Jon Humphries
@jdhl18.bsky.social
Cell Biologist. Manchester Metropolitan University.
Cell-ECM adhesion and proteomics, often in the context of cancer.
Google Scholar: https://scholar.google.com/citations?user=h9DWslsAAAAJ&hl=en
Orcid: https://orcid.org/0000-0002-8953-7079
Cell-ECM adhesion and proteomics, often in the context of cancer.
Google Scholar: https://scholar.google.com/citations?user=h9DWslsAAAAJ&hl=en
Orcid: https://orcid.org/0000-0002-8953-7079
Pinned
Jon Humphries
@jdhl18.bsky.social
· Oct 14
Just flagging up this conference that I'm helping with.
There will be fantastic speakers in sessions covering Melanoma evolution, microenvironment, host cell interactions, precision immunotherapy, emerging therapeutics and clinical trials / real-world data.
Scan the QR code for full details.
There will be fantastic speakers in sessions covering Melanoma evolution, microenvironment, host cell interactions, precision immunotherapy, emerging therapeutics and clinical trials / real-world data.
Scan the QR code for full details.
Reposted by Jon Humphries
‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission www.nature.com/articles/d41...
‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission
Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results.
www.nature.com
November 27, 2025 at 12:03 PM
‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission www.nature.com/articles/d41...
Reposted by Jon Humphries
Reposted by Jon Humphries
Last month, I found out I have hypermobile Ehlers Danlos Syndrome, after decades of chronic pain and medical disinterest.
I've decided to write publicly about this, not just about hypermobility and its health impacts, but about how it feels when doctors don't care:
medium.com/p/4fea6398b8ba
I've decided to write publicly about this, not just about hypermobility and its health impacts, but about how it feels when doctors don't care:
medium.com/p/4fea6398b8ba
Welcome to my body
After twenty years of pain and repeated medical dead ends, a stranger sent me a message on Instagram. It led to a diagnosis all the doctors…
medium.com
November 26, 2025 at 5:20 PM
Last month, I found out I have hypermobile Ehlers Danlos Syndrome, after decades of chronic pain and medical disinterest.
I've decided to write publicly about this, not just about hypermobility and its health impacts, but about how it feels when doctors don't care:
medium.com/p/4fea6398b8ba
I've decided to write publicly about this, not just about hypermobility and its health impacts, but about how it feels when doctors don't care:
medium.com/p/4fea6398b8ba
Reposted by Jon Humphries
Proudly delivered, label-free, in collaboration with @christieinstitute.bsky.social & The Christie Charity.
Limited places - please register early.
Looking forward to seeing many of you there! 🌟
🔗 Event link 👇
Limited places - please register early.
Looking forward to seeing many of you there! 🌟
🔗 Event link 👇
Unlocking TIL Therapy: A New Era for Melanoma Care in the UK
Join us for the Unlocking TIL Therapy: A New Era for Melanoma Care in the UK onsite at The Midland Hotel Manchester
www.eventbrite.co.uk
November 29, 2025 at 11:05 AM
Proudly delivered, label-free, in collaboration with @christieinstitute.bsky.social & The Christie Charity.
Limited places - please register early.
Looking forward to seeing many of you there! 🌟
🔗 Event link 👇
Limited places - please register early.
Looking forward to seeing many of you there! 🌟
🔗 Event link 👇
Reposted by Jon Humphries
Every case study like this should be balanced by one such as a 15-year-old with suicidal ideation unable to receive any help because CAMHS has been cut to virtual non-existence.
Huge respect to the papers for finding both an 88 year old worried about the tax bill on her 6 bedroom Kensington house and a 20 year old fretting about only being able to save £12k a year tax free.
Top work all around. These are not easy case studies to find.
Top work all around. These are not easy case studies to find.
November 29, 2025 at 9:46 AM
Every case study like this should be balanced by one such as a 15-year-old with suicidal ideation unable to receive any help because CAMHS has been cut to virtual non-existence.
Reposted by Jon Humphries
We invite you to submit your latest research to our upcoming special issue - Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: @franbottanelli.bsky.social & Giulia Zanetti, with our Editor @guijacquemet.bsky.social. journals.biologists.com/jcs/pages/im...
