Dan Harrison, MD
@danharrisonmd.bsky.social
Daddy, husband, and neurointensivist at BMC | NCC Associate PD | Passionate about education research, NeuroAPP training, and medical simulation
Reposted by Dan Harrison, MD
December 8, 2025 at 9:00 PM
Reposted by Dan Harrison, MD
updated the acute liver failure chapter
biggest change is increasing support for early CRRT to remove NH3 (to reduce elevated intracranial pressure)
now rec'd for clinically overt encephalopathy (Grade 2-4)
if admitting to ICU for ALF & encephalopathy, just dialyze
emcrit.org/ibcc/alf/ #EMIMCC
biggest change is increasing support for early CRRT to remove NH3 (to reduce elevated intracranial pressure)
now rec'd for clinically overt encephalopathy (Grade 2-4)
if admitting to ICU for ALF & encephalopathy, just dialyze
emcrit.org/ibcc/alf/ #EMIMCC
November 28, 2025 at 1:51 PM
updated the acute liver failure chapter
biggest change is increasing support for early CRRT to remove NH3 (to reduce elevated intracranial pressure)
now rec'd for clinically overt encephalopathy (Grade 2-4)
if admitting to ICU for ALF & encephalopathy, just dialyze
emcrit.org/ibcc/alf/ #EMIMCC
biggest change is increasing support for early CRRT to remove NH3 (to reduce elevated intracranial pressure)
now rec'd for clinically overt encephalopathy (Grade 2-4)
if admitting to ICU for ALF & encephalopathy, just dialyze
emcrit.org/ibcc/alf/ #EMIMCC
First "clamp rounds" in NCC with my senior fellow was a huge success! But what is the NCC equivalent? Don't typically hook the EVD up to suction ☠️ Clamp, 20/open, 10/open? Not quite as slick. Either way, thanks for the idea/analogy @gbosslet.bsky.social!
While everyone is away at #ATS2023, I am back at @iupccm caring for ICU patients
Today in the ICU, the fellow and I did "clamp rounds"
I find that I have three ICU rounding setups that correlate with chest tube management
A quick 🧵 on rounding styles and chest tubes
1/
Today in the ICU, the fellow and I did "clamp rounds"
I find that I have three ICU rounding setups that correlate with chest tube management
A quick 🧵 on rounding styles and chest tubes
1/
November 23, 2025 at 5:06 PM
First "clamp rounds" in NCC with my senior fellow was a huge success! But what is the NCC equivalent? Don't typically hook the EVD up to suction ☠️ Clamp, 20/open, 10/open? Not quite as slick. Either way, thanks for the idea/analogy @gbosslet.bsky.social!
Reposted by Dan Harrison, MD
Excited to share our newest work on free VPA: improving ability to predict levels with the Fraser equation. We reveal that the orig eq. is modestly accurate in an external cohort and make improvements to the eq, but confirm measurement remains ideal
@cbthepharmd.bsky.social
doi.org/10.1002/phar...
@cbthepharmd.bsky.social
doi.org/10.1002/phar...
November 17, 2025 at 11:27 AM
Excited to share our newest work on free VPA: improving ability to predict levels with the Fraser equation. We reveal that the orig eq. is modestly accurate in an external cohort and make improvements to the eq, but confirm measurement remains ideal
@cbthepharmd.bsky.social
doi.org/10.1002/phar...
@cbthepharmd.bsky.social
doi.org/10.1002/phar...
Reposted by Dan Harrison, MD
📊 Research Summary: Personalized resuscitation targeting capillary refill time modestly improved organ support–free days and composite outcomes in early septic shock, but showed no difference in mortality vs usual care.
#LIVES2025 @esicm.bsky.social
ja.ma/4huvHOa
#LIVES2025 @esicm.bsky.social
ja.ma/4huvHOa
October 29, 2025 at 1:50 PM
📊 Research Summary: Personalized resuscitation targeting capillary refill time modestly improved organ support–free days and composite outcomes in early septic shock, but showed no difference in mortality vs usual care.
