Stephan Hacker
@stephanhacker2.bsky.social
Assistant Professor at Leiden University. Covalent inhibitors and chemoproteomics for antibiotics. Views my own. he/him/his. https://orcid.org/0000-0001-5420-4824
Great to see our Nature Chemistry paper out in its final published and printed form.
If you want to check it out, you can find it here: www.nature.com/articles/s41...
#ChemSky #ChemBio #ChemicalProteomics #Chemoproteomics #ProteoProbes #ChemPro
If you want to check it out, you can find it here: www.nature.com/articles/s41...
#ChemSky #ChemBio #ChemicalProteomics #Chemoproteomics #ProteoProbes #ChemPro
November 21, 2025 at 11:08 AM
Great to see our Nature Chemistry paper out in its final published and printed form.
If you want to check it out, you can find it here: www.nature.com/articles/s41...
#ChemSky #ChemBio #ChemicalProteomics #Chemoproteomics #ProteoProbes #ChemPro
If you want to check it out, you can find it here: www.nature.com/articles/s41...
#ChemSky #ChemBio #ChemicalProteomics #Chemoproteomics #ProteoProbes #ChemPro
Great talk by Clive Chung at #ISCPDD. He presented his work on #ChemcalProteomics to find cysteine-directed covalent inhibitors. Exciting insights into NAIA chemistry and into the application to specific proteins of interest.
www.nature.com/articles/s41...
#ChemSky #ChemBio #ChemPro #ProteoProbes
www.nature.com/articles/s41...
#ChemSky #ChemBio #ChemPro #ProteoProbes
November 21, 2025 at 8:39 AM
Great talk by Clive Chung at #ISCPDD. He presented his work on #ChemcalProteomics to find cysteine-directed covalent inhibitors. Exciting insights into NAIA chemistry and into the application to specific proteins of interest.
www.nature.com/articles/s41...
#ChemSky #ChemBio #ChemPro #ProteoProbes
www.nature.com/articles/s41...
#ChemSky #ChemBio #ChemPro #ProteoProbes
Great talk by Itaru Hamachi at #ISCPDD. He talked about his group’s research into PhoxID. In this method, endogenous proteins are labeled with a photocatalyst by ligand-directed chemistry and used for proximity labeling of their environment.
www.pnas.org/doi/10.1073/...
#ChemSky #ChemBio
www.pnas.org/doi/10.1073/...
#ChemSky #ChemBio
November 20, 2025 at 2:40 PM
Great talk by Itaru Hamachi at #ISCPDD. He talked about his group’s research into PhoxID. In this method, endogenous proteins are labeled with a photocatalyst by ligand-directed chemistry and used for proximity labeling of their environment.
www.pnas.org/doi/10.1073/...
#ChemSky #ChemBio
www.pnas.org/doi/10.1073/...
#ChemSky #ChemBio
Amazing lecture by Zhengqiu Li at #ISCPDD. He presented his group’s exciting research into the recruitment of new E3 ligases for targeted protein degradation using diverse new electrophiles including of NEDD4 via an azirine.
pubs.acs.org/doi/full/10....
#TPD #ChemSky #ChemBio #ChemicalProteomics
pubs.acs.org/doi/full/10....
#TPD #ChemSky #ChemBio #ChemicalProteomics
November 20, 2025 at 9:24 AM
Amazing lecture by Zhengqiu Li at #ISCPDD. He presented his group’s exciting research into the recruitment of new E3 ligases for targeted protein degradation using diverse new electrophiles including of NEDD4 via an azirine.
pubs.acs.org/doi/full/10....
#TPD #ChemSky #ChemBio #ChemicalProteomics
pubs.acs.org/doi/full/10....
#TPD #ChemSky #ChemBio #ChemicalProteomics
Zhengqiu Li opens the 3rd International Symposium on Chemical Proteomics and Drug Discovery #ISCPDD in Guangzhou marking the start of two days of exciting reports on research in #ChemicalProteomics, #ChemBio, #Chemistry and #DrugDiscovery.
#ChemSky
#ChemSky
November 18, 2025 at 4:03 PM
Zhengqiu Li opens the 3rd International Symposium on Chemical Proteomics and Drug Discovery #ISCPDD in Guangzhou marking the start of two days of exciting reports on research in #ChemicalProteomics, #ChemBio, #Chemistry and #DrugDiscovery.
#ChemSky
#ChemSky
It was a great pleasure to be at the 3rd International Symposium on Chemical Proteomics and Drug Discovery #ISCPDD in Guangzhou. A huge thank you to Zhengqiu Li for the invitation and amazing hospitality. We had an amazing program. I will post some updates here soon.
#ChemBio #ChemSky #DrugDiscovery
#ChemBio #ChemSky #DrugDiscovery
November 18, 2025 at 11:09 AM
It was a great pleasure to be at the 3rd International Symposium on Chemical Proteomics and Drug Discovery #ISCPDD in Guangzhou. A huge thank you to Zhengqiu Li for the invitation and amazing hospitality. We had an amazing program. I will post some updates here soon.
#ChemBio #ChemSky #DrugDiscovery
#ChemBio #ChemSky #DrugDiscovery
Great @leidenscience.bsky.social Tuesday Talk by Ilze Bot of the @led3hub.bsky.social. She talked about her group's work into better understanding the involvement of #inflammation in the development of #atherosclerosis and its implications for therapy.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 11, 2025 at 3:45 PM
Great @leidenscience.bsky.social Tuesday Talk by Ilze Bot of the @led3hub.bsky.social. She talked about her group's work into better understanding the involvement of #inflammation in the development of #atherosclerosis and its implications for therapy.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Interesting talk by Petra de Jongh at the #Reedijk Symposium. She talked about the use of in situ/operando electron microscopy to better understand heterogeneous catalysts under conditions that are close to those used in industry-scale reactors.
#ChemSky #Catalysis
#ChemSky #Catalysis
November 7, 2025 at 3:28 PM
Interesting talk by Petra de Jongh at the #Reedijk Symposium. She talked about the use of in situ/operando electron microscopy to better understand heterogeneous catalysts under conditions that are close to those used in industry-scale reactors.
#ChemSky #Catalysis
#ChemSky #Catalysis
Very happy that Storm van der Voort - PhD in the group of Hermen Overkleeft and in our group - was selected for a talk at the #Reedijk Symposium. He gave an excellent presentation on using direct-to-biology to efficiently make covalent libraries for antibacterial screening
#ChemSky #ChemBio #ProudPI
#ChemSky #ChemBio #ProudPI
November 7, 2025 at 1:42 PM
Great talk by Jaco Geuchies at the #Reedijk Symposium of the Leiden Institute of Chemistry. He told us, how his group uses ultrafast spectroscopy to better understand the structure and properties of soft semiconductor materials such as metal-halide #perovskites. pubs.acs.org/doi/full/10....
#ChemSky
#ChemSky
November 7, 2025 at 1:30 PM
Great talk by Jaco Geuchies at the #Reedijk Symposium of the Leiden Institute of Chemistry. He told us, how his group uses ultrafast spectroscopy to better understand the structure and properties of soft semiconductor materials such as metal-halide #perovskites. pubs.acs.org/doi/full/10....
#ChemSky
#ChemSky
Insightful talk by Jeroen Codee at the #Reedijk Symposium. He talked about the importance of synthetic organic chemistry to make complex glycans to better understand #glycobiology. Very impressive, systematic work on glycosylation reactions. pubs.rsc.org/en/content/a...
#ChemSky #ChemBio #Glycotime
#ChemSky #ChemBio #Glycotime
November 7, 2025 at 12:54 PM
Insightful talk by Jeroen Codee at the #Reedijk Symposium. He talked about the importance of synthetic organic chemistry to make complex glycans to better understand #glycobiology. Very impressive, systematic work on glycosylation reactions. pubs.rsc.org/en/content/a...
#ChemSky #ChemBio #Glycotime
#ChemSky #ChemBio #Glycotime
Inspiring #Havinga Medal lecture by @craigmcrews.bsky.social at the #Reedijk Symposium. Amazing to hear him talk about the full story of the development of induced proximity into a new paradigm of event-driven pharmacology for #DrugDiscovery.
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
November 7, 2025 at 10:31 AM
Inspiring #Havinga Medal lecture by @craigmcrews.bsky.social at the #Reedijk Symposium. Amazing to hear him talk about the full story of the development of induced proximity into a new paradigm of event-driven pharmacology for #DrugDiscovery.
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD
Great talk by @kimmb1.bsky.social of our @led3hub.bsky.social at the #Reedijk Symposium. She talked about the power of activity-based probes to study protein function on the example of live cell imaging of myeloperoxidase activity to study NETosis. www.nature.com/articles/s42...
