Eugene Valkov
@eugenevalkov.bsky.social
mRNA regulation & decay | biochemistry | structural biology | molecular biology | cancer
All views are personal.
Google Scholar: tinyurl.com/EuValScholar
ORCID: 0000-0002-3721-1739
All views are personal.
Google Scholar: tinyurl.com/EuValScholar
ORCID: 0000-0002-3721-1739
👇🏻 that’s literary talent
Watching the getaway car. Look at that S car go 😲
Thieves have stolen €90,000 worth of fine French snails destined for some of the country’s most prestigious restaurants
November 28, 2025 at 12:26 AM
👇🏻 that’s literary talent
And finally: pecan pie, chocolate peanut butter cheesecake, and cranberry curd cake
November 27, 2025 at 11:42 PM
And finally: pecan pie, chocolate peanut butter cheesecake, and cranberry curd cake
A spiced and superjuicy turkey with butter and maple syrup glaze per @nigella.bsky.social
November 27, 2025 at 8:17 PM
A spiced and superjuicy turkey with butter and maple syrup glaze per @nigella.bsky.social
Hot apple cider 😋
November 27, 2025 at 7:45 PM
Hot apple cider 😋
It’s being made clear to me I’m not permitted to work today #thanksgiving
November 27, 2025 at 3:55 PM
It’s being made clear to me I’m not permitted to work today #thanksgiving
Functions of RNA m6A methylation at the molecular, genomic and organismal level: go.nature.com/484M6pB
Free to read here: rdcu.be/eR4zx
Free to read here: rdcu.be/eR4zx
November 27, 2025 at 12:58 PM
Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
ZAK activation at the collided ribosome - Nature
The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.
www.nature.com
November 26, 2025 at 12:55 PM
😱😱😱
November 26, 2025 at 12:27 PM
😱😱😱
Reposted by Eugene Valkov
We (Nordborg & Weigel labs) need input on the next generation of genome browsers & data download modes for the #Arabidopsis #1001GenomesPlus project. We have now a curated collection of over 500 long read genomes.
Please help us by filling out this questionnaire: docs.google.com/forms/d/e/1F...
Please help us by filling out this questionnaire: docs.google.com/forms/d/e/1F...
Next generation of 1001 Genomes Plus browser and data download
Please indicate all features you would like to see in a browser that displays features of completely sequenced Arabidopsis thaliana genomes
docs.google.com
November 24, 2025 at 2:49 PM
We (Nordborg & Weigel labs) need input on the next generation of genome browsers & data download modes for the #Arabidopsis #1001GenomesPlus project. We have now a curated collection of over 500 long read genomes.
Please help us by filling out this questionnaire: docs.google.com/forms/d/e/1F...
Please help us by filling out this questionnaire: docs.google.com/forms/d/e/1F...
Reposted by Eugene Valkov
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
November 19, 2025 at 11:22 PM
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
Reposted by Eugene Valkov
The bioRxiv and medRxiv sites are currently inaccessible because of an issue with the Cloudflare cybersecurity service. This is affecting many sites but we’re told it’s being resolved.
November 18, 2025 at 1:21 PM
The bioRxiv and medRxiv sites are currently inaccessible because of an issue with the Cloudflare cybersecurity service. This is affecting many sites but we’re told it’s being resolved.
Reposted by Eugene Valkov
🚨I am looking for a POSTDOC, LAB MANAGER/TECH and GRAD STUDENTS to join my new lab in beautiful Madison, WI.
We study how our brains perceive and represent the physical world around us using behavioral, computational, and neuroimaging methods.
paulunlab.psych.wisc.edu
#VisionScience #NeuroSkyence
We study how our brains perceive and represent the physical world around us using behavioral, computational, and neuroimaging methods.
paulunlab.psych.wisc.edu
#VisionScience #NeuroSkyence
November 17, 2025 at 9:43 PM
🚨I am looking for a POSTDOC, LAB MANAGER/TECH and GRAD STUDENTS to join my new lab in beautiful Madison, WI.
We study how our brains perceive and represent the physical world around us using behavioral, computational, and neuroimaging methods.
paulunlab.psych.wisc.edu
#VisionScience #NeuroSkyence
We study how our brains perceive and represent the physical world around us using behavioral, computational, and neuroimaging methods.
paulunlab.psych.wisc.edu
#VisionScience #NeuroSkyence
Reposted by Eugene Valkov
This is Fendi. He is seen here demonstrating the internationally acknowledged sign language for politely requesting uppies. 13/10 would pick him up immediately (TT: isthat_jojo)
November 17, 2025 at 11:41 PM
This is Fendi. He is seen here demonstrating the internationally acknowledged sign language for politely requesting uppies. 13/10 would pick him up immediately (TT: isthat_jojo)
Reposted by Eugene Valkov
We are seeking postdoctoral researchers to study viral RNA and macromolecular complexes using X-ray crystallography, cryo-EM, and biochemical methods.
