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charlesswanton.bsky.social
Charlie Swanton
@charlesswanton.bsky.social
1.3K followers 23 following 2 posts
Cancer Evolution and Genome Instability Lab Francis Crick Institute. Views my own
Posts Replies Media Videos
Reposted by Charlie Swanton
labwaggoner.bsky.social
Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @charlesswanton.bsky.social @ucl.ac.uk
November 9, 2025 at 10:19 PM
Reposted by Charlie Swanton
benjaminwerner.bsky.social
I am very excited that Imrans and @magnushaughey.bsky.social article in @aacrjournals.bsky.social is now online.

This was a great collaboration with @charlesswanton.bsky.social and Paul Mischel amongst many others.

A small thread will follow below.

aacrjournals.org/cancerdiscov...
Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in Glioblastoma
AbstractOncogenes amplified on extrachromosomal DNA (ecDNA) contribute to treatment resistance and poor survival across cancers. Currently, the spatiotemporal evolution of ecDNA remains poorly underst...
aacrjournals.org
September 8, 2025 at 2:08 PM
Reposted by Charlie Swanton
elizsmckenna.bsky.social
Now online in Cancer Discovery @aacrjournals.bsky.social: ecDNA–Driven Oncogene Spatial Heterogeneity & Evolution in Glioblastoma - by Imran Noorani, @magnushaughey.bsky.social, Paul Mischel, @charlesswanton.bsky.social, @benjaminwerner.bsky.social, and colleagues doi.org/10.1158/2159...
September 8, 2025 at 3:35 PM
Reposted by Charlie Swanton
crick.ac.uk
This research was led by Imran and co-first author Magnus Haughey, with senior authors Paul Mischel at @stanforddeptmed.bsky.social, @benjaminwerner.bsky.social at @qmucu.bsky.social, and @charlesswanton.bsky.social at the Crick.
September 8, 2025 at 4:17 PM
Reposted by Charlie Swanton
crick.ac.uk
Research from the Cancer Grand Challenges eDNyamiC team found that rogue rings of DNA appear early in glioblastoma, a very aggressive form of brain cancer.

Co-first author Imran Noorani explains how this work makes the case for early detection of these tumours.

www.crick.ac.uk/news/2025-09...
Rogue DNA rings reveal earliest clues to deadly brain cancer’s growth
In a new study, published today in Cancer Discovery, the eDyNAmiC team, led by Paul Mischel at Stanford University, and collaborator Charlie Swanton at the Crick, integrated genomic and imaging data f...
www.crick.ac.uk
September 8, 2025 at 4:17 PM
Reposted by Charlie Swanton
immunologypodcast.com
New in @cp-cancercell.bsky.social: Drs. Krijn Dijkstra, Sergio Quezada, Emile Voest, and @charlesswanton.bsky.social
established patient-derived #organoids to study immune invasion in #LungCancer. 🫁

Article: bit.ly/4ltQPp2
Discussion: bit.ly/3GP9NaK
July 22, 2025 at 5:29 PM
Reposted by Charlie Swanton
labwaggoner.bsky.social
Subclonal immune evasion in non-small cell lung cancer
www.cell.com/cancer-cell/... @cp-cancercell.bsky.social @charlesswanton.bsky.social
July 3, 2025 at 8:30 PM
Reposted by Charlie Swanton
sdecarne.bsky.social
New evidence that age-related clonal hematopoiesis (CHIP) drives solid cancer progression by remodelling the tumour immune microenvironment. Out in @nejm.org
Congrats @oriolpich.bsky.social, @elsabernard.bsky.social, Maria Zagorulya, @charlesswanton.bsky.social et al.