November 28, 2025 at 2:04 PM
We invite you to submit your latest research to our upcoming special issue - Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: @franbottanelli.bsky.social & Giulia Zanetti, with our Editor @guijacquemet.bsky.social. journals.biologists.com/jcs/pages/im...
Reposted by Jon Humphries
A perfect model for coming together this season: mouse skeletal muscles undergoing fusion, obviously.
In this mesmerizing confocal microscopy video, nuclei are labeled in green & cell bodies are labeled in red. Credit: Yue Lu, Elizabeth Chen Lab, University of Texas Southwestern Medical Center
In this mesmerizing confocal microscopy video, nuclei are labeled in green & cell bodies are labeled in red. Credit: Yue Lu, Elizabeth Chen Lab, University of Texas Southwestern Medical Center
November 28, 2025 at 9:18 PM
A perfect model for coming together this season: mouse skeletal muscles undergoing fusion, obviously.
In this mesmerizing confocal microscopy video, nuclei are labeled in green & cell bodies are labeled in red. Credit: Yue Lu, Elizabeth Chen Lab, University of Texas Southwestern Medical Center
In this mesmerizing confocal microscopy video, nuclei are labeled in green & cell bodies are labeled in red. Credit: Yue Lu, Elizabeth Chen Lab, University of Texas Southwestern Medical Center
Reposted by Jon Humphries
ERC success rates are tanking and the move is... even bigger grants for fewer people? smh
· #AcademicSky ·
The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.
The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.
ERC’s new €7m Plus Grants open to researchers at any career stage - Research Professional News
European Research Council president describes scheme as part attempt to lure US talent
www.researchprofessionalnews.com
November 28, 2025 at 10:14 PM
ERC success rates are tanking and the move is... even bigger grants for fewer people? smh
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells - Nature Communications
Aging impairs the regenerative capacity of skeletal muscle stem cells. Here, the authors identify a stem cell-specific fibronectin splice variant and show that its cell-autonomous secretion through th...
www.nature.com
November 29, 2025 at 8:49 AM
TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Breast cancer cell coculture induces normal lung fibroblast transition to CAFs, promoting tumor cell dormancy and therapy resistance
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 29, 2025 at 8:47 AM
Breast cancer cell coculture induces normal lung fibroblast transition to CAFs, promoting tumor cell dormancy and therapy resistance
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Talin–tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Talin–tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation | Journal of Cell Biology | Rockefeller University Press
Li et al. show that multidomain interactions between talin and tensin3 regulate integrin activity, fibrillar adhesion formation, fibronectin assembly, and
rupress.org
November 29, 2025 at 8:39 AM
Talin–tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Hemidesmosomes regulate epidermal differentiation during embryogenesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Hemidesmosomes regulate epidermal differentiation during embryogenesis
In skin epidermis, integrins mediate adhesion of basal keratinocytes to the underlying basement membrane. While high expression of integrins has been correlated with stemness, there is limited direct ...
www.biorxiv.org
November 29, 2025 at 8:38 AM
Hemidesmosomes regulate epidermal differentiation during embryogenesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…
www.sciencedirect.com
November 29, 2025 at 8:34 AM
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Integrin β4 Drives Immune Evasion and Therapeutic Resistance to PD-1 blockade in Bladder Cancer via MEK/ERK Signaling
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Integrin β4 Drives Immune Evasion and Therapeutic Resistance to PD-1 blockade in Bladder Cancer via MEK/ERK Signaling
Bladder cancer (BLCA) is one of the most prevalent malignancies of the urinary system and accounts for 90-95% of urothelial carcinomas. Muscle-invasiv…
www.sciencedirect.com
November 29, 2025 at 8:29 AM
Integrin β4 Drives Immune Evasion and Therapeutic Resistance to PD-1 blockade in Bladder Cancer via MEK/ERK Signaling
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Capped high-force integrin bond lifetimes and spacing-tuned binding frequency drive rapid fibroblast migration
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Capped high-force integrin bond lifetimes and spacing-tuned binding frequency drive rapid fibroblast migration | PNAS
Cell migration relies on balancing focal adhesion (FA) stability—necessary for traction
generation—and turnover—essential for forward translocation...
