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Reposted by Jon Humphries

Dominic Grün @dominicgrun.bsky.social · 3h

The Roadmap of the Human Liver Cell Atlas is out in @natrevgastrohep.nature.com laying out the scope and goals of our Human Liver Cell Atlas emerging from the @cziscience.bsky.social funded Liver Seed Network.
www.nature.com/articles/s41...

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Jon Humphries @jdhl18.bsky.social · 1h

Alternatively you can link to the registration and conference details via this link: sites.manchester.ac.uk/from-lab-to-...

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sites.manchester.ac.uk

Jon Humphries @jdhl18.bsky.social · 1h

Just flagging up this conference that I'm helping with.

There will be fantastic speakers in sessions covering Melanoma evolution, microenvironment, host cell interactions, precision immunotherapy, emerging therapeutics and clinical trials / real-world data.
Scan the QR code for full details.

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Reposted by Jon Humphries

Anna Obenauf @obenaufa.bsky.social · 15h

Excited to present at the @metastasisresearch.bsky.social webinar soon. Registration is free!

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Reposted by Jon Humphries

The Company of Biologists @biologists.bsky.social · 19h

We are highlighting Arnoud Sonnenberg, a distinguished cell biologist who served as a @jcellsci.bsky.social Editor for 19 years, as an extraordinary biologist. #100biologists
@asonnenberg.bsky.social

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Jon Humphries @jdhl18.bsky.social · 16h

Theoretically I think yes. That should work. Just n=1 opinion so far though 🤣

Jon Humphries @jdhl18.bsky.social · 17h

I'd assume then that you could take a targeted approach? SRM?
Im not sure how the more modern DIA methods could handle that. Given the dynamic range issue in plasma

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Jon Humphries @jdhl18.bsky.social · 17h

Do you know the protein sequence? How abundant is it? They're 2 questions that spring to my mind initially.

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Jon Humphries @jdhl18.bsky.social · 17h

Lab-grown human embryo model produces blood cells www.theguardian.com/science/2025...

Lab-grown human embryo model produces blood cells

Breakthrough raises new possibilities for regenerative medicine, which uses patient’s own cells to repair damaged tissues

www.theguardian.com

Reposted by Jon Humphries

Pedro Beltrao @pedrobeltrao.bsky.social · 5d

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

The functional landscape of the human ubiquitinome

Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...

www.biorxiv.org

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Reposted by Jon Humphries

Anne Carpenter @drannecarpenter.bsky.social · 3d

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further

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Jon Humphries @jdhl18.bsky.social · 2d

A human pan-disease blood atlas of the circulating proteome | Science www.science.org/doi/10.1126/...

A human pan-disease blood atlas of the circulating proteome

The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. Here, we present a pan-disease resource to enable the study of divers...

www.science.org

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Jon Humphries @jdhl18.bsky.social · 4d

Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice
www.jci.org/articles/vie...

JCI - Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice

www.jci.org

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Reposted by Jon Humphries

protaiomics.bsky.social @protaiomics.bsky.social · 6d

🌟Ready to apply?
16 fully funded PhD positions are open in ProtAIomics Doctoral Network!
Join 16 labs across Europe to advance AI-powered proteomics and drive discoveries in health & biotechnology.
👉 Apply here: www.protaiomics.eu
#Proteomics #ArtificialIntelligence #MSCA #PhDOpportunities

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Reposted by Jon Humphries

Pedro Beltrao @pedrobeltrao.bsky.social · 6d

Our group has a PhD position open in this Doctoral network. Our topic is around combining proteomics AI and protein structures. Look through the website below to look at all of the projects/groups and apply.

protaiomics.bsky.social @protaiomics.bsky.social · 6d

🌟Ready to apply?
16 fully funded PhD positions are open in ProtAIomics Doctoral Network!
Join 16 labs across Europe to advance AI-powered proteomics and drive discoveries in health & biotechnology.
👉 Apply here: www.protaiomics.eu
#Proteomics #ArtificialIntelligence #MSCA #PhDOpportunities

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Reposted by Jon Humphries

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · 6d

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews