Golnaz Vahedi
@vahedilab.bsky.social
Department of Genetics, Institute for Immunology and Immune Health, Epigenetics Institute, University of Pennsylvania
https://vahedilab.com/ https://www.instagram.com/vahedilaboratory/
https://vahedilab.com/ https://www.instagram.com/vahedilaboratory/
Pinned
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.
scim.ag
I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in
@sciimmunology.bsky.social scim.ag/4o12TOZ
@sciimmunology.bsky.social scim.ag/4o12TOZ
Reposted by Golnaz Vahedi
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
www.science.org
November 28, 2025 at 5:22 PM
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in
@sciimmunology.bsky.social scim.ag/4o12TOZ
@sciimmunology.bsky.social scim.ag/4o12TOZ
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.
scim.ag
November 26, 2025 at 6:55 PM
I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in
@sciimmunology.bsky.social scim.ag/4o12TOZ
@sciimmunology.bsky.social scim.ag/4o12TOZ
Reposted by Golnaz Vahedi
Congratulations to @ksusztak.bsky.social (@pennmedicine.bsky.social/ @penngenetics.bsky.social/ @chopresearch.bsky.social) on her election to the National Academy of Medicine! Learn more about Dr. Susztak & her research here➡️ www.med.upenn.edu/susztaklab/ #PSOMatNAM @nam.edu
October 23, 2025 at 4:07 PM
Congratulations to @ksusztak.bsky.social (@pennmedicine.bsky.social/ @penngenetics.bsky.social/ @chopresearch.bsky.social) on her election to the National Academy of Medicine! Learn more about Dr. Susztak & her research here➡️ www.med.upenn.edu/susztaklab/ #PSOMatNAM @nam.edu
Reposted by Golnaz Vahedi
Congratulations to Gerd Blobel (@chopresearch.bsky.social/ @pennmedicine.bsky.social/ @pennepigenetics.bsky.social) on his election to the National Academy of Medicine! Learn more about Dr. Blobel & his research here➡️ blobellab.squarespace.com #PSOMatNAM @nam.edu
October 22, 2025 at 5:03 PM
Congratulations to Gerd Blobel (@chopresearch.bsky.social/ @pennmedicine.bsky.social/ @pennepigenetics.bsky.social) on his election to the National Academy of Medicine! Learn more about Dr. Blobel & his research here➡️ blobellab.squarespace.com #PSOMatNAM @nam.edu
In this article, I share my perspective on leveraging AI and single-cell profiling to predict type 1 diabetes. It’s great to see the diverse insights contributed by other experts in the field: www.nature.com/articles/s42...
Artificial intelligence in metabolic research - Nature Metabolism
The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.
www.nature.com
October 7, 2025 at 9:26 PM
In this article, I share my perspective on leveraging AI and single-cell profiling to predict type 1 diabetes. It’s great to see the diverse insights contributed by other experts in the field: www.nature.com/articles/s42...
Reposted by Golnaz Vahedi
Thrilled to share my promotion to Associate Professor with tenure at @pitt-immunology.bsky.social! Huge thanks to my incredible lab, collaborators, department, colleagues, family & friends. Science is a team effort, and I'm so proud of our work & excited for what's next! Stay tuned!
Congratulations to Dr. Amanda Poholek @poholeklab.bsky.social for her promotion to Associate Professor with tenure! Learn more about Dr. Poholek and her research: buff.ly/q14wey8
October 6, 2025 at 3:34 PM
Thrilled to share my promotion to Associate Professor with tenure at @pitt-immunology.bsky.social! Huge thanks to my incredible lab, collaborators, department, colleagues, family & friends. Science is a team effort, and I'm so proud of our work & excited for what's next! Stay tuned!
The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...
Research Specialist A/B
University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...
wd1.myworkdaysite.com
September 23, 2025 at 9:47 PM
The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...
Reposted by Golnaz Vahedi
Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...
Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks - Nature Genetics
Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate ...
www.nature.com
September 18, 2025 at 8:50 PM
Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...
