Paula Haynes
@paulahyns.bsky.social
🔬🧬🧪🧠👩🔬 Instructor, MGH-Boston | neuron-glia lipid and mitochondrial metabolism in sleep and memory consolidation, APOE, Alzheimer's, Drosophila and mice https://scholar.google.com/citations?user=IYqGYj0AAAAJ&hl=en
This is interesting, but likely only the tip of the iceberg because normally inhibiting complex1 is NOT a good thing: it causes electron leak and massive oxidative damage. And it also does not normally feedback on glucose levels. www.science.org/doi/10.1126/...
Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
www.science.org
January 25, 2025 at 6:54 PM
This is interesting, but likely only the tip of the iceberg because normally inhibiting complex1 is NOT a good thing: it causes electron leak and massive oxidative damage. And it also does not normally feedback on glucose levels. www.science.org/doi/10.1126/...
Reposted by Paula Haynes
The link between mitochondrial bioenergetics and brain aging reported in Science. A beautiful study by our neighbours, Huan Ma lab demonstrates that restoring excitation-transcription coupling in mitochondria can improve memory function. This has a potential to reverse age-related cognitive decline.
Aged neurons don’t register energy need
Neuronal activity and mitochondrial gene expression become decoupled in aged mice
www.science.org
December 20, 2024 at 7:31 AM
The link between mitochondrial bioenergetics and brain aging reported in Science. A beautiful study by our neighbours, Huan Ma lab demonstrates that restoring excitation-transcription coupling in mitochondria can improve memory function. This has a potential to reverse age-related cognitive decline.
Reposted by Paula Haynes
Out today @NatureAging!
Life stress can accelerate aging and shorten lifespan, but how remains unclear.
We identify that hippocampal/cortical neurons acquire features of p16-dependent #senescence and DNA damage in mice exposed to chronic social stress.
Lyons et al. doi.org/10.1038/s435...
Life stress can accelerate aging and shorten lifespan, but how remains unclear.
We identify that hippocampal/cortical neurons acquire features of p16-dependent #senescence and DNA damage in mice exposed to chronic social stress.
Lyons et al. doi.org/10.1038/s435...
Chronic social stress induces p16-mediated senescent cell accumulation in mice - Nature Aging
Exploring the molecular consequences of exposing mice to social stress, Lyons et al. identify that hippocampal and cortical neurons acquire features of senescence, identifying a mechanism through whic...
doi.org
November 14, 2024 at 9:53 PM
Out today @NatureAging!
Life stress can accelerate aging and shorten lifespan, but how remains unclear.
We identify that hippocampal/cortical neurons acquire features of p16-dependent #senescence and DNA damage in mice exposed to chronic social stress.
Lyons et al. doi.org/10.1038/s435...
Life stress can accelerate aging and shorten lifespan, but how remains unclear.
We identify that hippocampal/cortical neurons acquire features of p16-dependent #senescence and DNA damage in mice exposed to chronic social stress.
Lyons et al. doi.org/10.1038/s435...
Reposted by Paula Haynes
Elucidating the spatiotemporal dynamics of glucose metabolism with genetically encoded fluorescent biosensors
doi.org/10.1016/j.cr...
doi.org/10.1016/j.cr...
November 16, 2024 at 9:20 AM
Elucidating the spatiotemporal dynamics of glucose metabolism with genetically encoded fluorescent biosensors
doi.org/10.1016/j.cr...
doi.org/10.1016/j.cr...
Reposted by Paula Haynes
Another starter pack of fine fine folks - New PIs! We're all figuring it out together! Please do (self-)nominate
go.bsky.app/KJXNgfZ
go.bsky.app/KJXNgfZ
November 8, 2024 at 2:09 PM
Another starter pack of fine fine folks - New PIs! We're all figuring it out together! Please do (self-)nominate
go.bsky.app/KJXNgfZ
go.bsky.app/KJXNgfZ
Reposted by Paula Haynes
Our latest preprint out on bioRxiv...we show that glymphatic function influences synuclein propagation in the brain 🧠
Influence of the Glymphatic System on α-Synuclein Propagation: Role of Aquaporin-4 and the Dystrophin-Associated Protein Complex https://www.biorxiv.org/content/10.1101/2024.09.11.612272v1
Influence of the Glymphatic System on α-Synuclein Propagation: Role of Aquaporin-4 and the Dystrophin-Associated Protein Complex https://www.biorxiv.org/content/10.1101/2024.09.11.612272v1
Propagation and aggregation of prion proteins, such as tau and -synuclein (Syn), are key pathologica
www.biorxiv.org
November 16, 2024 at 11:38 AM
Our latest preprint out on bioRxiv...we show that glymphatic function influences synuclein propagation in the brain 🧠
Reposted by Paula Haynes
Science
Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states
www.science.org/doi/10.1126/...
Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states
www.science.org/doi/10.1126/...
Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states
Psychedelics hold promise as alternate treatments for neuropsychiatric disorders. However, the neural mechanisms by which they drive adaptive behavioral effects remain unclear. We isolated the specifi...
www.science.org
November 15, 2024 at 1:49 AM
Science
Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states
www.science.org/doi/10.1126/...
Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states
www.science.org/doi/10.1126/...
Nedergaard lab- impaired increase of infra-slow (30s) norepinepherine-oscillations in APP/PS1 mice after sleep deprivation. Suggests Amyloid-β (or γ-secretase) may impair it's own glymphatic clearance...
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model
Cankar et al. report that sleep loss suppresses NREM norepinephrine oscillations in
a murine model of Alzheimer’s disease along with a parallel buildup of amyloid-β.
Thus, overexpression of amyloid-β ...
www.cell.com
November 16, 2024 at 1:13 AM
Nedergaard lab- impaired increase of infra-slow (30s) norepinepherine-oscillations in APP/PS1 mice after sleep deprivation. Suggests Amyloid-β (or γ-secretase) may impair it's own glymphatic clearance...
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Paula Haynes
Super useful tool to import list of people you were following on Twitter to 🦋
If you're just coming in from Twitter, a great way to reconnect with your community is to find the people you were following there with the Sky Follower Bridge. It works really well!
www.sky-follower-bridge.dev
www.sky-follower-bridge.dev
Sky Follower Bridge
Instantly find and follow the same users from your 𝕏 followers on Bluesky
www.sky-follower-bridge.dev
November 15, 2024 at 6:17 PM
Super useful tool to import list of people you were following on Twitter to 🦋
Reposted by Paula Haynes
Woo hoo! 1K new followers, welcome to 💙🦋!
For science-minded folks, there are some very cool tricks 🚀…
If you use any of these emojis: 👩🔬|👩🏻🔬|👩🏼🔬|👩🏽🔬|👩🏾🔬|👩🏿🔬 your post will index on a Women in STEM feed
If you use 🧪 a Science feed
If you use 🧠 a Neuroscience feed
Go get it 🚀🧪🧠👩🔬💙🎊
For science-minded folks, there are some very cool tricks 🚀…
If you use any of these emojis: 👩🔬|👩🏻🔬|👩🏼🔬|👩🏽🔬|👩🏾🔬|👩🏿🔬 your post will index on a Women in STEM feed
If you use 🧪 a Science feed
If you use 🧠 a Neuroscience feed
Go get it 🚀🧪🧠👩🔬💙🎊
November 12, 2024 at 10:25 AM
Woo hoo! 1K new followers, welcome to 💙🦋!
For science-minded folks, there are some very cool tricks 🚀…
If you use any of these emojis: 👩🔬|👩🏻🔬|👩🏼🔬|👩🏽🔬|👩🏾🔬|👩🏿🔬 your post will index on a Women in STEM feed
If you use 🧪 a Science feed
If you use 🧠 a Neuroscience feed
Go get it 🚀🧪🧠👩🔬💙🎊
For science-minded folks, there are some very cool tricks 🚀…
If you use any of these emojis: 👩🔬|👩🏻🔬|👩🏼🔬|👩🏽🔬|👩🏾🔬|👩🏿🔬 your post will index on a Women in STEM feed
If you use 🧪 a Science feed
If you use 🧠 a Neuroscience feed
Go get it 🚀🧪🧠👩🔬💙🎊
Reposted by Paula Haynes
This is a fantastic analysis from student journalists at Penn who have done a better job covering various interests, and the stakes, on our campus than many major media outlets have done all year…
Donors Rule Everything Around Me
When money talks, professors are silenced.
www.34st.com
March 18, 2024 at 9:03 PM
This is a fantastic analysis from student journalists at Penn who have done a better job covering various interests, and the stakes, on our campus than many major media outlets have done all year…
Reposted by Paula Haynes
We often assume textbook depictions can capture all of the diversity seen in living things--spoiler--they don't. Here's a remarkable example: Mitochondria in neuronal axons lack DNA and don't generate ATP!!! 🧪 1/2
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 18, 2024 at 2:08 PM
We often assume textbook depictions can capture all of the diversity seen in living things--spoiler--they don't. Here's a remarkable example: Mitochondria in neuronal axons lack DNA and don't generate ATP!!! 🧪 1/2
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...