Siegenthaler Lab
@siegenthalerlab.bsky.social
Neuroscience, meninges, blood-brain barrier, cake (or cookies)
http://siegenthalerlabcu.weebly.com/
http://siegenthalerlabcu.weebly.com/
Pinned
Hi Bluesky! I am Julie Siegenthaler, I am research faculty in Pediatrics at the University of Colorado, Anschutz Medical Campus in Aurora, Colorado USA - the @siegenthalerlab.bsky.social studies the meninges & brain vasculature & we ❤️ all CNS barriers...but the ones in the meninges are the best.
🚨 NIH F31 fellowship Sponsor❓- prior versions of the Sponsor document, there was a table of sponsor's & co-sponsor active or pending awards but this section is gone - should I beef up this area in my sponsor biosketch? Or am I missing where to include this information? Do we do a other support doc?
a batman logo is being projected on a dark background
ALT: a batman logo is being projected on a dark background
media.tenor.com
November 28, 2025 at 5:26 PM
🚨 NIH F31 fellowship Sponsor❓- prior versions of the Sponsor document, there was a table of sponsor's & co-sponsor active or pending awards but this section is gone - should I beef up this area in my sponsor biosketch? Or am I missing where to include this information? Do we do a other support doc?
Reposted by Siegenthaler Lab
📢Our latest #preprint list is now up on FocalPlane
This week we highlight the latest tools and techniques in microscopy. Drop us a note if we’ve missed a preprint that you’ve enjoyed reading.
focalplane.biologists.com/2025/11/28/m...
This week we highlight the latest tools and techniques in microscopy. Drop us a note if we’ve missed a preprint that you’ve enjoyed reading.
focalplane.biologists.com/2025/11/28/m...
Microscopy preprints – new tools and techniques in imaging - FocalPlane
Microscopy preprints – new tools and techniques in imaging - News
focalplane.biologists.com
November 28, 2025 at 3:16 PM
📢Our latest #preprint list is now up on FocalPlane
This week we highlight the latest tools and techniques in microscopy. Drop us a note if we’ve missed a preprint that you’ve enjoyed reading.
focalplane.biologists.com/2025/11/28/m...
This week we highlight the latest tools and techniques in microscopy. Drop us a note if we’ve missed a preprint that you’ve enjoyed reading.
focalplane.biologists.com/2025/11/28/m...
Reposted by Siegenthaler Lab
I was one of those immigrants, and we commit fewer crimes than people born here.
“Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the US by revoking their legal status.”
apnews.com/article/trum...
“Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the US by revoking their legal status.”
apnews.com/article/trum...
Trump says he wants to 'permanently pause' migration to the US from poorer countries
President Donald Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the United States by revoking their legal status...
apnews.com
November 28, 2025 at 3:19 PM
I was one of those immigrants, and we commit fewer crimes than people born here.
“Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the US by revoking their legal status.”
apnews.com/article/trum...
“Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the US by revoking their legal status.”
apnews.com/article/trum...
Reposted by Siegenthaler Lab
Same same but different
A mole, a cat, a dog, a turkey, a swallow, a sparrow, a barn owl, a very large duck, and a dormouse.
--
This isn't a children's book but a short essay I wrote about my view on the cerebellum.
vanderheijdenlab.com/resources/
A mole, a cat, a dog, a turkey, a swallow, a sparrow, a barn owl, a very large duck, and a dormouse.
--
This isn't a children's book but a short essay I wrote about my view on the cerebellum.
vanderheijdenlab.com/resources/
November 28, 2025 at 2:50 PM
Same same but different
A mole, a cat, a dog, a turkey, a swallow, a sparrow, a barn owl, a very large duck, and a dormouse.
--
This isn't a children's book but a short essay I wrote about my view on the cerebellum.
vanderheijdenlab.com/resources/
A mole, a cat, a dog, a turkey, a swallow, a sparrow, a barn owl, a very large duck, and a dormouse.
