Edna Ondari
@dnapluse.bsky.social
Reposted by Edna Ondari
Adding first author of the preprint @grahamheieis.bsky.social
Amitava Sinha & @weichhartlab.bsky.social from @preprintclub.bsky.social discuss a @biorxiv-immuno.bsky.social #preprint by Heieis et al. that identifies O-GlcNAcylation as a metabolic regulator of cell cycle, enabling macrophage tissue-residency and IL-4-driven alternative activation
O-GlcNAcylation shapes macrophage tissue residency and alternative activation
Nature Reviews Immunology - A preprint by Heieis et al. shows that O-GlcNAcylation regulates the alternative activation of macrophages and their tissue residency through effects on cell cycle and...
rdcu.be
February 11, 2026 at 10:15 AM
Adding first author of the preprint @grahamheieis.bsky.social
Reposted by Edna Ondari
ICYMI Out Now! Addendum: ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro #MicroSky
Addendum: ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro
Nature Microbiology, Published online: 06 February 2026; doi:10.1038/s41564-026-02267-wAddendum: ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro
go.nature.com
February 9, 2026 at 11:45 PM
ICYMI Out Now! Addendum: ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro #MicroSky
Reposted by Edna Ondari
"Ethical research requires that participant safety remains central, not subordinate to hypothesis testing....Vulnerability should never be seen as an opportunity to advance research at the expense of those it claims to serve." @natureportfolio.nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Whose ethics govern global health research?
Ethical research must not exploit scarcity as an experimental variable.
www.nature.com
February 5, 2026 at 1:57 PM
"Ethical research requires that participant safety remains central, not subordinate to hypothesis testing....Vulnerability should never be seen as an opportunity to advance research at the expense of those it claims to serve." @natureportfolio.nature.com
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Edna Ondari
What does competition for iron look like for pathogens in different environments? We had the chance to contribute to this great paper looking at Salmonella in the gut with the Cunrath Lab (UoStrasbourg). Salmonella relies on siderophore exploitation at low pH url: academic.oup.com/microlife/ar...
Salmonella relies on siderophore exploitation at low pH
Abstract. Salmonella enterica, a prominent enteric pathogen, employs sophisticated iron acquisition mechanisms to overcome host-imposed iron limitation, no
academic.oup.com
February 5, 2026 at 7:39 PM
What does competition for iron look like for pathogens in different environments? We had the chance to contribute to this great paper looking at Salmonella in the gut with the Cunrath Lab (UoStrasbourg). Salmonella relies on siderophore exploitation at low pH url: academic.oup.com/microlife/ar...
Reposted by Edna Ondari
#NatMicroPicks
More than just pumps? 🦠💊
Bacterial efflux pumps not only block drug entry but also disrupt intracellular drug–target interactions by preventing repeated drug rebinding
#MicroSky
www.science.org/doi/10.1126/...
More than just pumps? 🦠💊
Bacterial efflux pumps not only block drug entry but also disrupt intracellular drug–target interactions by preventing repeated drug rebinding
#MicroSky
www.science.org/doi/10.1126/...
Efflux pumps control intracellular drug-target kinetics by limiting rebinding in bacteria
Efflux pumps disrupt antibiotic rebinding inside bacterial cells, amplifying multidrug resistance.
www.science.org
February 7, 2026 at 5:51 PM
#NatMicroPicks
More than just pumps? 🦠💊
Bacterial efflux pumps not only block drug entry but also disrupt intracellular drug–target interactions by preventing repeated drug rebinding
#MicroSky
www.science.org/doi/10.1126/...
More than just pumps? 🦠💊
Bacterial efflux pumps not only block drug entry but also disrupt intracellular drug–target interactions by preventing repeated drug rebinding
#MicroSky
www.science.org/doi/10.1126/...
Reposted by Edna Ondari
Out Now! Addendum: ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro #MicroSky
Addendum: ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro
Nature Microbiology, Published online: 06 February 2026; doi:10.1038/s41564-026-02267-wAddendum: ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro
go.nature.com
February 6, 2026 at 11:43 PM
Out Now! Addendum: ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro #MicroSky
Reposted by Edna Ondari
Hospital sink biofilms harbor multidrug-resistant gram-negative organisms capable of disseminating beyond the drain. This talk examines the microbiology, transmission pathways, and infection prevention challenges posed by sink-associated reservoirs in healthcare settings. youtu.be/rREHiXMX9W4
What’s Lurking in Your Sink Faucet?
