Brandon Yates, PhD
@dryatesb.bsky.social
Instructor| Harvard Med| Research: Aging, Critical Illness, Musculoskeletal, ADRD, Geroscience, and Exercise Phys
Pinned
Brandon Yates, PhD
@dryatesb.bsky.social
· Sep 12
Low intrinsic capacity is associated with a blunted exercise‐induced cognitive enhancement in physically active middle‐aged and older adults
INTRODUCTION The World Health Organization supports intrinsic capacity (IC) as a framework for assessing and monitoring an older person's cognitive health. Low IC is associated with higher dementia ...
alz-journals.onlinelibrary.wiley.com
Low intrinsic capacity is associated with a blunted exercise‐induced cognitive enhancement in physically active middle‐aged and older adults - Yates - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Brandon Yates, PhD
Low intrinsic capacity is associated with a blunted exercise‐induced cognitive enhancement in physically active middle‐aged and older adults - Yates - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Low intrinsic capacity is associated with a blunted exercise‐induced cognitive enhancement in physically active middle‐aged and older adults
INTRODUCTION The World Health Organization supports intrinsic capacity (IC) as a framework for assessing and monitoring an older person's cognitive health. Low IC is associated with higher dementia ...
alz-journals.onlinelibrary.wiley.com
September 12, 2025 at 10:55 PM
Low intrinsic capacity is associated with a blunted exercise‐induced cognitive enhancement in physically active middle‐aged and older adults - Yates - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Brandon Yates, PhD
Skeletal Muscle and Fat-Free Mass: Related but Distinct Concepts in Body Composition
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Skeletal Muscle and Fat-Free Mass: Related but Distinct Concepts in Body Composition
www.sciencedirect.com
September 12, 2025 at 7:20 PM
Skeletal Muscle and Fat-Free Mass: Related but Distinct Concepts in Body Composition
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Low intrinsic capacity is associated with a blunted exercise‐induced cognitive enhancement in physically active middle‐aged and older adults - Yates - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Low intrinsic capacity is associated with a blunted exercise‐induced cognitive enhancement in physically active middle‐aged and older adults
INTRODUCTION The World Health Organization supports intrinsic capacity (IC) as a framework for assessing and monitoring an older person's cognitive health. Low IC is associated with higher dementia ...
alz-journals.onlinelibrary.wiley.com
September 12, 2025 at 10:55 PM
Low intrinsic capacity is associated with a blunted exercise‐induced cognitive enhancement in physically active middle‐aged and older adults - Yates - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Brandon Yates, PhD
Please repost!
We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky
We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky
Tenure-track Faculty Position in Biomechanics (Open Rank), University of Michigan, Ann Arbor, MI, USA -
Biomch-L
The School of Kinesiology (http://kines.umich.edu) at the University of Michigan invites applications and nominations for a tenure-track faculty position at the level of Assistant Professor, Associate...
biomch-l.isbweb.org
August 28, 2025 at 9:44 PM
Please repost!
We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky
We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky
Reposted by Brandon Yates, PhD
Intramuscular adipose tissue restricts functional muscle recovery
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Intramuscular adipose tissue restricts functional muscle recovery
Norris et al. demonstrate the detrimental role of intramuscular adipose tissue (IMAT)
on muscle regeneration. Following injury, IMAT inhibition enhances muscle regeneration
by increasing myofiber dens...
www.cell.com
July 17, 2025 at 5:35 PM
Intramuscular adipose tissue restricts functional muscle recovery
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Brandon Yates, PhD
Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
JCI Insight -
Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions
insight.jci.org
July 16, 2025 at 5:50 PM
Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Reposted by Brandon Yates, PhD
#Exercise continues to be the best medicine. A personalized exercise therapy and self-management support program is more effective than usual care alone in improving health-related quality of life at 12 months in adults with multimorbidity @naturemedicine.bsky.social www.nature.com/articles/s41...
Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial - Nature Medicine
The authors report findings from the MOBILIZE trial, which found that exercise therapy and self-management support improved patient-reported quality of life in individuals with multiple chronic condit...
www.nature.com
June 30, 2025 at 11:10 AM
#Exercise continues to be the best medicine. A personalized exercise therapy and self-management support program is more effective than usual care alone in improving health-related quality of life at 12 months in adults with multimorbidity @naturemedicine.bsky.social www.nature.com/articles/s41...
Reposted by Brandon Yates, PhD
🧪 Check out our new publication @ismcopenhagen.bsky.social highlighting important considerations for using CAF as a biomarker of muscle wasting, lead by 1st author Casper Soendenbroe 💪
⚠️Exercise timing and medication matter.
onlinelibrary.wiley.com/doi/10.1002/...
⚠️Exercise timing and medication matter.
onlinelibrary.wiley.com/doi/10.1002/...
Serum C‐Terminal Agrin Fragment With Acute and Long‐Term Exercise and Angiotensin II Type I Receptor Blockade
Background
Sarcopenia represents a major clinical and societal challenge facing rapidly aging populations. Accessible and specific biomarkers represent valuable tools, both in diagnosis and assessin.....
onlinelibrary.wiley.com
June 4, 2025 at 5:34 PM
🧪 Check out our new publication @ismcopenhagen.bsky.social highlighting important considerations for using CAF as a biomarker of muscle wasting, lead by 1st author Casper Soendenbroe 💪
⚠️Exercise timing and medication matter.
onlinelibrary.wiley.com/doi/10.1002/...
