Claudio Cantù
@claudiocantu81.bsky.social
Professor of Mol & Dev Bio @ Linköping University 🇮🇹🇸🇪
Group Leader at the Wallenberg Center For Molecular Medicine & SciLifeLab
https://liu.se/en/research/cantu-lab
Curious about how the genome responds to #WNT, but frankly passionate about all Science.
Group Leader at the Wallenberg Center For Molecular Medicine & SciLifeLab
https://liu.se/en/research/cantu-lab
Curious about how the genome responds to #WNT, but frankly passionate about all Science.
Pinned
Claudio Cantù
@claudiocantu81.bsky.social
· Mar 18
We are using CUT&RUN-LoV-U to map effectors of Signaling Pathways across tissue and stages of Mouse #DevBio🐭🧬
Do you want to join forces and collaborate to build the future of the TranscriptionFactorBinding(TFB)-OMICS?
www.biorxiv.org/content/10.1...
Do you want to join forces and collaborate to build the future of the TranscriptionFactorBinding(TFB)-OMICS?
www.biorxiv.org/content/10.1...
Our first release in the attempt to build the Transcription Factor Binding (TFB)-OMICS during #DevBio is now out in Development @dev-journal.bsky.social
doi.org/10.1242/dev....
👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue
doi.org/10.1242/dev....
👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue
In one tumor, despite the shared oncogenic driver mutations, there may be different cell types
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
Differential Wnt/β-Catenin Signaling via TCF7L2/LEF1 Binding Specificity Shapes Cellular and Tumor Phenotypes https://www.biorxiv.org/content/10.1101/2025.11.04.686471v1
November 10, 2025 at 10:04 AM
In one tumor, despite the shared oncogenic driver mutations, there may be different cell types
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
This is objectively an awesome paper 👇
Check out our new preprint on the evolution of enhancer loss. Turns out there are 50 ways to lose a function. We found four of them.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Distinct mechanisms decommission redundant enhancers to facilitate phenotypic evolution
The evolutionary loss of morphological traits is often driven by changes in gene regulation. Many developmental genes are controlled by multiple, redundant enhancers, raising the question of how robus...
www.biorxiv.org
October 29, 2025 at 6:11 AM
This is objectively an awesome paper 👇
I have 7452 unread emails in my professional inbox.
How should an academic deal with this?
How should an academic deal with this?
October 8, 2025 at 7:13 AM
I have 7452 unread emails in my professional inbox.
How should an academic deal with this?
How should an academic deal with this?
SOX2 and NR2F1 cooperate
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus
Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.
journals.biologists.com
August 11, 2025 at 12:55 PM
SOX2 and NR2F1 cooperate
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
Reposted by Claudio Cantù
A 6-year long study from the Lab is finally out @genomeresearch.bsky.social
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
July 15, 2025 at 7:58 AM
A 6-year long study from the Lab is finally out @genomeresearch.bsky.social
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Reposted by Claudio Cantù
Now out @genomeresearch.bsky.social this fantastic work in collaboration with Claudio Cantù's lab.
About how #Wnt signalling activation induces #CTCF binding and formation of new #chromatin #loops at #CREs of target genes.
genome.cshlp.org/content/earl...
About how #Wnt signalling activation induces #CTCF binding and formation of new #chromatin #loops at #CREs of target genes.
genome.cshlp.org/content/earl...
August 1, 2025 at 1:58 PM
Now out @genomeresearch.bsky.social this fantastic work in collaboration with Claudio Cantù's lab.
About how #Wnt signalling activation induces #CTCF binding and formation of new #chromatin #loops at #CREs of target genes.
genome.cshlp.org/content/earl...
About how #Wnt signalling activation induces #CTCF binding and formation of new #chromatin #loops at #CREs of target genes.
genome.cshlp.org/content/earl...
And of course it is #WNT who decides ⬇️
I wished to see what genes does beta-catenin regulates here!
I wished to see what genes does beta-catenin regulates here!
How "head" and "tail" are positioned in echinoderms and hemichordates? Comparative dev identifies ancient AP determination mechanisms! By Jennifer Fenner #PASEDB2025 #APaxis #seaurchin #wnt #hemichordates
July 25, 2025 at 1:21 PM
And of course it is #WNT who decides ⬇️
I wished to see what genes does beta-catenin regulates here!
I wished to see what genes does beta-catenin regulates here!
