Prof Deepak Modi
@drdeepaknmodi.bsky.social
Faculty at ICMR-NIRRCH 🇮🇳 Developmental biologist, embryo implantation, placentation and sex determination
We also develop organ on chip and organoids models of ♀️ rep tract and placenta
#womenshealth #gender #hoxgenes
🏳️🌈
We also develop organ on chip and organoids models of ♀️ rep tract and placenta
#womenshealth #gender #hoxgenes
🏳️🌈
Thrilled to share our discovery on the genetic switch that creates a hybrid EMT state for embryo implantation.
This work has broad implications as it explains control of physiologic EMT in adult tissues and it also shows that HOX genes have bifunctional roles
www.nature.com/articles/s41...
This work has broad implications as it explains control of physiologic EMT in adult tissues and it also shows that HOX genes have bifunctional roles
www.nature.com/articles/s41...
HOXA10-TWIST2 antagonism drives partial epithelial-to-mesenchymal transition for embryo implantation - Cell Death Discovery
Cell Death Discovery - HOXA10-TWIST2 antagonism drives partial epithelial-to-mesenchymal transition for embryo implantation
www.nature.com
November 14, 2025 at 12:43 PM
Thrilled to share our discovery on the genetic switch that creates a hybrid EMT state for embryo implantation.
This work has broad implications as it explains control of physiologic EMT in adult tissues and it also shows that HOX genes have bifunctional roles
www.nature.com/articles/s41...
This work has broad implications as it explains control of physiologic EMT in adult tissues and it also shows that HOX genes have bifunctional roles
www.nature.com/articles/s41...
Super tired after a 3 day long marathon meeting ... But it's satisfying when the job gets done
November 12, 2025 at 2:05 PM
Super tired after a 3 day long marathon meeting ... But it's satisfying when the job gets done
An AI based tool that predicts assisted reproduction outcomes in infertile men with a genetic cause
#infertility #ivf #male
link.springer.com/article/10.1...
#infertility #ivf #male
link.springer.com/article/10.1...
FertilitY Predictor—a machine learning-based web tool for the prediction of assisted reproduction outcomes in men with Y chromosome microdeletions - Journal of Assisted Reproduction and Genetics
Purpose Y chromosome microdeletions (YCMD) are a common cause of azoospermia and oligozoospermia in men. Herein, we developed a machine learning-based web tool to predict sperm retrieval rates and suc...
link.springer.com
November 8, 2025 at 6:00 AM
An AI based tool that predicts assisted reproduction outcomes in infertile men with a genetic cause
#infertility #ivf #male
link.springer.com/article/10.1...
#infertility #ivf #male
link.springer.com/article/10.1...
This is super amazing. The choices that we make are innate to us, social determinants shape that further.
This study in show that genes influence the tendencies, which through social and structural context, determine our educational choices and outcomes.
www.nature.com/articles/s41...
This study in show that genes influence the tendencies, which through social and structural context, determine our educational choices and outcomes.
www.nature.com/articles/s41...
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
www.nature.com
November 6, 2025 at 4:18 AM
This is super amazing. The choices that we make are innate to us, social determinants shape that further.
This study in show that genes influence the tendencies, which through social and structural context, determine our educational choices and outcomes.
www.nature.com/articles/s41...
This study in show that genes influence the tendencies, which through social and structural context, determine our educational choices and outcomes.
www.nature.com/articles/s41...
Organ on chip require close coordination of engineers & biologists. Discussed the evolution of this collaboration leding to placenta on chip development with Prof Abhijit Majumder at IIT B. Keeping attention of engeneering and getting them interested in biological nuances is a challange but exciting
November 5, 2025 at 4:28 AM
Organ on chip require close coordination of engineers & biologists. Discussed the evolution of this collaboration leding to placenta on chip development with Prof Abhijit Majumder at IIT B. Keeping attention of engeneering and getting them interested in biological nuances is a challange but exciting
I hate mondsys to begin with but the end of the day is satisfying as I spend the rest of the day looking the work done by my labmates and help them to make the plan for the comming week.
November 3, 2025 at 5:01 PM
I hate mondsys to begin with but the end of the day is satisfying as I spend the rest of the day looking the work done by my labmates and help them to make the plan for the comming week.
I am sure the Indians will get this joke
It doesn't matter what you eat between Dhanteras and Bhai Dhooj
What matters is what you eat between Bhai Dhooj and Dhanteras
#DiwaliMasti
😬😬😀😀
Ps Copied as recived
It doesn't matter what you eat between Dhanteras and Bhai Dhooj
What matters is what you eat between Bhai Dhooj and Dhanteras
#DiwaliMasti
😬😬😀😀
Ps Copied as recived
November 3, 2025 at 6:12 AM
I am sure the Indians will get this joke
It doesn't matter what you eat between Dhanteras and Bhai Dhooj
What matters is what you eat between Bhai Dhooj and Dhanteras
#DiwaliMasti
😬😬😀😀
Ps Copied as recived
It doesn't matter what you eat between Dhanteras and Bhai Dhooj
What matters is what you eat between Bhai Dhooj and Dhanteras
#DiwaliMasti
😬😬😀😀
Ps Copied as recived
Reposted by Prof Deepak Modi
A high-throughput cell-based platform for Rhinovirus C research and antiviral drug discovery
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A high-throughput cell-based platform for Rhinovirus C research and antiviral drug discovery
Rhinoviruses (RVs) are the most common cause of upper respiratory infections, yet RV-C is particularly associated with severe respiratory disease, including exacerbations of asthma and chronic obstruc...
