santiago, phd 🐈⬛
@santiagokique.bsky.social
Vnzln 🇻🇪 MD/PhD candidate @ Stanford 🌲
I study telomere biology in health and disease; I write about science and politics
blogs @ primafacie.substack.com
I study telomere biology in health and disease; I write about science and politics
blogs @ primafacie.substack.com
Pinned
the not so infinite typewriter
we left the typing monkeys alone and they're planting bombs under wall street
open.substack.com
new blog post on the ai bubble, why it won’t do what its backers need it to do, and why I think they keep getting duped that it will
open.substack.com/pub/primafac...
open.substack.com/pub/primafac...
Hits harder when you realize Paul Offit is actually one of the nicest people on earth (pediatric infectious disease physician).
December 1, 2025 at 1:21 PM
Hits harder when you realize Paul Offit is actually one of the nicest people on earth (pediatric infectious disease physician).
presidents trafficking drugs reminded me to put this book on my holiday wishlist
December 1, 2025 at 4:26 AM
presidents trafficking drugs reminded me to put this book on my holiday wishlist
Found some old Bolivar coins in my closet. The one on the right is a pre-Bolivarian revolution Bolivar (Bs) and the one of the left is one of the first ever Bolivar Fuerte (Bs.F), a reminted currency worth 1000 of the coin on the right. The bolivar has since had 2 further remintings, last in 2021
December 1, 2025 at 2:29 AM
Found some old Bolivar coins in my closet. The one on the right is a pre-Bolivarian revolution Bolivar (Bs) and the one of the left is one of the first ever Bolivar Fuerte (Bs.F), a reminted currency worth 1000 of the coin on the right. The bolivar has since had 2 further remintings, last in 2021
Reposted by santiago, phd 🐈⬛
Guys I just had an idea I don’t think anyone’s ever had before. What if there was a publication that, instead of reinforcing the liberal pieties of the woke mob, presented readers with heterodox positions that challenged groupthink? Does anyone have like eight million dollars so I can try this?
November 30, 2025 at 3:14 PM
Guys I just had an idea I don’t think anyone’s ever had before. What if there was a publication that, instead of reinforcing the liberal pieties of the woke mob, presented readers with heterodox positions that challenged groupthink? Does anyone have like eight million dollars so I can try this?
Reposted by santiago, phd 🐈⬛
We need to purge the elite
Tomorrow Grimes will DJ a livestream of immortality influencer Bryan Johnson tripping on shrooms to determine its effect on longevity. Mr. Beast and the CEO of Salesforce will be there too.
Grimes DJing Immortality Influencer's Shroom Trip With Special Guest Mr. Beast
Grimes is a fan of Bryan Johnson, the multimillionaire and immortality influencer who spends his time trying to fight death. He is perhaps best known for undergoing plasma transfusions with donations ...
stereogum.com
November 29, 2025 at 3:32 PM
We need to purge the elite
Reposted by santiago, phd 🐈⬛
Computer, please summarize everything PG Wodehouse ever wrote in ten seconds
rich dudes got freakier after butlers fell out of fashion, like say what you will about having domestic servants but clearly it was some sort of moderating force on old rich dudes having a fancy man follow you around saying shit like "oh dear sir, that wouldn't be very becoming"
November 29, 2025 at 9:34 PM
Computer, please summarize everything PG Wodehouse ever wrote in ten seconds
Reposted by santiago, phd 🐈⬛
Reposted by santiago, phd 🐈⬛
While Makary spreads bullshit about the origin of HIV.
(To be clear, this has been thoroughly investigated and fits neither the timing nor the molecular epidemiology of HIV).
(To be clear, this has been thoroughly investigated and fits neither the timing nor the molecular epidemiology of HIV).
![PDB: "if I were to ask you where did AIDS come from, what would you say?
Makary: The film 'thank you Dr Fauci' explores a non-tradi narrative which has not gotten the attention it deserves and that is that [HIV] may very well have come from a lab in Africa"](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:wojva3mvygznfwpmkdyujvul/bafkreignvi7dtc7q2t2ae23ya7v3qqnaqjxpxc3uzb5xaxad4ii3x375y4@jpeg)
November 29, 2025 at 3:11 AM
While Makary spreads bullshit about the origin of HIV.
(To be clear, this has been thoroughly investigated and fits neither the timing nor the molecular epidemiology of HIV).
(To be clear, this has been thoroughly investigated and fits neither the timing nor the molecular epidemiology of HIV).
November 27, 2025 at 4:53 PM
Reposted by santiago, phd 🐈⬛
this is amazing news - the HPV vaccine promises to eliminate cervical cancer in countries where uptake is high.
November 26, 2025 at 6:57 PM
this is amazing news - the HPV vaccine promises to eliminate cervical cancer in countries where uptake is high.
