David Shaywitz
@dshaywitz.bsky.social
Biology-grounded MD/PhD exec | Healthy aging & flourishing at scale | Evidence-based medicine x lifestyle × tech | Agency as engine of change | Strategic Advisor | Writer | kindwellhealth.com
Enjoyed my @wsj.com review of GLP1 book & want more?
- My @statnews.com on GLP1 incr agency: statnews.com/2025/06/17/w...
- My Stat on GLP1 wt loss->impt oppy metric-obsessed tech platforms missing: statnews.com/2025/11/13/w...
- My TR on preemptive health oppy: timmermanreport.com/2025/11/why-...
- My @statnews.com on GLP1 incr agency: statnews.com/2025/06/17/w...
- My Stat on GLP1 wt loss->impt oppy metric-obsessed tech platforms missing: statnews.com/2025/11/13/w...
- My TR on preemptive health oppy: timmermanreport.com/2025/11/why-...
Obesity drugs don’t just offer weight loss. They give patients agency
Many focus on what weight-loss drugs take away: pounds. But they also offer patients something new: a sense of agency.
statnews.com
November 29, 2025 at 7:49 PM
Enjoyed my @wsj.com review of GLP1 book & want more?
- My @statnews.com on GLP1 incr agency: statnews.com/2025/06/17/w...
- My Stat on GLP1 wt loss->impt oppy metric-obsessed tech platforms missing: statnews.com/2025/11/13/w...
- My TR on preemptive health oppy: timmermanreport.com/2025/11/why-...
- My @statnews.com on GLP1 incr agency: statnews.com/2025/06/17/w...
- My Stat on GLP1 wt loss->impt oppy metric-obsessed tech platforms missing: statnews.com/2025/11/13/w...
- My TR on preemptive health oppy: timmermanreport.com/2025/11/why-...
1/2 In today's @wsj.com, I review a new book describing the scientific origins and complex and still emerging effects on society and culture of GLP-1 medicines: wsj.com/arts-culture..., as this excerpt from review suggests. @alicecallahan.bsky.social @thgoetz.bsky.social @ashishkjha.bsky.social
November 29, 2025 at 1:31 PM
1/2 In today's @wsj.com, I review a new book describing the scientific origins and complex and still emerging effects on society and culture of GLP-1 medicines: wsj.com/arts-culture..., as this excerpt from review suggests. @alicecallahan.bsky.social @thgoetz.bsky.social @ashishkjha.bsky.social
I also just posted a companion TR piece looking at another aspect of the book: the contested history of GLP-1's discovery: timmermanreport.com/2025/11/a-ne... (plus other links related to GLP-1s as well as weight management issues & opportunities). @luketimmerman.bsky.social
November 28, 2025 at 4:02 PM
I also just posted a companion TR piece looking at another aspect of the book: the contested history of GLP-1's discovery: timmermanreport.com/2025/11/a-ne... (plus other links related to GLP-1s as well as weight management issues & opportunities). @luketimmerman.bsky.social
Just out - my latest @wsj.com book review: "Off the Scales," on the history of GLP-1s, emphasizing their complicated impact on society and culture: www.wsj.com/arts-culture... . (gift link).
‘Off the Scales’ Review: The Dawn of Ozempic
Pharmaceuticals that mimic hormones now provide effective medical tools to combat obesity. Their long-term effects on society remain to be seen.
www.wsj.com
November 28, 2025 at 3:48 PM
Just out - my latest @wsj.com book review: "Off the Scales," on the history of GLP-1s, emphasizing their complicated impact on society and culture: www.wsj.com/arts-culture... . (gift link).
Reposted by David Shaywitz
I feel this in my soul, but in my case it's human geneticists discovering something an animal or plant breeder did in the 1970s and publishing it Nature because "UK BioBank".
November 27, 2025 at 1:24 PM
I feel this in my soul, but in my case it's human geneticists discovering something an animal or plant breeder did in the 1970s and publishing it Nature because "UK BioBank".
On left: dimensions of health that McKinsey apparently sees; in my view, they (like many) are essentially stuck on biometrics (not a big surprise), and miss critically important, evidence-based but more difficult to quantify measures, as outlined in my diagram of flourishing health, right.
November 25, 2025 at 8:03 PM
On left: dimensions of health that McKinsey apparently sees; in my view, they (like many) are essentially stuck on biometrics (not a big surprise), and miss critically important, evidence-based but more difficult to quantify measures, as outlined in my diagram of flourishing health, right.
Reposted by David Shaywitz
"The growing popularity of these drugs [peptides]
shows that many people will experiment with them long before science confirms they work or are safe."
www.nytimes.com/2025/11/18/w...
my review erictopol.substack.com/p/the-peptid...
shows that many people will experiment with them long before science confirms they work or are safe."
www.nytimes.com/2025/11/18/w...
my review erictopol.substack.com/p/the-peptid...
