Base by Base
@basebybase.bsky.social
Base by Base is a podcast that explores the latest advances in genetics and genomics. Each episode breaks down key studies and their clinical relevance — one base at a time.
🎧 New PaperCast: Integrative VSMC genomics and pooled CRISPR nominate pleiotropic vascular genes; FES loss raises MMPs, atherosclerosis and blood pressure — listen https://basebybase.com/?episode=284-fes-vsmc-behavior-and-pleiotropic-vascular-genes-identif-1txvz8x
February 8, 2026 at 12:52 PM
🎧 New PaperCast: Integrative VSMC genomics and pooled CRISPR nominate pleiotropic vascular genes; FES loss raises MMPs, atherosclerosis and blood pressure — listen https://basebybase.com/?episode=284-fes-vsmc-behavior-and-pleiotropic-vascular-genes-identif-1txvz8x
🎧 New PaperCast: 'Interaction of identity and beliefs with genetic literacy' — a GALS survey of >4,000 US participants finds confidence in genetic knowledge explains ~25% of lite… https://basebybase.com/?episode=283-confidence-in-genetic-knowledge-drives-familiarity-knowl-17ljvj2
February 7, 2026 at 10:10 AM
🎧 New PaperCast: 'Interaction of identity and beliefs with genetic literacy' — a GALS survey of >4,000 US participants finds confidence in genetic knowledge explains ~25% of lite… https://basebybase.com/?episode=283-confidence-in-genetic-knowledge-drives-familiarity-knowl-17ljvj2
🎧 New episode: TWAS inflation from polygenicity scales with GWAS sample size and heritability; Liang et al. introduce a gene-specific variance-control in PrediXcan that calibrate… https://basebybase.com/?episode=282-gene-specific-variance-control-corrects-polygenicity-dri-119r3op
February 6, 2026 at 7:42 AM
🎧 New episode: TWAS inflation from polygenicity scales with GWAS sample size and heritability; Liang et al. introduce a gene-specific variance-control in PrediXcan that calibrate… https://basebybase.com/?episode=282-gene-specific-variance-control-corrects-polygenicity-dri-119r3op
🎧 New episode: Di Donato et al. map 290 ACTB/ACTG1 cases into eight non-muscle actinopathies and link BWCFF variants to altered actin polymerization — clinical and biochemical imp… https://basebybase.com/?episode=281-variant-level-mapping-of-actb-and-actg1-defines-eight-no-sf89fz
February 6, 2026 at 7:24 AM
🎧 New episode: Di Donato et al. map 290 ACTB/ACTG1 cases into eight non-muscle actinopathies and link BWCFF variants to altered actin polymerization — clinical and biochemical imp… https://basebybase.com/?episode=281-variant-level-mapping-of-actb-and-actg1-defines-eight-no-sf89fz
🎧 Twin models, GWAS, RNA-seq and methylation in 569 TwinsUK adipose biopsies implicate SCD, FADS and a 3p25.2 (PPARG) locus in regulating fatty acid composition https://basebybase.com/?episode=280-scd-fads-and-a-3p25-2-pparg-locus-shape-fatty-acid-compo-1t00df
February 4, 2026 at 9:02 AM
🎧 Twin models, GWAS, RNA-seq and methylation in 569 TwinsUK adipose biopsies implicate SCD, FADS and a 3p25.2 (PPARG) locus in regulating fatty acid composition https://basebybase.com/?episode=280-scd-fads-and-a-3p25-2-pparg-locus-shape-fatty-acid-compo-1t00df
🎧 New episode: Guest et al. warn universities that uncritical adoption of AI—LLMs, chatbots, closed-source tools—erodes academic freedom, integrity, and skills. Hear the evidence… https://basebybase.com/?episode=279-against-the-uncritical-adoption-of-ai-in-universities-ll-tq9y7x
February 3, 2026 at 11:00 AM
🎧 New episode: Guest et al. warn universities that uncritical adoption of AI—LLMs, chatbots, closed-source tools—erodes academic freedom, integrity, and skills. Hear the evidence… https://basebybase.com/?episode=279-against-the-uncritical-adoption-of-ai-in-universities-ll-tq9y7x