RIP Kotor remake
November 26, 2025 at 10:20 PM
RIP Kotor remake
Not hard to imagine a career-long HIV scientist would butt heads with Antivaximus prime at HHS and his lieutenant at NIH
November 25, 2025 at 4:16 AM
Not hard to imagine a career-long HIV scientist would butt heads with Antivaximus prime at HHS and his lieutenant at NIH
Reposted by santiago, phd 🐈⬛
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
Hearing news that Carl Dieffenbach, the Director of the Division of AIDS at #NIH (NIAID), has been removed from his position because he was "not aligned with HHS/OMB."
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
November 24, 2025 at 5:49 AM
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
New blog post on a curious rabbit hole I went down this past weekend thinking about a patient with apnea that led to the father of Toxicology by way of German mermaids. A 6 degrees of separation digression
open.substack.com/pub/primafac...
open.substack.com/pub/primafac...
the little mermaid's curse
the strange connection between automaticity and german mermaids
open.substack.com
November 25, 2025 at 4:12 AM
New blog post on a curious rabbit hole I went down this past weekend thinking about a patient with apnea that led to the father of Toxicology by way of German mermaids. A 6 degrees of separation digression
open.substack.com/pub/primafac...
open.substack.com/pub/primafac...
I actually think centrist Dems are more likely to support/endorse an MTG independent run for president than a progressive candidate that threatens a Newsom/Buttigieg type figure in the primary.
November 22, 2025 at 1:57 AM
I actually think centrist Dems are more likely to support/endorse an MTG independent run for president than a progressive candidate that threatens a Newsom/Buttigieg type figure in the primary.
Reposted by santiago, phd 🐈⬛
Breaking News: Robert F. Kennedy Jr. said he personally instructed the CDC to abandon its position that vaccines do not cause autism. The move underscores his determination to challenge scientific orthodoxy — in this case, that vaccines save lives — and bend the health department to his will.
RFK Jr. Says He Instructed CDC to Change Vaccines and Autism Language on Website
In an interview, Health Secretary Robert F. Kennedy Jr. cited gaps in vaccine safety research. His critics say he is ignoring a larger point: Vaccines save lives.
nyti.ms
November 21, 2025 at 6:56 PM
Breaking News: Robert F. Kennedy Jr. said he personally instructed the CDC to abandon its position that vaccines do not cause autism. The move underscores his determination to challenge scientific orthodoxy — in this case, that vaccines save lives — and bend the health department to his will.
English speaking world discovering Peak. If you’ve never seen this, would encourage sampling with the episode where one of the puppets is depressed
www.youtube.com/watch?v=lwYB...
www.youtube.com/watch?v=lwYB...
November 21, 2025 at 1:21 PM
English speaking world discovering Peak. If you’ve never seen this, would encourage sampling with the episode where one of the puppets is depressed
www.youtube.com/watch?v=lwYB...
www.youtube.com/watch?v=lwYB...
Reposted by santiago, phd 🐈⬛
November 18, 2025 at 8:24 PM
Every AI infrastructure graph looks like this. The exponential revenue generating event is always just around the corner and the capex commitments won’t get comically larger, we promise.
November 18, 2025 at 12:47 PM
Every AI infrastructure graph looks like this. The exponential revenue generating event is always just around the corner and the capex commitments won’t get comically larger, we promise.
Reposted by santiago, phd 🐈⬛
Bhattacharya's NIH made cuts to grants that disrupted trials, disproportionately impacting infectious disease trials & trials affecting minorities (e.g. trials on mitigating kidney disease, Alzheimer’s disease, & cervical cancer in minority populations).
These cuts were litigated in court.
1/x
These cuts were litigated in court.
1/x
A new study found the Trump administration’s cuts to NIH grants disrupted more than 380 clinical trials, affecting over 74,000 participants.
The cuts disproportionately impacted trials on infectious diseases and minority communities.
The cuts disproportionately impacted trials on infectious diseases and minority communities.
Federal cuts upended clinical trials. A new study reveals the toll.
Grants for 383 clinical trials were terminated and the funding disruptions affected more than 74,000 trial participants, according to new research.
www.washingtonpost.com
November 17, 2025 at 11:11 PM
Bhattacharya's NIH made cuts to grants that disrupted trials, disproportionately impacting infectious disease trials & trials affecting minorities (e.g. trials on mitigating kidney disease, Alzheimer’s disease, & cervical cancer in minority populations).
These cuts were litigated in court.
1/x
These cuts were litigated in court.
1/x
Reposted by santiago, phd 🐈⬛
I spent October traveling to schools throughout the South talking to students about American history. What I found were young people who understand we can tell a story that includes both the positive and the negative. As one 8th grader in Memphis said, “Doesn’t seem that hard, just say both things.”
Tell Students the Truth About American History
We owe it to Americans of all ages to be honest about the country’s past, including its contradictions.
www.theatlantic.com
November 17, 2025 at 4:57 PM
I spent October traveling to schools throughout the South talking to students about American history. What I found were young people who understand we can tell a story that includes both the positive and the negative. As one 8th grader in Memphis said, “Doesn’t seem that hard, just say both things.”