Doudna Lab
@doudna-lab.bsky.social
News from Jennifer Doudna's lab at UC Berkeley, Innovative Genomics Institute. Tweets from lab members and not Jennifer Doudna unless signed JD. Tweets represent personal views only.
doudnalab.org
doudnalab.org
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New in Science Magazine from the Doudna Lab and first author Owen Tuck: Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Read here: https://ow.ly/pIWQ50XtEtM
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin-like protease repeatedly acquired by multiple, ...
ow.ly
November 18, 2025 at 5:45 PM
New in Science Magazine from the Doudna Lab and first author Owen Tuck: Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Read here: https://ow.ly/pIWQ50XtEtM
Reposted by Doudna Lab
New from the @doudna-lab.bsky.social and first author @owentuck.bsky.social!
Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...
www.science.org
November 14, 2025 at 12:27 AM
New from the @doudna-lab.bsky.social and first author @owentuck.bsky.social!
Reposted by Doudna Lab
Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...
www.science.org
November 13, 2025 at 10:15 PM
Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/...
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social
Reposted by Doudna Lab
I'm hiring a lab technician to help me explore some exciting new questions about virus-host interactions! Biochemistry and/or mammalian cell culture experience is desired.
October 17, 2025 at 7:58 PM
I'm hiring a lab technician to help me explore some exciting new questions about virus-host interactions! Biochemistry and/or mammalian cell culture experience is desired.
Apply to work with us! careerspub.universityofcalifornia.edu/psc/ucm/EMPL...
An error has occurred.
careerspub.universityofcalifornia.edu
October 17, 2025 at 7:57 PM
Apply to work with us! careerspub.universityofcalifornia.edu/psc/ucm/EMPL...
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Thank you to the Blavatnik Family Foundation and The New York Academy of Sciences for honoring our research uniting human innate immunity and bacterial anti-phage defense at @danafarber.bsky.social @harvardmicro.bsky.social @harvard.edu
bit.ly/4pZUDkF
blavatnikawards.org/news/items/t...
bit.ly/4pZUDkF
blavatnikawards.org/news/items/t...
October 9, 2025 at 4:44 PM
Thank you to the Blavatnik Family Foundation and The New York Academy of Sciences for honoring our research uniting human innate immunity and bacterial anti-phage defense at @danafarber.bsky.social @harvardmicro.bsky.social @harvard.edu
bit.ly/4pZUDkF
blavatnikawards.org/news/items/t...
bit.ly/4pZUDkF
blavatnikawards.org/news/items/t...
Congratulations to my colleagues Omar Yaghi and John Clarke — the two latest UC Berkeley Nobel Laureates! Omar’s development of metal-organic frameworks changed the way we capture carbon, store energy, and harvest water from desert air. shorturl.at/GpBsu 1/2
UC Berkeley’s Omar Yaghi shares 2025 Nobel Prize in Chemistry - Berkeley News
Yaghi created a field called reticular chemistry, which involves stitching together molecular building blocks to form porous structures — metal-organic frameworks (MOFs) — with myriad applications.
shorturl.at
October 8, 2025 at 6:36 PM
Congratulations to my colleagues Omar Yaghi and John Clarke — the two latest UC Berkeley Nobel Laureates! Omar’s development of metal-organic frameworks changed the way we capture carbon, store energy, and harvest water from desert air. shorturl.at/GpBsu 1/2
"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
October 2, 2025 at 1:47 PM
"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
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then turned that knowledge into a global movement for conservation. Her work made it impossible to separate what we learn from our obligation to protect it. Generations of researchers have tried to follow that example." 2/2
October 2, 2025 at 4:51 AM
then turned that knowledge into a global movement for conservation. Her work made it impossible to separate what we learn from our obligation to protect it. Generations of researchers have tried to follow that example." 2/2
Reposted by Doudna Lab
From IGI Founder Jennifer Doudna: "Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats... 1/2
October 2, 2025 at 4:51 AM
From IGI Founder Jennifer Doudna: "Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats... 1/2
Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity.
Check out this work co-led with @benadler.bsky.social here:
www.nature.com/articles/s41...
Check out this work co-led with @benadler.bsky.social here:
www.nature.com/articles/s41...
