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Stephan Hacker @stephanhacker2.bsky.social · 15h

Exciting Tuesday Talk by Kim Bonger (@kimmb1.bsky.social) at @leidenscience.bsky.social. She talked about her group's exciting research into antigen-drug conjugates to target autoreactive B-cells as well as into CAR-T cell therapies for #cancer therapy. pubs.acs.org/doi/full/10....

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Reposted by Stephan Hacker

Leiden Early Drug Discovery & Development (LED3) @led3hub.bsky.social · 15h

Great talk by Kim Bonger (@kimmb1.bsky.social) at our Faculty's (@leidenscience.bsky.social) Tuesday Talks. She talked about her group's exciting research into precision medicine with a special focus on autoimmune diseases.
#ChemBio #ChemSky #DrugDiscovery

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Stephan Hacker @stephanhacker2.bsky.social · 1d

I also added him to my "Scientists to Follow 2" starter pack:

Scientists to follow: go.bsky.app/3SyoVNw
Scientists to follow 2: go.bsky.app/9keb2TP
(2/2)

Stephan Hacker @stephanhacker2.bsky.social · 1d

Great to see that Apostolos Liakopoulos (@apoliakopoulos.bsky.social), #AssistantProfessor from @utrechtuniversity.bsky.social, has joined us here.
Give him a follow, if you want to learn cool things about the lifestyles that #bacteria adopt to evade #antibiotics and about @apnet.bsky.social. (1/2)

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Stephan Hacker @stephanhacker2.bsky.social · 3d

Great interview with my @led3hub.bsky.social colleague @gillesvanwezel.bsky.social in C2W mens & molecule. He talks about new developments in #antibiotic #DrugDiscovery, the applications of #AI and opportunities to foster antibiotic development.
www.sciencelink.net/verdieping/p...
#ChemSky #ChemBio

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Reposted by Stephan Hacker

Leiden Early Drug Discovery & Development (LED3) @led3hub.bsky.social · 3d

How could #antibiotic research look like in the future? How can antibiotic development be made more economically rewarding?

Check out the interview with LED3 hub researcher @gillesvanwezel.bsky.social (Dutch only).
www.sciencelink.net/verdieping/p...
#ChemSky #ChemBio #DrugDiscovery

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Reposted by Stephan Hacker

Leiden Early Drug Discovery & Development (LED3) @led3hub.bsky.social · 3d

Hoe zou #antibioticaonderzoek er in de toekomst uit kunnen zien? Hoe kan de ontwikkeling van #antibiotica economisch aantrekkelijker worden gemaakt?

Als u geïnteresseerd bent in deze vragen, lees dan het interview met @gillesvanwezel.bsky.social

www.sciencelink.net/verdieping/p...
#Chemie #ChemBio

‘Prioriteren is het sleutelwoord’

De 'stille pandemie' van antibioticaresistentie kruipt verontrustend voort. Ondanks dat de farmaceutische industrie weinig interesse toont in het ontwikkelen van nieuwe antibiotica, zijn er genoeg ini...

www.sciencelink.net

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Stephan Hacker @stephanhacker2.bsky.social · 4d

This great @science.org paper by Vividion and @crick.ac.uk headed by Matt Patricelli and @juliandownward.bsky.social on covalent inhibitors of the PI3Kα-RAS interaction. Exciting project on #CovalentInhibitors and #ChemicalProteomics.
www.science.org/doi/10.1126/...
#ChemSky #ChemBio #DrugDiscovery

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Stephan Hacker @stephanhacker2.bsky.social · 5d

Join us in Berlin for the 25th Anniversary Symposium of ChemBioChem and ChemPhysChem on October 23rd and 24th. There will be a great line-up of speakers! www.cbc-cpc2025.org/programme

www.linkedin.com/posts/ld-org...

CC: @chemistryeurope.bsky.social

#structuralbiology #biomolecularanalysis #scientificsymposium #chembiochem #biophysics #drugdiscovery #ai #biomolecules | LD Organisation - Scientific Conference Producers

Discover the final programme of ChemBioChem and ChemPhysChem 25th Anniversary Symposium on Advances in Structural Analysis of Biomolecules! Join us for 1,5 days of exciting science showcasing: >> 14...

www.linkedin.com

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Stephan Hacker @stephanhacker2.bsky.social · 6d

- macrocycles (J. Miguel Mata of the @sebastianpomplun.bsky.social lab, chemrxiv.org/engage/chemr...)

- covalent inhibitors (our group, chemrxiv.org/engage/chemr...)

(3/3)

CycloSELs – Massive Screening Platform of barcode-free macrocycle libraries enables the identification of cell-penetrating PPI inhibitors

Synthetic macrocycles offer exceptional potential as therapeutics, combining the ability to engage challenging biological targets with favorable drug-like properties. However, most high-throughput dis...

chemrxiv.org

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Stephan Hacker @stephanhacker2.bsky.social · 6d

We heard a lot about various exciting modalities:

- bifunctional degraders (William Farnaby, chemrxiv.org/engage/chemr...)

- antibody-drug conjugates (Marc Robillard, www.nature.com/articles/s41...)