🎧 New episode: how FTC scrutiny of Illumina’s acquisition of Grail and evolving merger guidelines could reshape NGS markets, spin-offs, and startups in human genetics https://basebybase.com/?episode=278-illumina-grail-and-ftc-scrutiny-of-vertical-mergers-in-h-1t13yfv
February 2, 2026 at 8:59 AM
🎧 New episode: how FTC scrutiny of Illumina’s acquisition of Grail and evolving merger guidelines could reshape NGS markets, spin-offs, and startups in human genetics https://basebybase.com/?episode=278-illumina-grail-and-ftc-scrutiny-of-vertical-mergers-in-h-1t13yfv
🎧 New PaperCast episode: MDGA2 homozygous loss-of-function variants linked to autosomal-recessive developmental and epileptic encephalopathy; exome sequencing and neuronal assays… https://basebybase.com/?episode=277-mdga2-homozygous-loss-of-function-variants-in-developmen-90a0xz
February 2, 2026 at 1:48 AM
🎧 New PaperCast episode: MDGA2 homozygous loss-of-function variants linked to autosomal-recessive developmental and epileptic encephalopathy; exome sequencing and neuronal assays… https://basebybase.com/?episode=277-mdga2-homozygous-loss-of-function-variants-in-developmen-90a0xz
🎧 New episode: AlphaGenome — a 1 Mb multimodal DNA model predicts base‑pair‑resolution genome tracks and variant effects across splicing, expression and chromatin, matching or ex… https://basebybase.com/?episode=276-alphagenome-1-mb-multimodal-deep-model-predicts-regulato-1e4sixp
January 31, 2026 at 1:53 AM
🎧 New episode: AlphaGenome — a 1 Mb multimodal DNA model predicts base‑pair‑resolution genome tracks and variant effects across splicing, expression and chromatin, matching or ex… https://basebybase.com/?episode=276-alphagenome-1-mb-multimodal-deep-model-predicts-regulato-1e4sixp
🎧 PaperCast Base by Base: MIPseq/WES of 11,555 CHD probands implicates 60 dominant genes; NOTCH1 cysteine‑altering and transmitted MYH6 missense variants highlight mechanistic sub… https://basebybase.com/?episode=275-mipseq-wes-of-11-555-chd-probands-implicates-60-dominant-cxasq3
January 30, 2026 at 10:57 PM
🎧 PaperCast Base by Base: MIPseq/WES of 11,555 CHD probands implicates 60 dominant genes; NOTCH1 cysteine‑altering and transmitted MYH6 missense variants highlight mechanistic sub… https://basebybase.com/?episode=275-mipseq-wes-of-11-555-chd-probands-implicates-60-dominant-cxasq3
Reposted by Base by Base
This was a really great podcast that explains a scientific discovery about a cause of Retinitis Pigmentosa in a really clear way. The discovery has implications for other causes of blindness and possibly even neurodegenerative diseases like Alzheimer’s disease. #RP
🎧 AAV delivery of MCT2 to the RPE increases lactate uptake and prolongs cone survival and function across RP models — listen for the mechanisms and FLIM data https://basebybase.com/?episode=274-rpe-specific-mct2-gene-delivery-preserves-cones-and-visi-1vgo8ej
January 29, 2026 at 2:21 PM
This was a really great podcast that explains a scientific discovery about a cause of Retinitis Pigmentosa in a really clear way. The discovery has implications for other causes of blindness and possibly even neurodegenerative diseases like Alzheimer’s disease. #RP
🎧 AAV delivery of MCT2 to the RPE increases lactate uptake and prolongs cone survival and function across RP models — listen for the mechanisms and FLIM data https://basebybase.com/?episode=274-rpe-specific-mct2-gene-delivery-preserves-cones-and-visi-1vgo8ej
January 29, 2026 at 9:25 AM