--
This isn't a children's book but a short essay I wrote about my view on the cerebellum.
vanderheijdenlab.com/resources/
Reposted by Siegenthaler Lab
Huge congrats to DR. Henrike Berns (MD), who defended earlier this week with excellent results based on her paper investigating the function and consequences of Wnt11 mutations in humans and frogs 🐸 👏👏👏👏 we will miss you a lot!
November 27, 2025 at 9:29 PM
Huge congrats to DR. Henrike Berns (MD), who defended earlier this week with excellent results based on her paper investigating the function and consequences of Wnt11 mutations in humans and frogs 🐸 👏👏👏👏 we will miss you a lot!
Reposted by Siegenthaler Lab
Just a heads up: I just got a phishing attempt pretending to be from the #VisualSystemDevelopment #GRC. It looked pretty convincing at first glance, so be careful!
November 27, 2025 at 7:36 PM
Just a heads up: I just got a phishing attempt pretending to be from the #VisualSystemDevelopment #GRC. It looked pretty convincing at first glance, so be careful!
Reposted by Siegenthaler Lab
Kurz, Lütge, Ludewig et al. elucidate the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors & highlight the close lineage relationship of the progeny in the perivascular niche rupress.org/jem/article/...
November 26, 2025 at 6:02 PM
Kurz, Lütge, Ludewig et al. elucidate the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors & highlight the close lineage relationship of the progeny in the perivascular niche rupress.org/jem/article/...
Reposted by Siegenthaler Lab
Bah, who needs cohesin if you're at the right place (near). Grover once taught us the difference between near and far (my favourite Sesame Street piece), and now amazing work from @elphegenoralab.bsky.social led by @karissalhansen.bsky.social shows us how: www.science.org/doi/10.1126/...
Synergy between regulatory elements can render cohesin dispensable for distal enhancer function
Enhancers are critical genetic elements controlling transcription from promoters, yet how they convey regulatory information across large genomic distances remains unclear. Here, we engineer pluripote...
www.science.org
November 27, 2025 at 7:10 PM
Bah, who needs cohesin if you're at the right place (near). Grover once taught us the difference between near and far (my favourite Sesame Street piece), and now amazing work from @elphegenoralab.bsky.social led by @karissalhansen.bsky.social shows us how: www.science.org/doi/10.1126/...
Reposted by Siegenthaler Lab
One of the most exciting projects I have ever been involved in: Project Psyche! Read all about our ambitions and aims. It's ground breaking stuff, just mind blowing and even surreal (27 years ago we did single genes for lep phylogenetics)! @projectpsyche.bsky.social
www.cell.com/trends/ecolo...
www.cell.com/trends/ecolo...
Project Psyche: reference genomes for all Lepidoptera in Europe
Project Psyche is a transnational initiative to generate and study chromosome-level
reference genomes of all ~11 000 species of Lepidoptera (butterflies and moths) found
in Europe. Here, we describe t...
www.cell.com
November 27, 2025 at 8:46 AM
One of the most exciting projects I have ever been involved in: Project Psyche! Read all about our ambitions and aims. It's ground breaking stuff, just mind blowing and even surreal (27 years ago we did single genes for lep phylogenetics)! @projectpsyche.bsky.social
www.cell.com/trends/ecolo...
www.cell.com/trends/ecolo...
Reposted by Siegenthaler Lab
If you don't approve of attempts to sanitize history on the US's 250th birthday but want to learn more about the founding era, the state of the field continues to innovate & there are new books coming out like John's on Washington, mine on migration & @gauthamrao.bsky.social's on policing slavery.
My book about how Americans have remembered, forgotten, and manipulated the history of George Washington and slavery over the past 250 years comes out in April. And Titus Kaphar’s art makes it the one of the coolest covers you’ll see next year. uncpress.org/978146969352...
November 27, 2025 at 11:23 AM
If you don't approve of attempts to sanitize history on the US's 250th birthday but want to learn more about the founding era, the state of the field continues to innovate & there are new books coming out like John's on Washington, mine on migration & @gauthamrao.bsky.social's on policing slavery.
