Author | Lightnews

Reposted by Misha Rosenbach, MD

Rheum Cat @rheumcat.bsky.social · 4d

Chloe Villani at MGH on ICIs

The basics:

-113 FDA approved indications for ICIs with 12-65% response rate by tumor
-90% report iRAEs and rash is most common
-1-2% can get myocarditis with mortality about 50%
-iRAEs differ by ICI type

#ACR25

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Reposted by Misha Rosenbach, MD

Rheum Cat @rheumcat.bsky.social · 4d

A review of select immune checkpoints that have been identified

Immunology 101: T cells need 2 signals for full activation to migrate to the periphery

#ACR25

On T cells: CTLA4, PD1, LAG3, BTLA, and others

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Reposted by Misha Rosenbach, MD

Journal of Clinical Investigation @jci.org · 4d

Previously shared: In Sweet syndrome, skin cells keep immune cells alive longer, worsening inflammation

@misharosenbach.bsky.social & team identify long-lived neutrophils that can be blocked, offering comparable efficacy to high-dose corticosteroids in coculture assays: www.jci.org/articles/vie...

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Reposted by Misha Rosenbach, MD

PennMedCSO @pennmedcso.bsky.social · 8d

SAA1/FPR2 signaling between keratinocytes & neutrophils sustains chronic inflammation in Sweet syndrome ft Jianhe Huang, Satish Sati, Olivia Ahart, Emmanuel Rapp-Reyes, Linda Zhou, Robert Micheletti, William James @misharosenbach.bsky.social & Thomas Leung (Derm) @jci.org www.jci.org/articles/vie...

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Reposted by Misha Rosenbach, MD

Journal of Clinical Investigation @jci.org · 9d

In Sweet syndrome, skin cells keep immune cells alive longer, worsening inflammation.

@misharosenbach.bsky.social, Thomas H. Leung & team identify long-lived neutrophils that can be blocked, offering comparable efficacy to high-dose corticosteroids in coculture assays: www.jci.org/articles/vie...

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Reposted by Misha Rosenbach, MD

The American Society for Clinical Investigation @the-asci.org · 9d

In Sweet syndrome, skin cells keep immune cells alive longer, worsening inflammation.

ASCI member Thomas H. Leung & team identify long-lived neutrophils that can be blocked, offering comparable efficacy to high-dose corticosteroids in coculture assays: www.jci.org/articles/vie...

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Misha Rosenbach, MD @misharosenbach.bsky.social · 9d

Thank you for sharing this important work on neutrophilic diseases & #SweetSyndrome #Derm #DermSky #Dermatology

For more in a very brief mini 🧵 see below:

bsky.app/profile/mish...

Misha Rosenbach, MD @misharosenbach.bsky.social · Aug 27

I forgot to tag @jclinical-invest.bsky.social in the below #MedSky thread on Sweet Syndrome & our new pub exploring keratinocyte-neutrophil interactions leading to persistent skin neutrophils in Sweets

(Pics from dermnet.nz):
#DermSky

Misha Rosenbach, MD @misharosenbach.bsky.social · 9d

Thank you for tagging and for highlighting this important work! See here for a little more / mini 🧵:

bsky.app/profile/mish...

Misha Rosenbach, MD @misharosenbach.bsky.social · Aug 27

I forgot to tag @jclinical-invest.bsky.social in the below #MedSky thread on Sweet Syndrome & our new pub exploring keratinocyte-neutrophil interactions leading to persistent skin neutrophils in Sweets

(Pics from dermnet.nz):
#DermSky

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Misha Rosenbach, MD @misharosenbach.bsky.social · 9d

Thanks @jci.org for highlighting our group’s important work in #SweetSyndrome @pennmedcso.bsky.social #Derm #Dermatology @the-asci.org

Journal of Clinical Investigation @jci.org · 9d

In Sweet syndrome, skin cells keep immune cells alive longer, worsening inflammation.

@misharosenbach.bsky.social, Thomas H. Leung & team identify long-lived neutrophils that can be blocked, offering comparable efficacy to high-dose corticosteroids in coculture assays: www.jci.org/articles/vie...

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Misha Rosenbach, MD @misharosenbach.bsky.social · 9d

Thanks @the-asci.org for highlighting our group’s important work in #SweetSyndrome @pennmedcso.bsky.social #Derm #Dermatology @jci.org

The American Society for Clinical Investigation @the-asci.org · 9d

In Sweet syndrome, skin cells keep immune cells alive longer, worsening inflammation.

ASCI member Thomas H. Leung & team identify long-lived neutrophils that can be blocked, offering comparable efficacy to high-dose corticosteroids in coculture assays: www.jci.org/articles/vie...

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Reposted by Misha Rosenbach, MD

Jeremy Berg @jeremymberg.bsky.social · 15d

Large study of COVID outcomes with US Veterans with updated mRNA vaccines

www.nejm.org/doi/full/10....

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Association of 2024–2025 Covid-19 Vaccine with Covid-19 Outcomes in U.S. Veterans | NEJM

Amid the declining clinical severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and diminishing public uptake of annual coronavirus disease 2019 (Covid-19) vaccines, ...

www.nejm.org

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Reposted by Misha Rosenbach, MD

JAMA @jama.com · 23d

Inhaler-related #greenhouse gas emissions in the VA health system dropped 68% from 2008 to 2023, primarily due to policy and formulary changes favoring lower-emission inhaler options.

ja.ma/4nYMM54

Greenhouse gas emissions from inhaled medications, 2008-2023. Emissions from SAMA & SABA-SAMA decreased, ICS-LABA increased, SABA stable. Key events: CFC inhaler phase-out, VA formulary changes favoring DPI over MDI.

