Eudald Pascual
@eudaldpascual.bsky.social
EIPOD fellow between @viktri08.bsky.social and @multicellgenome.bsky.social labs, interested in the metabolic regulation of the cell cycle at the origin of animal multicellularity
linktr.ee/eudaldpascual
linktr.ee/eudaldpascual
Reposted by Eudald Pascual
Just uploaded our new preprint to @ecoevorxiv.bsky.social
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
November 26, 2025 at 3:06 PM
Just uploaded our new preprint to @ecoevorxiv.bsky.social
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Reposted by Eudald Pascual
Our attempt to give multinucleate cells the spotlight they deserve (seriously, they’re everywhere), led by the fearless @mrosjac.bsky.social and with @Markus Ganter
doi.org/10.32942/X2M...
We’d love your feedback while this goes through the peer review process!
#MicroEvoSky
#ProtistsonSky 🧪🌏
doi.org/10.32942/X2M...
We’d love your feedback while this goes through the peer review process!
#MicroEvoSky
#ProtistsonSky 🧪🌏
November 26, 2025 at 2:05 PM
Our attempt to give multinucleate cells the spotlight they deserve (seriously, they’re everywhere), led by the fearless @mrosjac.bsky.social and with @Markus Ganter
doi.org/10.32942/X2M...
We’d love your feedback while this goes through the peer review process!
#MicroEvoSky
#ProtistsonSky 🧪🌏
doi.org/10.32942/X2M...
We’d love your feedback while this goes through the peer review process!
#MicroEvoSky
#ProtistsonSky 🧪🌏
Reposted by Eudald Pascual
While 𝘝. 𝘷𝘦𝘳𝘮𝘪𝘧𝘰𝘳𝘮𝘪𝘴 max temp is around 45°C, we found 𝘐. 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 grows up to 63°C with optimal growth at 55-57°C🥵. We showed cellular replication via Ultrastructure Expansion Microscopy at 63°C. The previous limit for euks is 60°C!
November 25, 2025 at 8:22 PM
While 𝘝. 𝘷𝘦𝘳𝘮𝘪𝘧𝘰𝘳𝘮𝘪𝘴 max temp is around 45°C, we found 𝘐. 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 grows up to 63°C with optimal growth at 55-57°C🥵. We showed cellular replication via Ultrastructure Expansion Microscopy at 63°C. The previous limit for euks is 60°C!
Reposted by Eudald Pascual
Call for papers
Submit your latest in vivo and in vitro #DevBio research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells
Guest Editors: Alex Hughes and Rashmi Priya
Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
Submit your latest in vivo and in vitro #DevBio research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells
Guest Editors: Alex Hughes and Rashmi Priya
Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
November 25, 2025 at 1:07 PM
Call for papers
Submit your latest in vivo and in vitro #DevBio research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells
Guest Editors: Alex Hughes and Rashmi Priya
Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
Submit your latest in vivo and in vitro #DevBio research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells
Guest Editors: Alex Hughes and Rashmi Priya
Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
Reposted by Eudald Pascual
Our study on the role of the Pou4 gene in planarian neural regeneration has been published. Congratulations to the trainees and team members who led this work!
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians
A conserved POU4-dependent developmental program underlies mechanosensory neuron regeneration in adult planarians.
doi.org
November 20, 2025 at 6:46 PM
Our study on the role of the Pou4 gene in planarian neural regeneration has been published. Congratulations to the trainees and team members who led this work!
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
Reposted by Eudald Pascual
Drawing together findings from several projects over many years, we make a case that neural cell types in the Clytia larva have two embryological origins: i-cells and ectodermal.
bioRxiv 2025.11.17.688882; doi: doi.org/10.1101/2025...
bioRxiv 2025.11.17.688882; doi: doi.org/10.1101/2025...
November 19, 2025 at 7:43 AM
Drawing together findings from several projects over many years, we make a case that neural cell types in the Clytia larva have two embryological origins: i-cells and ectodermal.
bioRxiv 2025.11.17.688882; doi: doi.org/10.1101/2025...
bioRxiv 2025.11.17.688882; doi: doi.org/10.1101/2025...
Reposted by Eudald Pascual
Quite a busy day on #Bluesky !