#LIVES2025 @esicm.bsky.social
ja.ma/4huvHOa
#LIVES2025 @esicm.bsky.social
ja.ma/4huvHOa
Reposted by Dan Harrison, MD
Largest ever study of peripheral 23.4% NaCl with 863 administrations 😀
Some extravasation did occur, but it *didn't* lead to any major problems (tissue necrosis etc)
If someone is having an ICP crisis, you should worry about their BRAIN and not their ARM - their arm will be fine #EMIMCC
Some extravasation did occur, but it *didn't* lead to any major problems (tissue necrosis etc)
If someone is having an ICP crisis, you should worry about their BRAIN and not their ARM - their arm will be fine #EMIMCC
Silva et al: Safety of Peripherally Administered 23.4% Sodium Chloride
Link: link.springer.com/ar...
@neurocritical #neurocritcare
Link: link.springer.com/ar...
@neurocritical #neurocritcare
Safety of Peripherally Administered 23.4% Sodium Chloride
Neurocritical Care - For patients with increased intracranial pressure, prompt initiation of hyperosmolar therapy with 23.4% sodium chloride may minimize permanent neurological damage and prevent...
link.springer.com
October 28, 2025 at 5:38 PM
Largest ever study of peripheral 23.4% NaCl with 863 administrations 😀
Some extravasation did occur, but it *didn't* lead to any major problems (tissue necrosis etc)
If someone is having an ICP crisis, you should worry about their BRAIN and not their ARM - their arm will be fine #EMIMCC
Some extravasation did occur, but it *didn't* lead to any major problems (tissue necrosis etc)
If someone is having an ICP crisis, you should worry about their BRAIN and not their ARM - their arm will be fine #EMIMCC
Reposted by Dan Harrison, MD
Today, on World Trauma Day, empower your team and colleagues to improve patient outcomes during the critical first hours of a patient's neurological emergency. Designed for multidisciplinary practitioners, ENLS provides a consistent set of protocols, checklists and more: https://bit.ly/42HBcE3
October 17, 2025 at 11:50 AM
Today, on World Trauma Day, empower your team and colleagues to improve patient outcomes during the critical first hours of a patient's neurological emergency. Designed for multidisciplinary practitioners, ENLS provides a consistent set of protocols, checklists and more: https://bit.ly/42HBcE3
Reposted by Dan Harrison, MD
Do you use vasopression for MAP augmentation in your SCI patients?
In our newly published series, we describe significant hyponatremia frequently develops when used just to push up the MAP - quite literally induced SIADH
pubmed.ncbi.nlm.nih.gov/41051384/
In our newly published series, we describe significant hyponatremia frequently develops when used just to push up the MAP - quite literally induced SIADH
pubmed.ncbi.nlm.nih.gov/41051384/
October 7, 2025 at 6:42 PM
Do you use vasopression for MAP augmentation in your SCI patients?
In our newly published series, we describe significant hyponatremia frequently develops when used just to push up the MAP - quite literally induced SIADH
pubmed.ncbi.nlm.nih.gov/41051384/
In our newly published series, we describe significant hyponatremia frequently develops when used just to push up the MAP - quite literally induced SIADH
pubmed.ncbi.nlm.nih.gov/41051384/
This would be an amazing advance in the care of patients with neurologic disease if true (and accessible to patients)!
A gene therapy buzz: Did AMT-130 really slow Huntington's disease by 75% at 36 months? A press release say YES. The data not yet been subjected to peer review and publication.
uniqure.gcs-web.com/news-release...
uniqure.gcs-web.com/news-release...
September 24, 2025 at 8:48 PM
This would be an amazing advance in the care of patients with neurologic disease if true (and accessible to patients)!
Reposted by Dan Harrison, MD
A gene therapy buzz: Did AMT-130 really slow Huntington's disease by 75% at 36 months? A press release say YES. The data not yet been subjected to peer review and publication.
uniqure.gcs-web.com/news-release...
uniqure.gcs-web.com/news-release...
September 24, 2025 at 4:17 PM
A gene therapy buzz: Did AMT-130 really slow Huntington's disease by 75% at 36 months? A press release say YES. The data not yet been subjected to peer review and publication.
uniqure.gcs-web.com/news-release...
uniqure.gcs-web.com/news-release...
Come train with us! The BU/BMC NCC fellowship has an opening for a 1 or 2 year fellow beginning July 2026. Visit sfmatch.org/vacancies or message for details!
