Bryan Yipp
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bryanyipp.bsky.social
Bryan Yipp
@bryanyipp.bsky.social
120 followers 270 following 26 posts
MD trained scientist. Intensivist. Immunologist. Neutrophil biologist.
www.yipplab.com
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bryanyipp.bsky.social
Bryan Yipp @bryanyipp.bsky.social · May 30
Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social

www.cell.com/immunity/abs...
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...
www.cell.com
Reposted by Bryan Yipp
jci.org
A new theory helps explain blood clots complications in COVID-19

G. Gregory Neely & team discover P-selectin, expressed on the surface of activated platelets, suppresses SARS-CoV-2 infection in mice and promotes interaction between SARS-CoV-2 and the endothelial cells: www.jci.org/articles/vie...
November 25, 2025 at 5:15 PM
Reposted by Bryan Yipp
jengommerman.bsky.social
It’s been a great week for the GommerLab. Today I am proud of Dr. Albert Nguyen who as a student then a postdoc saw this work to the finish line. Also grateful to Dr. Chrys Brown (MSKCC) - Working together we learned new things about cDC2 biology. Yay team science!
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate - Nature Immunology
Nguyen et al. show that the splenic environment provides sequential signals via lymphotoxin and retinoic acid that guide cDC2A development and retention.
www.nature.com
November 21, 2025 at 1:15 PM
bryanyipp.bsky.social
www.jci.org/articles/vie...
JCI - P selectin promotes SARS-CoV-2 interactions with platelets and the endothelium
www.jci.org
November 20, 2025 at 4:12 PM
bryanyipp.bsky.social
www.nature.com/articles/s41...
Maternal stress triggers early-life eczema through fetal mast cell programming - Nature
Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to ...
www.nature.com
November 20, 2025 at 4:11 PM
Reposted by Bryan Yipp
jengommerman.bsky.social
Proud to share our work now out in Cell. We hope what we learned about IgA immune responses to rotavirus can be translated into better vaccines. Congratulations Dr. Kei Haniuda, an amazing PDF. TY
@uoftmedicine.bsky.social
for covering.

temertymedicine.utoronto.ca/news
Recent News
temertymedicine.utoronto.ca
November 17, 2025 at 11:12 PM
bryanyipp.bsky.social
Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells: Cell www.cell.com/cell/fulltex...
Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells
Long-lived plasma cells that secrete virus-specific IgA at the mucosae are a key determinant in preventing viral infection. Generation of this response is dependent on a unique subset of follicular he...
www.cell.com
November 17, 2025 at 4:09 PM
Reposted by Bryan Yipp
jci.org
ICYMI: Protection against the fungus among us after mold spore inhalation…

@fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs and neutrophils in the lung is necessary for antifungal activity.