Been a while since we have been #preLight -ed !
Discover HAK-Actin if you haven't already ;)
Been a while since we have been #preLight -ed !
Discover HAK-Actin if you haven't already ;)
Reliable actin labelling in expansion #microscopy 🔬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights
HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.
prelights.biologists.com
November 19, 2025 at 12:36 PM
Reposted by Eudald Pascual
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Reposted by Eudald Pascual
We are thrilled to announce the inaugural Metabolism in Development & Physiology virtual seminar, a new series connecting researchers across all stages & disciplines in metabolism!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg), &
🎙 Christopher Bell (Uni of Oxford)
See you there!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg), &
🎙 Christopher Bell (Uni of Oxford)
See you there!
October 28, 2025 at 4:13 PM
We are thrilled to announce the inaugural Metabolism in Development & Physiology virtual seminar, a new series connecting researchers across all stages & disciplines in metabolism!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg), &
🎙 Christopher Bell (Uni of Oxford)
See you there!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg), &
🎙 Christopher Bell (Uni of Oxford)
See you there!
Reposted by Eudald Pascual
We’re excited for our very first “Metabolism in Development & Physiology” seminar next week!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg)
🎙 Christopher Bell (Uni of Oxford)
Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg)
🎙 Christopher Bell (Uni of Oxford)
Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
November 3, 2025 at 2:09 PM
We’re excited for our very first “Metabolism in Development & Physiology” seminar next week!
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg)
🎙 Christopher Bell (Uni of Oxford)
Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
🗓 13 Nov 2025, 16:00 CET
🎙 Alexander Aulehla (EMBL Heidelberg)
🎙 Christopher Bell (Uni of Oxford)
Register here to join the the talks: forms.gle/Y8QzucogKKrZ...
Reposted by Eudald Pascual
💥Call for Speakers💥
Hey metabolism enthusiasts!
Do you, or someone you know, dive into the fascinating world of metabolism?
🔬 We are seeking speakers for the Metabolism in Development & Physiology seminars! Showcase your work & connect with our community!
👉 Apply at:
docs.google.com/forms/d/e/1F...
Hey metabolism enthusiasts!
Do you, or someone you know, dive into the fascinating world of metabolism?
🔬 We are seeking speakers for the Metabolism in Development & Physiology seminars! Showcase your work & connect with our community!
👉 Apply at:
docs.google.com/forms/d/e/1F...
Apply to give a talk on Metabolism in Development and Physiology
docs.google.com
November 18, 2025 at 3:40 PM
💥Call for Speakers💥
Hey metabolism enthusiasts!
Do you, or someone you know, dive into the fascinating world of metabolism?
🔬 We are seeking speakers for the Metabolism in Development & Physiology seminars! Showcase your work & connect with our community!
👉 Apply at:
docs.google.com/forms/d/e/1F...
Hey metabolism enthusiasts!
Do you, or someone you know, dive into the fascinating world of metabolism?
🔬 We are seeking speakers for the Metabolism in Development & Physiology seminars! Showcase your work & connect with our community!
👉 Apply at:
docs.google.com/forms/d/e/1F...
Reposted by Eudald Pascual
We are welcoming a new critter at the Centre - the Norwegian red sea cucumber! These colorful echinoderms will be featured in @emclaereboudt.bsky.social's #MSCActions project on chemosensation 🧪 Of course, they had a moment in the spotlight with our in-house photographer @alexandrejan.bsky.social ✨
It’s such a joy working with these beautiful animals 😍😍
Huge thanks to @alexandrejan.bsky.social for capturing my gorgeous little creatures!
Can’t wait to share more cuke science and photos soon — stay tuned!
@msarscentre.bsky.social
Huge thanks to @alexandrejan.bsky.social for capturing my gorgeous little creatures!
Can’t wait to share more cuke science and photos soon — stay tuned!
@msarscentre.bsky.social
November 18, 2025 at 1:01 PM
We are welcoming a new critter at the Centre - the Norwegian red sea cucumber! These colorful echinoderms will be featured in @emclaereboudt.bsky.social's #MSCActions project on chemosensation 🧪 Of course, they had a moment in the spotlight with our in-house photographer @alexandrejan.bsky.social ✨
Reposted by Eudald Pascual
It’s such a joy working with these beautiful animals 😍😍
Huge thanks to @alexandrejan.bsky.social for capturing my gorgeous little creatures!