New preprint in collaboration with the Faryabi lab: Optical Looping Interactive Viewing Engine (OLIVE), a web-based tool designed for high-throughput chromatin tracing data that functions similarly to genome browsers. If you work with these data, give a try: www.biorxiv.org/content/10.1...
July 13, 2025 at 5:12 PM
New preprint in collaboration with the Faryabi lab: Optical Looping Interactive Viewing Engine (OLIVE), a web-based tool designed for high-throughput chromatin tracing data that functions similarly to genome browsers. If you work with these data, give a try: www.biorxiv.org/content/10.1...
🚨 New #preprint alert!
We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety"🔗 www.biorxiv.org/content/10.1...
We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety"🔗 www.biorxiv.org/content/10.1...
June 26, 2025 at 3:43 PM
🚨 New #preprint alert!
We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety"🔗 www.biorxiv.org/content/10.1...
We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety"🔗 www.biorxiv.org/content/10.1...
Reposted by Golnaz Vahedi
🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
June 2, 2025 at 8:33 PM
🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
June 2, 2025 at 8:33 PM
🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd
Sometimes you only need to focus on good news: www.nytimes.com/2025/05/15/h...
Baby Is Healed With World’s First Personalized Gene-Editing Treatment
www.nytimes.com
May 16, 2025 at 12:42 PM
Sometimes you only need to focus on good news: www.nytimes.com/2025/05/15/h...
Reposted by Golnaz Vahedi
The recorded video of Dr. Golnaz Vahedi seminar entitled Chromatin topology at paralogous transcription factors is now available at “Global Immunotalks” YouTube Channel youtube.com/live/7aw_Qx5...
Please ask questions in the Youtube comment section for Golnaz.
Hope you enjoy it!
Please ask questions in the Youtube comment section for Golnaz.
Hope you enjoy it!
GLOBAL IMMUNOTALKS: Virtual immunology seminar series
YouTube video by GLOBAL IMMUNOTALKS
youtube.com
May 7, 2025 at 5:03 PM
The recorded video of Dr. Golnaz Vahedi seminar entitled Chromatin topology at paralogous transcription factors is now available at “Global Immunotalks” YouTube Channel youtube.com/live/7aw_Qx5...
Please ask questions in the Youtube comment section for Golnaz.
Hope you enjoy it!
Please ask questions in the Youtube comment section for Golnaz.
Hope you enjoy it!
Reposted by Golnaz Vahedi
Looking forward to our next #globalimmuno talk this Wednesday, May 7th, at 9am PST, noon EST, 4pm GMT by Dr. Golnaz Vahedi.
Title: “Chromatin topology at paralogous transcription factors”
ZOOM LINK: ucsd.zoom.us/j/91053505061
LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUNOTALKS
Title: “Chromatin topology at paralogous transcription factors”
ZOOM LINK: ucsd.zoom.us/j/91053505061
LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUNOTALKS
May 5, 2025 at 5:47 PM
Looking forward to our next #globalimmuno talk this Wednesday, May 7th, at 9am PST, noon EST, 4pm GMT by Dr. Golnaz Vahedi.
Title: “Chromatin topology at paralogous transcription factors”
ZOOM LINK: ucsd.zoom.us/j/91053505061
LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUNOTALKS
Title: “Chromatin topology at paralogous transcription factors”
ZOOM LINK: ucsd.zoom.us/j/91053505061
LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUNOTALKS
Reposted by Golnaz Vahedi
It takes a special talent to observe the phenotype of an ETS1 super-enhancer deletion and see into the evolution of paralogous transcription factors.
Holy 🤯, @vahedilab.bsky.social!
Holy 🤯, @vahedilab.bsky.social!
May 6, 2025 at 9:36 PM
It takes a special talent to observe the phenotype of an ETS1 super-enhancer deletion and see into the evolution of paralogous transcription factors.
Holy 🤯, @vahedilab.bsky.social!
Holy 🤯, @vahedilab.bsky.social!
