Hanbin Lee
@epigenci.bsky.social
PhD Student at UMich Statistics.
The account mostly trashes about urban planning and infrastructure.
Probability, Statistics, and Evolutionary Biology.
https://hanbin973.github.io
The account mostly trashes about urban planning and infrastructure.
Probability, Statistics, and Evolutionary Biology.
https://hanbin973.github.io
Pinned
Hanbin Lee
@epigenci.bsky.social
· Jul 19
Modelling complex traits with ancestral recombination graphs https://www.biorxiv.org/content/10.1101/2025.07.14.664631v1
My talk from this year's probgen is finally out.
Where do linear mixed models and random effects come from?
They emerge from *mutations* on Ancestral Recombination Graphs.
Where do linear mixed models and random effects come from?
They emerge from *mutations* on Ancestral Recombination Graphs.
REGENERON LOL
I realize there's a collective shrug from the media but I personally find it so deeply shameful & so utterly repulsive that the Director of the NIH, Jay Bhattacharya, and the Commissioner of Food and Drugs, Martin Makary, are rubbing shoulders with RFK Jr's buddy Russell Brand
Russell Brand FFS
Russell Brand FFS
i’ve added alt text
November 12, 2025 at 8:23 PM
REGENERON LOL
Reposted by Hanbin Lee
The Bipartisan Infrastructure Law passed 4 years ago. In new research @urbaninstitute.bsky.social we study its effects.
US transport spending increased by 30%, but:
—Funding for non-highway projects flatlined
—Construction cost increases resulted in no actual increase in infrastructure
US transport spending increased by 30%, but:
—Funding for non-highway projects flatlined
—Construction cost increases resulted in no actual increase in infrastructure
Federal Infrastructure Spending on Transportation, Four Years after the Infrastructure Investment and Jobs Act
The Bipartisan Infrastructure Law is up for reauthorization in 2026. New analysis shows that the act increased spending on transportation infrastructure, but…
www.urban.org
November 12, 2025 at 5:32 PM
The Bipartisan Infrastructure Law passed 4 years ago. In new research @urbaninstitute.bsky.social we study its effects.
US transport spending increased by 30%, but:
—Funding for non-highway projects flatlined
—Construction cost increases resulted in no actual increase in infrastructure
US transport spending increased by 30%, but:
—Funding for non-highway projects flatlined
—Construction cost increases resulted in no actual increase in infrastructure
I just started to wonder what counts as "evolutionary" research. Wonder if there's a recent philological research on it.
November 12, 2025 at 5:40 PM
I just started to wonder what counts as "evolutionary" research. Wonder if there's a recent philological research on it.
Reposted by Hanbin Lee
Today is the day! Our reply to the two concurrent critiques (from the same set of authors) is now published in the journal Intelligence 🧵 1/
November 12, 2025 at 3:31 PM
Today is the day! Our reply to the two concurrent critiques (from the same set of authors) is now published in the journal Intelligence 🧵 1/
The site frequency spectrum can be viewed as a de Finetti representation of the genotype whose prior distribution is a Wright-Fisher process etc.
November 12, 2025 at 12:35 PM
The site frequency spectrum can be viewed as a de Finetti representation of the genotype whose prior distribution is a Wright-Fisher process etc.
Reposted by Hanbin Lee
📣 New NBER Working Paper out today 📣
"The Consequences of Faculty Sexual Misconduct"
Sarah Cohodes & Katherine Leu
"The Consequences of Faculty Sexual Misconduct"
Sarah Cohodes & Katherine Leu
November 10, 2025 at 1:49 PM
📣 New NBER Working Paper out today 📣
"The Consequences of Faculty Sexual Misconduct"
Sarah Cohodes & Katherine Leu
"The Consequences of Faculty Sexual Misconduct"
Sarah Cohodes & Katherine Leu
The Senate snowball is rolling
BIG NEWS: Congresswoman-elect Adelita Grijalva will finally be sworn in as a member of Congress tomorrow.
She is likely to be the 218th vote on the Epstein discharge petition, which would force a full vote to release the Epstein files in their entirety.
She is likely to be the 218th vote on the Epstein discharge petition, which would force a full vote to release the Epstein files in their entirety.
November 11, 2025 at 7:51 PM
The Senate snowball is rolling
Reposted by Hanbin Lee
An empirical approach to evaluating the prevalence of long-lived balancing selection in humans--and important limitations. Work by @hannahmm.bsky.social
November 11, 2025 at 7:14 PM
An empirical approach to evaluating the prevalence of long-lived balancing selection in humans--and important limitations. Work by @hannahmm.bsky.social
In terms of accountability, the dems don't look any better than the president. At least, it's possible to blame the president for what the admin is doing but whom to blame among the dems? It's like an endless bureaucratic chain of phone calls.
November 11, 2025 at 1:40 AM
In terms of accountability, the dems don't look any better than the president. At least, it's possible to blame the president for what the admin is doing but whom to blame among the dems? It's like an endless bureaucratic chain of phone calls.
Haseman-Elston regression is bit of an irony for massive biobanks because it throws away the statistical precision that was gained by accounting for more samples. You might be able to analyze more data, but you don't get more information out of it.
November 10, 2025 at 11:01 PM
Haseman-Elston regression is bit of an irony for massive biobanks because it throws away the statistical precision that was gained by accounting for more samples. You might be able to analyze more data, but you don't get more information out of it.
Reposted by Hanbin Lee
BREAKING: The Supreme Court rejects a call to overturn its decision legalizing same-sex marriage nationwide.
Supreme Court rejects call to overturn its decision legalizing same-sex marriage nationwide
The Supreme Court has rejected a call to overturn its landmark decision that legalized same-sex marriage nationwide.
bit.ly
November 10, 2025 at 2:41 PM
BREAKING: The Supreme Court rejects a call to overturn its decision legalizing same-sex marriage nationwide.