Structural biology experience is required. Interested candidates should send a CV, a brief research statement, and 2–3 references to [email protected].
Structural biology experience is required. Interested candidates should send a CV, a brief research statement, and 2–3 references to [email protected].
November 16, 2025 at 9:17 PM
We are seeking postdoctoral researchers to study viral RNA and macromolecular complexes using X-ray crystallography, cryo-EM, and biochemical methods.
Structural biology experience is required. Interested candidates should send a CV, a brief research statement, and 2–3 references to [email protected].
Structural biology experience is required. Interested candidates should send a CV, a brief research statement, and 2–3 references to [email protected].
Reposted by Eugene Valkov
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Reposted by Eugene Valkov
Multiple tenure-track faculty positions at the UNC Lineberger Comprehensive Cancer Center in Chapel Hill!
We seek creative scientists working in fundamental molecular, cellular, and computational areas. Basic and translational cancer research, all ranks.
unc.peopleadmin.com/postings/309...
We seek creative scientists working in fundamental molecular, cellular, and computational areas. Basic and translational cancer research, all ranks.
unc.peopleadmin.com/postings/309...
Open Rank
The UNC Lineberger Comprehensive Cancer Center, in collaboration with departments in the School of Medicine and across the entire University of North Carolina at Chapel Hill, is seeking outstanding ca...
unc.peopleadmin.com
November 14, 2025 at 1:05 PM
Multiple tenure-track faculty positions at the UNC Lineberger Comprehensive Cancer Center in Chapel Hill!
We seek creative scientists working in fundamental molecular, cellular, and computational areas. Basic and translational cancer research, all ranks.
unc.peopleadmin.com/postings/309...
We seek creative scientists working in fundamental molecular, cellular, and computational areas. Basic and translational cancer research, all ranks.
unc.peopleadmin.com/postings/309...
Reposted by Eugene Valkov
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
November 12, 2025 at 4:01 PM
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
A #VeteransDay walk along the Monocacy Battlefield, Frederick, Maryland.
November 11, 2025 at 6:19 PM
A #VeteransDay walk along the Monocacy Battlefield, Frederick, Maryland.
Tremendous paper from Narry Kim’s lab identifying a sequence element that recruits cellular factors to exogenous mRNAs to ‘rejuvenate’ their poly(A) tails leading to a huge boost in output. Significant implications for therapeutics. Now, I wonder what the factor X is…
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RNA stability enhancers for durable base-modified mRNA therapeutics - Nature Biotechnology
A systematic screen identifies RNA elements that enhance the stability and translation of base-modified mRNA.
www.nature.com
November 10, 2025 at 9:34 PM
Tremendous paper from Narry Kim’s lab identifying a sequence element that recruits cellular factors to exogenous mRNAs to ‘rejuvenate’ their poly(A) tails leading to a huge boost in output. Significant implications for therapeutics. Now, I wonder what the factor X is…
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Eugene Valkov
Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing. #DirectRNAseq #Sequencing #RNAmodifications @nanoporetech.com
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 6, 2025 at 11:30 AM
Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing. #DirectRNAseq #Sequencing #RNAmodifications @nanoporetech.com
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
An autism spectrum disorder mutation in Topoisomerase 3β causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain
Abstract. The loss and mutation of Topoisomerase 3β (TOP3B), the only known eukaryotic topoisomerase with the ability to catalyze RNA strand passage reacti
academic.oup.com
November 10, 2025 at 12:24 AM
Reposted by Eugene Valkov
Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
An autism spectrum disorder mutation in Topoisomerase 3β causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain
Abstract. The loss and mutation of Topoisomerase 3β (TOP3B), the only known eukaryotic topoisomerase with the ability to catalyze RNA strand passage reacti
academic.oup.com
November 10, 2025 at 12:21 AM
Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
I’m perfectly fine with journals conducting reviews by their editors. What we, as a scientific community, need to learn is how to decouple journal titles from assessments for hiring or promotion.
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
November 9, 2025 at 12:35 PM
I’m perfectly fine with journals conducting reviews by their editors. What we, as a scientific community, need to learn is how to decouple journal titles from assessments for hiring or promotion.
Reposted by Eugene Valkov
CryoSift is now out @actacrystf.iucr.org doi.org/10.1107/S205... Thanks to all involved. Happy processing!
November 7, 2025 at 4:58 PM
CryoSift is now out @actacrystf.iucr.org doi.org/10.1107/S205... Thanks to all involved. Happy processing!