Reposted by Siegenthaler Lab
My book about how Americans have remembered, forgotten, and manipulated the history of George Washington and slavery over the past 250 years comes out in April. And Titus Kaphar’s art makes it the one of the coolest covers you’ll see next year. uncpress.org/978146969352...
November 26, 2025 at 11:31 PM
My book about how Americans have remembered, forgotten, and manipulated the history of George Washington and slavery over the past 250 years comes out in April. And Titus Kaphar’s art makes it the one of the coolest covers you’ll see next year. uncpress.org/978146969352...
Reposted by Siegenthaler Lab
PROMOTE YOUR BOOKS! EVERYONE WANTS TO HEAR ABOUT YOUR PUBLISHED BOOKS! Do not ask me how my writing is going.
Because @lollardfish.bsky.social says we should promote our books: utpress.utexas.edu/9781477313138/
Loving Sports When They Don't Love You Back
Triumphant wins, gut-wrenching losses, last-second shots, underdogs, competition, and loyalty—it’s fun to be a fan. But when a football player takes a hi...
utpress.utexas.edu
November 26, 2025 at 6:33 PM
PROMOTE YOUR BOOKS! EVERYONE WANTS TO HEAR ABOUT YOUR PUBLISHED BOOKS! Do not ask me how my writing is going.
Reposted by Siegenthaler Lab
Alcohol-related Hepatitis
Hepatocyte YAP ⏫Myofibroblast prolif/inflamm
Pro-fibrotic GDF15 paracrine
Human hepatocyte organoids in type 2 BME
AH vs Cirrhosis
⬇️Hepatocyte marker ALB CYP3A4 ALDOB
⬆️Cholangiocyte marker KRT19
+Spatial Matrisome
#JHEPRep 2025
www.sciencedirect.com/science/arti...
Hepatocyte YAP ⏫Myofibroblast prolif/inflamm
Pro-fibrotic GDF15 paracrine
Human hepatocyte organoids in type 2 BME
AH vs Cirrhosis
⬇️Hepatocyte marker ALB CYP3A4 ALDOB
⬆️Cholangiocyte marker KRT19
+Spatial Matrisome
#JHEPRep 2025
www.sciencedirect.com/science/arti...
November 27, 2025 at 12:40 PM
Alcohol-related Hepatitis
Hepatocyte YAP ⏫Myofibroblast prolif/inflamm
Pro-fibrotic GDF15 paracrine
Human hepatocyte organoids in type 2 BME
AH vs Cirrhosis
⬇️Hepatocyte marker ALB CYP3A4 ALDOB
⬆️Cholangiocyte marker KRT19
+Spatial Matrisome
#JHEPRep 2025
www.sciencedirect.com/science/arti...
Hepatocyte YAP ⏫Myofibroblast prolif/inflamm
Pro-fibrotic GDF15 paracrine
Human hepatocyte organoids in type 2 BME
AH vs Cirrhosis
⬇️Hepatocyte marker ALB CYP3A4 ALDOB
⬆️Cholangiocyte marker KRT19
+Spatial Matrisome
#JHEPRep 2025
www.sciencedirect.com/science/arti...
Reposted by Siegenthaler Lab
🚨Our lab has a new review article out today!
We revisit prostaglandins in cancer—how they’re produced, how PGE₂ reshapes immune responses in tumors, and what this means for future therapies.
Work led by team members Erik Müller & Bastian Kruse @bkru.bsky.social
🔗 doi.org/10.1182/bloo...
We revisit prostaglandins in cancer—how they’re produced, how PGE₂ reshapes immune responses in tumors, and what this means for future therapies.
Work led by team members Erik Müller & Bastian Kruse @bkru.bsky.social
🔗 doi.org/10.1182/bloo...
