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Adhithya Sankar @adhithyasankar.bsky.social · 5d

Time for wider adoption of salivary cortisone in endocrinology?
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone

jamanetwork.com/journals/jam...

Adult Adrenal Insufficiency

To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...

jamanetwork.com

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Reposted by Adhithya Sankar

akheel sͩyͬed @akheelsyed.bsky.social · 6d

Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam...
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults

Adult Adrenal Insufficiency

To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...

jamanetwork.com

1 1

Adhithya Sankar @adhithyasankar.bsky.social · Jun 22

www.nejm.org/doi/full/10....

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | NEJM

Orforglipron is a small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist in clinical development for type 2 diabetes and weight management. Additional data on the efficacy and ...

www.nejm.org

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Reposted by Adhithya Sankar

Diabetologia @diabetologiajnl.bsky.social · Jun 3

Does every person with type 2 diabetes respond the same way to GLP-1 receptor agonists? Recent clinical data suggest otherwise. #GLP1 #diabetes link.springer.com/article/10.1... 🔓

Heterogeneity in response to GLP-1 receptor agonists in type 2 diabetes in real-world clinical practice: insights from the DPV register – an IMI-SOPHIA study - Diabetologia

Aims/hypothesis Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a cornerstone in type 2 diabetes management. In this study we evaluated heterogeneity in body weight and glycaemic responses t...

link.springer.com

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Reposted by Adhithya Sankar

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · Mar 29

#Adrenocortical #carcinoma is a rare malignancy, in contrast to benign #adrenal tumours, which are among the most common human neoplasias with a prevalence of greater than 3% in adults older than 50 years www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky #OncSky

Adrenocortical carcinoma: a practical guide for clinicians

Adrenocortical carcinoma is a rare endocrine malignancy. The management of patients with adrenocortical carcinoma is challenging for several reasons, including its heterogeneous but frequently aggress...

www.thelancet.com

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Adhithya Sankar @adhithyasankar.bsky.social · Mar 23

www.nature.com/articles/s41...

GLP-1 receptor agonists causing euglycemic ketoacidosis in patients without diabetes: a brief review - International Journal of Obesity

International Journal of Obesity - GLP-1 receptor agonists causing euglycemic ketoacidosis in patients without diabetes: a brief review

www.nature.com

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Reposted by Adhithya Sankar

Daniel Drucker @danieljdrucker.bsky.social · Mar 8

How to think about evaluation of low testosterone levels, SHBG, clinical symptoms and possible benefits vs. real risks of treatment in the context of #obesity academic.oup.com/jcem/advance...

Approach to the patient: Low testosterone concentrations in men with obesity

Abstract. Pathologic hypogonadism occurs when serum testosterone is significantly and persistently reduced by irreversible organic (structural, genetic) di

academic.oup.com

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Reposted by Adhithya Sankar

GoggleDocs @goggledocs.bsky.social · Mar 5

#Finerenone: CV & renal protection across all #T2D therapies❗️

🔹 Pooled analysis: 15,365 pts w/ T2D + CKD or CV

🔸 Consistent benefit on 💔☠️, 🏥💔& kidney outcomes

🔹 ⤴️K+ ⤵️ with SGLT2i use

🔸 Benefit independent of SGLT2i/GLP-1 use

👉 Supports finerenone as a 🎯 in high-risk #T2D❗️

🔗 ggdocs.co/tx2a5r

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Adhithya Sankar @adhithyasankar.bsky.social · Feb 25

academic.oup.com/ejendo/advan...

Delphi Panel consensus on recommendations for thromboprophylaxis of venous thromboembolism in endogenous Cushing's syndrome: a Position Statement

AbstractObjective. To establish recommendations for thromboprophylaxis in patients with endogenous Cushing's syndrome (CS), addressing the elevated risk of

academic.oup.com

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Adhithya Sankar @adhithyasankar.bsky.social · Feb 11

Pleased to share our case report!

