Base by Base
@basebybase.bsky.social
Where genomics meets sound
Music & podcasts inspired by research
👇
basebybase.com
Music & podcasts inspired by research
👇
basebybase.com
🎧 New PaperCast: IndeLLM uses ESM2 protein language models to map and predict in-frame indels; a compact Siamese model reaches MCC 0.77 and tools are on GitHub/Colab https://basebybase.com/episodes/indellm-indel-siamese-model
February 17, 2026 at 8:54 PM
🎧 New PaperCast: IndeLLM uses ESM2 protein language models to map and predict in-frame indels; a compact Siamese model reaches MCC 0.77 and tools are on GitHub/Colab https://basebybase.com/episodes/indellm-indel-siamese-model
Reposted by Base by Base
🎙️Listen to @basebybase.bsky.social to learn more about the latest work from Wirth & colleagues!
February 17, 2026 at 3:32 PM
🎙️Listen to @basebybase.bsky.social to learn more about the latest work from Wirth & colleagues!
🎧 New PaperCast: INS R6C causes recessive insulin-deficient diabetes via impaired preproinsulin ER translocation; iPSC-derived βcell and population data clarify heterozygote risk https://basebybase.com/?episode=292-ins-r6c-signal-peptide-defect-reduces-preproinsulin-er-t-vf8bv9
February 17, 2026 at 12:34 PM
🎧 New PaperCast: INS R6C causes recessive insulin-deficient diabetes via impaired preproinsulin ER translocation; iPSC-derived βcell and population data clarify heterozygote risk https://basebybase.com/?episode=292-ins-r6c-signal-peptide-defect-reduces-preproinsulin-er-t-vf8bv9
🎧 New PaperCast: Relaxed-clock dating of pre-LECA gene duplications shows an Asgard archaeal host with cytoskeleton, endomembrane system and nucleus before mitochondrial acquisiti… https://basebybase.com/?episode=291-dated-gene-duplications-show-asgard-archaeal-host-comple-605svf
February 16, 2026 at 3:33 AM
🎧 New PaperCast: Relaxed-clock dating of pre-LECA gene duplications shows an Asgard archaeal host with cytoskeleton, endomembrane system and nucleus before mitochondrial acquisiti… https://basebybase.com/?episode=291-dated-gene-duplications-show-asgard-archaeal-host-comple-605svf
🎧 Two newborns with SMN1 exon 7 4-bp deletions (p.Arg288AlafsTer5) escaped PCR SMA screening but express a functional SMN protein that rescues smn1-deficient zebrafish and avoided… https://basebybase.com/?episode=290-smn1-p-arg288alafster5-exon-7-deletions-evade-pcr-newbor-z64oqq
February 16, 2026 at 2:45 AM
🎧 Two newborns with SMN1 exon 7 4-bp deletions (p.Arg288AlafsTer5) escaped PCR SMA screening but express a functional SMN protein that rescues smn1-deficient zebrafish and avoided… https://basebybase.com/?episode=290-smn1-p-arg288alafster5-exon-7-deletions-evade-pcr-newbor-z64oqq
🎧 MinION amplicon sequencing of murine Ifna/Ifnb and Actb reveals ~1.7% post-amplification chimeric reads linked to ligation conditions; long reads aid detection and filtering https://basebybase.com/?episode=289-minion-detection-of-chimeric-reads-in-murine-ifna-ifnb-a-19p2jwz
February 13, 2026 at 11:43 AM
🎧 MinION amplicon sequencing of murine Ifna/Ifnb and Actb reveals ~1.7% post-amplification chimeric reads linked to ligation conditions; long reads aid detection and filtering https://basebybase.com/?episode=289-minion-detection-of-chimeric-reads-in-murine-ifna-ifnb-a-19p2jwz
Deep inside the brain, lipid signals silently decide how neurons live and fade.
We turned that hidden story into a song ✨
open.spotify.com/track/7G8enP...
We turned that hidden story into a song ✨
open.spotify.com/track/7G8enP...