www.nejm.org/doi/full/10....
🧪
Tumor-Infiltrating Clonal Hematopoiesis | NEJM
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencie...
www.nejm.org
April 25, 2025 at 9:50 AM
Reposted by Charlie Swanton
crick.ac.uk
This research was led by @oriolpich.bsky.social, Elsa Bernard and Maria Zagorulya, with corresponding authors Elli Papaemmanuil, Elsa Bernard and @charlesswanton.bsky.social. The project was supported by @cancerresearchuk.org and @uclhresearch.bsky.social.
April 24, 2025 at 3:33 PM
Reposted by Charlie Swanton
crick.ac.uk
Researchers from the Crick, @ucl.ac.uk, @gr-research.bsky.social and @mskcancercenter.bsky.social have discovered that certain age-related genetic changes in the blood are associated with worse outcomes for cancer patients.

www.crick.ac.uk/news/2025-04...
Age-related genetic changes in the blood associated with poor cancer prognosis
Researchers from the Francis Crick Institute, UCL, Gustave Roussy and Memorial Sloan Kettering Cancer Center (MSK), have discovered that expansion of mutant blood cells, a phenomenon linked to ageing,...
www.crick.ac.uk
April 24, 2025 at 2:24 PM
charlesswanton.bsky.social
Super to work with Oriol Pich, Elsa Bernard Maria Zagorulya,
@PapaemmanuilLab exploring how the age related process CHIP might impact tumour biology; incredible team. Thank you to all our funders, CRUK, Crick, BCRF, Rosetrees Trust, Mark Foundation+ Royal Society

www.nejm.org/doi/full/10....
Tumor-Infiltrating Clonal Hematopoiesis | NEJM
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencie...
www.nejm.org
April 24, 2025 at 5:13 PM
Reposted by Charlie Swanton
bloodgenes.bsky.social
Wow!!! 🤯 Amazing, @oriolpich.bsky.social, @charlesswanton.bsky.social, and team!

www.nejm.org/doi/full/10....
Tumor-Infiltrating Clonal Hematopoiesis | NEJM
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencie...
www.nejm.org
April 24, 2025 at 12:54 AM
Reposted by Charlie Swanton
crick.ac.uk
Are you a clinician looking for a fully-funded postdoctoral research opportunity? 🩺

Take a look at our postdoctoral career development fellowships for clinicians, and see how you can join our vibrant community of clinician scientists.

Apply by 30 April ➡️ www.crick.ac.uk/careers-and-...
Postdoctoral clinical fellows
Opportunities for postdoctoral clinicians to consolidate their research experience.
www.crick.ac.uk
April 16, 2025 at 9:48 AM
Reposted by Charlie Swanton
elizsmckenna.bsky.social
@charlesswanton.bsky.social kicks off the @cancergrand.bsky.social Summit and mentions the commentaries on the impact of the original #CancerGrandChallenges teams published in the January issue of Cancer Discovery - you can read them here: aacrjournals.org/cancerdiscov...
March 5, 2025 at 2:42 PM
Reposted by Charlie Swanton
ldelarica.bsky.social
Please share! @charlesswanton.bsky.social @isidrolauscher.bsky.social
@peterlylab.bsky.social @maitehuartelab.bsky.social @florentmouliere.bsky.social @andreaventura.bsky.social @anton-henssen.bsky.social
February 24, 2025 at 10:29 AM
Reposted by Charlie Swanton
rbentham.bsky.social
A huge thanks to my co-authors, especially my PI Prof. Nicholas McGranahan for guiding all of this and @charlesswanton.bsky.social who gave his support throughout. Thanks also to @genomicsengland.bsky.social , @cruk-cityoflondon.bsky.social , UCL Cancer Institute, and @crick.ac.uk
February 18, 2025 at 3:24 PM
Reposted by Charlie Swanton
drsanjaypopat.bsky.social
Phenomenal data and unique insights from @charlesswanton.bsky.social and colleagues. Bravo!
February 19, 2025 at 7:11 PM
Reposted by Charlie Swanton
rbentham.bsky.social
And a final thanks to our funders without which none of this work would have been possible: @cancerresearchuk.org, @wellcometrust.bsky.social and Rosetrees as well as most importantly all the patients & participants.
February 18, 2025 at 3:24 PM
Reposted by Charlie Swanton
rbentham.bsky.social
🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells.