🎧 AAV delivery of MCT2 to the RPE increases lactate uptake and prolongs cone survival and function across RP models — listen for the mechanisms and FLIM data https://basebybase.com/?episode=274-rpe-specific-mct2-gene-delivery-preserves-cones-and-visi-1vgo8ej
🎧 New episode: CTVT-A captured a 15-Mb dicentric nuclear fragment (N-HT1) from a donor dog ~2,000 years ago; N-HT1 is transcriptionally active but appears selectively neutral https://basebybase.com/?episode=273-ctvt-a-acquires-15-mb-n-ht1-dicentric-nuclear-element-vi-23fpie
January 28, 2026 at 9:45 AM
🎧 New episode: CTVT-A captured a 15-Mb dicentric nuclear fragment (N-HT1) from a donor dog ~2,000 years ago; N-HT1 is transcriptionally active but appears selectively neutral https://basebybase.com/?episode=273-ctvt-a-acquires-15-mb-n-ht1-dicentric-nuclear-element-vi-23fpie
🎧 New PaperCast: Modern-human ADSL changes (A429V and regulatory haplotype) reduced enzyme activity, raised purine substrates in brain and altered female mouse water-seeking behav… https://basebybase.com/?episode=272-adsl-a429v-reduces-purine-biosynthesis-in-brain-and-alte-hm3a9a
January 27, 2026 at 8:59 AM
🎧 New PaperCast: Modern-human ADSL changes (A429V and regulatory haplotype) reduced enzyme activity, raised purine substrates in brain and altered female mouse water-seeking behav… https://basebybase.com/?episode=272-adsl-a429v-reduces-purine-biosynthesis-in-brain-and-alte-hm3a9a
🎧 New episode: EA PGI associations with years of education rose across UK birth cohorts 1946–1970 and were amplified in advantaged families — methods and implications discussed https://basebybase.com/?episode=271-rising-ea-pgi-prediction-of-educational-attainment-acros-1f9zw8k
January 26, 2026 at 2:41 AM
🎧 New episode: EA PGI associations with years of education rose across UK birth cohorts 1946–1970 and were amplified in advantaged families — methods and implications discussed https://basebybase.com/?episode=271-rising-ea-pgi-prediction-of-educational-attainment-acros-1f9zw8k
🎧 Single-molecule optical tweezers reveal human Topoisomerase IIIα–RMI1–RMI2 (TRR) processively relaxes negative DNA supercoils faster than PICH loop lifetimes, informing UFB res… https://basebybase.com/?episode=270-human-topoisomerase-iii-rmi1-rmi2-trr-processively-relax-1drah96
January 26, 2026 at 2:17 AM
🎧 Single-molecule optical tweezers reveal human Topoisomerase IIIα–RMI1–RMI2 (TRR) processively relaxes negative DNA supercoils faster than PICH loop lifetimes, informing UFB res… https://basebybase.com/?episode=270-human-topoisomerase-iii-rmi1-rmi2-trr-processively-relax-1drah96
🎧 New PaperCast episode: Mlh1–Pms1 directly makes strand-specific single-strand gaps to excise mismatches in reconstituted S. cerevisiae MMR https://basebybase.com/?episode=269-mlh1-pms1-endonuclease-creates-single-strand-gaps-to-exc-1bebnh
January 24, 2026 at 9:23 AM
🎧 New PaperCast episode: Mlh1–Pms1 directly makes strand-specific single-strand gaps to excise mismatches in reconstituted S. cerevisiae MMR https://basebybase.com/?episode=269-mlh1-pms1-endonuclease-creates-single-strand-gaps-to-exc-1bebnh
🎧 New PaperCast: β-cardiac myosin M493I disrupts the super-relaxed state, slows ADP release, and increases actin attachment and force—linking SRX loss to HCM hypercontractility https://basebybase.com/?episode=268-m493i-in-human-cardiac-myosin-srx-disruption-slow-adp-re-17pvu82
January 23, 2026 at 9:32 AM
🎧 New PaperCast: β-cardiac myosin M493I disrupts the super-relaxed state, slows ADP release, and increases actin attachment and force—linking SRX loss to HCM hypercontractility https://basebybase.com/?episode=268-m493i-in-human-cardiac-myosin-srx-disruption-slow-adp-re-17pvu82