A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
www.nature.com
October 2, 2025 at 3:25 AM
Reposted by Doudna Lab
Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today! www.nature.com/articles/s41...
The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature
The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.
www.nature.com
October 1, 2025 at 4:05 PM
Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today! www.nature.com/articles/s41...
Reposted by Doudna Lab
Bacteria use a decoy defense molecule to set a trap for viruses @doudna-lab.bsky.social @ucberkeleyofficial.bsky.social @ucirvine.bsky.social @aaronwhiteley.bsky.social @colorado.edu @aesully98.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 1, 2025 at 5:34 PM
Bacteria use a decoy defense molecule to set a trap for viruses @doudna-lab.bsky.social @ucberkeleyofficial.bsky.social @ucirvine.bsky.social @aaronwhiteley.bsky.social @colorado.edu @aesully98.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Doudna Lab
Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
www.nature.com
October 1, 2025 at 5:57 PM
Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
Reposted by Doudna Lab
Out today in @nature.com, a new paper from @doudna-lab.bsky.social lab, co-first authors @erinedoherty.bsky.social + @benadler.bsky.social and collaborators at @ucsandiego.bsky.social unveils a powerful new defense strategy in the arms war between viruses + microbes. Read here: ow.ly/mPQI50X5g68
October 1, 2025 at 7:47 PM
Out today in @nature.com, a new paper from @doudna-lab.bsky.social lab, co-first authors @erinedoherty.bsky.social + @benadler.bsky.social and collaborators at @ucsandiego.bsky.social unveils a powerful new defense strategy in the arms war between viruses + microbes. Read here: ow.ly/mPQI50X5g68
Congrats to Doudna lab postdoc @erinedoherty.bsky.social! 🎊
Congrats to our 2025 MCB Outstanding Postdoc Award recipients who are being honored for their excellence in research, leadership, and service! 👏🎉Erin Doherty @erinedoherty.bsky.social, Kevin Eislmayr, Naohiro Kuwayama, & Joseph Lobel
mcb.berkeley.edu/news-and-eve...
mcb.berkeley.edu/news-and-eve...
September 30, 2025 at 5:43 PM
Congrats to Doudna lab postdoc @erinedoherty.bsky.social! 🎊
New pre-print from Doudna lab members @erinedoherty.bsky.social & @jnoms.bsky.social ✨
Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.
Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.
Excited to share our new preprint co-led by @jnoms.bsky.social!
Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
Divergent viral phosphodiesterases for immune signaling evasion
Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...
www.biorxiv.org
August 22, 2025 at 7:36 PM
New pre-print from Doudna lab members @erinedoherty.bsky.social & @jnoms.bsky.social ✨
Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.
Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.
Reposted by Doudna Lab
@jenniferdoudna.bsky.social @doudna-lab.bsky.social
talks about the history and future of #CRISPR with Cleo Abram! Check out the interview: www.youtube.com/watch?v=0OXa...
talks about the history and future of #CRISPR with Cleo Abram! Check out the interview: www.youtube.com/watch?v=0OXa...
August 21, 2025 at 6:45 PM
@jenniferdoudna.bsky.social @doudna-lab.bsky.social
talks about the history and future of #CRISPR with Cleo Abram! Check out the interview: www.youtube.com/watch?v=0OXa...
talks about the history and future of #CRISPR with Cleo Abram! Check out the interview: www.youtube.com/watch?v=0OXa...
Reposted by Doudna Lab
In a recent paper, IGI's @jenniferdoudna.bsky.social @doudna-lab.bsky.social and Jill Banfield @banfieldlab.bsky.social collaborate with UCLA's @jacobsenucla.bsky.social to create a new, tiny #CRISPR tool for quicker, easier plant genome editing! Read more in this Q&A with Steve: ow.ly/6Szs50VGElf
Tiny CRISPR Tool Opens the Door to Faster, Simpler Plant Genome Editing
Tiny CRISPR Tool Opens the Door to Faster, Simpler Plant Genome Editing - Innovative Genomics Institute (IGI)
ow.ly
July 31, 2025 at 11:17 PM
In a recent paper, IGI's @jenniferdoudna.bsky.social @doudna-lab.bsky.social and Jill Banfield @banfieldlab.bsky.social collaborate with UCLA's @jacobsenucla.bsky.social to create a new, tiny #CRISPR tool for quicker, easier plant genome editing! Read more in this Q&A with Steve: ow.ly/6Szs50VGElf
‼️ New pre-print from co-leads @owentuck.bsky.social and Jason Hu! Check out this fascinating example of how coevolution enables defense system innovation.