September 24, 2025 at 2:30 PM
Come train with us! The BU/BMC NCC fellowship has an opening for a 1 or 2 year fellow beginning July 2026. Visit sfmatch.org/vacancies or message for details!
Reposted by Dan Harrison, MD
During my own job search, I was struck by how wildly academic offers vary—from $0 startup 😬 to multi-million-dollar packages 💰. Inspired by online datasets (ex: www.reddit.com/r/AskAcademi...), we surveyed PCCM physicians about their offers 📊.
September 22, 2025 at 8:58 PM
During my own job search, I was struck by how wildly academic offers vary—from $0 startup 😬 to multi-million-dollar packages 💰. Inspired by online datasets (ex: www.reddit.com/r/AskAcademi...), we surveyed PCCM physicians about their offers 📊.
Reposted by Dan Harrison, MD
hi, medical toxicologist that knows a lot about Tylenol here👋 Claiming that tylenol use in pregnancy causes autism is fearmongering
here's what you need to know 🧵
here's what you need to know 🧵
September 22, 2025 at 3:09 PM
hi, medical toxicologist that knows a lot about Tylenol here👋 Claiming that tylenol use in pregnancy causes autism is fearmongering
here's what you need to know 🧵
here's what you need to know 🧵
Reposted by Dan Harrison, MD
INCC Keynote speaker Dr. Altaf Saadi presenting her keynote this morning, "Bending the Arc: How Health Care Professionals Can Speak Up and Out for Change." #NCS2025
September 20, 2025 at 2:14 PM
INCC Keynote speaker Dr. Altaf Saadi presenting her keynote this morning, "Bending the Arc: How Health Care Professionals Can Speak Up and Out for Change." #NCS2025
Reposted by Dan Harrison, MD
Dr. Brian Coffey, this year's DEI Abstract Award Winner, presented on his abstract, "Toward Equitable Care After Cardiac Arrest: The Impact of Race, Ethnicity and Insurance on Outcome at Two Safety Net Hospitals." #NCS2025
September 20, 2025 at 2:38 PM
Dr. Brian Coffey, this year's DEI Abstract Award Winner, presented on his abstract, "Toward Equitable Care After Cardiac Arrest: The Impact of Race, Ethnicity and Insurance on Outcome at Two Safety Net Hospitals." #NCS2025
Reposted by Dan Harrison, MD
Switching from 1% to 2% propofol in ICU sedation cut greenhouse gas emissions, waste, and costs, with savings equal to over seven Paris–New York flights annually, showing concentration adjustment as a path to greener critical care. zurl.co/DHWbi
September 21, 2025 at 8:00 AM
Switching from 1% to 2% propofol in ICU sedation cut greenhouse gas emissions, waste, and costs, with savings equal to over seven Paris–New York flights annually, showing concentration adjustment as a path to greener critical care. zurl.co/DHWbi
The COMA (certain of missing awesome) has begun 😭 Hoping for a productive meeting for all my friends and colleagues at #ncs2025 @caseyalbin.bsky.social @namorrismd.bsky.social @ajwpharm.bsky.social
Afternoon workshops on ENLS simulation and 2025 informatics/big data/AI have kicked off! Annual Meeting workshops provide attendees the opportunity to learn in small-group settings and gain expertise from neurocritical care professionals with hands-on engagement. #NCS2025
September 18, 2025 at 8:17 PM
The COMA (certain of missing awesome) has begun 😭 Hoping for a productive meeting for all my friends and colleagues at #ncs2025 @caseyalbin.bsky.social @namorrismd.bsky.social @ajwpharm.bsky.social
Reposted by Dan Harrison, MD
Afternoon workshops on ENLS simulation and 2025 informatics/big data/AI have kicked off! Annual Meeting workshops provide attendees the opportunity to learn in small-group settings and gain expertise from neurocritical care professionals with hands-on engagement. #NCS2025
September 18, 2025 at 7:35 PM
Afternoon workshops on ENLS simulation and 2025 informatics/big data/AI have kicked off! Annual Meeting workshops provide attendees the opportunity to learn in small-group settings and gain expertise from neurocritical care professionals with hands-on engagement. #NCS2025
In academia, this fleeting moment of internally derived self-worth is quickly followed by reviewer 2's feedback:
September 16, 2025 at 1:12 AM
In academia, this fleeting moment of internally derived self-worth is quickly followed by reviewer 2's feedback:
Reposted by Dan Harrison, MD
Do you give 23.4% #hypertonicsaline at your center? If not, why not? Will this data help?
link.springer.com/ar...
