cellular biology research will be considered. Not sure if you'd fit? Reach out to me. Please share! #microsky
Reposted by Félix Ramos-León
Curious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
doi.org
July 2, 2025 at 10:07 AM
Curious about plasmid biology? Our latest paper is out now in Nature Communications! 🚨
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
doi.org/10.1038/s414...
We analyzed thousands of diverse bacterial plasmids to shed light for the first time on a key aspect of plasmid biology: plasmid copy number. 1/7 👇
Reposted by Félix Ramos-León
I’m excited to share my recent postdoc work. Here, we interrogate how different phage infection outcomes (productive vs. restrictive) affect the expression of phage defense systems. We find that a restricted infection not only inhibits the phage but also induces increased immune protein abundance.
Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses https://www.biorxiv.org/content/10.1101/2025.11.13.688357v1
November 15, 2025 at 6:10 PM
I’m excited to share my recent postdoc work. Here, we interrogate how different phage infection outcomes (productive vs. restrictive) affect the expression of phage defense systems. We find that a restricted infection not only inhibits the phage but also induces increased immune protein abundance.
Reposted by Félix Ramos-León
Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp 🦠🤯
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp | mBio
Alarmone synthetases are intracellular enzymes that promote bacterial survival by
responding to environmental stress. Although extracellular alarmone production has
been reported in Streptomyces, the ...
journals.asm.org
November 15, 2025 at 12:42 PM
Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp 🦠🤯
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
From Boyuan Wang and John Whitney
journals.asm.org/doi/10.1128/...
Reposted by Félix Ramos-León
Molecular insights into phycobilisome assembly pathway reveal crystalline bodies in cyanobacteria https://www.biorxiv.org/content/10.1101/2025.11.13.688327v1
November 14, 2025 at 4:17 AM
Molecular insights into phycobilisome assembly pathway reveal crystalline bodies in cyanobacteria https://www.biorxiv.org/content/10.1101/2025.11.13.688327v1
Reposted by Félix Ramos-León
Structure and encapsulation of carbonic anhydrase within the α-carboxysome from Halothiobacillus neapolitanus:
www.pnas.org/doi/10.1073/...
@selimlab.bsky.social Probably interesting for the SPP initiative.
@pnas.org
www.pnas.org/doi/10.1073/...
@selimlab.bsky.social Probably interesting for the SPP initiative.
@pnas.org
Structure and encapsulation of carbonic anhydrase within the α-carboxysome | PNAS
Carboxysomes in cyanobacteria and certain proteobacteria enable efficient CO2 fixation
by encapsulating ribulose-1,5-bisphosphate carboxylase/oxyge...
www.pnas.org
November 13, 2025 at 12:12 PM
Structure and encapsulation of carbonic anhydrase within the α-carboxysome from Halothiobacillus neapolitanus:
www.pnas.org/doi/10.1073/...
@selimlab.bsky.social Probably interesting for the SPP initiative.
@pnas.org
www.pnas.org/doi/10.1073/...
@selimlab.bsky.social Probably interesting for the SPP initiative.
@pnas.org
Reposted by Félix Ramos-León
Reposted by Félix Ramos-León
EVENT - Apply today for the John Innes/Rudjer Bošković: Applied #Molecular #Microbiology Summer School (Microbial Specialised Metabolites: Discovery, Biosynthesis and Function)
🗓️ 12 - 20 Sept 2026
📍Inter-University Centre, Dubrovnik, Croatia
Deadline: 23 Jan 2026
www.jic.ac.uk/training-car...
🗓️ 12 - 20 Sept 2026
📍Inter-University Centre, Dubrovnik, Croatia
Deadline: 23 Jan 2026
www.jic.ac.uk/training-car...
Applied Molecular Microbiology | John Innes Centre
John Innes/Rudjer Bošković – Summer Schools in Applied Molecular Microbiology Applications are invited for a summer school on Microbial Specialised Metabolites: Discovery…
www.jic.ac.uk
November 7, 2025 at 5:18 PM
EVENT - Apply today for the John Innes/Rudjer Bošković: Applied #Molecular #Microbiology Summer School (Microbial Specialised Metabolites: Discovery, Biosynthesis and Function)
🗓️ 12 - 20 Sept 2026
📍Inter-University Centre, Dubrovnik, Croatia
Deadline: 23 Jan 2026
www.jic.ac.uk/training-car...