The Internet Loves Peptide Therapy. Is It Really a Miracle Cure?
www.nytimes.com
November 25, 2025 at 3:10 PM
"The growing popularity of these drugs [peptides]
shows that many people will experiment with them long before science confirms they work or are safe."
www.nytimes.com/2025/11/18/w...
my review erictopol.substack.com/p/the-peptid...
shows that many people will experiment with them long before science confirms they work or are safe."
www.nytimes.com/2025/11/18/w...
my review erictopol.substack.com/p/the-peptid...
Fun feature on musicals in today's NYT, asking, "If you had to convince a nonbeliever, in just a few minutes, why they should make musical theater their religion, what evidence would you offer?" & offering response: www.nytimes.com/2025/11/24/t.... Would **love** @jackviertel.bsky.social POV here...
5 Minutes That Will Make You Love Musicals
www.nytimes.com
November 25, 2025 at 9:54 AM
Fun feature on musicals in today's NYT, asking, "If you had to convince a nonbeliever, in just a few minutes, why they should make musical theater their religion, what evidence would you offer?" & offering response: www.nytimes.com/2025/11/24/t.... Would **love** @jackviertel.bsky.social POV here...
Now out in & just in time for your long Thanksgiving drive: my annual podcast recs, from Acquired & Ground Truths @erictopol.bsky.social to Not Otherwise Specified @lisarosenbaum.bsky.social & Grand Rounds @ai.nejm.org to The Rest is History & excellence actually timmermanreport.com/2025/11/reco...
Recommended Podcasts (and A Few Books), 2025 Year-End Edition - TimmermanReport.com
It’s time for my annual feature: recommended podcasts (and a few books) for TR readers to consider. As usual, these suggestions generally steer clear of politics; they also aren’t the only podcasts I ...
timmermanreport.com
November 24, 2025 at 6:33 PM
Now out in & just in time for your long Thanksgiving drive: my annual podcast recs, from Acquired & Ground Truths @erictopol.bsky.social to Not Otherwise Specified @lisarosenbaum.bsky.social & Grand Rounds @ai.nejm.org to The Rest is History & excellence actually timmermanreport.com/2025/11/reco...
1/Enjoyed this @statnews.com piece by @mgurven.bsky.social offering sensible perspective on improving life expectancy of populations, incl increasing physical activity, "the best anti-aging remedy we have, an all-purpose longevity extender." www.statnews.com/2025/11/20/l...
The anti-aging gold rush should focus on quality of life, not just quantity
“If Moore’s law applies to life expectancy the way it does to electronics, then we’ll have to spend and innovate exponentially more to keep pace,” writes Michael D. Gurven.
www.statnews.com
November 24, 2025 at 1:03 PM
1/Enjoyed this @statnews.com piece by @mgurven.bsky.social offering sensible perspective on improving life expectancy of populations, incl increasing physical activity, "the best anti-aging remedy we have, an all-purpose longevity extender." www.statnews.com/2025/11/20/l...
Reposted by David Shaywitz
In my latest TR column, I discuss how pts & many innovative docs, frustrated by system & skeptical it's fixable, are heading to the relatively underemphasized space of preemption & seeking health engagement there. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social @euanashley.bsky.social
Why Patients – And Many Innovative Doctors – Are Pursuing Health Outside the System - TimmermanReport.com
Our current system of delivering care is awful from the perspective of seemingly every stakeholder. It frustrates, enrages, saddens, and depletes patients and physicians alike. No one designed it this...
timmermanreport.com
November 23, 2025 at 10:59 AM
In my latest TR column, I discuss how pts & many innovative docs, frustrated by system & skeptical it's fixable, are heading to the relatively underemphasized space of preemption & seeking health engagement there. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social @euanashley.bsky.social
Reposted by David Shaywitz
Hudson River Run.
November 23, 2025 at 2:43 PM
Hudson River Run.
Good piece describing current comprehensive testing efforts so popular in consumer hlth, despised by med establishment b/c of v real concerns abt false +s: nytimes.com/2025/11/22/b.... Today: reasonable worry; in future, w more/richer/longitudinal data-likely less true
@danielsodickson.bsky.social
@danielsodickson.bsky.social
The Rise of the ‘Just in Case’ M.R.I.
nytimes.com
November 23, 2025 at 12:48 PM
Good piece describing current comprehensive testing efforts so popular in consumer hlth, despised by med establishment b/c of v real concerns abt false +s: nytimes.com/2025/11/22/b.... Today: reasonable worry; in future, w more/richer/longitudinal data-likely less true
@danielsodickson.bsky.social
@danielsodickson.bsky.social
Strongly endorse what @halle.blue calling for here, in this concise piece published by @chrissyfarr.bsky.social Second Opinion: secondopinion.media/p/should-pat.... OF COURSE pts should have access to med grade AI!! Access to AI can't be what makes docs special or valuable. @bijans.bsky.social
Should patients have access to medical-grade AI?
