Miguel Mesquita
@miguelmmesquita.bsky.social
Naive lymphocyte asking directions, wandering from paper to paper. PhD student @GIMM completely obsessed how macrophages exist.
Reposted by Miguel Mesquita
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
November 19, 2025 at 3:20 PM
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
Reposted by Miguel Mesquita
🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism.
www.embopress.org/doi/full/10....
(1/9)
www.embopress.org/doi/full/10....
(1/9)
Homeostatic control of energy metabolism by monocyte-derived macrophages | The EMBO Journal
imageimageMacrophages play critical roles in the homeostatic control systems that maintain vital
parameters within physiological ranges. This study characterizes how mouse monocyte-derived
macrophages...
www.embopress.org
November 19, 2025 at 2:11 PM
🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism.
www.embopress.org/doi/full/10....
(1/9)
www.embopress.org/doi/full/10....
(1/9)
Reposted by Miguel Mesquita
Better late than never, but I am thrilled to share our newest research from the Treeck lab!!! www.nature.com/articles/s41...
The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound - Nature Microbiology
FIKK effector kinases underwent rapid evolutionary expansion and are a druggable target in Plasmodium falciparum.
www.nature.com
June 23, 2025 at 1:28 PM
Better late than never, but I am thrilled to share our newest research from the Treeck lab!!! www.nature.com/articles/s41...
Rewring lipid metabolism to sustain thermoregulation during sepsis. Don’t let it get cold! A very interesting piece from Miguel Soares lab @elmiguelche.bsky.social @gimmfoundation.bsky.social
A bioenergetic basis for multiorgan dysfunction in sepsis https://www.biorxiv.org/content/10.1101/2025.06.12.659280v1
June 18, 2025 at 8:34 AM
Rewring lipid metabolism to sustain thermoregulation during sepsis. Don’t let it get cold! A very interesting piece from Miguel Soares lab @elmiguelche.bsky.social @gimmfoundation.bsky.social
Rethinking jaundice | Science www.science.org/doi/10.1126/...
Excellent work to start the week in full force! Miguel Soares lab uncovers a protective role for bilirubin, a product of heme catabolism, during malaria infection. A must read!
Excellent work to start the week in full force! Miguel Soares lab uncovers a protective role for bilirubin, a product of heme catabolism, during malaria infection. A must read!
Rethinking jaundice
A buildup of unconjugated bilirubin may be a protective response to malaria
www.science.org
June 16, 2025 at 11:43 AM
Rethinking jaundice | Science www.science.org/doi/10.1126/...
Excellent work to start the week in full force! Miguel Soares lab uncovers a protective role for bilirubin, a product of heme catabolism, during malaria infection. A must read!
Excellent work to start the week in full force! Miguel Soares lab uncovers a protective role for bilirubin, a product of heme catabolism, during malaria infection. A must read!
Reposted by Miguel Mesquita
A metabolite-based resistance mechanism against malaria | Science www.science.org/doi/10.1126/...
@gimmfoundation.bsky.social
@gimmfoundation.bsky.social
A metabolite-based resistance mechanism against malaria
Jaundice is a common presentation of Plasmodium falciparum malaria, which arises from the accumulation of circulating bilirubin. It is not understood whether it represents an adaptive or maladaptive r...
www.science.org
June 12, 2025 at 6:35 PM
A metabolite-based resistance mechanism against malaria | Science www.science.org/doi/10.1126/...
@gimmfoundation.bsky.social
@gimmfoundation.bsky.social
Reposted by Miguel Mesquita
📼 A coluna de Salgueiro Maia dirige-se para o Quartel da GNR no Largo do Carmo. https://j.mp/QuartelGNR #25a74
- YouTube
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
j.mp
April 25, 2025 at 11:25 AM
📼 A coluna de Salgueiro Maia dirige-se para o Quartel da GNR no Largo do Carmo. https://j.mp/QuartelGNR #25a74
For portuguese readers. Tomorrow is Portugal’s liberty day and it was never so fragile.
A necessary awakening call for what’s happening indoors and outdoors, comparing malaria infection with other parasites.
expresso.pt/opiniao/2025...
A necessary awakening call for what’s happening indoors and outdoors, comparing malaria infection with other parasites.
expresso.pt/opiniao/2025...
25 de Abril sempre! Malária nunca mais!
<p>Tal como na malária, também não existe uma vacina contra o fascismo. Apenas a educação, a liberdade, a justiça e a empatia nos podem proteger</p>
expresso.pt
April 24, 2025 at 11:45 AM
For portuguese readers. Tomorrow is Portugal’s liberty day and it was never so fragile.
A necessary awakening call for what’s happening indoors and outdoors, comparing malaria infection with other parasites.
expresso.pt/opiniao/2025...
A necessary awakening call for what’s happening indoors and outdoors, comparing malaria infection with other parasites.
expresso.pt/opiniao/2025...
Reposted by Miguel Mesquita
Bilirubin metabolism in the liver orchestrates antiviral innate immunity in the body @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
March 28, 2025 at 1:58 AM
Bilirubin metabolism in the liver orchestrates antiviral innate immunity in the body @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Miguel Mesquita
Time to give an update on the fantastic work by @taniafpaulo.bsky.social during her PhD, now published in @royalsocietypublishing.org on the evolution of resistance and disease tolerance mechanisms to oral infection in #Drosophila
royalsocietypublishing.org/doi/10.1098/...
#infection #immunity 🤓🎊
royalsocietypublishing.org/doi/10.1098/...
#infection #immunity 🤓🎊
Evolution of resistance and disease tolerance mechanisms to oral bacterial infection in Drosophila melanogaster | Open Biology
Pathogens exert strong selection on hosts that evolve and deploy different defensive
strategies, namely minimizing pathogen exposure (avoidance), directly promoting pathogen
elimination (resistance) a...
royalsocietypublishing.org
March 15, 2025 at 12:08 PM
Time to give an update on the fantastic work by @taniafpaulo.bsky.social during her PhD, now published in @royalsocietypublishing.org on the evolution of resistance and disease tolerance mechanisms to oral infection in #Drosophila
royalsocietypublishing.org/doi/10.1098/...
#infection #immunity 🤓🎊
royalsocietypublishing.org/doi/10.1098/...
#infection #immunity 🤓🎊
Reposted by Miguel Mesquita
What childhood was like before vaccines www.vox.com/health/40268...
What childhood was like before vaccines
The anti-vax movement has gone mainstream, but before these shots, grief and loss marked the lives of children.
www.vox.com
March 6, 2025 at 2:47 PM
What childhood was like before vaccines www.vox.com/health/40268...