Author | Lightnews

Reposted by Eslam Maher

Peter Tennant @pwgtennant.bsky.social · 1d

DEBATE: "Is AI the future of health and social science?"

For those in London on 15 Dec 2025, don't miss this fun in person debate between me and David Bann sponsored by @ncrm.ac.uk!

Will the arguments change anyone's mind? 🤔

Sign up to attend IN PERSON: www.eventbrite.co.uk/e/is-ai-the-...

Flyer advertising debate on 15 Dec 2025 at 5:30pm at Punnet Hall, 20 Bedford Way, IOE, London, entitled 'Is AI the future of health and social science?'

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Eslam Maher @eslammaher.bsky.social · 1d

An interactive session by Cytel to discuss any of the FDA Oncology guidances! October 29th, 2pm London

cytel.com/news-and-eve...

Office Hours - FDA’s Oncology Guidances:  Leveraging Advances in Oncology Trial Design for Regulatory Approval

cytel.com

Reposted by Eslam Maher

London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 1d

Low participation in medical trials puts millions of young people at risk

Wendy Macdowall tells The Guardian about underrepresented groups in #research & need to understand how experiences of interventions differ

#PublicHealth

www.theguardian.com/society/2025...

Low participation in medical trials puts millions of young people at risk

Exclusive: Data shows gen Z could miss out on new treatments because so few sign up for trials and studies in England

www.theguardian.com

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Eslam Maher @eslammaher.bsky.social · 2d

University of California affiliated scholars took home five awards across medicine, physics, and chemistry in a single month www.universityofcalifornia.edu/press-room/u....

University of California sets world record for Nobel Prizes in a single year

“These remarkable achievements by five UC-affiliated Nobel Prize winners reflect the very best of the world-changing teaching, research, and public service happening across our University,” said UC Pr...

www.universityofcalifornia.edu

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Eslam Maher @eslammaher.bsky.social · 2d

The agenda for @rinpharma.bsky.social 2025 conference is pretty cool events.zoom.us/ev/Ai-geyS63...

R/Pharma 2025

events.zoom.us

Eslam Maher @eslammaher.bsky.social · 4d

nQuery's webinar on ICH E20. October 23
www.statsols.com/guides/impac...

Impact of ICH E20 on Adaptive Design in Clinical Trials

Learn about adaptive design in clinical trials, key principles from ICH E20, and practical implications in our free webinar.

www.statsols.com

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Eslam Maher @eslammaher.bsky.social · 4d

FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Dosages for First-In-Human Trials aacrjournals.org/clincancerre...

FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Dosages for First-In-Human Trials

Abstract. Dosage optimization has become a focus in oncology drug development, as highlighted by recent U.S. Food and Drug Administration initiatives including Project Optimus. Traditionally, most onc...

aacrjournals.org

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Eslam Maher @eslammaher.bsky.social · 6d

A good example of this getting out of hand bec no safety rules were set in place is: ascopubs.org/doi/10.1200/...

where no formal toxicity rules were set in place, and the trial stopped only at stage 1 when 22 patients were enrolled and 7 died and the regimen was not recommended.

E2205: A phase II study to measure response rate and toxicity of neoadjuvant chemoradiotherapy (CRT) with oxaliplatin (OX) and infusional 5-fluorouracil (5-FU) plus cetuximab (C) followed by postopera...

4064 Background: One approach to treating resectable esophageal adenocarcinoma is CRT followed by surgery; however, recurrence is common. To improve on this, we designed a single-arm, phase II trial ...

ascopubs.org

Eslam Maher @eslammaher.bsky.social · 6d

Group-sequential designs: Interim analysis, primary analysis, confirmatory analysis, updated analysis, and decisive analysis... trialsjournal.biomedcentral.com/articles/10....

Clinical trials with interim analyses: standardizing terminology to increase clarity - Trials

Interim analyses for group-sequential decision-making are prevalent in clinical trials. Methodology is well established and has been routinely implemented over the last decades. Still, confusions and ...

trialsjournal.biomedcentral.com

Eslam Maher @eslammaher.bsky.social · 7d

Only ~1-2% of published trials that use the Simon's two-stage design reported an adjusted inference. And looks like <1% actually do the stage 2 test at all.

Isn't this so disappointing given that it is so easy to do? Peer reviewers, funders?

From 2021: ascopubs.org/doi/10.1200/...

Two-Stage Single-Arm Trials Are Rarely Analyzed Effectively or Reported Adequately | JCO Precision Oncology

PURPOSETwo-stage single-arm designs have historically been the most common design used in phase II oncology. They remain a mainstay today, particularly for trials in rare subgroups. Consequently, it i...

ascopubs.org

Eslam Maher @eslammaher.bsky.social · 7d

MD Anderson Cancer Center has an institutional policy that phase 2 trials using treatments with limited prior safety data must have formal toxicity monitoring.

Bayesian sequential monitoring is simple to design and ensures patient safety. It should be mandatory for all early-phase trials worldwide.

Bayesian Clinical Trials at The University of Texas MD Anderson Cancer Center: An Update

In our previous article (Biswas, et al. Clinical Trials 2009), we showed that Bayesian methods had established a foothold in developing therapies in our institutional oncology trials. In this article,...

pmc.ncbi.nlm.nih.gov

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Eslam Maher @eslammaher.bsky.social · 7d

“Skepticism is the highest duty and blind faith the one unpardonable sin.”