www.biorxiv.org
November 2, 2025 at 7:38 AM
A high-throughput cell-based platform for Rhinovirus C research and antiviral drug discovery
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Prof Deepak Modi
Kids exposed to COVID in utero may be at higher risk for autism, other brain problems www.cidrap.umn.edu/covid-19/kid...
Kids exposed to COVID in utero may be at higher risk for autism, other brain problems
www.cidrap.umn.edu
November 2, 2025 at 4:54 AM
Kids exposed to COVID in utero may be at higher risk for autism, other brain problems www.cidrap.umn.edu/covid-19/kid...
We wrote this review for medical students to summarise the diagnostic criteria and pathophysiology of #endometriosis
fertilityscienceresearch.org/a-primer-on-...
fertilityscienceresearch.org/a-primer-on-...
A Primer on Clinical Classification and Pathophysiology of Endometriosis
A Primer on Clinical Classification and Pathophysiology of Endometriosis
fertilityscienceresearch.org
November 2, 2025 at 1:49 PM
We wrote this review for medical students to summarise the diagnostic criteria and pathophysiology of #endometriosis
fertilityscienceresearch.org/a-primer-on-...
fertilityscienceresearch.org/a-primer-on-...
A lazy sunday and a talk on genetics of infertility is both exciting and boring
November 2, 2025 at 1:44 PM
A lazy sunday and a talk on genetics of infertility is both exciting and boring
Reposted by Prof Deepak Modi
Success. Nearly 259 Foldscope deployed in hands of unsuspecting candy crazy kids. Halloween is always more colorful with the microscopes - specially in a few weeks they could look at the micro-fauna of the teeth with so much sugar consumption.
November 1, 2025 at 10:10 AM
Success. Nearly 259 Foldscope deployed in hands of unsuspecting candy crazy kids. Halloween is always more colorful with the microscopes - specially in a few weeks they could look at the micro-fauna of the teeth with so much sugar consumption.
Reposted by Prof Deepak Modi
Revolutionize pancreatic cancer care through a human-centered design sprint, creating a seamless "one narrative" network that prioritizes patient context and accelerates diagnosis and tre...
🧵 Thread below
Full analysis: https://helixbrief.com/article/b7c077e7-adb2-4b1a-b7af-1d3e1177ef52
🧵 Thread below
Full analysis: https://helixbrief.com/article/b7c077e7-adb2-4b1a-b7af-1d3e1177ef52
November 1, 2025 at 8:35 PM
Revolutionize pancreatic cancer care through a human-centered design sprint, creating a seamless "one narrative" network that prioritizes patient context and accelerates diagnosis and tre...
🧵 Thread below
Full analysis: https://helixbrief.com/article/b7c077e7-adb2-4b1a-b7af-1d3e1177ef52
🧵 Thread below
Full analysis: https://helixbrief.com/article/b7c077e7-adb2-4b1a-b7af-1d3e1177ef52
Reposted by Prof Deepak Modi
#DBfeature 🐭
Wnt3a plays an important role in Wolffian duct development by regulating apicobasal polarity.
By Hayashi, S., Suzuki, H., Takada, S., & Takemoto, T.
doi.org/10.1016/j.yd...
Wnt3a plays an important role in Wolffian duct development by regulating apicobasal polarity.
By Hayashi, S., Suzuki, H., Takada, S., & Takemoto, T.
doi.org/10.1016/j.yd...
October 29, 2025 at 6:49 PM
#DBfeature 🐭
Wnt3a plays an important role in Wolffian duct development by regulating apicobasal polarity.
By Hayashi, S., Suzuki, H., Takada, S., & Takemoto, T.
doi.org/10.1016/j.yd...
Wnt3a plays an important role in Wolffian duct development by regulating apicobasal polarity.
By Hayashi, S., Suzuki, H., Takada, S., & Takemoto, T.
doi.org/10.1016/j.yd...
Reposted by Prof Deepak Modi
Back home after an exciting day at #THSTI listening to the outcomes and future projections of the #GARBH-INi program. Indias largest cohort that has recorded the perinatal and birth outcomes of pregnent women at a very high granularity integrated with multiomics readouts. A flagship program of #DBT
October 30, 2025 at 7:31 PM
Back home after an exciting day at #THSTI listening to the outcomes and future projections of the #GARBH-INi program. Indias largest cohort that has recorded the perinatal and birth outcomes of pregnent women at a very high granularity integrated with multiomics readouts. A flagship program of #DBT
Large Language Models Struggled in Responding to Menopause Questions
— The models performed better on symptom-related questions versus treatment-related ones
www.medpagetoday.com/meetingcover...