Can’t wait to share more cuke science and photos soon — stay tuned!
@msarscentre.bsky.social
Huge thanks to @alexandrejan.bsky.social for capturing my gorgeous little creatures!
Can’t wait to share more cuke science and photos soon — stay tuned!
@msarscentre.bsky.social
November 18, 2025 at 11:27 AM
It’s such a joy working with these beautiful animals 😍😍
Huge thanks to @alexandrejan.bsky.social for capturing my gorgeous little creatures!
Can’t wait to share more cuke science and photos soon — stay tuned!
@msarscentre.bsky.social
Huge thanks to @alexandrejan.bsky.social for capturing my gorgeous little creatures!
Can’t wait to share more cuke science and photos soon — stay tuned!
@msarscentre.bsky.social
Reposted by Eudald Pascual
Our paper on the role of neurons in Nematostella head regeneration is now out at @currentbiology.bsky.social Big thank you to all collaborators, it was a pleasure!
Ectopic head regeneration after nervous system ablation in a sea anemone: Current Biology www.cell.com/current-biol...
Ectopic head regeneration after nervous system ablation in a sea anemone: Current Biology www.cell.com/current-biol...
Ectopic head regeneration after nervous system ablation in a sea anemone
Via genetic ablation of neurons, Mazloumi Gavgani et al. show that the nervous system
is essential for defining axial polarity during whole-body regeneration in the sea
anemone Nematostella vectensis.
www.cell.com
November 18, 2025 at 10:00 AM
Our paper on the role of neurons in Nematostella head regeneration is now out at @currentbiology.bsky.social Big thank you to all collaborators, it was a pleasure!
Ectopic head regeneration after nervous system ablation in a sea anemone: Current Biology www.cell.com/current-biol...
Ectopic head regeneration after nervous system ablation in a sea anemone: Current Biology www.cell.com/current-biol...
Reposted by Eudald Pascual
Register now for our one-day symposium at the MRC Laboratory of Medical Sciences on environmental and metabolic control of early development on 4 December 2025!
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
November 14, 2025 at 4:56 PM
Register now for our one-day symposium at the MRC Laboratory of Medical Sciences on environmental and metabolic control of early development on 4 December 2025!
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
Reposted by Eudald Pascual
I will be participating in this EvoDevo course in Madrid, organised by @patrialvarezcam.bsky.social and other colleagues.
sites.google.com/view/evodevo...
I will be covering scRNA-seq, other topics are transcriptomics, ATAC-seq, phylogenomics
Registration closes on Nov 20!
Dates: Dec 15-18
sites.google.com/view/evodevo...
I will be covering scRNA-seq, other topics are transcriptomics, ATAC-seq, phylogenomics
Registration closes on Nov 20!
Dates: Dec 15-18
November 14, 2025 at 12:48 PM
I will be participating in this EvoDevo course in Madrid, organised by @patrialvarezcam.bsky.social and other colleagues.
sites.google.com/view/evodevo...
I will be covering scRNA-seq, other topics are transcriptomics, ATAC-seq, phylogenomics
Registration closes on Nov 20!
Dates: Dec 15-18
sites.google.com/view/evodevo...
I will be covering scRNA-seq, other topics are transcriptomics, ATAC-seq, phylogenomics
Registration closes on Nov 20!
Dates: Dec 15-18
Reposted by Eudald Pascual
Join our upcoming course on cutting-edge evolutionary & genomic methods for Evo-Devo studies!
We'll cover: comparative & single-cell transcriptomics,ATAC-seq, phylogenomics, comparative genomics, gene regulation, and much more
Spots still available: sites.google.com/view/evodevo...
We'll cover: comparative & single-cell transcriptomics,ATAC-seq, phylogenomics, comparative genomics, gene regulation, and much more
Spots still available: sites.google.com/view/evodevo...
I will be participating in this EvoDevo course in Madrid, organised by @patrialvarezcam.bsky.social and other colleagues.
sites.google.com/view/evodevo...
I will be covering scRNA-seq, other topics are transcriptomics, ATAC-seq, phylogenomics
Registration closes on Nov 20!