www.pnas.org
November 29, 2025 at 8:23 AM
Capped high-force integrin bond lifetimes and spacing-tuned binding frequency drive rapid fibroblast migration
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
The integrin odyssey – a journey full of fundamental discoveries
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
The integrin odyssey – a journey full of fundamental discoveries
Summary: This Perspective highlights the key discoveries in integrin research that laid the foundation for a successful field.
journals.biologists.com
November 24, 2025 at 4:46 PM
The integrin odyssey – a journey full of fundamental discoveries
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Jon Humphries
In agreement with my friend @kkjetelina.bsky.social who writes today: "I suggest the general public avoid the CDC website."
yourlocalepidemiologist.substack.com/p/cdc-false-...
www.wsj.com/health/healt...
yourlocalepidemiologist.substack.com/p/cdc-false-...
www.wsj.com/health/healt...
November 21, 2025 at 3:39 PM
In agreement with my friend @kkjetelina.bsky.social who writes today: "I suggest the general public avoid the CDC website."
yourlocalepidemiologist.substack.com/p/cdc-false-...
www.wsj.com/health/healt...
yourlocalepidemiologist.substack.com/p/cdc-false-...
www.wsj.com/health/healt...
Mechanobiology:
Microtubules provide a mechanical link for YAP/TAZ signalling
www.nature.com/articles/s41...
Microtubules provide a mechanical link for YAP/TAZ signalling
www.nature.com/articles/s41...
Microtubules provide a mechanical link for YAP/TAZ signalling - Nature Reviews Molecular Cell Biology
A study finds that mechanical activation leads to microtubule rearrangement, facilitating the proteasomal degradation of an inhibitor of YAP/TAZ, thus promoting YAP/TAZ nuclear translocation.
www.nature.com
November 20, 2025 at 7:53 AM
Mechanobiology:
Microtubules provide a mechanical link for YAP/TAZ signalling
www.nature.com/articles/s41...
Microtubules provide a mechanical link for YAP/TAZ signalling
www.nature.com/articles/s41...
Reposted by Jon Humphries
Excited to share our new preprint in @biorxiv-neursci.bsky.social
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
August 28, 2025 at 10:25 AM
Excited to share our new preprint in @biorxiv-neursci.bsky.social
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"
Instead of a 🧵 the paper is summarised in this video.
www.biorxiv.org/content/10.1...
Reposted by Jon Humphries
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Jon Humphries
The project is now live on FindaPhD and open for applications. Deadline December 4th
*Fully funded 4-year PhD studentship available*
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpool on FindAPhD...
PhD Project - MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpo...
www.findaphd.com
October 31, 2025 at 10:07 AM
The project is now live on FindaPhD and open for applications. Deadline December 4th
Reposted by Jon Humphries
An exciting project to understand cellular ageing in health and disease.
Deadline for applications is 4th Dec.
www.findaphd.com/phds/project...
Pls see also our group websites:
TobiasZech: tzech6.wixsite.com/zechlab
• Chris Toseland: www.toseland-
lab.com
Deadline for applications is 4th Dec.
www.findaphd.com/phds/project...
Pls see also our group websites:
TobiasZech: tzech6.wixsite.com/zechlab
• Chris Toseland: www.toseland-
lab.com
www.findaphd.com
November 19, 2025 at 12:13 PM
An exciting project to understand cellular ageing in health and disease.
Deadline for applications is 4th Dec.
www.findaphd.com/phds/project...
Pls see also our group websites:
TobiasZech: tzech6.wixsite.com/zechlab
• Chris Toseland: www.toseland-
lab.com
Deadline for applications is 4th Dec.
www.findaphd.com/phds/project...
Pls see also our group websites:
TobiasZech: tzech6.wixsite.com/zechlab
• Chris Toseland: www.toseland-
lab.com
Reposted by Jon Humphries
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Anoikis resistance and cancer
bmccancer.biomedcentral.com/articles/10....
bmccancer.biomedcentral.com/articles/10....
Anoikis resistance and cancer - BMC Cancer
Normal epithelial cells detach from extracellular matrix during normal homeostasis by a selective process called epithelial extrusion. Thereafter, they undergo apoptosis, in a phenomenon called anoiki...
bmccancer.biomedcentral.com
November 17, 2025 at 11:42 PM
Anoikis resistance and cancer
bmccancer.biomedcentral.com/articles/10....
bmccancer.biomedcentral.com/articles/10....