Prostaglandins in cancer revisited: principles of production, mechanisms of immune regulation, and therapeutic perspectives
The cyclooxygenase (COX) signaling pathway is frequently dysregulated in cancer, resulting in aberrant production of prostaglandins - a distinct class of b
doi.org
November 27, 2025 at 12:35 PM
🚨Our lab has a new review article out today!
We revisit prostaglandins in cancer—how they’re produced, how PGE₂ reshapes immune responses in tumors, and what this means for future therapies.
Work led by team members Erik Müller & Bastian Kruse @bkru.bsky.social
🔗 doi.org/10.1182/bloo...
We revisit prostaglandins in cancer—how they’re produced, how PGE₂ reshapes immune responses in tumors, and what this means for future therapies.
Work led by team members Erik Müller & Bastian Kruse @bkru.bsky.social
🔗 doi.org/10.1182/bloo...
Reposted by Siegenthaler Lab
I was lucky enough to inherit a bunch of racks where a graduate student had labelled all of them with Rack jokes 😂, perfect. I am dead at Racksputin.
November 26, 2025 at 5:37 PM
I was lucky enough to inherit a bunch of racks where a graduate student had labelled all of them with Rack jokes 😂, perfect. I am dead at Racksputin.
Reposted by Siegenthaler Lab
Frikkin amazing stuff.
November 26, 2025 at 8:29 AM
Frikkin amazing stuff.
Reposted by Siegenthaler Lab
Turns out Mamdani's controversial proposal for government-run supermarkets isn't so novel. Other cities also are toying with the idea to bring fresh, affordable food to communities that do not have easy access to it. Good WSJ read (gift link)
www.wsj.com/real-estate/...
www.wsj.com/real-estate/...
Inside Atlanta’s First Government-Funded Supermarket
The goal is for the store to become profitable without any government subsidy within three years.
www.wsj.com
November 25, 2025 at 3:36 PM
Turns out Mamdani's controversial proposal for government-run supermarkets isn't so novel. Other cities also are toying with the idea to bring fresh, affordable food to communities that do not have easy access to it. Good WSJ read (gift link)
www.wsj.com/real-estate/...
www.wsj.com/real-estate/...
Reposted by Siegenthaler Lab
Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
Evolution of taste processing shifts dietary preference - Nature
Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...
www.nature.com
November 26, 2025 at 4:33 PM
Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
Reposted by Siegenthaler Lab
Gelsolin as a selective #Pericyte marker vs #SmoothMuscleCell Fibroblast in mouse #SkeletalMuscle
Antibody R&D MAB8170 Cryosection
BulkRNAseq
(SkM PDGFRβ+SMA− pericyte vs PDGFRβ+SMA+ SMC) vs (Brain pericyte vs SMC)
#SciRep 2025
www.nature.com/articles/s41...
Antibody R&D MAB8170 Cryosection
BulkRNAseq
(SkM PDGFRβ+SMA− pericyte vs PDGFRβ+SMA+ SMC) vs (Brain pericyte vs SMC)
#SciRep 2025
www.nature.com/articles/s41...
November 26, 2025 at 8:53 PM
Gelsolin as a selective #Pericyte marker vs #SmoothMuscleCell Fibroblast in mouse #SkeletalMuscle
Antibody R&D MAB8170 Cryosection
BulkRNAseq
(SkM PDGFRβ+SMA− pericyte vs PDGFRβ+SMA+ SMC) vs (Brain pericyte vs SMC)
#SciRep 2025
www.nature.com/articles/s41...
Antibody R&D MAB8170 Cryosection
BulkRNAseq
(SkM PDGFRβ+SMA− pericyte vs PDGFRβ+SMA+ SMC) vs (Brain pericyte vs SMC)
#SciRep 2025
www.nature.com/articles/s41...