Of course, LLMs don't know much about female bodies.
— The models performed better on symptom-related questions versus treatment-related ones
www.medpagetoday.com/meetingcover...
Of course, LLMs don't know much about female bodies.
Large Language Models Struggled in Responding to Menopause Questions
The models performed better on symptom-related questions versus treatment-related ones
www.medpagetoday.com
October 30, 2025 at 7:20 PM
Reposted by Prof Deepak Modi
Infants with mannose-binding lectin (MBL) insufficiency face a higher risk of recurrent wheezing after severe RSV bronchiolitis, linked to Haemophilus airway colonization and weaker immun...
🧵 Thread below
Full analysis: https://helixbrief.com/article/772e99a1-3021-4989-ac93-c4fb570a75c6
🧵 Thread below
Full analysis: https://helixbrief.com/article/772e99a1-3021-4989-ac93-c4fb570a75c6
October 30, 2025 at 3:58 PM
Infants with mannose-binding lectin (MBL) insufficiency face a higher risk of recurrent wheezing after severe RSV bronchiolitis, linked to Haemophilus airway colonization and weaker immun...
🧵 Thread below
Full analysis: https://helixbrief.com/article/772e99a1-3021-4989-ac93-c4fb570a75c6
🧵 Thread below
Full analysis: https://helixbrief.com/article/772e99a1-3021-4989-ac93-c4fb570a75c6
Look who called me 🤣🤣🤣
October 29, 2025 at 2:45 PM
Look who called me 🤣🤣🤣
Reposted by Prof Deepak Modi
📣 New preprint! Stoked to share a fantastic collaboration with @campaslab.bsky.social!
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 3:34 PM
📣 New preprint! Stoked to share a fantastic collaboration with @campaslab.bsky.social!
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos.
Check out the 🧵 👇
@mpi-cbg.de @poldresden.bsky.social
Here is a review, where we summarised role of HOX genes in adult tissue
From it's role in segmentation, in adult uterus it acts like a signalling regulator and its disruption is associated with endometrial pathologies like #endometriosis and endometrial #cancer.
link.springer.com/article/10.1...
From it's role in segmentation, in adult uterus it acts like a signalling regulator and its disruption is associated with endometrial pathologies like #endometriosis and endometrial #cancer.
link.springer.com/article/10.1...
Role of HOXA10 in pathologies of the endometrium - Reviews in Endocrine and Metabolic Disorders
HOXA10 belongs to the homeobox gene family and is essential for uterine biogenesis, endometrial receptivity, embryo implantation, and stromal cell decidualization. Available evidence suggests that the...
link.springer.com
October 27, 2025 at 6:48 PM
Here is a review, where we summarised role of HOX genes in adult tissue
From it's role in segmentation, in adult uterus it acts like a signalling regulator and its disruption is associated with endometrial pathologies like #endometriosis and endometrial #cancer.
link.springer.com/article/10.1...
From it's role in segmentation, in adult uterus it acts like a signalling regulator and its disruption is associated with endometrial pathologies like #endometriosis and endometrial #cancer.
link.springer.com/article/10.1...
Genetically controlled induction of menstruation in the mouse is a game changer for both basic and applied research in endometrium and it's disorders.
A really amazing model and a great resource
Kudos @cagricevrim.bsky.social and team for this.
Very excited
www.biorxiv.org/content/10.1...
A really amazing model and a great resource
Kudos @cagricevrim.bsky.social and team for this.
Very excited
www.biorxiv.org/content/10.1...
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 27, 2025 at 6:08 PM
Genetically controlled induction of menstruation in the mouse is a game changer for both basic and applied research in endometrium and it's disorders.
A really amazing model and a great resource
Kudos @cagricevrim.bsky.social and team for this.
Very excited
www.biorxiv.org/content/10.1...
A really amazing model and a great resource
Kudos @cagricevrim.bsky.social and team for this.
Very excited
www.biorxiv.org/content/10.1...
Reposted by Prof Deepak Modi
My institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15.
www.mskcc.org/research/ski...
www.mskcc.org/research/ski...
Faculty Positions
The Sloan Kettering Institute is seeking innovative scientists to join our faculty.
www.mskcc.org
October 27, 2025 at 2:45 PM
My institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15.
www.mskcc.org/research/ski...
www.mskcc.org/research/ski...
Reposted by Prof Deepak Modi
A 3D endometrium-on-a-chip reveals the role of conceptus-derived factors CAPG and PDI in conceptus-endometrial communication https://www.biorxiv.org/content/10.1101/2024.09.04.611146v1
A 3D endometrium-on-a-chip reveals the role of conceptus-derived factors CAPG and PDI in conceptus-endometrial communication https://www.biorxiv.org/content/10.1101/2024.09.04.611146v1
Early embryo loss affects all mammalian species, including humans and agriculturally important food-
www.biorxiv.org
September 5, 2024 at 5:18 AM
A 3D endometrium-on-a-chip reveals the role of conceptus-derived factors CAPG and PDI in conceptus-endometrial communication https://www.biorxiv.org/content/10.1101/2024.09.04.611146v1