#neurocritcare
link.springer.com/ar...
#neurocritcare
Safety of Peripherally Administered 23.4% Sodium Chloride
Neurocritical Care - For patients with increased intracranial pressure, prompt initiation of hyperosmolar therapy with 23.4% sodium chloride may minimize permanent neurological damage and prevent...
link.springer.com
September 10, 2025 at 2:09 PM
Do you give 23.4% #hypertonicsaline at your center? If not, why not? Will this data help?
link.springer.com/ar...
#neurocritcare
link.springer.com/ar...
#neurocritcare
New preprint - A Modified Delphi Consensus-based Comprehensive Checklist and Angoff Standard for Assessment of Competency in Brain Death/Death by Neurologic Criteria Determination. Thanks to co-authors, especially @namorrismd.bsky.social! www.medrxiv.org/content/10.1... #neurology #critcare #MedEd
A Modified Delphi Consensus-based Comprehensive Checklist and Angoff Standard for Assessment of Competency in Brain Death/Death by Neurologic Criteria Determination
Objective: To develop a comprehensive checklist, define critical actions, and establish a minimal passing standard for adult and pediatric critical care clinicians as well as other providers to facili...
www.medrxiv.org
August 30, 2025 at 1:00 AM
New preprint - A Modified Delphi Consensus-based Comprehensive Checklist and Angoff Standard for Assessment of Competency in Brain Death/Death by Neurologic Criteria Determination. Thanks to co-authors, especially @namorrismd.bsky.social! www.medrxiv.org/content/10.1... #neurology #critcare #MedEd
Reposted by Dan Harrison, MD
🆕💫PROTECT RCT
Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT) #IDsky #EMIMCC @pulmcrit.bsky.social
journal.chestnet.org/article/S001...
Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT) #IDsky #EMIMCC @pulmcrit.bsky.social
journal.chestnet.org/article/S001...
Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT)
This trial was inconclusive regarding the impact of ceftriaxone prophylaxis to reduce
the incidence of EOP after OHCA but ceftriaxone was associated with less frequent
administration of open-label ant...
journal.chestnet.org
August 28, 2025 at 10:19 PM
🆕💫PROTECT RCT
Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT) #IDsky #EMIMCC @pulmcrit.bsky.social
journal.chestnet.org/article/S001...
Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT) #IDsky #EMIMCC @pulmcrit.bsky.social
journal.chestnet.org/article/S001...
Reposted by Dan Harrison, MD
I spent 2020 taking care of critically-ill COVID patients & was so grateful to receive the vaccine that felt like a miracle of science. The vaccine reduces the risk of transmission to vulnerable people & since then has saved millions of lives. What are we even doing now? apnews.com/article/vacc...
August 27, 2025 at 6:56 PM
I spent 2020 taking care of critically-ill COVID patients & was so grateful to receive the vaccine that felt like a miracle of science. The vaccine reduces the risk of transmission to vulnerable people & since then has saved millions of lives. What are we even doing now? apnews.com/article/vacc...
Reposted by Dan Harrison, MD
ICU Facts:
In my experience, in any decent size ICU (~15 beds), at any point in time, there is at least 1 patient with unequal pupils (anisocoria). People are often freaking out & rush to get a CT brain to rule out intracranial bleeding... Just think hard before reflexively doing this
In my experience, in any decent size ICU (~15 beds), at any point in time, there is at least 1 patient with unequal pupils (anisocoria). People are often freaking out & rush to get a CT brain to rule out intracranial bleeding... Just think hard before reflexively doing this
August 14, 2025 at 10:43 PM
ICU Facts:
In my experience, in any decent size ICU (~15 beds), at any point in time, there is at least 1 patient with unequal pupils (anisocoria). People are often freaking out & rush to get a CT brain to rule out intracranial bleeding... Just think hard before reflexively doing this
In my experience, in any decent size ICU (~15 beds), at any point in time, there is at least 1 patient with unequal pupils (anisocoria). People are often freaking out & rush to get a CT brain to rule out intracranial bleeding... Just think hard before reflexively doing this