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Mike Martynowycz @sciencemick.bsky.social · Sep 21

…unacceptable. How is this allowed? #VSA2025 #QSA-19

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Mike Martynowycz @sciencemick.bsky.social · Aug 15

👀
The Frontiers of Structure | Science | AAAS www.science.org/content/blog...

The Frontiers of Structure

www.science.org

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Mike Martynowycz @sciencemick.bsky.social · Jul 5

Seed to sub-Å!
We just solved crambin at 0.85Å with #MicroED straight from spontaneous nanocrystals, phased ab-initio from a 5-res helix. Video shows diffraction ➜ ugly start map ➜ beautiful spheres. Preprint: www.biorxiv.org/content/10.1...
#StructuralBiology #CryoEM

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Mike Martynowycz @sciencemick.bsky.social · Jul 2

Whoa! Check out this bug!

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Mike Martynowycz @sciencemick.bsky.social · May 19

Dog is 8

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Reposted by Mike Martynowycz

Aaron Rupar @atrupar.com · Mar 24

nightmare group chat

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Reposted by Mike Martynowycz

Max Clabbers @maxclabbers.bsky.social · Mar 12

Our latest paper is out!

We combine direct electron detection and energy filtering to boost the SNR of our MicroED data

This work was done at HHMI and UCLA with @sciencemick.bsky.social who now runs his own lab at UB-HWI, Johan Hattne, and Tamir Gonen

www.nature.com/articles/s41...

Energy filtering enables macromolecular MicroED data at sub-atomic resolution - Nature Communications

High-resolution data are crucial for accurate structural modeling. Here, authors enhance MicroED data quality using energy filtering, achieving sub-atomic resolution protein data and uncovering diffus...

www.nature.com

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Mike Martynowycz @sciencemick.bsky.social · Mar 6

Our work in Nature Comms demonstrates how energy filtering, plasma FIB, and direct electron detectors in counting mode can push MicroED to sub-atomic resolution!

Proud to have done this work back at UCLA. Hoping to bring similar capabilities to Buffalo.

📄 Read the paper: doi.org/10.1038/s414...

Energy filtering enables macromolecular MicroED data at sub-atomic resolution - Nature Communications

High-resolution data are crucial for accurate structural modeling. Here, authors enhance MicroED data quality using energy filtering, achieving sub-atomic resolution protein data and uncovering diffus...

doi.org

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Reposted by Mike Martynowycz

Daniel Colón-Ramos @dacolon.bsky.social · Feb 7

Ardem, I am sorry. In this middle of this chaos, HHMI will always hold the dubious distinction of being the first organization, federal or private, to cut an ongoing and funded DEI program. In the darkest hour, it ran for the hills. As a member of those groups, I can’t tell you how painful this is.

Ardem Patapoutian @ardemp.bskyverified.social · Feb 7

Folks, let’s not be too quick to blame. HHMI is a progressive institution with strong leadership, doing what it can while navigating legal challenges. They get top legal advice on what’s possible, and these are tough times. Let’s not demonize one of the good ones!

Ardem Patapoutian @ardemp.bskyverified.social · Feb 7

Got a message today that HHMI remains deeply committed to the existing research programs that include the Investigator, Freeman Hrabowski Scholar, Hanna Gray Fellows, and Gilliam Fellow programs: "We do not anticipate changes to these or any other research or science education programs at HHMI."

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Reposted by Mike Martynowycz

Tad O @togo.bsky.social · Feb 8

arstechnica.com/science/2025...

National Institutes of Health radically cuts support to universities

Sudden and drastic change will make it hard for researchers to keep the lights on.

arstechnica.com

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Mike Martynowycz @sciencemick.bsky.social · Jan 8

I’m happy to share that @HWMRI has merged with @UBuffalo. My lab will stay at HWI, and my title is changing. I’m starting a new position as a tenure track Assistant Professor at the Jacob’s School of Medicine at the University at Buffalo!

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Mike Martynowycz @sciencemick.bsky.social · Dec 20

Super happy to share our latest work! A detailed protocol for #MicroED sample prep available @NatureProtocols! It covers #FIB, grid making, sample handling, #CryoFLM, and more! Hope it helps!

www.nature.com/articles/s41...

Comprehensive microcrystal electron diffraction sample preparation for cryo-EM - Nature Protocols

We present a protocol for preparing microcrystal samples for cryo-EM diffraction imaging, including room temperature solid-state small molecules and soluble and membrane protein crystals.

www.nature.com

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Reposted by Mike Martynowycz

The Onion @theonion.com · Dec 16

‘No Way To Prevent This,’ Says Only Nation Where This Regularly Happens theonion.com/no-way-to-pr...

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Mike Martynowycz @sciencemick.bsky.social · Dec 9

Excited to share our new work! We shed light on the sociology of virus-induced condensates supporting reovirus assembly and replication. Visualized using #CryoET #CryoEM and #FIBmilling

www.nature.com/articles/s41...

Great collab w/ @xianxia13 @zhou_lab Xiaoyu Liu @gonenlab