Reposted by Siegenthaler Lab
Great article by @alexwitze.bsky.social on hurdles to attend SACNAS and NSBP/NSHP this year, with quotes from me & @astrojennifer.bsky.social: "even with all the barriers and uncertainties, people showed up, supported one another, and shared their science and stories with honesty and resilience". 👏
Following Trump's DEI cuts, attendance has plunged at some conferences for scientists from underrepresented groups. The loss of federal support means fewer chances for people to network, share science, and develop new career paths.
Still, attendees say "the sense of solidarity remains strong".
Still, attendees say "the sense of solidarity remains strong".
‘Anti-woke’ policies blamed for falling attendance at some US conferences
Scientific meetings that support Black, Latino and Indigenous researchers are grappling with funding cuts and other restrictions.
www.nature.com
November 26, 2025 at 8:35 PM
Great article by @alexwitze.bsky.social on hurdles to attend SACNAS and NSBP/NSHP this year, with quotes from me & @astrojennifer.bsky.social: "even with all the barriers and uncertainties, people showed up, supported one another, and shared their science and stories with honesty and resilience". 👏
Reposted by Siegenthaler Lab
NEW from me - NSF cancels grant scheme for social science research.
Seems the NSF quietly archived ALL calls for DDRIG grants in the SBE directorate. This is a massive blow for PhD students wanting to do cutting-edge social science research. 🏺🧪
Seems the NSF quietly archived ALL calls for DDRIG grants in the SBE directorate. This is a massive blow for PhD students wanting to do cutting-edge social science research. 🏺🧪
Today's biggest science news: Doomed comet explodes | Comet 3I/ATLAS course alteration | Dark matter detected?
Wednesday, Nov. 26, 2025: Your daily feed of the biggest discoveries and breakthroughs making headlines.
www.livescience.com
November 26, 2025 at 9:01 PM
NEW from me - NSF cancels grant scheme for social science research.
Seems the NSF quietly archived ALL calls for DDRIG grants in the SBE directorate. This is a massive blow for PhD students wanting to do cutting-edge social science research. 🏺🧪
Seems the NSF quietly archived ALL calls for DDRIG grants in the SBE directorate. This is a massive blow for PhD students wanting to do cutting-edge social science research. 🏺🧪
Reposted by Siegenthaler Lab
Following Trump's DEI cuts, attendance has plunged at some conferences for scientists from underrepresented groups. The loss of federal support means fewer chances for people to network, share science, and develop new career paths.
Still, attendees say "the sense of solidarity remains strong".
Still, attendees say "the sense of solidarity remains strong".
‘Anti-woke’ policies blamed for falling attendance at some US conferences
Scientific meetings that support Black, Latino and Indigenous researchers are grappling with funding cuts and other restrictions.
www.nature.com
November 25, 2025 at 8:43 PM
Following Trump's DEI cuts, attendance has plunged at some conferences for scientists from underrepresented groups. The loss of federal support means fewer chances for people to network, share science, and develop new career paths.
Still, attendees say "the sense of solidarity remains strong".
Still, attendees say "the sense of solidarity remains strong".
Reposted by Siegenthaler Lab
If anyone wondering about academic funding in Aus, this is the stark reality at present. I have written countless letters to politicians like @mehreenfaruqi.bsky.social, @davidpocock.bsky.social who like to say they are leading this conversation in Aus but it is really like shouting into the void.
Australian #NHMRC Ideas grants are out. 8.1% success rate. Lowest since the scheme began. Congrats to the successful few, as it looks like less than 200 were funded. 🧪
November 26, 2025 at 8:13 PM
If anyone wondering about academic funding in Aus, this is the stark reality at present. I have written countless letters to politicians like @mehreenfaruqi.bsky.social, @davidpocock.bsky.social who like to say they are leading this conversation in Aus but it is really like shouting into the void.
Reposted by Siegenthaler Lab
Reposted by Siegenthaler Lab
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast
The budding yeast, Saccharomyces cerevisiae, is the workhorse of the brewing industry. Brewers have domesticated a vast array of different strains with traits that complement the beers they wish to br...
www.biorxiv.org
November 26, 2025 at 8:18 PM
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...