⚠️Exercise timing and medication matter.
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Brandon Yates, PhD
Lower minute-level physical activity is associated with higher odds of cognitive impairment in older adults
A&D: Transitional Research & Clinical Intervention reports activity variability could indicate cognitive health status #TRCI #AlzResearch
alz-journals.onlinelibrary.wiley.com/doi/full/10....
A&D: Transitional Research & Clinical Intervention reports activity variability could indicate cognitive health status #TRCI #AlzResearch
alz-journals.onlinelibrary.wiley.com/doi/full/10....
Activity variability: A novel physical activity metric and its association with cognitive impairment
INTRODUCTION Evidence suggests that engaging in a high volume of daily or weekly physical activity may reduce the risk of cognitive impairment due to Alzheimer's disease and related dementias (ADRD)...
alz-journals.onlinelibrary.wiley.com
April 24, 2025 at 2:58 PM
Lower minute-level physical activity is associated with higher odds of cognitive impairment in older adults
A&D: Transitional Research & Clinical Intervention reports activity variability could indicate cognitive health status #TRCI #AlzResearch
alz-journals.onlinelibrary.wiley.com/doi/full/10....
A&D: Transitional Research & Clinical Intervention reports activity variability could indicate cognitive health status #TRCI #AlzResearch
alz-journals.onlinelibrary.wiley.com/doi/full/10....
Metabolite signatures of chronological age, aging, survival, and longevity: Cell Reports www.cell.com/cell-reports...
Metabolite signatures of chronological age, aging, survival, and longevity
Metabolism plays a crucial role in both aging and aging-related diseases, but the
metabolites that serve as pivotal biomarkers of aging are not fully known. Sebastiani
et al. analyze metabolites in pl...
www.cell.com
April 12, 2025 at 9:04 PM
Metabolite signatures of chronological age, aging, survival, and longevity: Cell Reports www.cell.com/cell-reports...
Reposted by Brandon Yates, PhD
New @science.org
Discovery of a mechanism for cancer cachexia (components of severe apathy, depression) explained by a neuroimmune circuit
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Discovery of a mechanism for cancer cachexia (components of severe apathy, depression) explained by a neuroimmune circuit
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
April 10, 2025 at 6:21 PM
New @science.org
Discovery of a mechanism for cancer cachexia (components of severe apathy, depression) explained by a neuroimmune circuit
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Discovery of a mechanism for cancer cachexia (components of severe apathy, depression) explained by a neuroimmune circuit
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Brandon Yates, PhD
If you’re looking to boost your brain, start exercising! Studies show that 30-60 minutes of aerobic (cardio) exercise, 3-4 times per week, can lower your risk of developing Alzheimer’s disease and other dementias. Aerobic exercise increases your heart rate and enhances blood flow to the brain.
April 10, 2025 at 2:51 PM
If you’re looking to boost your brain, start exercising! Studies show that 30-60 minutes of aerobic (cardio) exercise, 3-4 times per week, can lower your risk of developing Alzheimer’s disease and other dementias. Aerobic exercise increases your heart rate and enhances blood flow to the brain.
Reposted by Brandon Yates, PhD
The metabolic drivers of interferon-gamma release: glycolysis and acetyl CoA
academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv...
The metabolic drivers of IFN-γ release: glycolysis and acetyl CoA ride in the front seat
Abstract. Interferon gamma (IFN-γ) is a pleotropic cytokine which is a central mediator of the immune response to pathogen infection, while also playing im
academic.oup.com
April 4, 2025 at 7:00 PM
The metabolic drivers of interferon-gamma release: glycolysis and acetyl CoA
academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv...
Reposted by Brandon Yates, PhD
Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community
Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia
www.nature.com/articles/s41...
Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia
www.nature.com/articles/s41...
Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community - Nature Medicine
In a community-based cohort of more than 2,000 older adults from Sweden, blood biomarkers for Alzheimer’s disease were able to predict dementia up to 16 years before disease onset.
www.nature.com
March 31, 2025 at 2:33 PM
Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community
Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia
www.nature.com/articles/s41...
Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia
www.nature.com/articles/s41...
Reposted by Brandon Yates, PhD
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research | Nature Metabolism
Great collaboration led by Satchin Panda and team! Happy to contribute.
Time to take timing into consideration!!
www.nature.com/articles/s42...
Great collaboration led by Satchin Panda and team! Happy to contribute.
Time to take timing into consideration!!
www.nature.com/articles/s42...
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism
This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...
www.nature.com
March 17, 2025 at 7:40 PM
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research | Nature Metabolism
Great collaboration led by Satchin Panda and team! Happy to contribute.
Time to take timing into consideration!!
www.nature.com/articles/s42...
Great collaboration led by Satchin Panda and team! Happy to contribute.
Time to take timing into consideration!!
www.nature.com/articles/s42...
