@mattiaquattro.bsky.social
pretty cool concept
November 26, 2025 at 3:33 PM
pretty cool concept
Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice | Molecular Medicine link.springer.com/article/10.1... @myoblue.bsky.social intriguing new role for FAPs: source of follistatin to control muscle mass
Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice - Molecular Medicine
Background Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogen...
link.springer.com
November 25, 2025 at 12:41 PM
Deletion of fibro-adipogenic progenitors-specific follistatin impairs muscle function and accelerates skeletal muscle atrophy in obese mice | Molecular Medicine link.springer.com/article/10.1... @myoblue.bsky.social intriguing new role for FAPs: source of follistatin to control muscle mass
Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets | Nature Communications www.nature.com/articles/s41... @myoblue.bsky.social possible new mechanism for statin-driven myopathy
Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets - Nature Communications
Statins lower blood plasma cholesterol but can cause muscle-related issues including life-threatening rhabdomyolysis. Here the authors show that atorvastatin binds as triplets to the skeletal muscle R...
www.nature.com
November 25, 2025 at 12:39 PM
Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets | Nature Communications www.nature.com/articles/s41... @myoblue.bsky.social possible new mechanism for statin-driven myopathy
Reposted
“The number of cyberattacks is not relenting”
Hackers are ramping up attacks on academic institutions to access valuable data and to demand ransoms
go.nature.com/49tiOCc
Hackers are ramping up attacks on academic institutions to access valuable data and to demand ransoms
go.nature.com/49tiOCc
Cyberattacks' harm to universities is growing — and so are their effects on research
Hackers are ramping up attacks on academic institutions to access valuable data and to demand ransoms.
go.nature.com
November 21, 2025 at 3:03 PM
“The number of cyberattacks is not relenting”
Hackers are ramping up attacks on academic institutions to access valuable data and to demand ransoms
go.nature.com/49tiOCc
Hackers are ramping up attacks on academic institutions to access valuable data and to demand ransoms
go.nature.com/49tiOCc
Reposted
Exclusive: Scientists at the U.S. Centers for Disease Control and Prevention have been told to phase out all of their monkey research, Science has learned. https://scim.ag/48foQEk
Exclusive: CDC to end all monkey research
Studies related to HIV and other infectious diseases will be phased out, sources say; fate of the agency's animals remains unclear
www.science.org
November 21, 2025 at 3:08 PM
Exclusive: Scientists at the U.S. Centers for Disease Control and Prevention have been told to phase out all of their monkey research, Science has learned. https://scim.ag/48foQEk
Reposted
Excited to share Emma Sutton's recently published Ph.D. research! By using cells, worms and mice, we report that mifepristone, a glucocorticoid receptor anatagonist, alone and in combination with an approved SMN-dependent therapy, has the potential to improve SMA disease pathology.
rdcu.be/eQpXG
rdcu.be/eQpXG
Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice
Scientific Reports - Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice
rdcu.be
November 19, 2025 at 11:20 AM
Excited to share Emma Sutton's recently published Ph.D. research! By using cells, worms and mice, we report that mifepristone, a glucocorticoid receptor anatagonist, alone and in combination with an approved SMN-dependent therapy, has the potential to improve SMA disease pathology.
rdcu.be/eQpXG
rdcu.be/eQpXG
Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis | Nature Communications www.nature.com/articles/s41... @myoblue.bsky.social
Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis - Nature Communications
In mdx mouse fetuses, the lack of dystrophin markedly impairs secondary myogenesis due to reduced muscle stem cell polarity. AAK1 deletion restores polarity and rescues secondary myogenesis, revealing...
www.nature.com
November 18, 2025 at 1:35 PM
Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis | Nature Communications www.nature.com/articles/s41... @myoblue.bsky.social
Reposted
www.nature.com/articles/s42... cancer promotes cachexia by disrupting cAMP signaling in muscle @myoblue.bsky.social
Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia - Nature Metabolism
Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in mice.
www.nature.com
November 17, 2025 at 2:11 AM
www.nature.com/articles/s42... cancer promotes cachexia by disrupting cAMP signaling in muscle @myoblue.bsky.social
Reposted
IN MEMORIAM: A totipotent embryologist: John B. Gurdon
(1933–2025)
By Thoru Pederson
➡️ https://tinyurl.com/gd353471OA
*Photo courtesy of the Cold Spring Harbor Laboratory Archives.
