Rhys Allan
@rhyscienceallan.bsky.social
Scientist at WEHI research, fascinated by the DNA circuitry of the immune system https://www.wehi.edu.au/researcher/rhys-allan/
Pinned
The long non-coding RNA Dreg1 is required for optimal ILC2 development
Gata3 is an essential transcription factor for the development of several distinct immune cell lineages such as T cells, natural killer (NK) cells and innate lymphoid cells (ILC). As such, the levels ...
www.biorxiv.org
I am excited to share our latest study by Sara Quon in collaboration with @ajithvasanthan.bsky.social entitled “The lncRNA Dreg1 is required for optimal ILC2 development” www.biorxiv.org/content/10.1...
Reposted by Rhys Allan
I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in
@sciimmunology.bsky.social scim.ag/4o12TOZ
@sciimmunology.bsky.social scim.ag/4o12TOZ
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.
scim.ag
November 26, 2025 at 6:55 PM
I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in
@sciimmunology.bsky.social scim.ag/4o12TOZ
@sciimmunology.bsky.social scim.ag/4o12TOZ
Reposted by Rhys Allan
Interested in #3DGenomics #4Dnucleome? Like #Barcelona? Would like to enjoy doing #science and to have fun during your #PhD?
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Doctoral INPhINIT fellowships - Incoming Call 2026
We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.
lacaixafoundation.org
November 26, 2025 at 8:56 AM
Interested in #3DGenomics #4Dnucleome? Like #Barcelona? Would like to enjoy doing #science and to have fun during your #PhD?
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Apply now to La Caixa Foundation Doctoral #INPhINIT fellowships with us. DM or email in case of interest... 👇🏼👍🏼
lacaixafoundation.org/en/doctoral-...
Please, repost... 🔄🙏🏼
Reposted by Rhys Allan
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D @sciimmunology.bsky.social @vahedilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 21, 2025 at 7:41 PM
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D @sciimmunology.bsky.social @vahedilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Rhys Allan
Only 𝟏𝟐𝐡𝐫 𝐥𝐞𝐟𝐭 to submit your abstract and secure earlybird registration rates! The deadline is 𝐦𝐢𝐝𝐧𝐢𝐠𝐡𝐭 𝐅𝐫𝐢𝐝𝐚𝐲 𝟐𝟏 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫. Don't forget to apply for awards if you're eligible! www.lornegenome.org/registrations
Registrations — Lorne Genome
Registrations are now open! Secure your ticket to attend Lorne Genome 2022!
www.lornegenome.org
November 21, 2025 at 12:54 AM
Only 𝟏𝟐𝐡𝐫 𝐥𝐞𝐟𝐭 to submit your abstract and secure earlybird registration rates! The deadline is 𝐦𝐢𝐝𝐧𝐢𝐠𝐡𝐭 𝐅𝐫𝐢𝐝𝐚𝐲 𝟐𝟏 𝐍𝐨𝐯𝐞𝐦𝐛𝐞𝐫. Don't forget to apply for awards if you're eligible! www.lornegenome.org/registrations
Reposted by Rhys Allan
We are excited to welcome 𝐀/𝐏𝐫𝐨𝐟 𝐉𝐞𝐧𝐧 𝐁𝐫𝐨𝐩𝐡𝐲 as an invited speaker at Lorne Genome 2026, whose lab uses genetic engineering of plants and their microbiomes to uncover stress resilience mechanisms and advance agricultural innovation https://www.lornegenome.org/jenn-brophy
November 20, 2025 at 7:26 AM
We are excited to welcome 𝐀/𝐏𝐫𝐨𝐟 𝐉𝐞𝐧𝐧 𝐁𝐫𝐨𝐩𝐡𝐲 as an invited speaker at Lorne Genome 2026, whose lab uses genetic engineering of plants and their microbiomes to uncover stress resilience mechanisms and advance agricultural innovation https://www.lornegenome.org/jenn-brophy
Reposted by Rhys Allan
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Reposted by Rhys Allan
The Medical Research Future Fund (MRFF) funds medical research in Australia. Only half the funds have been released. If you're an Australian and able to vote please use the form below to email your local MP to release the full amount of the MRFF
aamri.org.au/mrff/
aamri.org.au/mrff/
Half the Funding. Half the Future. - AAMRI
The Medical Research Future Fund (MRFF) was designed to deliver $1 billion each year in new, lifesaving funding for medical research. We know through financial modelling that the full amount can be re...
aamri.org.au
November 16, 2025 at 9:14 PM
The Medical Research Future Fund (MRFF) funds medical research in Australia. Only half the funds have been released. If you're an Australian and able to vote please use the form below to email your local MP to release the full amount of the MRFF
aamri.org.au/mrff/
aamri.org.au/mrff/
Reposted by Rhys Allan
Excited to share matchbox. It’s super fast and versatile to search for patterns in reads, I’m curious to see all the uses it will find!
