Gemma Noviello
@gemnov.bsky.social
Researcher in Epigenetics, CRISPRing around. MSCA Postdoctoral Fellow at EMBL Rome (Hackett lab). Before: Max Planck for Molecular Genetics (Ph.D.), Exeter Uni, Pasteur Institute, Sapienza Uni - Pessimismo dell' intelligenza/Ottimismo della volontà.
Reposted by Gemma Noviello
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
November 17, 2025 at 11:39 AM
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
When I write something ironic on the internet I am terrified that #ChatGPT or something will pick it up and not understand the irony. Currently I use emoticons hoping that #LLMs have my same understanding of facial expressions... Then I remember they don't have faces (yet). 😳
November 27, 2025 at 7:29 AM
Last week I attended the #EMBL postdoc retreat in Strasbourg and it was really nice to meet some old friends and get to know the fantastic community of postdocs from all @embl.org . It is true the old say " #postdocs make the world go 'round". 😉 Pic of my group winning it all
November 27, 2025 at 7:10 AM
Reposted by Gemma Noviello
1/2. “The COP of Truth cannot ignore science. 75% of carbon emissions come from fossil fuels. Today we are not even allowed to discuss pathways for a just and equitable transition away from fossil fuels.” Colombia at the close of #COP30.
November 22, 2025 at 5:49 PM
1/2. “The COP of Truth cannot ignore science. 75% of carbon emissions come from fossil fuels. Today we are not even allowed to discuss pathways for a just and equitable transition away from fossil fuels.” Colombia at the close of #COP30.
November 21, 2025 at 2:55 PM
Reposted by Gemma Noviello
“One mile on a bike is a $.42 economic gain to society, one mile driving is a $.20 loss.”
“Which means that Copenhagen, a city of 1.2 million people, saves $357 million a year on health costs because something like 80% of its population commutes by bike.” #CityMakingMath
Some costs aren’t costs.
“Which means that Copenhagen, a city of 1.2 million people, saves $357 million a year on health costs because something like 80% of its population commutes by bike.” #CityMakingMath
Some costs aren’t costs.
One mile on a bike is a $.42 economic gain to society, one mile driving is a $.20 loss
Copenhagen, the bicycle-friendliest place on the planet, publishes a biannual Bicycle Account, and buried in its pages is a rather astonishing fact.
grist.org
November 21, 2025 at 12:40 AM
“One mile on a bike is a $.42 economic gain to society, one mile driving is a $.20 loss.”
“Which means that Copenhagen, a city of 1.2 million people, saves $357 million a year on health costs because something like 80% of its population commutes by bike.” #CityMakingMath
Some costs aren’t costs.
“Which means that Copenhagen, a city of 1.2 million people, saves $357 million a year on health costs because something like 80% of its population commutes by bike.” #CityMakingMath
Some costs aren’t costs.
Reposted by Gemma Noviello
"Children’s toymaker FoloToy says it’s pulling its AI-powered teddy bear “Kumma” after a safety group found that the cuddly companion was giving wildly inappropriate and even dangerous responses, including tips on how to find and light matches, and detailed explanations about sexual kinks"
AI-Powered Stuffed Animal Pulled From Market After Disturbing Interactions With Children
FoloToy says it's suspended sales of its AI-powered teddy bear after researchers found it gave wildly inappropriate and dangerous answers.
futurism.com
November 17, 2025 at 10:52 AM
"Children’s toymaker FoloToy says it’s pulling its AI-powered teddy bear “Kumma” after a safety group found that the cuddly companion was giving wildly inappropriate and even dangerous responses, including tips on how to find and light matches, and detailed explanations about sexual kinks"
Reposted by Gemma Noviello
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
www.nature.com
November 17, 2025 at 7:24 AM
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
C-boy's a legend!
November 10, 2025 at 9:06 AM
C-boy's a legend!
Reposted by Gemma Noviello
Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).
Rosalind Franklin and the damage of gender harassment
Spurred by a recent report on sexual harassment in academia, our columnist revisits a historical case and reflects on what has changed—and what hasn’t
www.science.org
November 7, 2025 at 7:58 PM
Thinking only of Rosalind Franklin today, and what was stolen from her (and so many other female scientists alongside her).
Reposted by Gemma Noviello
A List of Things Said to Have Been Ruined by Women
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November 6, 2025 at 8:43 PM
A List of Things Said to Have Been Ruined by Women
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Super interesting science here 👇🏽
🧬 Interested in dissecting dose-dependent transcriptional regulation through epigenome editing and synthetic biology for your PhD? Apply by 07.01.2026 to join the lab of @eddaschulz.bsky.social @molgen.mpg.de & #IMPRS-BAC #gradschool.
👉 www.molgen.mpg.de/5099133/schu...
👉 www.molgen.mpg.de/5099133/schu...