YouTube video by American Society for Microbiology
youtu.be
February 6, 2026 at 10:26 PM
Hospital sink biofilms harbor multidrug-resistant gram-negative organisms capable of disseminating beyond the drain. This talk examines the microbiology, transmission pathways, and infection prevention challenges posed by sink-associated reservoirs in healthcare settings. youtu.be/rREHiXMX9W4
Reposted by Edna Ondari
ICYMI: Out now! Out Now! Quantifying the real-world impact of antibiotic use and genetic determinants of resistance on gonococcal dynamics
Quantifying the real-world impact of antibiotic use and genetic determinants of resistance on gonococcal dynamics
Nature Microbiology, Published online: 30 January 2026; doi:10.1038/s41564-025-02235-wPhylodynamic modelling shows how the changing antibiotic landscape and genetic determinants of resistance shape real-world gonococcal dynamics. Experiments validated that determinants with identical resistance phenotype differed in impact on fitness.
go.nature.com
February 4, 2026 at 7:11 PM
ICYMI: Out now! Out Now! Quantifying the real-world impact of antibiotic use and genetic determinants of resistance on gonococcal dynamics
Reposted by Edna Ondari
Also universities.
hot take: newspapers should not be run by people who dislike reading and thinking
February 4, 2026 at 3:23 PM
Also universities.
www.nature.com/articles/d41...
“They’re trying to use African children to prove a case for reducing vaccines in the US,”
"That's problematic"...
No...it's beyond the pale.
“They’re trying to use African children to prove a case for reducing vaccines in the US,”
"That's problematic"...
No...it's beyond the pale.
Guinea-Bissau suspends US-funded vaccine trial as African scientists question its motives
Officials at the US Department of Health and Human Services, which awarded funding for the controversial study, say it will proceed as planned.
www.nature.com
January 31, 2026 at 12:34 AM
www.nature.com/articles/d41...
“They’re trying to use African children to prove a case for reducing vaccines in the US,”
"That's problematic"...
No...it's beyond the pale.
“They’re trying to use African children to prove a case for reducing vaccines in the US,”
"That's problematic"...
No...it's beyond the pale.
Reposted by Edna Ondari
A newly sequenced 5500-year-old genome of Treponema pallidum rewrites the origins of syphilis, according to a new study in Science.
Learn more: https://scim.ag/3Zpv2W2
Learn more: https://scim.ag/3Zpv2W2
A 5500-year-old Treponema pallidum genome from Sabana de Bogotá, Colombia
Treponematosis, a bacterial infection caused by Treponema pallidum subspecies and T. carateum (yaws, bejel, syphilis, pinta), has afflicted humans for millennia. Despite paleopathological evidence and...
scim.ag
January 23, 2026 at 9:12 PM
A newly sequenced 5500-year-old genome of Treponema pallidum rewrites the origins of syphilis, according to a new study in Science.
Learn more: https://scim.ag/3Zpv2W2
Learn more: https://scim.ag/3Zpv2W2
Reposted by Edna Ondari
New study in Cell Metabolism: Microbial metabolite FAD mobilizes adipocyte lipid remodeling to enhance cancer immunotherapy efficacy
#microsky #microbiota #cancer @cp-cellmetabolism.bsky.social
www.sciencedirect.com/science/arti...
#microsky #microbiota #cancer @cp-cellmetabolism.bsky.social
www.sciencedirect.com/science/arti...
Microbial metabolite FAD mobilizes adipocyte lipid remodeling to enhance cancer immunotherapy efficacy
Crosstalk between gut microbiota and adipose tissue critically shapes immunotherapy responses in patients with cancer. An obesity-associated microbial…
www.sciencedirect.com
January 22, 2026 at 9:15 AM
New study in Cell Metabolism: Microbial metabolite FAD mobilizes adipocyte lipid remodeling to enhance cancer immunotherapy efficacy
#microsky #microbiota #cancer @cp-cellmetabolism.bsky.social
www.sciencedirect.com/science/arti...
#microsky #microbiota #cancer @cp-cellmetabolism.bsky.social
www.sciencedirect.com/science/arti...
Impact of databases on genomic survey of Salmonella antimicrobial resistance and virulence factor functional genes across the African continent
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 22, 2026 at 9:41 AM
Impact of databases on genomic survey of Salmonella antimicrobial resistance and virulence factor functional genes across the African continent
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Edna Ondari
ICYMI: New Online! Heterogeneity, dynamics and organelle interactions of lipid droplets
Heterogeneity, dynamics and organelle interactions of lipid droplets
Nature Reviews Molecular Cell Biology, Published online: 15 January 2026; doi:10.1038/s41580-025-00945-xLipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactions with other organelles influence physiology and contribute to disease.
dlvr.it
January 18, 2026 at 5:30 PM
ICYMI: New Online! Heterogeneity, dynamics and organelle interactions of lipid droplets
Reposted by Edna Ondari
Salmonella relies on siderophore exploitation at low pH
#microLife by @ferrytin.bsky.social et al from Olivier Cunrath
academic.oup.com/microlife/ad...
#microLife by @ferrytin.bsky.social et al from Olivier Cunrath
academic.oup.com/microlife/ad...
Salmonella relies on siderophore exploitation at low pH
Abstract. Salmonella enterica, a prominent enteric pathogen, employs sophisticated iron acquisition mechanisms to overcome host-imposed iron limitation, no
academic.oup.com
January 18, 2026 at 1:18 PM
Salmonella relies on siderophore exploitation at low pH
#microLife by @ferrytin.bsky.social et al from Olivier Cunrath
academic.oup.com/microlife/ad...
