Jonathan Rosenblum
@jsrosenblum.bsky.social
|| Challah baker | Cocktail maker | Photo taker ||
Pinned
Maybe another useful entry point for this recent article about why several very successful academics have left Harvard to more efficiently bring their science to patients.
NIH is amazing, but it's not intended for making medicine.
www.harvardmagazine.com/2025/01/harv...
#medsky
1/3
NIH is amazing, but it's not intended for making medicine.
www.harvardmagazine.com/2025/01/harv...
#medsky
1/3
Reminder: Your enzyme having that name DOES NOT mean that's all it does.
Metabolic enzymes like PGDH have a bunch of substrates and the enzyme is usually named for the first and/or easiest to assay.
Regardless, cool report on a cool drug target
#chemsky #chemchat
Metabolic enzymes like PGDH have a bunch of substrates and the enzyme is usually named for the first and/or easiest to assay.
Regardless, cool report on a cool drug target
#chemsky #chemchat
Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration
Aging or injury to the joints can lead to cartilage degeneration and osteoarthritis (OA), for which there are limited effective treatments. We found that expression of 15-hydroxy prostaglandin dehydro...
www.science.org
November 30, 2025 at 9:28 PM
Reposted by Jonathan Rosenblum
It may not feel like it now, but this is a very dangerous time to be a criminal in the White House, and a great time to be a patriot. And the job of those patriots right now is to be as loud as possible to minimize the collateral damage. But make no mistake: there will be accountability. /fin
November 29, 2025 at 3:32 PM
It may not feel like it now, but this is a very dangerous time to be a criminal in the White House, and a great time to be a patriot. And the job of those patriots right now is to be as loud as possible to minimize the collateral damage. But make no mistake: there will be accountability. /fin
Risk, meet reward
November 29, 2025 at 5:21 AM
Risk, meet reward
Reposted by Jonathan Rosenblum
TRUMP: If you’re trafficking drugs to the U.S. via the Caribbean I will kill you.
ALSO TRUMP: If you’re doing time because you helped traffic 400 tons of cocaine to the U.S. via Honduras you get a “Full and Complete Pardon.”
www.justice.gov/archives/opa...
ALSO TRUMP: If you’re doing time because you helped traffic 400 tons of cocaine to the U.S. via Honduras you get a “Full and Complete Pardon.”
www.justice.gov/archives/opa...
November 29, 2025 at 2:39 AM
TRUMP: If you’re trafficking drugs to the U.S. via the Caribbean I will kill you.
ALSO TRUMP: If you’re doing time because you helped traffic 400 tons of cocaine to the U.S. via Honduras you get a “Full and Complete Pardon.”
www.justice.gov/archives/opa...
ALSO TRUMP: If you’re doing time because you helped traffic 400 tons of cocaine to the U.S. via Honduras you get a “Full and Complete Pardon.”
www.justice.gov/archives/opa...
Reposted by Jonathan Rosenblum
The MAHA pitch was supposed to be that Americans don’t really need insurance, vaccines, or other “establishment” medical care — they just need better nutrition and less exposure to environmental toxins.
And yet: www.nytimes.com/2025/11/26/h...
And yet: www.nytimes.com/2025/11/26/h...
F.D.A. Withdraws Rule to Require Testing Cosmetics Made With Talc for Asbestos
www.nytimes.com
November 28, 2025 at 11:08 PM
The MAHA pitch was supposed to be that Americans don’t really need insurance, vaccines, or other “establishment” medical care — they just need better nutrition and less exposure to environmental toxins.
And yet: www.nytimes.com/2025/11/26/h...
And yet: www.nytimes.com/2025/11/26/h...
Reposted by Jonathan Rosenblum
this should go without saying but if you were one of the lucky few we did get out of Afghanistan during the withdrawal and we got you out because you'd been working with us, deportation back is likely a death sentence.
November 27, 2025 at 1:54 AM
this should go without saying but if you were one of the lucky few we did get out of Afghanistan during the withdrawal and we got you out because you'd been working with us, deportation back is likely a death sentence.
