Lyle McKinnon
@sijuiwhatwhat.bsky.social
Mucosal Immunology researcher based at University of Manitoba in Canada. Lab focused on HIV, HPV, & other STIs. Work in Kenya, Uganda & wherever!
Reposted by Lyle McKinnon
Expansion of genital Tregs reduces neutrophil influx and maintains mucosal barrier integrity during inflammatory bacteria challenge in this work from Lyle McKinnon @sijuiwhatwhat.bsky.social and colleagues
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
September 4, 2025 at 1:37 PM
Expansion of genital Tregs reduces neutrophil influx and maintains mucosal barrier integrity during inflammatory bacteria challenge in this work from Lyle McKinnon @sijuiwhatwhat.bsky.social and colleagues
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
Our paper on regulatory T cells and genital inflammation just out in @mucosalimmunol.bsky.social www.mucosalimmunology.org/article/S193...
Expansion of genital Tregs reduces neutrophil influx and maintains mucosal barrier integrity during inflammatory bacteria challenge
Inflammation in the female genital tract (FGT) is central to the initiation of an
effective host immune response against pathogens that are transmitted across this
surface. However, if dysregulated, i...
www.mucosalimmunology.org
August 29, 2025 at 3:50 PM
Our paper on regulatory T cells and genital inflammation just out in @mucosalimmunol.bsky.social www.mucosalimmunology.org/article/S193...
Reposted by Lyle McKinnon
Integrin α4ꞵ7 as a predictor of HIV acquisition: One thread in a complex tapestry: buff.ly/2B0tUne
Tosin E. Omole & @sijuiwhatwhat.bsky.social provide a Commentary on Kawthar Machmach et al. buff.ly/CuRieKh
Tosin E. Omole & @sijuiwhatwhat.bsky.social provide a Commentary on Kawthar Machmach et al. buff.ly/CuRieKh
August 14, 2025 at 3:33 PM
Integrin α4ꞵ7 as a predictor of HIV acquisition: One thread in a complex tapestry: buff.ly/2B0tUne
Tosin E. Omole & @sijuiwhatwhat.bsky.social provide a Commentary on Kawthar Machmach et al. buff.ly/CuRieKh
Tosin E. Omole & @sijuiwhatwhat.bsky.social provide a Commentary on Kawthar Machmach et al. buff.ly/CuRieKh
Reposted by Lyle McKinnon
As promised, a 'skeet' -orial on our paper published last week !
Now online! Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
Robot-assisted analysis and theoretical modeling of TCR/CAR crosstalk enable the design of adoptive T cell therapies that maximize anti-tumor activity and minimize toxicity in healthy tissues.
dlvr.it
April 14, 2025 at 1:05 PM
As promised, a 'skeet' -orial on our paper published last week !
Can’t find delta airlines on here, but if I could I would tag them & say hey, look at this!
January 6, 2025 at 4:35 PM
Can’t find delta airlines on here, but if I could I would tag them & say hey, look at this!
Our recent work on a4b7 & HIV risk in heterosexual men & women from South Africa, Kenya & Uganda. Congrats to my student @TosinOmole2 who led this massive effort & thanks to Glenda & Jai & teams for access to great cohorts! academic.oup.com/jid/advance-...
Pre-HIV α4β7hi CD4+ T cells and HIV risk among heterosexual individuals in Africa
CD4+ T cells that express the gut homing integrin α4β7 are more readily infected by HIV, but as predictors of HIV acquisition, associations differ by cohor
academic.oup.com
December 25, 2024 at 5:13 PM
Our recent work on a4b7 & HIV risk in heterosexual men & women from South Africa, Kenya & Uganda. Congrats to my student @TosinOmole2 who led this massive effort & thanks to Glenda & Jai & teams for access to great cohorts! academic.oup.com/jid/advance-...
Reposted by Lyle McKinnon
Always a tough call at @science.org what to name the Breakthrough of the Year. But as someone interested in infectious diseases and living with HIV, this is truly a remarkable breakthrough.
We now have yet another amazing tool to stop new HIV infections. We need to use them all!
🧪 #IDsky #HIVsky
We now have yet another amazing tool to stop new HIV infections. We need to use them all!
🧪 #IDsky #HIVsky
Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months.
Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn
Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn
December 12, 2024 at 7:49 PM
Always a tough call at @science.org what to name the Breakthrough of the Year. But as someone interested in infectious diseases and living with HIV, this is truly a remarkable breakthrough.
We now have yet another amazing tool to stop new HIV infections. We need to use them all!
🧪 #IDsky #HIVsky
We now have yet another amazing tool to stop new HIV infections. We need to use them all!
🧪 #IDsky #HIVsky
How does this thing work?
November 21, 2024 at 12:42 AM
How does this thing work?