November 4, 2025 at 2:25 PM
Super interesting science here 👇🏽
Reposted by Gemma Noviello
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
November 3, 2025 at 10:04 AM
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
Yesterday I gave a talk titled "Dividi et impera: Flow-Cytometry for FACS-based CRISPR screens and beyond" during the Flow Cytometry course organised by @embl.org & EMBLRome facilities. It was nice connecting w/ other users & the specialists from the facilities to hear the latest. FC & #FACS rock 🌈
October 30, 2025 at 6:11 PM
Reposted by Gemma Noviello
For the record, Melissa's main targets of Jamaica, Haiti, Cuba, and the Bahamas account for, respectively, 0.016%, 0.0089%, 0.064%, and 0.0038% of the global annual total of CO2 emissions.
October 28, 2025 at 8:31 PM
For the record, Melissa's main targets of Jamaica, Haiti, Cuba, and the Bahamas account for, respectively, 0.016%, 0.0089%, 0.064%, and 0.0038% of the global annual total of CO2 emissions.
Yesterday we hosted @graeffjohannes.bsky.social , first speaker of the seminar series organised by and for @embl.org Rome fellows. It was a fantastic #neuro #epigenetics talk (our 2 favourite things). #EMBL #EMBLRome
October 25, 2025 at 3:55 PM
Yesterday we hosted @graeffjohannes.bsky.social , first speaker of the seminar series organised by and for @embl.org Rome fellows. It was a fantastic #neuro #epigenetics talk (our 2 favourite things). #EMBL #EMBLRome
Reposted by Gemma Noviello
Remember this one? “Humans aren’t very efficient movers—until you put us on a bicycle, when we become some of the most energy-efficient land travelers in the animal kingdom.” Via Scientific American @sciam.bsky.social #CityMakingMath
The Most Efficient Traveler Isn’t a Bird or a Fish—It’s You on a Bike
A famous graphic, now updated, compares locomotion in the animal kingdom
www.scientificamerican.com
October 16, 2025 at 11:24 PM
Remember this one? “Humans aren’t very efficient movers—until you put us on a bicycle, when we become some of the most energy-efficient land travelers in the animal kingdom.” Via Scientific American @sciam.bsky.social #CityMakingMath
Reposted by Gemma Noviello
🧬 New study from the Kinkley Lab! 🧬 In collaboration with the Vingron and Hnisz labs at the MPIMG the team has gained new insights how the epigenetic reader PHF13 regulates it´s affinity to bind to chromatin.
Read more: www.molgen.mpg.de/2025-07-28-o...
Congrats to first author Francesca Rossi!
Read more: www.molgen.mpg.de/2025-07-28-o...
Congrats to first author Francesca Rossi!
August 1, 2025 at 8:13 AM
🧬 New study from the Kinkley Lab! 🧬 In collaboration with the Vingron and Hnisz labs at the MPIMG the team has gained new insights how the epigenetic reader PHF13 regulates it´s affinity to bind to chromatin.
Read more: www.molgen.mpg.de/2025-07-28-o...
Congrats to first author Francesca Rossi!
Read more: www.molgen.mpg.de/2025-07-28-o...
Congrats to first author Francesca Rossi!
Happy to see this insightful and rigorous work published in its final form! Congrats to all authors and in particular to super hard-working first author @tschwammle.bsky.social and to @eddaschulz.bsky.social for the brilliant guidance.
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 1:36 PM
Happy to see this insightful and rigorous work published in its final form! Congrats to all authors and in particular to super hard-working first author @tschwammle.bsky.social and to @eddaschulz.bsky.social for the brilliant guidance.
Reposted by Gemma Noviello
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal
imageimagePaternal environmental exposures have been linked with modulation of phenotype and
disease risk in offspring via largely unclear mechanisms. This study employs in vitro
fertilization and sin...
www.embopress.org
September 27, 2025 at 7:28 AM
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
September 27, 2025 at 9:46 AM
Reposted by Gemma Noviello
This may be the most important paper ever published about NIH funded research.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
What if NIH had been 40% smaller?
Replaying history with less NIH funding shows widespread impacts on drug-linked research
www.science.org
September 25, 2025 at 9:20 PM
This may be the most important paper ever published about NIH funded research.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Gemma Noviello
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
September 24, 2025 at 9:45 PM
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
Reposted by Gemma Noviello
A quick guide on "How to fall downstairs":
Step 1
Step 6
Step 8, 9, 10, 11.
Step 1
Step 6
Step 8, 9, 10, 11.
September 23, 2025 at 5:59 AM
A quick guide on "How to fall downstairs":
Step 1
Step 6
Step 8, 9, 10, 11.
Step 1
Step 6
Step 8, 9, 10, 11.
Reposted by Gemma Noviello
Nobel laureate Jennifer Doudna tells Jeffrey Goldberg that vaccinations have been so successful that "there's been a collective forgetting that measles, and mumps, and rubella—these used to be diseases that would kill people in fairly large numbers." #TAF25 bit.ly/46a5DUE
September 18, 2025 at 4:34 PM
Nobel laureate Jennifer Doudna tells Jeffrey Goldberg that vaccinations have been so successful that "there's been a collective forgetting that measles, and mumps, and rubella—these used to be diseases that would kill people in fairly large numbers." #TAF25 bit.ly/46a5DUE