Nature Reviews Cardiology, Published online: 12 January 2026; doi:10.1038/s41569-026-01248-0Oral anticoagulants are the cornerstone of stroke risk prevention in patients with atrial fibrillation, regardless of whether sinus rhythm is restored. Evidence from two new randomized trials questions the need for long-term treatment with oral anticoagulants after successful ablation of atrial fibrillation and promises to change clinical practice.

Nature Reviews Cardiology, Published online: 02 January 2026; doi:10.1038/s41569-025-01227-xIn this Review, Park and Fishman summarize the biology, function and disease of the cardiac conduction system and discuss how this knowledge could help to improve clinical risk assessment and the development of therapies, including biological pacemakers and interventions to promote cardiac conduction system regeneration.

Nature Reviews Cardiology, Published online: 02 January 2026; doi:10.1038/s41569-025-01244-wFrailty is common in older individuals, but can occur independently of advanced age, multimorbidity or disability. In this Review, Nguyen and colleagues draw on evidence from clinical guidelines and randomized controlled trials to provide an in-depth discussion of the unique challenges associated with cardiovascular pharmacotherapy in older patients with frailty.