Dates: Dec 15-18
sites.google.com/view/evodevo...
I will be covering scRNA-seq, other topics are transcriptomics, ATAC-seq, phylogenomics
Registration closes on Nov 20!
Dates: Dec 15-18
November 14, 2025 at 1:48 PM
Join our upcoming course on cutting-edge evolutionary & genomic methods for Evo-Devo studies!
We'll cover: comparative & single-cell transcriptomics,ATAC-seq, phylogenomics, comparative genomics, gene regulation, and much more
Spots still available: sites.google.com/view/evodevo...
We'll cover: comparative & single-cell transcriptomics,ATAC-seq, phylogenomics, comparative genomics, gene regulation, and much more
Spots still available: sites.google.com/view/evodevo...
Reposted by Eudald Pascual
Taken together, we argue that cell cycle progression and forward regulatory interactions promote transcriptome maturation, which fosters multilineage competence in cardiopharyngeal progenitors.
November 15, 2025 at 10:03 AM
Taken together, we argue that cell cycle progression and forward regulatory interactions promote transcriptome maturation, which fosters multilineage competence in cardiopharyngeal progenitors.
Reposted by Eudald Pascual
I am grateful to my current lab members Jonas and Noah who have more than pitched in, and helped make the analysis available for all to navigate online: christiaenlab-sars.com/scRNA-seq-da...
Christiaen Lab - SARS Atlas Datasets
christiaenlab-sars.com
November 15, 2025 at 10:11 AM
I am grateful to my current lab members Jonas and Noah who have more than pitched in, and helped make the analysis available for all to navigate online: christiaenlab-sars.com/scRNA-seq-da...
Reposted by Eudald Pascual
We are pleased to announce our next #SEBD2026 meeting! The meeting will take place in El Rompido, Huelva, from the 28th to the 30th of October 2026 #savethedate @cabd-upo-csic.bsky.social @isdb.bsky.social @gfeev.bsky.social @ijdb.bsky.social @devbiol.bsky.social @devdynamics.bsky.social
November 14, 2025 at 7:53 AM
We are pleased to announce our next #SEBD2026 meeting! The meeting will take place in El Rompido, Huelva, from the 28th to the 30th of October 2026 #savethedate @cabd-upo-csic.bsky.social @isdb.bsky.social @gfeev.bsky.social @ijdb.bsky.social @devbiol.bsky.social @devdynamics.bsky.social
Reposted by Eudald Pascual
Re-upping this with a Bluetorial in a shameless act of self-promotion. 1/n
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 15, 2025 at 8:15 AM
Re-upping this with a Bluetorial in a shameless act of self-promotion. 1/n
Reposted by Eudald Pascual
Proud to have been part of this very nice piece of work and this great collaboration. Congratulations to all. www.science.org/doi/10.1126/...
Single-nucleus profiling highlights the all-brain echinoderm nervous system
A sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.
www.science.org
November 14, 2025 at 8:41 AM
Proud to have been part of this very nice piece of work and this great collaboration. Congratulations to all. www.science.org/doi/10.1126/...
Reposted by Eudald Pascual
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 5, 2025 at 2:45 PM
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Reposted by Eudald Pascual
Happy to share Jialin's first publication. She did a great job exploring the transition to land in animals. Co-supervised by the great Jordi Paps and me and in collaboration with Davide Pisani and @phil-donoghue.bsky.social
Nature research paper: Convergent genome evolution shaped the emergence of terrestrial animals
go.nature.com/4i0i61w
go.nature.com/4i0i61w
Convergent genome evolution shaped the emergence of terrestrial animals - Nature
Comparisons of 154 genomes from 21 animal phyla and outgroups have been used to reconstruct ancestral adaptation to life on land across 11 distinct terrestrialization events, revealing strong evidence for convergent genomic evolution across the animal kingdom and recurring periods of terrestrial colonization.
go.nature.com
November 13, 2025 at 3:18 PM
Happy to share Jialin's first publication. She did a great job exploring the transition to land in animals. Co-supervised by the great Jordi Paps and me and in collaboration with Davide Pisani and @phil-donoghue.bsky.social
Reposted by Eudald Pascual
November 13, 2025 at 7:23 PM