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Mick Craig

@mickcraig.bsky.social

2.7K followers 3.2K following 680 posts

Glaswegian Neuroscientist running a systems neuro lab @uofglasgow.bsky.social. Interests: ephys, interneurons, thalamus, oscillations, dementia, schiz & neuroinflammation. Dad, leftie, runner, wannabe chef, atheist. He/him https://craiglab.org/

craiglab.org

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Mick Craig @mickcraig.bsky.social · Jun 11

Preprint alert! An update to our main neuroinflammation in depression project. A brief 🧵.

tl;dr altered ahalamostriatal signalling appears to undelie depression / anhedonia in both humans and a preclinical mouse model. Glia & infiltrating immune cells all contribute

www.biorxiv.org/content/10.1...

Immune-mediated inflammation modulates the thalamostriatal circuitry regulating depression-like behaviour in both mice and humans

Major depressive disorder (MDD) affects 3.8% of the world population, representing a significant contribution to the global burden of disease (WHO). Around a quarter of people living with MDD demonstr...

www.biorxiv.org

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Reposted by Mick Craig

PLOS Biology @plosbiology.org · 17h

Excitatory input from #PrefrontalCortex to #hippocampus pyramidal cells is believed to be mediated through the thalamic nucleus reuniens. @mickcraig.bsky.social &co show in rodents that this brain pathway is unexpectedly minor, contrary to assumptions in the field @plosbiology.org 🧪 plos.io/48u6mle

Monosynaptic retrograde tracing from hippocampus proper shows no cells originating from nucleus reuniens (NRe), unless the starter cells are present in subiculum region. Left: Injection site for dorsal CA1 and viral spreads for the helper virus (green cells). B and D, Injection site of a dCA1 injection: green cells contain helper virus and red cells are pseudotyped rabies virus positive and starter cells (yellow) shown closer on the inset, shown by arrowheads. C and E, No cells found in any thalamic section containing NRe.

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Mick Craig @mickcraig.bsky.social · 22h

I would also take a look here for some more recent rodent evidence of reuniens playing a re in extinction of fear memory: www.nature.com/articles/s41...

Client Challenge

www.nature.com

Mick Craig @mickcraig.bsky.social · 22h

This is a great question! We've never really studied fear memory in our lab but @memorycontrol.bsky.social has done a lot of thinking on the potential rule of reuniens in fear memory. This is a great place to start - www.memorycontrol.net/2021Anderson....

www.memorycontrol.net

Mick Craig @mickcraig.bsky.social · 23h

Thanks man, appreciate that! 🙏

Reposted by Mick Craig

Kayleigh McKee, Cheerer for the Dolls ⏬️ AnimeUSA! @ghaspey.bsky.social · 1d

I'll say it: I think its rly annoying and frankly amateurish that writers are constantly told their villains must be understandable or have sympathetic motivation to be interesting or realistic when all our big villains irl are in fact rich, stupid, selfish, trickster dillweeds and always have been

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Mick Craig @mickcraig.bsky.social · 1d

Delighted that our main #TeamReuniens paper is finally out in @plosbiology.org. Been a long time in the making, congratulations to Lilya and all the team. A thread to follow soon, after I've had some sleep... #NeuroSkyence

journals.plos.org/plosbiology/...

Hippocampal pyramidal cells of the CA1 region are not a major target of the thalamic nucleus reuniens

Excitatory input from the prefrontal cortex to hippocampus pyramidal cells is commonly believed to be mediated through the thalamic nucleus reuniens brain region. This study shows in rodents that this...

journals.plos.org

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Mick Craig @mickcraig.bsky.social · 2d

Did a slightly early Thanksgiving meal today and my pumpkin pie set! I take a somewhat freestyle approach in the kitchen so have a patchy track record with pumpkin pie, but I actually read a recipe and measured a little today. Enjoy tomorrow for those to celebrate! 🍁🇨🇦

Reposted by Mick Craig

Dr. Cat Hicks @grimalkina.bsky.social · 2d

No comment on what THIS company is doing because (*shudder*), but if you want to follow REAL scientists on this look at groups like: www.ucdavis.edu/news/brain-c...

publicly 👏 funded 👏 research 👏 changing 👏 lives 👏

Brain-Computer Interface Allows Man With ALS to ‘Speak’

A brain-computer interface (BCI) developed by UC Davis Health accurately translates brain signals into speech. The device implanted in the brain of a man with ALS is the most accurate system of its ki...

www.ucdavis.edu

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Mick Craig @mickcraig.bsky.social · 3d

I finally made a lab website, a mere 9 years after starting... oops. It's still a bit rudimentary but it'll do for now... craiglab.org

Craig Lab

Translational neurobiology

craiglab.org

Reposted by Mick Craig

Yeshes.Online 📎🌻🖖♾️ @yeshes.online · 3d

Not going to lie, this is spot on and frankly, yeah, this IS how I feel and if I wasn't clear, placing this because she did it better than I would have and to be certain, in less time. 😜

If this is #cringe, then cringe away because I'm not.