Lipid Constellations
open.spotify.com
February 12, 2026 at 3:59 PM
Deep inside the brain, lipid signals silently decide how neurons live and fade.
We turned that hidden story into a song ✨
open.spotify.com/track/7G8enP...
We turned that hidden story into a song ✨
open.spotify.com/track/7G8enP...
🎧 New episode: cryo-EM and proteomics reveal α1/α6-containing GABAA receptor assemblies in rat cerebellum and the PZ-II-029 binding mode at α+/γ− sites https://basebybase.com/?episode=288-cryo-em-of-rat-cerebellar-1-6-gabaa-receptors-reveals-pz-1hyyneq
February 12, 2026 at 9:27 AM
🎧 New episode: cryo-EM and proteomics reveal α1/α6-containing GABAA receptor assemblies in rat cerebellum and the PZ-II-029 binding mode at α+/γ− sites https://basebybase.com/?episode=288-cryo-em-of-rat-cerebellar-1-6-gabaa-receptors-reveals-pz-1hyyneq
🎧 New PaperCast episode: EPOP and MTF2 tune PRC2 activity via GA- and GCN-rich linker DNA to direct de novo H3K27me3 deposition in mESCs — Listen now https://basebybase.com/?episode=287-epop-and-mtf2-modulate-prc2-h3k27me3-deposition-via-ga-a-14vo9wa
February 11, 2026 at 8:58 AM
🎧 New PaperCast episode: EPOP and MTF2 tune PRC2 activity via GA- and GCN-rich linker DNA to direct de novo H3K27me3 deposition in mESCs — Listen now https://basebybase.com/?episode=287-epop-and-mtf2-modulate-prc2-h3k27me3-deposition-via-ga-a-14vo9wa
🎵 open.spotify.com/track/30OmCJ...
Beneath the noise of millions of genomes,
there are quiet signals shaping how our bodies work.
This song came from that idea ✨
Beneath the noise of millions of genomes,
there are quiet signals shaping how our bodies work.
This song came from that idea ✨
Pulse Beneath the Signal
open.spotify.com
February 11, 2026 at 2:48 AM
🎵 open.spotify.com/track/30OmCJ...
Beneath the noise of millions of genomes,
there are quiet signals shaping how our bodies work.
This song came from that idea ✨
Beneath the noise of millions of genomes,
there are quiet signals shaping how our bodies work.
This song came from that idea ✨
🎵 open.spotify.com/track/4cN9TD...
Chromosomes don’t act randomly —
they follow hidden rhythms to stay organized.
This song came from that idea ✨
Chromosomes don’t act randomly —
they follow hidden rhythms to stay organized.
This song came from that idea ✨
Electric Lines Between the Stars
open.spotify.com
February 11, 2026 at 1:26 AM
🎵 open.spotify.com/track/4cN9TD...
Chromosomes don’t act randomly —
they follow hidden rhythms to stay organized.
This song came from that idea ✨
Chromosomes don’t act randomly —
they follow hidden rhythms to stay organized.
This song came from that idea ✨
Reposted by Base by Base
The Mani Peninsula, off the southern coast of Greece, is home to a group of genetically isolated people called Deep Maniots.
A new DNA analysis links them to Greece’s premedieval past.
Learn more: https://scim.ag/4qrtW7k
A new DNA analysis links them to Greece’s premedieval past.
Learn more: https://scim.ag/4qrtW7k
February 11, 2026 at 12:08 AM
The Mani Peninsula, off the southern coast of Greece, is home to a group of genetically isolated people called Deep Maniots.
A new DNA analysis links them to Greece’s premedieval past.
Learn more: https://scim.ag/4qrtW7k
A new DNA analysis links them to Greece’s premedieval past.