A 6-year long study from the Lab is finally out @genomeresearch.bsky.social
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
July 15, 2025 at 7:58 AM
A 6-year long study from the Lab is finally out @genomeresearch.bsky.social
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Reposted by Claudio Cantù
These NPG spinoff journals are out of control
June 29, 2025 at 4:50 PM
These NPG spinoff journals are out of control
Reposted by Claudio Cantù
At the WNT GRC and am lowkey obsessed with the ducks of Bates College 🦆 Love seeing them right outside the meeting room 🪶
June 24, 2025 at 11:27 PM
At the WNT GRC and am lowkey obsessed with the ducks of Bates College 🦆 Love seeing them right outside the meeting room 🪶
Reposted by Claudio Cantù
We had previously shown that TBX3 and #WNT cooperate in limb #DevBio
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes
www.pnas.org
May 12, 2025 at 7:33 AM
We had previously shown that TBX3 and #WNT cooperate in limb #DevBio
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
Reposted by Claudio Cantù
The latest upgrading of the #supercomputer Berzelius @liu.se has now been completed. Its doubled capacity enables researchers across Sweden to tackle current and future challenges in areas such as materials science, bioinformatics and machine learning #research #science
tinyurl.com/ydduwzc7
tinyurl.com/ydduwzc7
Stronger Berzelius ready for the research of the future
The latest upgrading of the supercomputer Berzelius at LiU has now been completed. Its doubled capacity enables researchers across Sweden to tackle current and future challenges in areas such as mater...
tinyurl.com
June 4, 2025 at 12:03 PM
The latest upgrading of the #supercomputer Berzelius @liu.se has now been completed. Its doubled capacity enables researchers across Sweden to tackle current and future challenges in areas such as materials science, bioinformatics and machine learning #research #science
tinyurl.com/ydduwzc7
tinyurl.com/ydduwzc7
Reposted by Claudio Cantù
A big upgrading of the supercomputer Berzelius has been completed thanks to a donation from @kawresearch.bsky.social.
Its doubled capacity enables researchers across Sweden to tackle challenges in areas as materials science, bioinformatics and machine learning.
liu.se/en/news-item... #AcademicSky
Its doubled capacity enables researchers across Sweden to tackle challenges in areas as materials science, bioinformatics and machine learning.
liu.se/en/news-item... #AcademicSky
Stronger Berzelius ready for the research of the future
The latest upgrading of the supercomputer Berzelius at LiU has now been completed. Its doubled capacity enables researchers across Sweden to tackle current and future challenges in areas such as mater...
liu.se
June 4, 2025 at 12:06 PM
A big upgrading of the supercomputer Berzelius has been completed thanks to a donation from @kawresearch.bsky.social.
Its doubled capacity enables researchers across Sweden to tackle challenges in areas as materials science, bioinformatics and machine learning.
liu.se/en/news-item... #AcademicSky
Its doubled capacity enables researchers across Sweden to tackle challenges in areas as materials science, bioinformatics and machine learning.
liu.se/en/news-item... #AcademicSky
This ⬇️ is the @liu.se crew @kawresearch.bsky.social @scilifelab.se
On its way to #PALS2025 in superb Göteborg!
On its way to #PALS2025 in superb Göteborg!
June 2, 2025 at 4:17 PM
This ⬇️ is the @liu.se crew @kawresearch.bsky.social @scilifelab.se
On its way to #PALS2025 in superb Göteborg!
On its way to #PALS2025 in superb Göteborg!
Reposted by Claudio Cantù
A study led by @claudiocantu81.bsky.social show how the protein TBX3, key in early development, resurfaces in aggressive cancers – making them harder to treat.
New insights, new hope for targeted therapies.
🔗 liu.se/en/news-item...
#research #cancer
New insights, new hope for targeted therapies.
🔗 liu.se/en/news-item...
#research #cancer
Mechanism in embryonic development makes cancer aggressive
Tumour cells in colorectal cancer exploit an important signalling pathway that normally controls embryo development. Researchers have now shown how a protein that controls limb development make colore...
liu.se
May 27, 2025 at 6:28 AM
A study led by @claudiocantu81.bsky.social show how the protein TBX3, key in early development, resurfaces in aggressive cancers – making them harder to treat.
New insights, new hope for targeted therapies.
🔗 liu.se/en/news-item...
#research #cancer
New insights, new hope for targeted therapies.
🔗 liu.se/en/news-item...
#research #cancer
Join as for the Nordic #DevBio talks - ZOOM Link upon request 💚
Today talks #DevBio from @ki.se 🇸🇪
Talks by
@genanderlab.bsky.social
and
Ning Xu Landén
We cannot wait! 💚
Talks by
@genanderlab.bsky.social
and
Ning Xu Landén
We cannot wait! 💚
What #DevBio is going on in the North?
🐭🪰🪱🐈⬛🐰🫎🇩🇰🇸🇪🇫🇮🇳🇴🇮🇸
Check it out in our monthly Online Seminars:
www.swedbo.se/nordic-devel...
🐭🪰🪱🐈⬛🐰🫎🇩🇰🇸🇪🇫🇮🇳🇴🇮🇸
Check it out in our monthly Online Seminars:
www.swedbo.se/nordic-devel...