— Thomas Henry Huxley, Essays on Controversial Questions (1889)

Reposted by Eslam Maher

Peter Tennant @pwgtennant.bsky.social · 8d

Last year, I had a paper rejected after 18 months with the @amjepi.bsky.social.

It's the first time I've had a paper rejected after being invited for revisions. And the first time I've had a paper sent out to completely new reviewers.

It stung so hard that it's taken me a year to look at again.

Catherine E. de Vries @catherinedevries.bsky.social · 8d

Every academic career is built on rejection, but we don’t show it.
 CVs list publications, grants & awards, not rejected manuscripts, unfunded proposals, or failures.
 But those invisible rejections shape us more than our successes ever do.

👉 catherineeunicedevries.substack.com/p/fail-bette...

🧵

Fail Better: Why Your Rejections Will Shape You More Than Your Publications

The Art of Learning from Rejection

catherineeunicedevries.substack.com

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Eslam Maher @eslammaher.bsky.social · 10d

A lot of "beliefs" don't make sense to me once I put 95% confidence or credible intervals around its estimates..

Eslam Maher @eslammaher.bsky.social · 10d

I hope you share the code so we can show you why it is so wrong :)

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Reposted by Eslam Maher

Harriet Rumgay @harrietjr.bsky.social · 14d

Just out: the new IARC Evidence Summary Brief on alcohol and cancer 📰🍷

Proud to have contributed to this important work highlighting the global burden, economic impact, and the urgent need for policy action.

Check it out here 👉 www.iarc.who.int/featured-new...

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Reposted by Eslam Maher

Paul Naish @paulnaish.bsky.social · 15d

Handling Missingness, Failures, and Non-Convergence in Simulation Studies: A Review of Current Practices and Recommendations

@amstatnews.bsky.social #openaccess www.tandfonline.com/doi/full/10....

Handling Missingness, Failures, and Non-Convergence in Simulation Studies: A Review of Current Practices and Recommendations

Simulation studies are commonly used in methodological research for the empirical evaluation of data analysis methods. They generate artificial datasets under specified mechanisms and compare the p...

www.tandfonline.com

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Eslam Maher @eslammaher.bsky.social · 15d

UK clinical trial approval times twice as fast with AI and reforms www.gov.uk/government/n...

UK clinical trial approval times twice as fast with AI and reforms

Patients receive earlier access to life-saving treatments as UK trial approval times cut in half from 91 to just 41 days.

www.gov.uk

Reposted by Eslam Maher

Nature @nature.com · 16d

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/48QDdAJ

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

go.nature.com

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Eslam Maher @eslammaher.bsky.social · 20d

RIP Jane Goodall, a truly inspirational human.

Nicholas A. Christakis @nachristakis.bsky.social · 21d

A giant of a scientist, Jane Goodall, has died. www.cnn.com/2025/10/01/e...

Conservationist Jane Goodall, whose work revolutionized the study of primates, has died | CNN

Jane Goodall, whose lifelong work as a primatologist helped broaden the world’s understanding of animal behavior and emotions, has died, her institute said Wednesday. She was 91.

www.cnn.com

Eslam Maher @eslammaher.bsky.social · 23d

FDA Project Optimus guidance specifically states that it doesn't address radiopharmaceuticals. They have now posted a draft guidance for dose optimization for those agents here: www.fda.gov/regulatory-i...

Oncology Therapeutic Radiopharmaceuticals: Dosage Optimization

Oncology Therapeutic Radiopharmaceuticals: Dosage Optimization During Clinical Development

www.fda.gov

Eslam Maher @eslammaher.bsky.social · 23d

Free webinar series on simulation guided trial design using FACTS www.berryconsultants.com/resource/fac...

FACTS Webinar Series – Simulation Guided Trial Design Using FACTS | News and Events

Berry Consultants is pleased to announce a complimentary 10-part webinar series focused on simulation guided trial design using FACTS software to be held October through December 2025.

www.berryconsultants.com

Eslam Maher @eslammaher.bsky.social · 24d

Looks like BOIN is already replacing 3+3 designs
ascopubs.org/doi/10.1200/...

Impact of Food and Drug Administration Project Optimus Guidance on Design of Early-Phase Clinical Trials | JCO Oncology Advances

PURPOSEFirst-in-human phase I trials serve as a critical bridge from laboratory research to clinical application. The US Food and Drug Administration (FDA) Project Optimus, launched in 2021, aims to r...

ascopubs.org

Eslam Maher @eslammaher.bsky.social · 24d

RIP John Searle
en.wikipedia.org/wiki/John_Se...

John Searle - Wikipedia

en.wikipedia.org

Reposted by Eslam Maher

London School of Hygiene & Tropical Medicine @lshtm.bsky.social · 29d

Paracetamol use during pregnancy does not increase risk of autism

Laurie Tomlinson explains best available evidence shows #paracetamol safe to take during pregnancy & urges parents to seek reputable sources of information, & medical advice from GP.

www.lshtm.ac.uk/newsevents/n...

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