Lightnews — Scholar-powered news

John Janetzko

@jjanetzko.bsky.social

1.1K followers 660 following 68 posts

Asst. Prof. Univ of Colorado. Chemist. Sometimes structural biologist. Molecular microscopist 🔬. Usually found thinking about PTMs, GPCRs and protein dynamics. Bike racer 🚴🏼‍♂️.👦 & 🐶 dad, 🇨🇦, 🎓 Stanford/Harvard/UToronto.

Posts Media Videos Starter Packs

John Janetzko @jjanetzko.bsky.social · 2d

The issue of Molecular Pharmacology edited by @nicoleperryhauser.bsky.social and me is finally finished!

As always, it was a joy to work together, and I think we succeeded in compiling some great papers from young GPCR investigators 🤩

Check it out 👇

www.sciencedirect.com/science/arti...

www.sciencedirect.com

Reposted by John Janetzko

Nicki Perry-Hauser @nicoleperryhauser.bsky.social · 3d

A new special issue entitled “Emerging Voices in GPCR Biology” is now available in Molecular Pharmacology, highlighting innovative research led by early-career investigators (ECIs) across key areas of G protein-coupled receptor (GPCR) science.

www.sciencedirect.com/science/arti...

Emerging Voices in GPCR Biology

www.sciencedirect.com

1 4 2

Reposted by John Janetzko

Oded Rechavi @odedrechavi.bsky.social · 11d

Thanking the reviewers

1 12 130

John Janetzko @jjanetzko.bsky.social · Sep 6

A lab that collects data together stays together. Feeling like the luckiest PI to work with such great folks 🤩🔬 @cuanschutz.bsky.social @cu-bmg.bsky.social

Reposted by John Janetzko

CU Cancer Center @cucancercenter.bsky.social · Aug 17

We have new members! Welcome to the CU Cancer Center! 👏

Welcome New Members graphic. Nicole Kaiser, PharmD, Vicki Catenacci, MD, Mohammad Bilal, MD, John Janetzko, PhD, Wyatt Shields, PhD, Christine Conageski, MD, Ally Nguyen, PhD, Matthew Witkowski, PhD, Peter Fecci, MD, PhD, Stephanie McGrath, DVM, Glen Peterson, DNP, Brenna McGinn, PhD, MSM.

2 3

Reposted by John Janetzko

Jeremy Berg @jeremymberg.bsky.social · Aug 3

The acknowledgements section speaks to considerable privilege. Without a senior author, he and his classmate were provided with lab space, purified protein, and technical help. Their paper was communicated to PNAS. I doubt many undergraduate researchers have received comparable support.

31/n

1 4 11

John Janetzko @jjanetzko.bsky.social · Jul 30

So you’re saying there’s a chance

John Janetzko @jjanetzko.bsky.social · Jul 29

Tbf lottery still has to be lower chance, but point is very well taken

1 2

Reposted by John Janetzko

Harmit Singh Malik @harmitmalik.bsky.social · Jul 29

With news that NIH grant success rates are now below 5%, consider the effort that goes into one of these grants (apart from you, who submitted 60 AI-written grants)- why would you put in that much effort knowing your chances are only slightly better than winning a lottery? 1/

8 20 100

Reposted by John Janetzko

Ardem Patapoutian @ardemp.bskyverified.social · Jul 22

No better time to call or email your members of Congress. Next year’s NIH budget is being debated in the Senate. A new nonpartisan campaign is making it easy to defend science and protect America’s innovation. Just follow this link to contact your representatives: www.protectscienceandinnovation.org

1 28 33

Reposted by John Janetzko

Drug Monkey @drugmonkey.bsky.social · Jul 20

We are going to hear a lot in the near future about how University brass “has to make hard decisions”. Twill be interesting to see who those hard decisions land upon.

7 7 50

Reposted by John Janetzko

Eric Topol @erictopol.bsky.social · Jul 6

Summary Table of the massive defunding of biomedical research in the United States
www.nytimes.com/interactive/...

60 1K 1.6K

Reposted by John Janetzko

Jeremy Berg @jeremymberg.bsky.social · Jul 6

A short Bluetorial about my early days as the Director of the National Institute of General Medical Sciences (NIGMS) at NIH.

The importance of feeling responsibility and taking pride in doing the best job you can

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

media.tenor.com

5 72 260

John Janetzko @jjanetzko.bsky.social · Jun 27

Oh no. This is insanity! Hopefully if we do twist the pretzel in 2026 it gets untwisted again in 2028.

Reposted by John Janetzko

Jay Hesselberth @jayhesselberth.bsky.social · Jun 20

Excited to see this collaborative work with Olivia Rissland's lab finally out. We found lots of 2A peptides and an entirely new 2A class.

www.cell.com/cell-reports...

Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences

Rao et al. identified thousands of previously unknown 2A peptides across both viruses and eukaryotes using an HMMER analysis. The authors further identified a unique class of 2A peptides, class B, who...

www.cell.com

2 22 65

John Janetzko @jjanetzko.bsky.social · Jun 14

The world is in chaos, but we still need to rally with our people!

Janetzko-Bell lab and friends happy hour to celebrate grant submissions, new additions and scientific accomplishments 🎉

@cu-bmg.bsky.social

1 5

Reposted by John Janetzko

Sen. Cory Booker @booker.senate.gov · Jun 14

In America, we have no kings.

140 580 2.6K

John Janetzko @jjanetzko.bsky.social · Jun 11

🥴

John Janetzko @jjanetzko.bsky.social · Jun 10

Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild.
Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story.

www.biorxiv.org/content/10.1...

Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement

Arrestin proteins bind active G protein-coupled receptors (GPCRs) through coordinated protein-protein, protein-phosphate, and protein-lipid interactions to attenuate G protein signaling and promote GP...

www.biorxiv.org

2 4 29

John Janetzko @jjanetzko.bsky.social · Jun 7

Sometimes this job can feel like a lot. But sometimes it’s the best job you could imagine. Your whole lab tells you they want to come in on Saturday to finish an experiment we’ve worked up to and you get to see the look of amazement on your tech’s face when her first negative stain works 😍

John Janetzko @jjanetzko.bsky.social · May 31

Fml

Reposted by John Janetzko

Sean Eddy @cryptogenomicon.bsky.social · May 26

Federal funding to Harvard is primarily for basic research labs, a government-university partnership that has been US policy for 80 years since the end of WWII. International undergraduate student tuition is not federally funded. Anyone trying to confuse these two things is trying to play you.

11 37

Reposted by John Janetzko

Dr. David Miller 🏳️‍🌈 @davidimiller.bsky.social · Apr 18

So: In 2017, Congress made this happen:

NIH: Proposed 22% cut --> 9% increase
NSF: Proposed 11% cut --> 4% increase
NOAA: Proposed 16% cut --> 4% increase

Obviously, 2025 is not 2017. A lot is diff now. But still:

💰 Congress, not WH, sets budgets.

📞 Public support & calls to Congress matter.

2 100 200

John Janetzko @jjanetzko.bsky.social · May 31

Is there a way to read the whole article?

Reposted by John Janetzko

Randall Munroe @xkcd.com · May 29

Mass Spec

xkcd.com/3094/

[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.

28 470 3.9K