(1933–2025)
By Thoru Pederson
➡️ https://tinyurl.com/gd353471OA
*Photo courtesy of the Cold Spring Harbor Laboratory Archives.
November 14, 2025 at 7:36 PM
IN MEMORIAM: A totipotent embryologist: John B. Gurdon
(1933–2025)
By Thoru Pederson
➡️ https://tinyurl.com/gd353471OA
*Photo courtesy of the Cold Spring Harbor Laboratory Archives.
(1933–2025)
By Thoru Pederson
➡️ https://tinyurl.com/gd353471OA
*Photo courtesy of the Cold Spring Harbor Laboratory Archives.
Reposted
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
Based on an acute exercise model, Yan et al. identify lactate as a positive regulator
of autophagy in skeletal muscle. Lactate triggers muscle autophagy via K921 lactylation-dependent
inactivation of ...
www.cell.com
November 12, 2025 at 4:33 PM
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
Dystrophinopathy in ACTION: The first 500 males enrolled in the Advanced Cardiac Therapies Improving Outcomes Network prospective dystrophinopathy registry - ScienceDirect www.sciencedirect.com/science/arti... @myoblue.bsky.social @cardiosky11.bsky.social
Dystrophinopathy in ACTION: The first 500 males enrolled in the Advanced Cardiac Therapies Improving Outcomes Network prospective dystrophinopathy registry
The Advanced Cardiac Therapies Improving Outcomes Network formed a dystrophinopathy registry to define cardiac diagnostics, management, and advanced t…
www.sciencedirect.com
November 11, 2025 at 7:23 PM
Dystrophinopathy in ACTION: The first 500 males enrolled in the Advanced Cardiac Therapies Improving Outcomes Network prospective dystrophinopathy registry - ScienceDirect www.sciencedirect.com/science/arti... @myoblue.bsky.social @cardiosky11.bsky.social
Reposted
Vaccines save lives in more ways than one.
Flu, COVID, HIV, HCV, and HZV were associated with an increased risk of major cardiovascular events. Vaccines may have important role in reducing the risk of cardiovascular disease… #IDSky #vaccine #COVID
www.ahajournals.org/doi/10.1161/...
Flu, COVID, HIV, HCV, and HZV were associated with an increased risk of major cardiovascular events. Vaccines may have important role in reducing the risk of cardiovascular disease… #IDSky #vaccine #COVID
www.ahajournals.org/doi/10.1161/...
Viral Infections and Risk of Cardiovascular Disease: Systematic Review and Meta‐Analysis | Journal of the American Heart Association
www.ahajournals.org
October 31, 2025 at 4:37 AM
Vaccines save lives in more ways than one.
Flu, COVID, HIV, HCV, and HZV were associated with an increased risk of major cardiovascular events. Vaccines may have important role in reducing the risk of cardiovascular disease… #IDSky #vaccine #COVID
www.ahajournals.org/doi/10.1161/...
Flu, COVID, HIV, HCV, and HZV were associated with an increased risk of major cardiovascular events. Vaccines may have important role in reducing the risk of cardiovascular disease… #IDSky #vaccine #COVID
www.ahajournals.org/doi/10.1161/...
Reposted
Ohio house committee held a third hearing on permanent Daylight Saving Time. All written testimony opposed (thank you!). No oral testimony occurred (we spoke at the second hearing in May). No discussion or vote occurred. Tell your OH state reps NO on HCR 10!