May 19, 2025 at 8:15 AM
Join as for the Nordic #DevBio talks - ZOOM Link upon request 💚
Reposted by Claudio Cantù
En ny studie från @ki.se har identifierat en mekanism som celler använder för att hantera näringsbrist. Den nya rönen öppnar för potentiella terapeutiska tillämpningar #forskning med stöd av Knut och Alice Wallenbergs Stiftelse #medicin #biologi @pelechanolab.bsky.social
tinyurl.com/y724wte5
tinyurl.com/y724wte5
Ny studie avslöjar hur celler anpassar sig till näringsbrist
En ny studie från Karolinska Institutet har identifierat en mekanism som celler använder för att hantera näringsbrist. När näringstillgången är låg gör cellerna små förändringar i hur ribosomer – cell...
tinyurl.com
May 16, 2025 at 8:45 AM
En ny studie från @ki.se har identifierat en mekanism som celler använder för att hantera näringsbrist. Den nya rönen öppnar för potentiella terapeutiska tillämpningar #forskning med stöd av Knut och Alice Wallenbergs Stiftelse #medicin #biologi @pelechanolab.bsky.social
tinyurl.com/y724wte5
tinyurl.com/y724wte5
Reposted by Claudio Cantù
🧪
We had previously shown that TBX3 and #WNT cooperate in limb #DevBio
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes
www.pnas.org
May 12, 2025 at 8:15 AM
🧪
Reposted by Claudio Cantù
Article in PNAS: The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal #cancer to regulate metastasis genes #Research supported by Knut and Alice Wallenberg Foundation #Biology #Science #Colorectalcancer @claudiocantu81.bsky.social
tinyurl.com/yuvkd7b8
tinyurl.com/yuvkd7b8
May 12, 2025 at 8:53 AM
Article in PNAS: The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal #cancer to regulate metastasis genes #Research supported by Knut and Alice Wallenberg Foundation #Biology #Science #Colorectalcancer @claudiocantu81.bsky.social
tinyurl.com/yuvkd7b8
tinyurl.com/yuvkd7b8
We had previously shown that TBX3 and #WNT cooperate in limb #DevBio
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes
www.pnas.org
May 12, 2025 at 7:33 AM
We had previously shown that TBX3 and #WNT cooperate in limb #DevBio
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
Reposted by Claudio Cantù
Our paper on epithelial dynamics and scutoids in the sea star embryo doi.org/10.1242/dev.... was shortlisted for Outstanding Papers of 2024 prize in @dev-journal.bsky.social! Congrats to co-authors @lmescu.bsky.social, Antonio Tagua and Deirdre Lyons
journals.biologists.com/dev/collecti...
journals.biologists.com/dev/collecti...
Outstanding Paper Prize 2024 | Development | The Company of Biologists
Each year, Development awards an Outstanding paper prize to the study that we judge to have made an exceptional contribution to the journal in the previous
journals.biologists.com
May 6, 2025 at 3:06 PM
Our paper on epithelial dynamics and scutoids in the sea star embryo doi.org/10.1242/dev.... was shortlisted for Outstanding Papers of 2024 prize in @dev-journal.bsky.social! Congrats to co-authors @lmescu.bsky.social, Antonio Tagua and Deirdre Lyons
journals.biologists.com/dev/collecti...
journals.biologists.com/dev/collecti...
Reposted by Claudio Cantù
Our 'Honest conversations' series is a place for people to write about the ups and downs in their academic journey and create frank conversations around less-discussed topics.
Read the posts, keep the conversations going, and perhaps write a post yourself:
thenode.biologists.com/honest-conve...
Read the posts, keep the conversations going, and perhaps write a post yourself:
thenode.biologists.com/honest-conve...
April 25, 2025 at 8:48 AM
Our 'Honest conversations' series is a place for people to write about the ups and downs in their academic journey and create frank conversations around less-discussed topics.
Read the posts, keep the conversations going, and perhaps write a post yourself:
thenode.biologists.com/honest-conve...
Read the posts, keep the conversations going, and perhaps write a post yourself:
thenode.biologists.com/honest-conve...
“The alternative to thinking in evolutionary terms is not to think at all.”
P.B. Medawar
P.B. Medawar
April 24, 2025 at 12:37 PM
“The alternative to thinking in evolutionary terms is not to think at all.”
P.B. Medawar
P.B. Medawar
OMG, I would want to take this job 👇
My group is hiring a new Postdoc to work on gene regulation and chromatin in Nematostella. Please RT!
For more information see here:
gahanlab.com
tinyurl.com/34xke35d
For more information see here:
gahanlab.com
tinyurl.com/34xke35d
April 24, 2025 at 7:46 AM
OMG, I would want to take this job 👇