🗓️ 12 - 20 Sept 2026
📍Inter-University Centre, Dubrovnik, Croatia
Deadline: 23 Jan 2026
www.jic.ac.uk/training-car...
Reposted by Félix Ramos-León
Heroic work by @bluebirdsjunk.bsky.social in pulling this mammoth study together
'Staphylococcus haemolyticus Population Genomics Provides Insights into Pathogenicity and Commensalism'
www.biorxiv.org/content/10.1...
'Staphylococcus haemolyticus Population Genomics Provides Insights into Pathogenicity and Commensalism'
www.biorxiv.org/content/10.1...
Staphylococcus haemolyticus Population Genomics Provides Insights into Pathogenicity and Commensalism
Staphylococcus haemolyticus is a common commensal bacterium but also an opportunistic pathogen, frequently implicated in bacteraemia and sepsis in preterm neonates and immunocompromised patients. Desp...
www.biorxiv.org
November 11, 2025 at 10:04 AM
Heroic work by @bluebirdsjunk.bsky.social in pulling this mammoth study together
'Staphylococcus haemolyticus Population Genomics Provides Insights into Pathogenicity and Commensalism'
www.biorxiv.org/content/10.1...
'Staphylococcus haemolyticus Population Genomics Provides Insights into Pathogenicity and Commensalism'
www.biorxiv.org/content/10.1...
Reposted by Félix Ramos-León
The cell envelope of diderm bacteria: a unified scaffold, not a stack of layers www.sciencedirect.com/science/arti... #jcampubs
November 10, 2025 at 4:39 PM
The cell envelope of diderm bacteria: a unified scaffold, not a stack of layers www.sciencedirect.com/science/arti... #jcampubs
Reposted by Félix Ramos-León
📢 Postdoc position: Biochemistry & Bacterial cell biology
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
November 10, 2025 at 6:15 PM
📢 Postdoc position: Biochemistry & Bacterial cell biology
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
Reposted by Félix Ramos-León
Our latest work is out in PNAS!🎉
We show that nonequilibrium polysome dynamics help drive sister chromosomes apart. The closing division septum also contributes via steric interactions.👇
www.pnas.org/doi/10.1073/...
#MicroSky #Microbiology #Biophysics #CellBiology
We show that nonequilibrium polysome dynamics help drive sister chromosomes apart. The closing division septum also contributes via steric interactions.👇
www.pnas.org/doi/10.1073/...
#MicroSky #Microbiology #Biophysics #CellBiology
November 9, 2025 at 2:05 AM
Our latest work is out in PNAS!🎉
We show that nonequilibrium polysome dynamics help drive sister chromosomes apart. The closing division septum also contributes via steric interactions.👇
www.pnas.org/doi/10.1073/...
#MicroSky #Microbiology #Biophysics #CellBiology
We show that nonequilibrium polysome dynamics help drive sister chromosomes apart. The closing division septum also contributes via steric interactions.👇
www.pnas.org/doi/10.1073/...
#MicroSky #Microbiology #Biophysics #CellBiology
Reposted by Félix Ramos-León
🚨 Publication alert! We are stoked to report the structural basis for activity of a novel class of antimicrobials targeting Gram positive priority pathogens in @natcomms.nature.com. There is something for everyone on this paper, and I will highlight a few things below 👇 1/9 doi.org/10.1038/s414...
A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens - Nature Communications
In this work, Urem et al. characterize the mode of action as well as mechanism of reduced susceptibility related to a class of antimicrobials that is in development for the treatment of infections wit...
doi.org
November 6, 2025 at 10:29 AM
🚨 Publication alert! We are stoked to report the structural basis for activity of a novel class of antimicrobials targeting Gram positive priority pathogens in @natcomms.nature.com. There is something for everyone on this paper, and I will highlight a few things below 👇 1/9 doi.org/10.1038/s414...
Reposted by Félix Ramos-León
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
August 31, 2025 at 6:44 PM
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Reposted by Félix Ramos-León
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
November 6, 2025 at 3:51 PM
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
Reposted by Félix Ramos-León
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...