#ChemBio #ChemSky
#ChemBio #ChemSky
November 7, 2025 at 9:07 AM
Great talk by @kimmb1.bsky.social of our @led3hub.bsky.social at the #Reedijk Symposium. She talked about the power of activity-based probes to study protein function on the example of live cell imaging of myeloperoxidase activity to study NETosis. www.nature.com/articles/s42...
#ChemBio #ChemSky
#ChemBio #ChemSky
I was very happy to host Nicolas Winssinger today for a well-attended @led3hub.bsky.social Lecture.
He gave us exciting insights into the power of nucleic acid assemblies. Very exciting data on a highly selective thrombin inhibitor that can be switched off on demand. www.nature.com/articles/s41...
He gave us exciting insights into the power of nucleic acid assemblies. Very exciting data on a highly selective thrombin inhibitor that can be switched off on demand. www.nature.com/articles/s41...
October 30, 2025 at 3:35 PM
I was very happy to host Nicolas Winssinger today for a well-attended @led3hub.bsky.social Lecture.
He gave us exciting insights into the power of nucleic acid assemblies. Very exciting data on a highly selective thrombin inhibitor that can be switched off on demand. www.nature.com/articles/s41...
He gave us exciting insights into the power of nucleic acid assemblies. Very exciting data on a highly selective thrombin inhibitor that can be switched off on demand. www.nature.com/articles/s41...
Very excited to be in Utrecht for the @apnet.bsky.social general assembly and our first in-person workshop on strategic career development. Very much looking forward to meeting everyone!
October 28, 2025 at 10:28 AM
Very excited to be in Utrecht for the @apnet.bsky.social general assembly and our first in-person workshop on strategic career development. Very much looking forward to meeting everyone!
I had an amazing time at the 25th anniversary symposium of ChemBioChem and ChemPhysChem #ChemBioPhys2025.
We had two days of exciting science and important interactions. Thank you to the organizers from @chemistryeurope.bsky.social and especially to @rubenragg.bsky.social.
#ChemSky #ChemBio
We had two days of exciting science and important interactions. Thank you to the organizers from @chemistryeurope.bsky.social and especially to @rubenragg.bsky.social.
#ChemSky #ChemBio
October 24, 2025 at 3:31 PM
I had an amazing time at the 25th anniversary symposium of ChemBioChem and ChemPhysChem #ChemBioPhys2025.
We had two days of exciting science and important interactions. Thank you to the organizers from @chemistryeurope.bsky.social and especially to @rubenragg.bsky.social.
#ChemSky #ChemBio
We had two days of exciting science and important interactions. Thank you to the organizers from @chemistryeurope.bsky.social and especially to @rubenragg.bsky.social.
#ChemSky #ChemBio
@rubenragg.bsky.social and Meghan Lucas close a great #ChemBioPhys2025 symposium and present the poster prizes. Congratulations to the winners.
Very curious to see, what the next 25 years of ChemBioChem and ChemPhysChem of @chemistryeurope.bsky.social will bring.
#ChemSky #ChemBio
Very curious to see, what the next 25 years of ChemBioChem and ChemPhysChem of @chemistryeurope.bsky.social will bring.
#ChemSky #ChemBio
October 24, 2025 at 3:29 PM
@rubenragg.bsky.social and Meghan Lucas close a great #ChemBioPhys2025 symposium and present the poster prizes. Congratulations to the winners.
Very curious to see, what the next 25 years of ChemBioChem and ChemPhysChem of @chemistryeurope.bsky.social will bring.
#ChemSky #ChemBio
Very curious to see, what the next 25 years of ChemBioChem and ChemPhysChem of @chemistryeurope.bsky.social will bring.
#ChemSky #ChemBio
#ChemBioPhys2025 comes to a close with an exciting lecture by @klanglab.bsky.social. Genetic code expansion to site-specifically study PTMs in cells. Great insights into hijacking an ABC transporter to increase uptake for many exciting amino acids. www.nature.com/articles/s41...
#ChemSky #ChemBio
#ChemSky #ChemBio
October 24, 2025 at 3:10 PM
#ChemBioPhys2025 comes to a close with an exciting lecture by @klanglab.bsky.social. Genetic code expansion to site-specifically study PTMs in cells. Great insights into hijacking an ABC transporter to increase uptake for many exciting amino acids. www.nature.com/articles/s41...
#ChemSky #ChemBio
#ChemSky #ChemBio
Interesting talk by Claus Seidel at #ChemBioPhys2025. He talked about the use of Förster resonance energy transfer (FRET) to understand the dynamics and function of transient states in single enzyme molecules. www.nature.com/articles/s41...