We have a term *live corpse*(산송장) in Korea. Pretty much applies to a group of people in DC tonight.
November 10, 2025 at 3:26 AM
We have a term *live corpse*(산송장) in Korea. Pretty much applies to a group of people in DC tonight.
Well American politics is certainly bad for mental sanity.
November 10, 2025 at 2:44 AM
Well American politics is certainly bad for mental sanity.
I LOVE Dobzhansky's famous quote and my research thesis is a minor twist of it but I recently came to hate that quote at the same time because it's being used as an excuse for doing bad research that involves some amount of evobio.
November 9, 2025 at 3:10 PM
I LOVE Dobzhansky's famous quote and my research thesis is a minor twist of it but I recently came to hate that quote at the same time because it's being used as an excuse for doing bad research that involves some amount of evobio.
Reposted by Hanbin Lee
Watson's misogynistic and racist comments not only embarrassed Watson and those associated with him, they also gave license to others to express similar views about the genetic inferiority of different groups of human beings and even acceptable steps for dealing this this.
10/13
10/13
November 9, 2025 at 1:33 AM
Watson's misogynistic and racist comments not only embarrassed Watson and those associated with him, they also gave license to others to express similar views about the genetic inferiority of different groups of human beings and even acceptable steps for dealing this this.
10/13
10/13
Yeah. Legacy admission is certainly correlated to this kind of stuff.
Breaking News: Cornell University reached an agreement with the Trump administration that would restore hundreds of millions in funding to the university. It's expected to pay a $30 million fine to the government and to invest $30 million in agriculture and farming programs.
Cornell Reaches Deal with Trump Administration to Restore Research Funds
The Ivy League university had warned of layoffs after the Trump administration stripped it of funds this year. The cuts were among the deepest in higher education.
nyti.ms
November 8, 2025 at 2:28 PM
Yeah. Legacy admission is certainly correlated to this kind of stuff.
The most remarkable price tag I've seen here in the US is the Ann Arbor - Detroit bus service that costs only 6$.
November 8, 2025 at 12:25 PM
The most remarkable price tag I've seen here in the US is the Ann Arbor - Detroit bus service that costs only 6$.
Reposted by Hanbin Lee
Gen AI and labor market signaling. Fascinating research: jesse-silbert.github.io/website/silb...
jesse-silbert.github.io
November 7, 2025 at 11:12 AM
Gen AI and labor market signaling. Fascinating research: jesse-silbert.github.io/website/silb...
I'm getting better everyday in cooking low-grade beef because anything better than that is easily 40$+ per package.
November 7, 2025 at 1:17 PM
I'm getting better everyday in cooking low-grade beef because anything better than that is easily 40$+ per package.
Reposted by Hanbin Lee
academic.oup.com/evlett/advan...
So exciting to see a new method to model the evolution of G (and P) matrices on phylogenies. Another step in the direction of trying to bridge micro and macroevolution
So exciting to see a new method to model the evolution of G (and P) matrices on phylogenies. Another step in the direction of trying to bridge micro and macroevolution
Multivariate trait evolution: models for the evolution of the quantitative genetic G-matrix on phylogenies
Abstract. Genetic covariance matrices (G-matrices) are a key focus for research and predictions from quantitative genetic evolutionary models of multiple t
academic.oup.com
November 7, 2025 at 8:58 AM
academic.oup.com/evlett/advan...
So exciting to see a new method to model the evolution of G (and P) matrices on phylogenies. Another step in the direction of trying to bridge micro and macroevolution
So exciting to see a new method to model the evolution of G (and P) matrices on phylogenies. Another step in the direction of trying to bridge micro and macroevolution
Pleiotropy and stabilizing selection are magic.
November 7, 2025 at 3:27 AM
Pleiotropy and stabilizing selection are magic.
Reposted by Hanbin Lee
@kjgilbert.bsky.social [https://kjgilbert.github.io/research/] has you covered:
November 4, 2025 at 6:50 PM
@kjgilbert.bsky.social [https://kjgilbert.github.io/research/] has you covered:
Reposted by Hanbin Lee
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
www.nature.com
November 7, 2025 at 12:05 AM
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Reposted by Hanbin Lee
An Imbens retrospective on experimental v. non-experimental methods — looks like a must-read www.aeaweb.org/articles?id=...
Comparing Experimental and Nonexperimental Methods: What Lessons Have We Learned Four Decades after LaLonde (1986)?
(Fall 2025) - In 1986, Robert LaLonde published an article comparing nonexperimental estimates to experimental benchmarks (LaLonde 1986). He concluded that the nonexperimental methods at the time coul...
www.aeaweb.org
November 6, 2025 at 4:47 PM
An Imbens retrospective on experimental v. non-experimental methods — looks like a must-read www.aeaweb.org/articles?id=...
I greatly appreciate Ochoa group's long-lasting effort to define the quantity first and trying to estimate it. They've been stressing that PCs are unnecessary in LMMs are in fact harmful in certain cases. I have some thoughts.
(1/n)
academic.oup.com/genetics/adv...
(1/n)
academic.oup.com/genetics/adv...
Kinship estimation bias carries over to heritability estimation bias using variance components
Abstract. Heritability is a fundamental parameter of diseases and other traits, quantifying the contribution of genetics to that trait. Kinship matrices ar
academic.oup.com
November 5, 2025 at 10:43 PM
I greatly appreciate Ochoa group's long-lasting effort to define the quantity first and trying to estimate it. They've been stressing that PCs are unnecessary in LMMs are in fact harmful in certain cases. I have some thoughts.
(1/n)
academic.oup.com/genetics/adv...
(1/n)
academic.oup.com/genetics/adv...