Out today in @naturegenet.bsky.social :
doi.org/10.1038/s41588-025-02086-5
🧵👇
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer - Nature Genetics
Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating ...
www.nature.com
February 18, 2025 at 3:24 PM
Reposted by Charlie Swanton
natcancer.nature.com
💫New Article

Dhruva Biswas, Nicolai J. Birkbak & @charlesswanton.bsky.social and team present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcinoma.

www.nature.com/articles/s43...
Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma - Nature Cancer
Swanton and colleagues present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcino...
www.nature.com
January 10, 2025 at 4:12 PM
Reposted by Charlie Swanton
uclnews.bsky.social
A new test, developed by a team led by @charlesswanton.bsky.social from UCL Cancer Institute & @crick.ac.uk, can better predict lung cancer survival at the point of diagnosis and could help to inform treatment decisions
www.ucl.ac.uk/news/2025/ja...
Lung cancer test better predicts survival in early stages of disease
A new test, developed by researchers from UCL Cancer Institute and the Francis Crick Institute, can better predict lung cancer survival at the point of diagnosis, which could inform treatment decision...
www.ucl.ac.uk
January 13, 2025 at 10:51 AM
Reposted by Charlie Swanton
crick.ac.uk
Scientists at the Crick, @ucl.ac.uk , @uclh.bsky.social and Personalis have found that a test to detect circulating tumour DNA can help predict the outcome of lung cancer treatments 🧪
First authors: James Black, Gabor Bartha
Senior author: @charlesswanton.bsky.social
www.crick.ac.uk/news-and-rep...
Tumour DNA in the blood can predict lung cancer outcome
Scientists from the Francis Crick Institute, UCL, UCLH and Personalis have found that a test to detect circulating tumour DNA can predict lung cancer outcome in a Cancer Research UK-funded study.
www.crick.ac.uk
January 13, 2025 at 11:36 AM
Reposted by Charlie Swanton
healthcare-europe.bsky.social
Scientists led by James Black, Gabor Bartha and @charlesswanton.bsky.social from 🇬🇧 @crick.ac.uk, 🇬🇧 @ucl.ac.uk, 🇬🇧 @uclh.bsky.social and 🇬🇧 Personalis have tested a method which detects circulating tumour DNA (ctDNA), to predict the risk of #lungcancer relapse before surgery.
Predicting lung cancer outcomes with tumour DNA in the blood
Scientists from the Francis Crick Institute, UCL, UCLH and Personalis have found that a test to detect circulating tumour DNA can predict lung cancer outcome in a Cancer Research UK-funded study.
dlvr.it
January 16, 2025 at 7:30 AM
Reposted by Charlie Swanton
lambalastair.bsky.social
Good to be involved in the @cancerresearchuk.org #ClinicalReseachers meeting at @rcn.org.uk Cavendish Sq.

Great opportunity to meet other #ClinicianScientists, network & discuss high quality science.

@thineskrishna.bsky.social @charlesswanton.bsky.social
@clareturnbull.bsky.social
February 6, 2025 at 10:29 AM
Reposted by Charlie Swanton
johannajoyce.bsky.social
Thrilled our review was selected as a #science #highlight in this #Cell timeline of the last decade 🧪

"Embracing #cancer complexity: Hallmarks of systemic disease"

Swanton et al, 2024

www.sciencedirect.com/science/arti...

@charlesswanton.bsky.social
@cancerresearchuk.org
@cp-cell.bsky.social
This figure represents "Tumor micro- and macro-environments" with an illustration of the complex tumor ecosystem. Interactions between diverse components of the tumor micro- and macro-environments are depicted, involving influences of the host, as well as external factors, on tumor growth and metastatic dissemination.
January 27, 2025 at 1:00 PM