Reposted by Brandon Yates, PhD
Higher levels of physical activity are linked to lower plasma p-Tau217 (blood biomarker for Alzheimer's disease) and better cognition
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Physical Activity, Alzheimer Plasma Biomarkers, and Cognition
This cross-sectional study examines associations among physical activity, plasma biomarkers, and cognition in a multicenter cohort of patients with and without cognitive impairment.
jamanetwork.com
March 5, 2025 at 4:16 PM
Higher levels of physical activity are linked to lower plasma p-Tau217 (blood biomarker for Alzheimer's disease) and better cognition
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Associations between moderate-to-vigorous physical activity, p-tau181, and cognition in healthy older adults with memory complaints: a secondary analysis from the MAPT - The Lancet Healthy Longevity www.thelancet.com/journals/lan...
Associations between moderate-to-vigorous physical activity, p-tau181, and cognition in healthy older adults with memory complaints: a secondary analysis from the MAPT
Our findings suggest that engaging in more moderate-to-vigorous physical activity
might help to slow the age-related neurodegenerative process, although p-tau pathophysiology
seems to mitigate the ben...
www.thelancet.com
February 25, 2025 at 8:31 PM
Associations between moderate-to-vigorous physical activity, p-tau181, and cognition in healthy older adults with memory complaints: a secondary analysis from the MAPT - The Lancet Healthy Longevity www.thelancet.com/journals/lan...
Ever wondered why exercise is associated with reduced depression?
Here I had the honor of highlighting a seminal finding where they showed how muscle health impacts depression.
Here I had the honor of highlighting a seminal finding where they showed how muscle health impacts depression.
New content online: Tryptophan metabolism, exercise and depression
Tryptophan metabolism, exercise and depression
Nature Reviews Endocrinology, Published online: 11 February 2025; doi:10.1038/s41574-025-01090-3Tryptophan metabolism, exercise and depression
www.nature.com
February 13, 2025 at 1:00 PM
Ever wondered why exercise is associated with reduced depression?
Here I had the honor of highlighting a seminal finding where they showed how muscle health impacts depression.
Here I had the honor of highlighting a seminal finding where they showed how muscle health impacts depression.
Reposted by Brandon Yates, PhD
NEWS&VIEWS | João V. Esteves & Kristin I. Stanford @osuwexmed.bsky.social
The authors discuss the two studies highlighting the dual role of a novel #myokine, #Feimin, in regulating #metabolism and #exercise 💪 🐭 👥
https://bit.ly/3CNZ6mE
The authors discuss the two studies highlighting the dual role of a novel #myokine, #Feimin, in regulating #metabolism and #exercise 💪 🐭 👥
https://bit.ly/3CNZ6mE
The dual role of feimin in metabolism and exercise - Nature Metabolism
Back-to-back studies present evidence that feimin, a myokine, regulates glucose homeostasis and exercise performance. The secretory and intracellular roles of feimin provide insights into potential therapies for metabolic disease as well as for improving exercise performance.
bit.ly
February 12, 2025 at 4:31 PM
NEWS&VIEWS | João V. Esteves & Kristin I. Stanford @osuwexmed.bsky.social
The authors discuss the two studies highlighting the dual role of a novel #myokine, #Feimin, in regulating #metabolism and #exercise 💪 🐭 👥
https://bit.ly/3CNZ6mE
The authors discuss the two studies highlighting the dual role of a novel #myokine, #Feimin, in regulating #metabolism and #exercise 💪 🐭 👥
https://bit.ly/3CNZ6mE
Poorer objective sleep quality and irregular sleep were associated with poorer functional capacity in older adults. academic.oup.com/sleep/advanc...
Associations between objectively measured sleep characteristics and six-minute walk distance in older adults: the Disparities in Sleep and Cognitive Outcomes (DISCO) study
AbstractStudy Objectives. A decline in physical functioning in older adults has been associated with a higher risk of chronic diseases. Subjective sleep di
academic.oup.com
February 5, 2025 at 9:24 PM
Poorer objective sleep quality and irregular sleep were associated with poorer functional capacity in older adults. academic.oup.com/sleep/advanc...
Reposted by Brandon Yates, PhD
An immunome in 550 older adults and young adult controls demonstrated age-related changes at high-resolution along with some unique immune signatures
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits
This study provides one of the most comprehensive immune profiles of elderly individuals,
uncovering high-resolution immune changes associated with aging. Our findings highlight
clinically relevant im...
www.thelancet.com
January 27, 2025 at 11:40 PM
An immunome in 550 older adults and young adult controls demonstrated age-related changes at high-resolution along with some unique immune signatures
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
Reposted by Brandon Yates, PhD
Brain-derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice
faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com/doi/10.1096/...
Brain‐derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice
This study investigated BDNF's role in skeletal muscle adaptations to aerobic exercise in mice. It examined acute and chronic exercise effects on BDNF response and compared chronic BDNF treatment to ...
faseb.onlinelibrary.wiley.com
January 25, 2025 at 6:31 PM
Brain-derived neurotrophic factor drives muscle adaptation similar to aerobic training in mice
faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com/doi/10.1096/...