October 24, 2025 at 2:34 PM
Interesting talk by Claus Seidel at #ChemBioPhys2025. He talked about the use of Förster resonance energy transfer (FRET) to understand the dynamics and function of transient states in single enzyme molecules. www.nature.com/articles/s41...
Interesting talk by Jan Götze at #ChemBioPhys2025. He gave exciting insights into his group's research into the importance of Förster resonance energy transfer (FRET) in the photosynthetic complexes.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
October 24, 2025 at 1:33 PM
Interesting talk by Jan Götze at #ChemBioPhys2025. He gave exciting insights into his group's research into the importance of Förster resonance energy transfer (FRET) in the photosynthetic complexes.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Interesting talk by Anahita Khammari at #ChemBioPhys2025. She talked about her research into investigating the interaction of the deubiquitinase USP48 with its inhibitor ML364 and its analogs using docking approaches.
onlinelibrary.wiley.com/doi/full/10....
#ChemSky #ChemBio #DrugDiscovery
onlinelibrary.wiley.com/doi/full/10....
#ChemSky #ChemBio #DrugDiscovery
October 24, 2025 at 1:20 PM
Interesting talk by Anahita Khammari at #ChemBioPhys2025. She talked about her research into investigating the interaction of the deubiquitinase USP48 with its inhibitor ML364 and its analogs using docking approaches.
onlinelibrary.wiley.com/doi/full/10....
#ChemSky #ChemBio #DrugDiscovery
onlinelibrary.wiley.com/doi/full/10....
#ChemSky #ChemBio #DrugDiscovery
Exciting lecture by Stefan Raunser (@raunser-lab.bsky.social) at #ChemBioPhys2025. He talked about his group's amazing science to better understand actin filament disassembly to better understand muscle function. (1/2) www.cell.com/cell/fulltex...
#ChemBio #ChemSky #cryoEM #muscles
#ChemBio #ChemSky #cryoEM #muscles
October 24, 2025 at 12:56 PM
Exciting lecture by Stefan Raunser (@raunser-lab.bsky.social) at #ChemBioPhys2025. He talked about his group's amazing science to better understand actin filament disassembly to better understand muscle function. (1/2) www.cell.com/cell/fulltex...
#ChemBio #ChemSky #cryoEM #muscles
#ChemBio #ChemSky #cryoEM #muscles
After the lunch break, #ChemBioPhys2025 continues with an excellent lecture by Sandrine Lévêque-Fort (@slfort.bsky.social). She talked about exciting single-molecule microscopy technologies using modulated illumination with great 3D resolution. www.nature.com/articles/s41...
October 24, 2025 at 12:16 PM
After the lunch break, #ChemBioPhys2025 continues with an excellent lecture by Sandrine Lévêque-Fort (@slfort.bsky.social). She talked about exciting single-molecule microscopy technologies using modulated illumination with great 3D resolution. www.nature.com/articles/s41...
It was a huge pleasure to host the morning session of #ChemBioPhys2025. A huge thank you to the speakers @gassergroup.bsky.social, Harald Schwalbe, @ezgikaraca.bsky.social, Stephen Kent, Joseph Braymer, Hsuan-Ai Chen, @borisvauzeilles.bsky.social and @romanrenger.bsky.social. I learned a lot!
October 24, 2025 at 12:06 PM
It was a huge pleasure to host the morning session of #ChemBioPhys2025. A huge thank you to the speakers @gassergroup.bsky.social, Harald Schwalbe, @ezgikaraca.bsky.social, Stephen Kent, Joseph Braymer, Hsuan-Ai Chen, @borisvauzeilles.bsky.social and @romanrenger.bsky.social. I learned a lot!
In the final lecture of the morning session at #ChemBioPhys2025, @romanrenger.bsky.social from Exciting Instruments talked about, how they add dynamics to structural biology using smFRET and FCCS.
academic.oup.com/nar/article/...
#ChemSky #ChemBio #DrugDiscovery
academic.oup.com/nar/article/...
#ChemSky #ChemBio #DrugDiscovery
October 24, 2025 at 11:50 AM
In the final lecture of the morning session at #ChemBioPhys2025, @romanrenger.bsky.social from Exciting Instruments talked about, how they add dynamics to structural biology using smFRET and FCCS.
academic.oup.com/nar/article/...
#ChemSky #ChemBio #DrugDiscovery
academic.oup.com/nar/article/...
#ChemSky #ChemBio #DrugDiscovery