Careful Rams.
21-0 in the first half against a team you should destroy is the most dangerous lead in the NFL.
21-0 in the first half against a team you should destroy is the most dangerous lead in the NFL.
November 24, 2025 at 2:14 AM
Careful Rams.
21-0 in the first half against a team you should destroy is the most dangerous lead in the NFL.
21-0 in the first half against a team you should destroy is the most dangerous lead in the NFL.
And awesome.
Why have I never thought of suspending my bathing suit before?
Why have I never thought of suspending my bathing suit before?
November 22, 2025 at 3:31 AM
And awesome.
Why have I never thought of suspending my bathing suit before?
Why have I never thought of suspending my bathing suit before?
The guy who said nobody should listen to his medical advice is personally rewriting the Centers of Disease Control website.
What kind of person does this?
Someone you cannot trust.
What kind of person does this?
Someone you cannot trust.
November 21, 2025 at 7:02 PM
The guy who said nobody should listen to his medical advice is personally rewriting the Centers of Disease Control website.
What kind of person does this?
Someone you cannot trust.
What kind of person does this?
Someone you cannot trust.
Reposted by Jonathan Rosenblum
Can’t believe the whole country has to suffer through the return of Dickensian childhood diseases because the worst, most ignorant attention-demanders decided other people’s expertise makes them feel bad
November 20, 2025 at 4:19 AM
Can’t believe the whole country has to suffer through the return of Dickensian childhood diseases because the worst, most ignorant attention-demanders decided other people’s expertise makes them feel bad
Weird and stupid
November 20, 2025 at 5:09 AM
Weird and stupid
Reposted by Jonathan Rosenblum
We've seen some remarkable outcomes in people with advanced, refractory cancers, including pancreatic, melanoma, and renal, with personalized neoantigen mRNA vaccines.
But this work is now endangered.
www.scientificamerican.com/article/pers...
But this work is now endangered.
www.scientificamerican.com/article/pers...
November 18, 2025 at 7:16 PM
We've seen some remarkable outcomes in people with advanced, refractory cancers, including pancreatic, melanoma, and renal, with personalized neoantigen mRNA vaccines.
But this work is now endangered.
www.scientificamerican.com/article/pers...
But this work is now endangered.
www.scientificamerican.com/article/pers...
People are so weird
November 18, 2025 at 2:59 AM
People are so weird
Reposted by Jonathan Rosenblum
Of course the White House is leaning into this. Because apparently they don't realize we exported more higher ed last year than natural gas & coal *combined*
November 17, 2025 at 6:20 PM
Of course the White House is leaning into this. Because apparently they don't realize we exported more higher ed last year than natural gas & coal *combined*
Reposted by Jonathan Rosenblum
Important new analysis identifying the scope of clinical trials disrupted because of NIH shenanigans.
> 74 thousand trial participants affected
jamanetwork.com/journals/jam...
1/4
> 74 thousand trial participants affected
jamanetwork.com/journals/jam...
1/4
Clinical Trials Affected by Research Grant Terminations at the National Institutes of Health
This cross-sectional study summarizes the number of trials with terminated grants from the National Institutes of Health (NIH) and calculates the proportion of affected trials among those with previou...
jamanetwork.com
November 17, 2025 at 5:45 PM
Important new analysis identifying the scope of clinical trials disrupted because of NIH shenanigans.
> 74 thousand trial participants affected
jamanetwork.com/journals/jam...
1/4
> 74 thousand trial participants affected
jamanetwork.com/journals/jam...
1/4
Reposted by Jonathan Rosenblum
As expected, Canada has lost its measles-free status because of the long-running outbreak there. With it goes the #measles elimination status of the entire zone of the Americas, the only division of the #WHO to ever have achieved measles elimination. www.statnews.com/2025/11/10/m...
Canada loses measles elimination status — as does the entire Americas region
Canada has formally lost its measles elimination status, the country’s public health agency announced, triggering the loss of that status throughout all of the Americas.
www.statnews.com
November 10, 2025 at 2:49 PM
As expected, Canada has lost its measles-free status because of the long-running outbreak there. With it goes the #measles elimination status of the entire zone of the Americas, the only division of the #WHO to ever have achieved measles elimination. www.statnews.com/2025/11/10/m...
November 9, 2025 at 1:21 AM
I read Tbe Double Helix when I was in graduate school.
The thing that most impacted me then and has stuck with me til now: they went on a ski trip (or some other vacation) when they were on the cusp of solving the structure.
How!?!
The thing that most impacted me then and has stuck with me til now: they went on a ski trip (or some other vacation) when they were on the cusp of solving the structure.
How!?!
Great thread from Jeremy. But 16/41 leapt out and reminded me again of learning about base pairing in high school. That was _the_ moment I knew I wanted to study biochemistry.
Now I really must go read Heraclitean Fire...
Now I really must go read Heraclitean Fire...
He may not have fully understood this, but Crick did because of his work on helical diffraction. The question of where the bases were remained. According to The Double Helix, Watson was focused on this and eventually figured out the A-T and G-C pairing that proved so important.
16/41
16/41
November 8, 2025 at 3:04 PM
I read Tbe Double Helix when I was in graduate school.
The thing that most impacted me then and has stuck with me til now: they went on a ski trip (or some other vacation) when they were on the cusp of solving the structure.
How!?!
The thing that most impacted me then and has stuck with me til now: they went on a ski trip (or some other vacation) when they were on the cusp of solving the structure.
How!?!
Reposted by Jonathan Rosenblum
And here's a YouTube link. www.youtube.com/watch?v=Oj0P...
"Rovina's Choice" Shows How The Shutdown of U.S.A.I.D. Has Already Killed Hundreds of Thousands
YouTube video by The New Yorker
www.youtube.com
November 6, 2025 at 10:36 PM
And here's a YouTube link. www.youtube.com/watch?v=Oj0P...
Could this be true?
Francis Crick, an academic for half a century, applied for only a SINGLE grant?!
www.nature.com/articles/d41...
Francis Crick, an academic for half a century, applied for only a SINGLE grant?!
www.nature.com/articles/d41...
November 6, 2025 at 9:03 PM
Could this be true?
Francis Crick, an academic for half a century, applied for only a SINGLE grant?!
www.nature.com/articles/d41...
Francis Crick, an academic for half a century, applied for only a SINGLE grant?!
www.nature.com/articles/d41...
Reposted by Jonathan Rosenblum
The plaintiffs have experienced violence for exercising their First Amendment rights under the constitution, Ellis says.
Some have had that protected expression chilled by the violence from federal agents, Ellis says.
Some have had that protected expression chilled by the violence from federal agents, Ellis says.
November 6, 2025 at 4:51 PM
The plaintiffs have experienced violence for exercising their First Amendment rights under the constitution, Ellis says.
Some have had that protected expression chilled by the violence from federal agents, Ellis says.
Some have had that protected expression chilled by the violence from federal agents, Ellis says.
Thinking a lot about this thread tonight.
A thread about keeping one’s head above water under the current conditions and not being incapacitated by rage, fear, despair or some mixture of those (1/11)
November 5, 2025 at 2:11 AM
Thinking a lot about this thread tonight.
Reposted by Jonathan Rosenblum
A poll from the journal Nature found that 75% of researchers in the U.S. are considering leaving the country. That includes a man who’s been dubbed the "Mozart of Math." (This PBS story on the scientific brain drain is heartbreaking & ominous for medicine, imo.) www.youtube.com/watch?v=yLvO...
Top researchers consider leaving U.S. amid funding cuts: 'The science world is ending'
YouTube video by PBS NewsHour
www.youtube.com
October 30, 2025 at 1:23 PM
A poll from the journal Nature found that 75% of researchers in the U.S. are considering leaving the country. That includes a man who’s been dubbed the "Mozart of Math." (This PBS story on the scientific brain drain is heartbreaking & ominous for medicine, imo.) www.youtube.com/watch?v=yLvO...
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November 2, 2025 at 9:17 PM
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