October 29, 2025 at 2:11 AM
Ohio house committee held a third hearing on permanent Daylight Saving Time. All written testimony opposed (thank you!). No oral testimony occurred (we spoke at the second hearing in May). No discussion or vote occurred. Tell your OH state reps NO on HCR 10!
Reposted
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government
www.nature.com/articles/d41...
www.nature.com/articles/d41...
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
www.nature.com
October 29, 2025 at 11:10 AM
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy | Nature Communications www.nature.com/articles/s41... #myoblue @myoblue.bsky.social
Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy - Nature Communications
Defective neurotransmission is a hallmark of spinal muscular atrophy (SMA). Here, the authors show that local presynaptic Munc13-1synthesis is defective in SMA and that modification of the Munc13-1 mR...
www.nature.com
October 29, 2025 at 1:05 PM
Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy | Nature Communications www.nature.com/articles/s41... #myoblue @myoblue.bsky.social
Reposted
PENNSYLVANIA State Rep Joe McAndrew files HR 349 for permanent Daylight Saving Time. Would put sunrise past 8am for 3 months, to nearly 9am. Tell your PA state reps NO on HR 349—and yes instead on HB 119 for permanent Standard Time! 🔗👇
October 23, 2025 at 11:21 PM
PENNSYLVANIA State Rep Joe McAndrew files HR 349 for permanent Daylight Saving Time. Would put sunrise past 8am for 3 months, to nearly 9am. Tell your PA state reps NO on HR 349—and yes instead on HB 119 for permanent Standard Time! 🔗👇
Reposted
Honestly, why do we even have Daylight Saving Time?
October 21, 2025 at 10:43 PM
Honestly, why do we even have Daylight Saving Time?
www.researchsquare.com/article/rs-7... intriguing preprint on myonuclei motility in muscular dystrophy, particularly in light of centronucleation and regeneration #myoblue
NuMA1 controls myonuclear motility in striated skeletal muscle through AMPK activity and is impaired in Duchenne Muscular Dystrophy
Skeletal muscle consists in a bundle of thousands post-mitotic multinucleated cells, called myofibers, in which myonuclei are evenly spaced and positioned at the periphery. This myonuclear positioning...
www.researchsquare.com
October 13, 2025 at 1:04 PM
www.researchsquare.com/article/rs-7... intriguing preprint on myonuclei motility in muscular dystrophy, particularly in light of centronucleation and regeneration #myoblue
Scientist on front lines of overdose crisis receives MacArthur 'genius' award : NPR www.npr.org/2025/10/08/n...
Scientist on front lines of overdose crisis receives MacArthur 'genius' award
Nabarun Dasgupta was recognized with a MacArthur "genius" award for work studying the deadly overdose crisis. He's also a front-line organizer, helping people survive.
www.npr.org
October 9, 2025 at 3:07 PM
Scientist on front lines of overdose crisis receives MacArthur 'genius' award : NPR www.npr.org/2025/10/08/n...
How Trump's research cuts affect a 4-year-old in heart failure : NPR www.npr.org/2025/10/09/n... this is tragic
This 4-year-old's heart is failing. A federal grant that might help him was canceled
A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down.
www.npr.org
October 9, 2025 at 3:05 PM
How Trump's research cuts affect a 4-year-old in heart failure : NPR www.npr.org/2025/10/09/n... this is tragic
Reposted
Canadians, tell your MPs and MLAs/MPPs/MNAs/MHAs to listen to sleep doctors, support permanent Standard Time and not permanent Daylight Saving Time!
October 6, 2025 at 6:41 PM
Canadians, tell your MPs and MLAs/MPPs/MNAs/MHAs to listen to sleep doctors, support permanent Standard Time and not permanent Daylight Saving Time!
Reposted
So sad to hear the news - John truly was an inspiration to so many, and one of a kind.
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
October 7, 2025 at 4:02 PM
So sad to hear the news - John truly was an inspiration to so many, and one of a kind.
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