www.jci.org/articles/vie...
November 2, 2025 at 2:01 PM
Reposted by Bryan Yipp
drusqui.bsky.social
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
October 28, 2025 at 4:41 PM
bryanyipp.bsky.social
www.nature.com/articles/d41...
Google Scholar tool gives extra credit to first and last authors
Researchers welcome the initiative, but say it doesn’t go far enough to capture the nuance of researcher productivity and impact.
www.nature.com
October 26, 2025 at 12:57 AM
bryanyipp.bsky.social
Less is more: Academic publishing needs ‘radical change,’ Cambridge press report concludes  – Retraction Watch share.google/uh38CzCZHGwW...
Less is more: Academic publishing needs ‘radical change,’ Cambridge press report concludes
Academic publishing needs “renewed focus and collective action” to embrace new approaches and ensure the future of the industry, concludes a report from Cambridge University Press, released last we…
share.google
October 23, 2025 at 12:19 AM
Reposted by Bryan Yipp
theonlylabever.bsky.social
Happy to share new work from #theonlylabever, lead by the phenomenal @sltai.bsky.social - who developed a tool to study the biology of ILC3s, identifying their role in controlling CSF2-dependent myeloid cells. 🤗
@mucosalimmunol.bsky.social @societymucosalimm.bsky.social
OA: doi.org/10.1016/j.mu...
October 15, 2025 at 5:11 AM
Reposted by Bryan Yipp
cp-immunity.bsky.social
Sensory neurons shape local macrophage identity via TGF-β signaling
Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local interactions between sensory nerves and macrophages activate TGF-β, which imprints and maintains nerve-associated macrophages that contribute to regeneration after tissue injury.
dlvr.it
October 15, 2025 at 7:55 PM
Reposted by Bryan Yipp
labwaggoner.bsky.social
Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells
www.nature.com/articles/s41... @natimmunol.nature.com @idoyagalab.bsky.social
October 14, 2025 at 5:53 PM
bryanyipp.bsky.social
www.nature.com/articles/s41...
Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells - Nature Immunology
Pucella, Maqueda-Alfaro and colleagues distinguish three developmentally related subsets of mouse plasmacytoid dendritic cells that differ in their ability to produce type I interferon and their susce...
www.nature.com
October 14, 2025 at 7:46 PM
bryanyipp.bsky.social
Mast cells regulate the brain-dura interface and CSF dynamics: Cell www.cell.com/cell/fulltex...
Mast cells regulate the brain-dura interface and CSF dynamics
Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...
www.cell.com
October 2, 2025 at 3:04 PM
Reposted by Bryan Yipp
rupress.org
Paul Kubes & Daniel Mucida are @jem.org Academic Editors! Paul studies how myeloid cells integrate into healthy tissues & maintain homeostasis at Queen's University. Daniel studies how gut immune system balances response & tolerance at @rockefelleruniv.bsky.social - bios: rupress.org/jem/pages/ed...
September 25, 2025 at 3:01 PM
Reposted by Bryan Yipp
cp-immunity.bsky.social
Trio fatale: Neutrophils, NETs, and necrosis
In a recent issue of Nature, Adrover et al. report a neutrophil subset that induces pleomorphic tumor necrosis through NET-mediated vascular occlusion. This process drives epithelial-to-mesenchymal transition and metastasis of perinecrotic cancer cells, reframing necrosis as an active process and uncovering targetable mechanisms to combat cancer dissemination.
dlvr.it
September 13, 2025 at 12:52 PM
Reposted by Bryan Yipp
cp-immunity.bsky.social
Born to be wild: Wildings stay the course
The immune system of wildlings—mice with a wild-derived microbiota—has features similar to that in adult humans. In this issue of Immunity, Oh et al. demonstrate the long-term stability of wildling microbiota and immune traits, establishing these mice as an accessible, transferable model for immunology research.
dlvr.it
September 13, 2025 at 2:48 PM
Reposted by Bryan Yipp
labwaggoner.bsky.social
Perspective @cp-immunity.bsky.social A roadmap for defining “extrafollicular” B cell responses
www.cell.com/immunity/ful... @stephanieeisen.bsky.social @vinuesalab.bsky.social et al
September 22, 2025 at 4:40 PM
Reposted by Bryan Yipp
cp-immunity.bsky.social
Online now: A roadmap for defining “extrafollicular” B cell responses
A roadmap for defining “extrafollicular” B cell responses
The term “extrafollicular” is now being used expansively to describe a variety of B cell processes beyond the original use of the term, potentially obscuring important distinct immunological processes. We discuss current uses of the term extrafollicular and propose a framework to help classify these evolving concepts in B cell biology.
dlvr.it
September 22, 2025 at 2:49 PM
Reposted by Bryan Yipp
maxkrummel.bsky.social
How will our increasingly deep understanding of diverse immune archetypes in cancers guide our search for cures?

This perspective describes a future in which we discover drugs based on transitions of tissue/immunobiology through intermediate states, to health. authors.elsevier.com/a/1llig5TA51...
Conceptualization of drugs, akin to chemical catalysts that promote sequential transitions in tissues https://authors.elsevier.com/a/1llig5TA51lD9X
September 17, 2025 at 12:53 PM
Reposted by Bryan Yipp
sciencex.bsky.social
Pain-sensing nerve cells in the lungs play a key role in controlling inflammation linked to pulmonary fibrosis, suggesting new avenues for managing lung scarring through neurological therapies. doi.org/g93vst
Pain-detecting nerve cells could yield new way to manage lung scarring
Researchers at the University of Calgary studying a lethal lung disease called pulmonary fibrosis have found that neurons known to help detect pain are also critical for reducing harmful lung inflammation that leads to the disease.
medicalxpress.com
September 16, 2025 at 8:04 PM
Reposted by Bryan Yipp
nizet.bsky.social
Pleased to share and briefly highlight our new manuscript just published 𝘑𝘊𝘐 𝘐𝘯𝘴𝘪𝘨𝘩𝘵 (a short🧵)

"A STING-adjuvanted outer membrane vesicle nanoparticle vaccine protects against lethal 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘢𝘦𝘳𝘶𝘨𝘪𝘯𝘰𝘴𝘢 pneumonia"

🔗 doi.org/10.1172/jci....
September 11, 2025 at 2:37 AM
Reposted by Bryan Yipp
payalyokota.bsky.social
Check out this cool new work from Deep's lab at Yale about how nerve associated macs play critical role in controlling homeostasis and reducing inflammation in adipose tissue across lifespan. #Freshoffthepress

www.nature.com/articles/s43...
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation - Nature Aging
Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate inflammation and control lip...
www.nature.com
September 2, 2025 at 10:08 PM