Reposted by Golnaz Vahedi
Congratulations to Katalin Karikó (@PennNSG), Virginia Lee (@pennpathlabmed.bsky.social), @ejohnwherry.bsky.social (@PennSysPharmATT) & Mark Devlin (@physatpenn) on their election to @nasonline.org! tinyurl.com/5eehdtms
April 30, 2025 at 6:30 PM
Congratulations to Katalin Karikó (@PennNSG), Virginia Lee (@pennpathlabmed.bsky.social), @ejohnwherry.bsky.social (@PennSysPharmATT) & Mark Devlin (@physatpenn) on their election to @nasonline.org! tinyurl.com/5eehdtms
Reposted by Golnaz Vahedi
Super excited to be launching NimbusImage.com! Cloud-based image analysis to democratize machine learning!
Documentation here!
docs.nimbusimage.com
Documentation here!
docs.nimbusimage.com
NimbusImage
NimbusImage.com
March 17, 2025 at 2:46 PM
Super excited to be launching NimbusImage.com! Cloud-based image analysis to democratize machine learning!
Documentation here!
docs.nimbusimage.com
Documentation here!
docs.nimbusimage.com
Congrats to Atishay and Carlos for their review article on the epigenetics regulation of T cells: www.nature.com/articles/s41...
The epigenetic landscape of fate decisions in T cells - Nature Immunology
Vahedi and colleagues review the mechanisms shaping the epigenetic landscape of CD4+ and CD8+ T cells during development and differentiation.
www.nature.com
March 19, 2025 at 4:15 PM
Congrats to Atishay and Carlos for their review article on the epigenetics regulation of T cells: www.nature.com/articles/s41...
Reposted by Golnaz Vahedi
Accuracy of gene regulatory network inference is increased by combining multiome single-cell and atlas-scale bulk data go.nature.com/43YySqO
rdcu.be/ebBio
rdcu.be/ebBio
Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data - Nature Biotechnology
Accuracy of gene regulatory network inference is increased by combining multiome single-cell and atlas-scale bulk data.
go.nature.com
March 13, 2025 at 1:25 PM
Accuracy of gene regulatory network inference is increased by combining multiome single-cell and atlas-scale bulk data go.nature.com/43YySqO
rdcu.be/ebBio
rdcu.be/ebBio
Reposted by Golnaz Vahedi
Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.
March 7, 2025 at 11:46 PM
Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.
Reposted by Golnaz Vahedi
Disease diagnostics using machine learning of B cell and T cell receptor sequences
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
Disease diagnostics using machine learning of B cell and T cell receptor sequences
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen ...
www.science.org
February 21, 2025 at 1:12 AM
Disease diagnostics using machine learning of B cell and T cell receptor sequences
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
www.science.org/doi/10.1126/...
TL;DR: BCRs ARE ALL YOU NEED!
(Well actually .... keep reading) 1/
Reposted by Golnaz Vahedi
Researchers at Fred Hutch have discovered an overlooked mechanism driving aggressive breast and brain tumors involving genes so ancient — more than 2 billion years old — that they fly under the radar of standard genetic sequencing methods. 1/9 www.science.org/doi/10.1126/...
February 13, 2025 at 7:28 PM
Researchers at Fred Hutch have discovered an overlooked mechanism driving aggressive breast and brain tumors involving genes so ancient — more than 2 billion years old — that they fly under the radar of standard genetic sequencing methods. 1/9 www.science.org/doi/10.1126/...
Reposted by Golnaz Vahedi
This is outstanding. All academic scientists should be required to watch this.
Make sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social
Please share widely!
www.youtube.com/watch?v=yxTD...
Please share widely!
www.youtube.com/watch?v=yxTD...
Facilities and Administrative (F&A) Costs Explainer
YouTube video by Association of American Universities
www.youtube.com
February 11, 2025 at 7:52 PM
This is outstanding. All academic scientists should be required to watch this.
Reposted by Golnaz Vahedi
🏆 Presenting the front page of tomorrow's Inquirer, memorializing the Eagles' second Super Bowl win.
February 10, 2025 at 4:28 AM
🏆 Presenting the front page of tomorrow's Inquirer, memorializing the Eagles' second Super Bowl win.