Excited to finally share this work!
We noticed a pair of genes - a nuclease and a protease - shuffles between antiviral systems. We show how proteolysis activates the nuclease, triggering defense in known and unknown immune contexts.
tinyurl.com/2uwwy4ty
We noticed a pair of genes - a nuclease and a protease - shuffles between antiviral systems. We show how proteolysis activates the nuclease, triggering defense in known and unknown immune contexts.
tinyurl.com/2uwwy4ty
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...
tinyurl.com
July 29, 2025 at 9:18 PM
‼️ New pre-print from co-leads @owentuck.bsky.social and Jason Hu! Check out this fascinating example of how coevolution enables defense system innovation.
Reposted by Doudna Lab
A new Pediatric Center for CRISPR Cures builds on the recent saved life of Baby KJ, who expeditiously had bespoke in vivo base genome editing
@jenniferdoudna.bsky.social @doudna-lab.bsky.social
@innovativegenomics.bsky.social
@chanzuckerberg.bsky.social
erictopol.substack.com/p/new-center...
@jenniferdoudna.bsky.social @doudna-lab.bsky.social
@innovativegenomics.bsky.social
@chanzuckerberg.bsky.social
erictopol.substack.com/p/new-center...
July 8, 2025 at 1:33 PM
A new Pediatric Center for CRISPR Cures builds on the recent saved life of Baby KJ, who expeditiously had bespoke in vivo base genome editing
@jenniferdoudna.bsky.social @doudna-lab.bsky.social
@innovativegenomics.bsky.social
@chanzuckerberg.bsky.social
erictopol.substack.com/p/new-center...
@jenniferdoudna.bsky.social @doudna-lab.bsky.social
@innovativegenomics.bsky.social
@chanzuckerberg.bsky.social
erictopol.substack.com/p/new-center...
Reposted by Doudna Lab
“What we’ve done here is uncover the secret sauce that makes typical #Cas9 — the original Nobel molecule — so efficient and precise." – Co-first author Honglue Shi of the @doudna-lab.bsky.social on his recent paper in Molecular Cell
Read here: innovativegenomics.org/uncovering-c...
Read here: innovativegenomics.org/uncovering-c...
June 24, 2025 at 5:16 PM
“What we’ve done here is uncover the secret sauce that makes typical #Cas9 — the original Nobel molecule — so efficient and precise." – Co-first author Honglue Shi of the @doudna-lab.bsky.social on his recent paper in Molecular Cell
Read here: innovativegenomics.org/uncovering-c...
Read here: innovativegenomics.org/uncovering-c...
Reposted by Doudna Lab
Thanks to the BBC's The Inquiry program for great conversations with IGI's @jenniferdoudna.bsky.social @doudna-lab.bsky.social and @urnov.bsky.social about Baby KJ, #CRISPR on-demand, and the future of personalized medicine!
Listen here: www.bbc.com/audio/play/w...
Photo credit: TODAY
Listen here: www.bbc.com/audio/play/w...
Photo credit: TODAY
June 12, 2025 at 9:20 PM
Thanks to the BBC's The Inquiry program for great conversations with IGI's @jenniferdoudna.bsky.social @doudna-lab.bsky.social and @urnov.bsky.social about Baby KJ, #CRISPR on-demand, and the future of personalized medicine!
Listen here: www.bbc.com/audio/play/w...
Photo credit: TODAY
Listen here: www.bbc.com/audio/play/w...
Photo credit: TODAY
Registration is open for the 2025 Computational Structural Virology Symposium, featuring Doudna lab postdoc @jnoms.bsky.social!
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
June 12, 2025 at 8:34 PM
Registration is open for the 2025 Computational Structural Virology Symposium, featuring Doudna lab postdoc @jnoms.bsky.social!
Reposted by Doudna Lab
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
June 12, 2025 at 8:31 PM
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!