#microLife by @ferrytin.bsky.social et al from Olivier Cunrath
academic.oup.com/microlife/ad...
Reposted by Edna Ondari
Excited to see this work on the cover of #MolecularCell. A massive, open #cryoEM #cryoET dataset capturing molecular organization inside intact cells, pushing what’s possible for #visualproteomics, method development, and computational reuse. Congratulations to the authors.
ter.li/of4cgh
ter.li/of4cgh
January 16, 2026 at 10:03 AM
Excited to see this work on the cover of #MolecularCell. A massive, open #cryoEM #cryoET dataset capturing molecular organization inside intact cells, pushing what’s possible for #visualproteomics, method development, and computational reuse. Congratulations to the authors.
ter.li/of4cgh
ter.li/of4cgh
Reposted by Edna Ondari
People think that anyone can do the job of communicating to the public but the fact is the profession of telling people stuff and doing it a way they understand, process, and engage with is actually an incredibly highly skilled job that many, many people lack the training and ability to do.
January 18, 2026 at 8:59 AM
People think that anyone can do the job of communicating to the public but the fact is the profession of telling people stuff and doing it a way they understand, process, and engage with is actually an incredibly highly skilled job that many, many people lack the training and ability to do.
Reposted by Edna Ondari
Personalized Antibiogram: A Novel Multi-Task Machine Learning Framework for Simultaneous Prediction of Antimicrobial Resistance Profile with Enhanced Detection of Carbapenem Resistance in Enterobacteriaceae
https://doi.org/10.1093/cid/ciag027
https://doi.org/10.1093/cid/ciag027
January 17, 2026 at 12:16 PM
Personalized Antibiogram: A Novel Multi-Task Machine Learning Framework for Simultaneous Prediction of Antimicrobial Resistance Profile with Enhanced Detection of Carbapenem Resistance in Enterobacteriaceae
https://doi.org/10.1093/cid/ciag027
https://doi.org/10.1093/cid/ciag027
Reposted by Edna Ondari
A paper in Nature Microbiology presents Antimicrobial Single-Cell Testing, a large-scale live-cell imaging approach that quantifies bacterial killing in real time at single-cell resolution, which can predict treatment outcomes. go.nature.com/3Nwnez8 #microsky 🧪
January 17, 2026 at 2:52 PM
A paper in Nature Microbiology presents Antimicrobial Single-Cell Testing, a large-scale live-cell imaging approach that quantifies bacterial killing in real time at single-cell resolution, which can predict treatment outcomes. go.nature.com/3Nwnez8 #microsky 🧪
Reposted by Edna Ondari
Another recall. This time for Salmonella in chocolate bars manufactured in Raleigh N. Carolina. The products were distributed nationwide & sold as Mint Leaf bars under the Spring & Mulberry label. Food inspection has diminished under the Trump regime. Consumers become aware after illnesses emerge👇
FDA Announces Nationwide Recall Of Chocolate Bars Made In North Carolina
The voluntary recall focuses on date-sweetened Mint Leaf chocolate bars from Raleigh-based Spring & Mulberry.
www.southernliving.com
January 15, 2026 at 10:24 PM
Another recall. This time for Salmonella in chocolate bars manufactured in Raleigh N. Carolina. The products were distributed nationwide & sold as Mint Leaf bars under the Spring & Mulberry label. Food inspection has diminished under the Trump regime. Consumers become aware after illnesses emerge👇
Reposted by Edna Ondari
At least 45 people in nearly two dozen states have been sickened with salmonella food poisoning tied to the Super Greens brand of diet supplement powder, federal health officials said. https://cnn.it/4qo5fK0
January 15, 2026 at 3:05 AM
At least 45 people in nearly two dozen states have been sickened with salmonella food poisoning tied to the Super Greens brand of diet supplement powder, federal health officials said. https://cnn.it/4qo5fK0
Reposted by Edna Ondari
What is better than one? Two connected papers!
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
December 19, 2025 at 2:06 PM
What is better than one? Two connected papers!
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
#NewResearch
S protein of Streptococcus pneumoniae activates PBP1a and coordinates with a wider GpsB-associated multi-protein complex to regulate peptidoglycan remodelling and cell division.
#MicroSky 🦠
www.nature.com/articles/s41...
Reposted by Edna Ondari
Precious Matsoso, a public-health official based in Pretoria, South Africa, brokered the world’s first pandemic-preparedness treaty after years of hard-fought negotiations. She’s part of Nature’s 10 for 2025. 🧪
The first global pandemic treaty — and the woman who made it happen
Precious Matsoso is part of Nature’s 10, a list of people who shaped science in 2025.
go.nature.com
January 2, 2026 at 2:36 PM
Precious Matsoso, a public-health official based in Pretoria, South Africa, brokered the world’s first pandemic-preparedness treaty after years of hard-fought negotiations. She’s part of Nature’s 10 for 2025. 🧪