(2/3)

Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening

Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative d...

chemrxiv.org

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Stephan Hacker @stephanhacker2.bsky.social · 6d

A huge thank you to Scott Webster and Daan van der Es for putting together an amazing session on new modalities for drug discovery at the Dutch Medicines Days and for selecting me to present some of our work in this session. (1/3)

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Stephan Hacker @stephanhacker2.bsky.social · 6d

I was very happy that I was able to present some of our group's work on profiling the targets of covalent inhibitors at the Dutch Medicines Days. I hope I was able to give interesting insights into the monitoring of diverse amino acids in the proteome. chemrxiv.org/engage/chemr...

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Stephan Hacker @stephanhacker2.bsky.social · 6d

Interesting talk by Miguel Mata of the @sebastianpomplun.bsky.social lab at the Dutch Medicines Days. He talked about his innovative research on self-encoded libraries of macrocycles to identify potent protein-binders using affinity-selection MS. chemrxiv.org/engage/chemr...

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Stephan Hacker @stephanhacker2.bsky.social · 6d

Great talk by Marc Robillard of Tagworks at the Dutch Medicines Days. He talked about their groundbreaking work on antibody-drug conjugates that release their payload through click-to-release chemistry and, thereby, circumvent the need for antibody internalization. www.nature.com/articles/s41...

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Stephan Hacker @stephanhacker2.bsky.social · 6d

Great talk by William Farnaby at the Dutch Medicines Days. He talked about his group's work on using direct-to-biology approaches to efficiently screen for bifunctional degraders on the example of a CNS-active GSK3 degrader. chemrxiv.org/engage/chemr...

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Stephan Hacker @stephanhacker2.bsky.social · 6d

Exciting talk by Pavel Sinitcyn of Utrecht University at the Dutch Medicines Days. He talked about the power of combining MS-based #proteomics with #MachineLearning in order to improve protein, phosphopeptide and immunopeptide identification. www.nature.com/articles/s41...

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Stephan Hacker @stephanhacker2.bsky.social · 6d

Interesting talk by Tudor Oprea at the Dutch Medicines Days. He talked about the use of #MachineLearning and #ArtificialIntelligence for #DrugDiscovery. Exciting applications to finding the right targets and the right molecules for them. www.annualreviews.org/content/jour...

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Stephan Hacker @stephanhacker2.bsky.social · 6d

Great talk by Jeroen de Ridder at the Dutch Medicines Days. Exciting insights into using nanopore sequencing on material obtained during surgery and analyzing it with deep-learning to classify the tumor type within about an hour to guide surgery decisions. www.nature.com/articles/s41...

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Stephan Hacker @stephanhacker2.bsky.social · 6d

Great Ariëns Award Lecture by @lukeanthonyoneill.bsky.social from Trinity College Dublin. He talked about the importance of studying immunometabolism to better understand and treat #obesity. Interesting insights into the role of the electrophilic compound itaconate. www.nature.com/articles/s42...

Metabolic Messengers: itaconate - Nature Metabolism

McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.

www.nature.com

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Stephan Hacker @stephanhacker2.bsky.social · 6d

Very much looking forward to hosting Nicolas Winssinger for a @led3hub.bsky.social Lecture on October 30th.

If you are interested in nucleic acid-encoded libraries, mark your calendars and join us in Leiden @leidenscience.bsky.social.

www.universiteitleiden.nl/en/science/l...

#ChemBio #ChemSky

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Reposted by Stephan Hacker

Leiden Early Drug Discovery & Development (LED3) @led3hub.bsky.social · 7d

We are very happy that Tudor Oprea from Expert Systems Inc. visited us today for a talk. He talked about the use of Machine Learning and Artificial Intelligence in Drug Discovery.

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Stephan Hacker @stephanhacker2.bsky.social · 7d

Finally, he gave an overview of the tools that they are developing for small molecules regarding e.g. the prediction of potency and #ADMET properties. (5/5) predict.expertsystems.app

Predict Molecular Properties from SMILES | Expert Systems

Predict molecular properties (ADMET, permeability, kinase binding, etc.) from SMILES strings or CSV files.

predict.expertsystems.app

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Stephan Hacker @stephanhacker2.bsky.social · 7d

Next, he discussed the design of a Bcl-2 inhibitor that is highly selective over Bcl-xL. (4/5) www.sciencedirect.com/science/arti...

A Novel Selective BCL2 Inhibitor with Limited Immune Suppression and Improved Safety Compared to Venetoclax

BCL2 is a key pro-survival protein that is overexpressed in many cancers. The first generation BCL2 inhibitor venetoclax has proved highly effective i…

www.sciencedirect.com

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Stephan Hacker @stephanhacker2.bsky.social · 7d

He then talked about the three pillars of #DrugDiscovery, to which, in his view, #ArtificialIntelligence can make the biggest contributions at the moment:
- understanding diseases
- selecting the right targets
- predicting suitable therapeutic modalities
(3/5) www.annualreviews.org/content/jour...

Artificial Intelligence for Drug Discovery: Are We There Yet?

Drug discovery is adapting to novel technologies such as data science, informatics, and artificial intelligence (AI) to accelerate effective treatment development while reducing costs and animal exper...

www.annualreviews.org

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