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...
November 18, 2025 at 1:26 AM
Excited to share matchbox. It’s super fast and versatile to search for patterns in reads, I’m curious to see all the uses it will find!
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...
Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team!
www.biorxiv.org/content/10.1...
Reposted by Rhys Allan
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
November 15, 2025 at 9:53 AM
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Proud to contribute to this important supplement! The burden of asthma is too high. We need to stretch for a CURE!!!
The CURE Asthma initiative is an unprecedented opportunity for accelerating the translation of research findings and bringing curative therapies within reach.
Available now as a supplement in the MJA
buff.ly/BK7aPac
Available now as a supplement in the MJA
buff.ly/BK7aPac
November 17, 2025 at 9:17 AM
Proud to contribute to this important supplement! The burden of asthma is too high. We need to stretch for a CURE!!!
Reposted by Rhys Allan
Wonderful to see the beautiful preprint from Sabate et al now published - TADs are also dynamic structures in human cells, with remarkably similar parameters between mESCs and HCT116 cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 15, 2025 at 5:24 PM
Wonderful to see the beautiful preprint from Sabate et al now published - TADs are also dynamic structures in human cells, with remarkably similar parameters between mESCs and HCT116 cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Rhys Allan
In this episode we talked with @andersshansen.bsky.social from MIT about his work on the impact of 3D genome structures on gene expression and advanced techniques like Region Capture Micro-C for mapping genome organisation. #podcast #epigenetics
Listen here: activemotif.com/podcasts-and...
Listen here: activemotif.com/podcasts-and...
November 14, 2025 at 8:01 AM
In this episode we talked with @andersshansen.bsky.social from MIT about his work on the impact of 3D genome structures on gene expression and advanced techniques like Region Capture Micro-C for mapping genome organisation. #podcast #epigenetics
Listen here: activemotif.com/podcasts-and...
Listen here: activemotif.com/podcasts-and...
Reposted by Rhys Allan
New WEHI research shows caspase-8 is a driver of severe COVID-19 through modulation of inflammation, but not through induction of apoptosis.
The landmark study is the first to clarify the protein's role in COVID disease in vivo.
Published in Nature Communications.
rdcu.be/ePJoA
🧵1/2
The landmark study is the first to clarify the protein's role in COVID disease in vivo.
Published in Nature Communications.
rdcu.be/ePJoA
🧵1/2
November 14, 2025 at 1:00 AM
New WEHI research shows caspase-8 is a driver of severe COVID-19 through modulation of inflammation, but not through induction of apoptosis.
The landmark study is the first to clarify the protein's role in COVID disease in vivo.
Published in Nature Communications.
rdcu.be/ePJoA
🧵1/2
The landmark study is the first to clarify the protein's role in COVID disease in vivo.
Published in Nature Communications.
rdcu.be/ePJoA
🧵1/2
Reposted by Rhys Allan
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Rhys Allan
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Rhys Allan
Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program @cp-immunity.bsky.social @monashuniversity.bsky.social www.cell.com/immunity/ful...
November 4, 2025 at 5:46 PM
Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program @cp-immunity.bsky.social @monashuniversity.bsky.social www.cell.com/immunity/ful...
Reposted by Rhys Allan
1/ 🚀 AEBP2 isn’t what we thought.
You were told that AEBP2 promotes PRC2 activity on chromatin.
We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.
👉 surl.li/cgwqcq
A thread 🧵
You were told that AEBP2 promotes PRC2 activity on chromatin.
We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.
👉 surl.li/cgwqcq
A thread 🧵
October 31, 2025 at 10:53 AM
1/ 🚀 AEBP2 isn’t what we thought.
You were told that AEBP2 promotes PRC2 activity on chromatin.
We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.
👉 surl.li/cgwqcq
A thread 🧵
You were told that AEBP2 promotes PRC2 activity on chromatin.
We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity.
👉 surl.li/cgwqcq
A thread 🧵
Reposted by Rhys Allan
1/ It's long been assumed that AEBP2 recruit PRC2 to chromatin. Now, we show that AEBP2 usually does the exact opposite:
The only isoform of AEBP2 that is expressed in most cell types and tissues inhibits the chromatin-binding activity of PRC2. www.embopress.org/doi/full/10....
The only isoform of AEBP2 that is expressed in most cell types and tissues inhibits the chromatin-binding activity of PRC2. www.embopress.org/doi/full/10....
Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2 | The EMBO Journal
imageimageAEBP2 is an accessory subunit of the PRC2 complex previously implicated both in promoting
and antagonizing Polycomb repressive activity. This study reveals that its alternative
isoforms, AEB...
www.embopress.org
October 31, 2025 at 10:42 PM
1/ It's long been assumed that AEBP2 recruit PRC2 to chromatin. Now, we show that AEBP2 usually does the exact opposite:
The only isoform of AEBP2 that is expressed in most cell types and tissues inhibits the chromatin-binding activity of PRC2. www.embopress.org/doi/full/10....
The only isoform of AEBP2 that is expressed in most cell types and tissues inhibits the chromatin-binding activity of PRC2. www.embopress.org/doi/full/10....
Reposted by Rhys Allan
In this episode we talked with @pasquelab.bsky.social from KU Leuven about his work on the reprogramming of cell identity through epigenetic mechanisms, particularly during early development and cellular reprogramming. #epigenetics #podcast
Listen here: activemotif.com/podcasts-vin...
Listen here: activemotif.com/podcasts-vin...
October 31, 2025 at 8:01 AM
In this episode we talked with @pasquelab.bsky.social from KU Leuven about his work on the reprogramming of cell identity through epigenetic mechanisms, particularly during early development and cellular reprogramming. #epigenetics #podcast
Listen here: activemotif.com/podcasts-vin...
Listen here: activemotif.com/podcasts-vin...
Reposted by Rhys Allan
WEHI stands behind the @aamri.bsky.social campaign to strengthen the sector and secure the future of medical research.
Join the call to release the full MRFF and support our scientists to keep saving lives.
Find out more: www.aamri.org.au/mrff
#releasethefullmrff
Join the call to release the full MRFF and support our scientists to keep saving lives.
Find out more: www.aamri.org.au/mrff
#releasethefullmrff
October 31, 2025 at 12:02 AM
WEHI stands behind the @aamri.bsky.social campaign to strengthen the sector and secure the future of medical research.
Join the call to release the full MRFF and support our scientists to keep saving lives.
Find out more: www.aamri.org.au/mrff
#releasethefullmrff
Join the call to release the full MRFF and support our scientists to keep saving lives.
Find out more: www.aamri.org.au/mrff
#releasethefullmrff
Reposted by Rhys Allan
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
rdcu.be
October 28, 2025 at 11:24 AM
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
Reposted by Rhys Allan
What controls how our genes switch on and off across the 3D genome? Dr. Bing Ren from
@nygenome
will dive deep into transcriptional insulators and the mysteries behind CTCF/Cohesin loop extrusion. Don’t miss his talk, ‘Mechanisms and Modulators of Transcriptional Insulators’ !
@nygenome
will dive deep into transcriptional insulators and the mysteries behind CTCF/Cohesin loop extrusion. Don’t miss his talk, ‘Mechanisms and Modulators of Transcriptional Insulators’ !
October 28, 2025 at 9:00 PM
What controls how our genes switch on and off across the 3D genome? Dr. Bing Ren from
@nygenome
will dive deep into transcriptional insulators and the mysteries behind CTCF/Cohesin loop extrusion. Don’t miss his talk, ‘Mechanisms and Modulators of Transcriptional Insulators’ !
@nygenome
will dive deep into transcriptional insulators and the mysteries behind CTCF/Cohesin loop extrusion. Don’t miss his talk, ‘Mechanisms and Modulators of Transcriptional Insulators’ !
Reposted by Rhys Allan
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
October 27, 2025 at 11:49 AM
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
Reposted by Rhys Allan
Here, we show that the unique regulatory landscape of ecDNA enables an ancient LINE to resurrect and act as an enhancer of Myc. This was so fun with @katerinakraft.bsky.social and @mattjones.bsky.social and others. www.nature.com/articles/s41...
Enhancer activation from transposable elements in extrachromosomal DNA - Nature Cell Biology
Kraft, Murphy, Jones et al. identify extrachromosomal DNA (ecDNA)-interacting elements (EIEs) enriched for transposable elements within ecDNA in colorectal cancer cells. They show that EIE 14 integrat...
www.nature.com
October 21, 2025 at 9:43 AM
Here, we show that the unique regulatory landscape of ecDNA enables an ancient LINE to resurrect and act as an enhancer of Myc. This was so fun with @katerinakraft.bsky.social and @mattjones.bsky.social and others. www.nature.com/articles/s41...
Reposted by Rhys Allan
Thanks also very much to Anne Trafton from MIT News for writing a nice article about the findings:
news.mit.edu/2025/surpris...
news.mit.edu/2025/surpris...
October 20, 2025 at 7:05 PM
Thanks also very much to Anne Trafton from MIT News for writing a nice article about the findings:
news.mit.edu/2025/surpris...
news.mit.edu/2025/surpris...