Learn more: https://scim.ag/4qrtW7k
Reposted by Base by Base
In the latest Science Sessions episode, Lauren Meyers of UT Austin discusses lessons from the 2022-2023 influenza season on the effectiveness of flu vaccines. Listen now: https://ow.ly/iCVJ50YcoK8
February 10, 2026 at 6:02 PM
In the latest Science Sessions episode, Lauren Meyers of UT Austin discusses lessons from the 2022-2023 influenza season on the effectiveness of flu vaccines. Listen now: https://ow.ly/iCVJ50YcoK8
🎧 Featured this @pnas.org paper on Base by Base—bringing peer-reviewed findings to broader audiences and helping expand the reach of CC BY science. basebybase.com?episode=286-...
February 10, 2026 at 4:41 PM
🎧 Featured this @pnas.org paper on Base by Base—bringing peer-reviewed findings to broader audiences and helping expand the reach of CC BY science. basebybase.com?episode=286-...
🎧 Deep mutational scanning maps ~8,500 mutations in the Nipah virus fusion protein F, revealing constrained fusion-peptide interfaces and antibody-escape sites — listen https://basebybase.com/?episode=286-deep-mutational-scanning-of-nipah-virus-fusion-protein-f-w7vsbc
February 10, 2026 at 12:09 PM
🎧 Deep mutational scanning maps ~8,500 mutations in the Nipah virus fusion protein F, revealing constrained fusion-peptide interfaces and antibody-escape sites — listen https://basebybase.com/?episode=286-deep-mutational-scanning-of-nipah-virus-fusion-protein-f-w7vsbc
Reposted by Base by Base
Thanks to @basebybase.bsky.social for covering our @ajhgnews.bsky.social paper on genetic literacy! Great summary of how people understand and relate to genetics.
🎧 New PaperCast: 'Interaction of identity and beliefs with genetic literacy' — a GALS survey of >4,000 US participants finds confidence in genetic knowledge explains ~25% of lite… https://basebybase.com/?episode=283-confidence-in-genetic-knowledge-drives-familiarity-knowl-17ljvj2
February 9, 2026 at 9:58 PM
Thanks to @basebybase.bsky.social for covering our @ajhgnews.bsky.social paper on genetic literacy! Great summary of how people understand and relate to genetics.
🎧 New PaperCast: ESBX (Tb927.3.1660) in Trypanosoma brucei links RNA Pol I localization at the ESB to activation of the active BES and repression of inactive BESs, revealing a key… https://basebybase.com/?episode=285-esbx-tb927-3-1660-integrates-esb-rna-pol-i-localization--4uuaqp
February 9, 2026 at 8:48 AM
🎧 New PaperCast: ESBX (Tb927.3.1660) in Trypanosoma brucei links RNA Pol I localization at the ESB to activation of the active BES and repression of inactive BESs, revealing a key… https://basebybase.com/?episode=285-esbx-tb927-3-1660-integrates-esb-rna-pol-i-localization--4uuaqp
🎧 New PaperCast: Integrative VSMC genomics and pooled CRISPR nominate pleiotropic vascular genes; FES loss raises MMPs, atherosclerosis and blood pressure — listen https://basebybase.com/?episode=284-fes-vsmc-behavior-and-pleiotropic-vascular-genes-identif-1txvz8x
February 8, 2026 at 12:52 PM
🎧 New PaperCast: Integrative VSMC genomics and pooled CRISPR nominate pleiotropic vascular genes; FES loss raises MMPs, atherosclerosis and blood pressure — listen https://basebybase.com/?episode=284-fes-vsmc-behavior-and-pleiotropic-vascular-genes-identif-1txvz8x
🎧 New PaperCast: 'Interaction of identity and beliefs with genetic literacy' — a GALS survey of >4,000 US participants finds confidence in genetic knowledge explains ~25% of lite… https://basebybase.com/?episode=283-confidence-in-genetic-knowledge-drives-familiarity-knowl-17ljvj2
February 7, 2026 at 10:10 AM