🎧 New PaperCast Base by Base: Englander shows H-T and NMR H-H exchange reveal two DNA base-pair opening modes — single-base microsecond events and multi-base ms soliton-like loops https://basebybase.com/?episode=267-dna-base-pair-opening-modes-and-soliton-like-loops-revea-1gnueqx
January 22, 2026 at 9:00 AM
🎧 New PaperCast Base by Base: Englander shows H-T and NMR H-H exchange reveal two DNA base-pair opening modes — single-base microsecond events and multi-base ms soliton-like loops https://basebybase.com/?episode=267-dna-base-pair-opening-modes-and-soliton-like-loops-revea-1gnueqx
🎧 PaperCast Base by Base: TOP1α and TOP3β are upregulated in HPV31-positive keratinocytes and are differentially required for viral replication through distinct effects on R-loops… https://basebybase.com/?episode=266-top1-and-top3-differentially-regulate-hpv31-replication--utfwox
January 21, 2026 at 10:01 AM
🎧 PaperCast Base by Base: TOP1α and TOP3β are upregulated in HPV31-positive keratinocytes and are differentially required for viral replication through distinct effects on R-loops… https://basebybase.com/?episode=266-top1-and-top3-differentially-regulate-hpv31-replication--utfwox
🎧 New episode: How the lncRNA ANTSR acts as a conserved multiallelic sex-determining locus across Aculeata (ants, bees, wasps), functioning via heterozygosity despite no sequence… https://basebybase.com/?episode=265-antsr-lncrna-and-the-conserved-multiallelic-sex-determin-keh0qq
January 20, 2026 at 9:16 AM
🎧 New episode: How the lncRNA ANTSR acts as a conserved multiallelic sex-determining locus across Aculeata (ants, bees, wasps), functioning via heterozygosity despite no sequence… https://basebybase.com/?episode=265-antsr-lncrna-and-the-conserved-multiallelic-sex-determin-keh0qq
🎧 New Base by Base episode is live: Episode 264 — Single-TF rejuvenation: EZH2, E2F3, STAT3, ZFX identified by TRDP/Perturb-seq rejuvenate human fibroblasts and mouse liver • The study used passaged… basebybase.com?episode=264-...
January 19, 2026 at 9:20 AM
🎧 New Base by Base episode is live: Episode 264 — Single-TF rejuvenation: EZH2, E2F3, STAT3, ZFX identified by TRDP/Perturb-seq rejuvenate human fibroblasts and mouse liver • The study used passaged… basebybase.com?episode=264-...
🎧 New Base by Base episode is live — γPNA Janus-base triplets selectively bind expanded rCUG repeats, displace MBNL1, and partially rescue splicing in DM1 myotubes — listen basebybase.com?episode=263-...
January 19, 2026 at 1:48 AM
🎧 New Base by Base episode is live — γPNA Janus-base triplets selectively bind expanded rCUG repeats, displace MBNL1, and partially rescue splicing in DM1 myotubes — listen basebybase.com?episode=263-...
🎧 New Base by Base episode is live: Episode 262 — Human Langerhans cells reprogrammed by tick saliva (CXCR4/CCR7 migration and IDO1/IRF4 tolerance) • The study uses clinical human… basebybase.com?episode=262-...
January 17, 2026 at 10:52 AM
🎧 New Base by Base episode is live: Episode 262 — Human Langerhans cells reprogrammed by tick saliva (CXCR4/CCR7 migration and IDO1/IRF4 tolerance) • The study uses clinical human… basebybase.com?episode=262-...
🎧 New Base by Base episode is live: Episode 261 — MHz-XPCS reveals anomalous ferritin diffusion and nanoscale cage trapping • The study probes crowded ferritin solutions using meg… basebybase.com?episode=261-...
January 17, 2026 at 10:51 AM
🎧 New Base by Base episode is live: Episode 261 — MHz-XPCS reveals anomalous ferritin diffusion and nanoscale cage trapping • The study probes crowded ferritin solutions using meg… basebybase.com?episode=261-...