secondopinion.media
November 23, 2025 at 12:28 PM
Strongly endorse what @halle.blue calling for here, in this concise piece published by @chrissyfarr.bsky.social Second Opinion: secondopinion.media/p/should-pat.... OF COURSE pts should have access to med grade AI!! Access to AI can't be what makes docs special or valuable. @bijans.bsky.social
In my latest TR column, I discuss how pts & many innovative docs, frustrated by system & skeptical it's fixable, are heading to the relatively underemphasized space of preemption & seeking health engagement there. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social @euanashley.bsky.social
Why Patients – And Many Innovative Doctors – Are Pursuing Health Outside the System - TimmermanReport.com
Our current system of delivering care is awful from the perspective of seemingly every stakeholder. It frustrates, enrages, saddens, and depletes patients and physicians alike. No one designed it this...
timmermanreport.com
November 23, 2025 at 10:59 AM
In my latest TR column, I discuss how pts & many innovative docs, frustrated by system & skeptical it's fixable, are heading to the relatively underemphasized space of preemption & seeking health engagement there. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social @euanashley.bsky.social
New TR -why patients-and many innovative doctors-are building health outside what feels like our impossibly broken system. Starting point=preemption, secret sauce=talent, & focus on agency & meaning, as well as relevant biometrics. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social
Why Patients – And Many Innovative Doctors – Are Pursuing Health Outside the System - TimmermanReport.com
Our current system of delivering care is awful from the perspective of seemingly every stakeholder. It frustrates, enrages, saddens, and depletes patients and physicians alike. No one designed it this...
timmermanreport.com
November 22, 2025 at 7:12 PM
New TR -why patients-and many innovative doctors-are building health outside what feels like our impossibly broken system. Starting point=preemption, secret sauce=talent, & focus on agency & meaning, as well as relevant biometrics. timmermanreport.com/2025/11/why-... @alicecallahan.bsky.social
Tx for flagging, @thgoetz.bsky.social -what a well-done visual feature, kudos @alicecallahan.bsky.social & team. The impact of a changing food environment is also key theme of important book by nutrition scientist @kevinh-phd.bsky.social & @juliabelluz.bsky.social timmermanreport.com/2025/10/food...
November 21, 2025 at 5:32 PM
Tx for flagging, @thgoetz.bsky.social -what a well-done visual feature, kudos @alicecallahan.bsky.social & team. The impact of a changing food environment is also key theme of important book by nutrition scientist @kevinh-phd.bsky.social & @juliabelluz.bsky.social timmermanreport.com/2025/10/food...
Reposted by David Shaywitz
It's sad that AI conference reviewers use "incremental" as reason to reject a paper -- e.g., "the contribution of this paper is incremental; reject". Where do they think most progress in science comes from, and what eventually fuels big discoveries?
November 19, 2025 at 9:54 PM
It's sad that AI conference reviewers use "incremental" as reason to reject a paper -- e.g., "the contribution of this paper is incremental; reject". Where do they think most progress in science comes from, and what eventually fuels big discoveries?
Reposted by David Shaywitz
Pretty New York City.
November 19, 2025 at 11:49 PM
Pretty New York City.
Wow: powerful & impt Timmerman Report piece by Dr. Amanda Banks abt the (v real) dark side of GLP-1s: exacerbation of eating disorders, as she poignantly discusses (telling us at end about her personal interest in this "as mom of a daughter in recovery"): timmermanreport.com/2025/11/the-...
The Dark Side of the GLP-1 Weight Loss Drugs: Eating Disorders - TimmermanReport.com
There has been much fanfare about the acquisition by Pfizer of Metsera, the developer of injectable and oral GLP-1 agonists and other peptides for the treatment of obesity. The $10 billion price tag, ...
timmermanreport.com
November 18, 2025 at 12:35 PM
Wow: powerful & impt Timmerman Report piece by Dr. Amanda Banks abt the (v real) dark side of GLP-1s: exacerbation of eating disorders, as she poignantly discusses (telling us at end about her personal interest in this "as mom of a daughter in recovery"): timmermanreport.com/2025/11/the-...
I assumed this was a pitch-perfect parody; apparently, it’s real…
Sensors and wearables for animals ...
Garmin straps one on the horse's tail and a business model is born
www.garmin.com/en-CA/p/1277...
Garmin straps one on the horse's tail and a business model is born
www.garmin.com/en-CA/p/1277...
November 18, 2025 at 3:16 AM
I assumed this was a pitch-perfect parody; apparently, it’s real…