🎧 New PaperCast: 'Interaction of identity and beliefs with genetic literacy' — a GALS survey of >4,000 US participants finds confidence in genetic knowledge explains ~25% of lite… https://basebybase.com/?episode=283-confidence-in-genetic-knowledge-drives-familiarity-knowl-17ljvj2
🎧 New episode: TWAS inflation from polygenicity scales with GWAS sample size and heritability; Liang et al. introduce a gene-specific variance-control in PrediXcan that calibrate… https://basebybase.com/?episode=282-gene-specific-variance-control-corrects-polygenicity-dri-119r3op
February 6, 2026 at 7:42 AM
🎧 New episode: TWAS inflation from polygenicity scales with GWAS sample size and heritability; Liang et al. introduce a gene-specific variance-control in PrediXcan that calibrate… https://basebybase.com/?episode=282-gene-specific-variance-control-corrects-polygenicity-dri-119r3op
🎧 New episode: Di Donato et al. map 290 ACTB/ACTG1 cases into eight non-muscle actinopathies and link BWCFF variants to altered actin polymerization — clinical and biochemical imp… https://basebybase.com/?episode=281-variant-level-mapping-of-actb-and-actg1-defines-eight-no-sf89fz
February 6, 2026 at 7:24 AM
🎧 New episode: Di Donato et al. map 290 ACTB/ACTG1 cases into eight non-muscle actinopathies and link BWCFF variants to altered actin polymerization — clinical and biochemical imp… https://basebybase.com/?episode=281-variant-level-mapping-of-actb-and-actg1-defines-eight-no-sf89fz
🎧 Twin models, GWAS, RNA-seq and methylation in 569 TwinsUK adipose biopsies implicate SCD, FADS and a 3p25.2 (PPARG) locus in regulating fatty acid composition https://basebybase.com/?episode=280-scd-fads-and-a-3p25-2-pparg-locus-shape-fatty-acid-compo-1t00df
February 4, 2026 at 9:02 AM
🎧 Twin models, GWAS, RNA-seq and methylation in 569 TwinsUK adipose biopsies implicate SCD, FADS and a 3p25.2 (PPARG) locus in regulating fatty acid composition https://basebybase.com/?episode=280-scd-fads-and-a-3p25-2-pparg-locus-shape-fatty-acid-compo-1t00df
🎧 New episode: Guest et al. warn universities that uncritical adoption of AI—LLMs, chatbots, closed-source tools—erodes academic freedom, integrity, and skills. Hear the evidence… https://basebybase.com/?episode=279-against-the-uncritical-adoption-of-ai-in-universities-ll-tq9y7x
February 3, 2026 at 11:00 AM
🎧 New episode: Guest et al. warn universities that uncritical adoption of AI—LLMs, chatbots, closed-source tools—erodes academic freedom, integrity, and skills. Hear the evidence… https://basebybase.com/?episode=279-against-the-uncritical-adoption-of-ai-in-universities-ll-tq9y7x
🎧 New episode: how FTC scrutiny of Illumina’s acquisition of Grail and evolving merger guidelines could reshape NGS markets, spin-offs, and startups in human genetics https://basebybase.com/?episode=278-illumina-grail-and-ftc-scrutiny-of-vertical-mergers-in-h-1t13yfv
February 2, 2026 at 8:59 AM
🎧 New episode: how FTC scrutiny of Illumina’s acquisition of Grail and evolving merger guidelines could reshape NGS markets, spin-offs, and startups in human genetics https://basebybase.com/?episode=278-illumina-grail-and-ftc-scrutiny-of-vertical-mergers-in-h-1t13yfv
🎧 New PaperCast episode: MDGA2 homozygous loss-of-function variants linked to autosomal-recessive developmental and epileptic encephalopathy; exome sequencing and neuronal assays… https://basebybase.com/?episode=277-mdga2-homozygous-loss-of-function-variants-in-developmen-90a0xz
February 2, 2026 at 1:48 AM
🎧 New PaperCast episode: MDGA2 homozygous loss-of-function variants linked to autosomal-recessive developmental and epileptic encephalopathy; exome sequencing and neuronal assays… https://basebybase.com/?episode=277-mdga2-homozygous-loss-of-function-variants-in-developmen-90a0xz