From the CringeTikToks community on Reddit: Brutally spot-on. 😳👇

Explore this post and more from the CringeTikToks community

www.reddit.com

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Mick Craig @mickcraig.bsky.social · 4d

Are we still doing #FluorescenceFriday? #NeuroSkyence

Ventral hippocampal pyramidal cells transduced with rabies (cyan), helper proteins (magenta), or both. Part of a monosynaptic circuit tracing experiment

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Reposted by Mick Craig

Dr Nick @nmwilkinson.bsky.social · 13d

For Starmer and Labour the point is to beat Reform in elections. Maybe this will work, to that end.

But for the public and the nation, the important thing is to defeat the fascism and its racism. And this approach will achieve the very opposite

Adam Bienkov @adambienkov.bsky.social · 13d

Once again Labour's strategy is to say that racism is terrible, and therefore we will defeat the racists by giving them almost everything they want
bylinetimes.com/2025/10/01/k...

Keir Starmer's Farage-Dominated Conference Takes Labour Up a 'Darker Path' Towards a Reform Government

The Prime Minister's condemnations of Reform's racist rhetoric, was undermined by him accepting the central premise of Nigel Farage's anti-migrant politics, argues Adam Bienkov

bylinetimes.com

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Mick Craig @mickcraig.bsky.social · 14d

Details on how to apply can be found here: www.gla.ac.uk/postgraduate...

University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences

NorthWest Bio is a new BBSRC-funded doctoral training partnership. Discover more about the programme and how to apply.

www.gla.ac.uk

Mick Craig @mickcraig.bsky.social · 14d

Fully funded #FindAPhD! We'll be studying neurobiology of motivation in mice hunting crickets, using a combination of genetic manipulations, behaviour and in vivo ephys. Co-suprvised by the amazing @agonru.bsky.social and Gareth Arnott at QUB. #Neuroskyence Pls share

www.gla.ac.uk/postgraduate...

University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Animal Biology in Health & Disease - Mick Craig

www.gla.ac.uk

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Mick Craig @mickcraig.bsky.social · 16d

Damn, this must have been quite the faff! Congratulations to you and the team 💪💪

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Reposted by Mick Craig

Butt Lab - Oxford @interneuron.bsky.social · 26d

A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!

www.sciencedirect.com/science/arti...

GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex

Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…

www.sciencedirect.com

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Reposted by Mick Craig

Jan Broder Engler @jbengler.de · Jul 8

This is how you can test selected comparisons in #tidyplots 0.3.1 📋

#rstats #dataviz #phd

library(tidyplots)

study |>
tidyplot(x = treatment, y = score, color = treatment) |>
add_mean_dash() |>
add_sem_errorbar() |>
add_data_points() |>
add_test_pvalue(comparisons = list(c(1,3),c(2,4)))

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Mick Craig @mickcraig.bsky.social · 17d

Machiavellan. Love it 😂

Mick Craig @mickcraig.bsky.social · 17d

Daaaaammmmn. Impressive.

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Mick Craig @mickcraig.bsky.social · 17d

This is interesting. Yeah, people are petty. I had a big name in the field send a tetchy email as I discussed a caveat of their work in a review (I was very complementary overall). Never meet your heroes... 🙄🫣

Mick Craig @mickcraig.bsky.social · 17d

Ah, fair enough. It's still a brave move, I guess someone has to lead from the front. Well done!

Mick Craig @mickcraig.bsky.social · 17d

This is a sensible approach and definitely part of my reluctance...

Reposted by Mick Craig

iucounu @iucounu.bsky.social · Sep 5

Spider-Man asking dinosaur mad scientist Sauron why he is using his 170 seat majority to constantly fuck up instead of fixing Britain and Sauron saying that’s the way he likes it

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Mick Craig @mickcraig.bsky.social · 17d

Interesting. Is this the norm in computational biology? It's unusual for the kid of reviews I get, but not unheard of. This journal publishes the reviews too, so I was torn between being accountable for my review and, erm, hiding behind anonymity, I guess. Review was fair but I was still reluctant 🤔

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Mick Craig @mickcraig.bsky.social · 17d

Do you ever sign a peer review? I reviewed a paper last night and the journal have the option to sign the review. I almost did but then decided against it. #NeuroSkyence

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