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Reposted by Misha Rosenbach, MD

The Lancet @thelancet.com · 27d

The world produces enough food, yet billions lack access to healthy & sustainable diets. A new EAT–Lancet report presents a science-based approach to improve health, safeguard our environment & provide for a projected 9.6 billion people by 2050.

🔗 bit.ly/3W7rxlP

Cover of the 2025 EAT–Lancet report, featuring an image of a person scooping up green vegetables in their hands from a large plate. The report quote: “The targets of the EAT–Lancet Commission for healthy people on a healthy planet with just food systems can only be met through concerted global action and unprecedented levels of transformative change.”

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · Sep 15

A 42-year-old man presented with an expanding, asymptomatic rash on his trunk. Examination showed multiple papulosquamous plaques on the torso and a larger patch with central clearing and peripheral scaling on the left side. Read the full case details: nej.md/4m9mawS

#MedSky #DermSky

Images in Clinical Medicine
Pityriasis Rosea

Panels A and B: Photos of the patient’s trunk and left side. An inset shows a close-up of the lesion on the left side.

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Reposted by Misha Rosenbach, MD

The JID Innovations @thejidinnovations.bsky.social · Sep 16

What treatments work for dermatologic immune-related adverse events (D-irAEs)? www.jidinnovations.org/article/S266... #medderm #dermsky

Assessing Treatment Efficacy for Dermatologic Immune-related Adverse Events: A Systematic Review

The management of dermatologic immune-related adverse events (D-irAEs) remains inconsistent due to variability in treatment responses and a lack of standardized guidelines. Establishing evidence-based...

www.jidinnovations.org

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Reposted by Misha Rosenbach, MD

the JID Journal @thejidjournal.bsky.social · Sep 19

The latest issue of the JID is now live.
Dive into the October issue at www.jidonline.org/current
#DermatologyJournal #dermatology #dermsky #dermatologists #dermresearch #dermscience #dermatologyresearch

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · Sep 8

A 71-year-old man presented with a 2-year history of a darkening line on his left thumbnail. Also noted were a brown discoloration of the left thumbnail and hyperpigmentation of the proximal nail fold and tip of the thumb. Read the full case details: nej.md/4ngdaHb

#MedSky #DermSky

Images in Clinical Medicine
Hutchinson’s Sign in Subungual Melanoma In Situ

Panels A and B: Photos of the patient's thumbnail

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · Sep 12

A 44-year-old man presented with a 4-day history of an itchy rash and a 2-day history of fever and malaise. The rash had first appeared on the scalp and then spread across the body within 24 hours. What is the most likely diagnosis? nej.md/IC09112025

#MedSky #DermSky

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Misha Rosenbach, MD @misharosenbach.bsky.social · Sep 5

I’m skeptical
#DermSky
#Dermatology

The Wall Street Journal @wsj.com · Sep 5

South Korea has long been a mecca for skincare enthusiasts, and part of Rejuran’s success is due to a broader interest in Korea-born beauty products and rituals. But some American doctors remain skeptical.

🔗 on.wsj.com/41Fp6dd

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Reposted by Misha Rosenbach, MD

NEJM.org @nejm.org · Sep 4

A previously healthy 42-year-old man presented with a 20-day history of an expanding, asymptomatic rash on his trunk. The initial lesion had been a red spot on the patient’s left side. Ten days after that spot had first appeared, smaller lesions had developed elsewhere. 1/2

#MedSky #DermSky

Image Challenge
What is the diagnosis?

Photos of the patient’s trunk and left side. An inset shows a close-up of the lesion on the left side.

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Reposted by Misha Rosenbach, MD

AMA @ama-assn.org · Sep 3

The AMA strongly opposes Florida’s plan to end all vaccine mandates, and urges Florida to reconsider. This unprecedented rollback would undermine decades of public health progress and place children and communities at increased risk. spr.ly/63328ABvBq

AMA statement on Florida ending all vaccine mandates

AMA strongly opposes Florida’s plan to end all vaccine mandates, including those required for school attendance, and urges Florida to reconsider.

spr.ly

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Reposted by Misha Rosenbach, MD

Nature @nature.com · Sep 3

Nature research paper: Maternal stress triggers early-life eczema through fetal mast cell programming

go.nature.com/3UPz8Vm

Maternal stress triggers early-life eczema through fetal mast cell programming - Nature

Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to otherwise harmless mechanical friction after birth.

go.nature.com

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Reposted by Misha Rosenbach, MD

Infectious Diseases Fellowship at Indiana University @iuidfellowship.bsky.social · Sep 3

www.nejm.org/doi/full/10....

Fatal Toxic Shock Syndrome Associated with Clostridium sordellii after Medical Abortion | NEJM

Endometritis and toxic shock syndrome associated with Clostridium sordellii have previously been reported after childbirth and, in one case, after medical abortion. We describe four deaths due to e...

www.nejm.org

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Reposted by Misha Rosenbach, MD

Infectious Diseases Fellowship at Indiana University @iuidfellowship.bsky.social · Sep 3

#idboardreview 25 F person who injects drugs, swam in gulf shore few wks ago, no trauma, no pets, no shellfish consumed. Sepsis, R exquisitely painful arm, MRI enhancement of chest wall, shoulder, arm, & forearm. Surgical cultures shown. Dx? #medEd #idmedEd #idsky

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Reposted by Misha Rosenbach, MD

Atul Gawande @agawande.bsky.social · Sep 1

9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American."

It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...

Opinion | We Ran the C.D.C.: Kennedy Is Endangering Every American’s Health

www.nytimes.com

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