RAI is known to worsen TED in Graves’ disease, but what about nodular thyroid disease?

Assessment of TPO antibody, and not just TRAb prior to RAI may be informative in guiding decision-making around steroid prophylaxis.

casereports.bmj.com/content/18/2...

De novo Graves’ thyroid eye disease after radioiodine treatment for toxic nodular thyroid disease

It is well known that radioactive iodine treatment (RAI) for thyrotoxicosis in Graves’ disease can precipitate worsening of thyroid eye disease (TED), particularly in susceptible patients. Less common...

casereports.bmj.com

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Reposted by Adhithya Sankar

akheel sͩyͬed @akheelsyed.bsky.social · Feb 7

Obesity is the third most important predictor of heart disease. We discuss pathophysiology and management including roles of anti-obesity medications and bariatric surgery.
@ncaresearchnhs.bsky.social

www.sciencedirect.com/science/arti...

Obesity Management for Patients with Coronary Artery Disease and Heart Failure

www.sciencedirect.com

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Reposted by Adhithya Sankar

akheel sͩyͬed @akheelsyed.bsky.social · Feb 3

Accurate prediction of long-term postoperative weight loss is important for advising patients undergoing bariatric surgery.
@adhithyasankar.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/39887840/

@ncaresearchnhs.bsky.social

Actual weight loss trajectories after bariatric surgery compared with the SOPHIA prediction tool: An observational comparison study - PubMed

The SOPHIA study tool provides accurate postoperative weight forecasts for some subgroups of patients, but its precision diminishes with time. This study reiterates the necessity for better personaliz...

pubmed.ncbi.nlm.nih.gov

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Adhithya Sankar @adhithyasankar.bsky.social · Jan 30

@akheelsyed.bsky.social

Adhithya Sankar @adhithyasankar.bsky.social · Jan 30

How well can we predict weight loss after bariatric surgery?

Our study assessed the SOPHIA weight prediction tool in our patient population.

dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

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Reposted by Adhithya Sankar

GoggleDocs @goggledocs.bsky.social · Jan 18

Peri-operative management of GLP-1 RAs & SGLT2 inhibitors❗️

🔹 New 🇬🇧 consensus: GLP-1 RAs can continue, but risks of aspiration must be assessed.

🔸SGLT2i should be stopped 1 day pre-op to avoid euglycemic DKA.

❗️shared decision-making & tailored approaches to optimise safety.

🔗 ggdocs.co/4r995z

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Reposted by Adhithya Sankar

NEJM.org @nejm.org · Dec 23

🧵 Cancer Cachexia and the Brain Stem (a thread)

In NEJM, Groarke et al. report the results of a phase 2 clinical trial of ponsegromab therapy for cancer cachexia in patients with elevated humoral levels of growth differentiation factor 15 (GDF-15). nej.md/3XE645a 1/10

#MedSky #ScienceSky

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Adhithya Sankar @adhithyasankar.bsky.social · Dec 10

jnnp.bmj.com/content/earl...

Cardiovascular risk and obesity impact loss of grey matter volume earlier in males than females

Background It remains imperative to discover the time course that cardiovascular risk factors influence neurodegeneration in males and females and decipher whether the apolipoprotein (APOE) genotype m...

jnnp.bmj.com

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Reposted by Adhithya Sankar

akheel sͩyͬed @akheelsyed.bsky.social · Dec 6

www.telegraph.co.uk/health-fitne...

The real reason men get belly fat (and how to get rid of it)

Research suggests it’s more dangerous to be an overweight man than woman. Here’s why – and what you can do about it

www.telegraph.co.uk

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Adhithya Sankar @adhithyasankar.bsky.social · Dec 9

Eye-opening patient story regarding ACC and mitotane

Vin Tangpricha, MD, PhD @vtangpricha.bsky.social · Dec 8

A physician’s personal story of his battle vs Adrenal Cancer published in #EndocrinePractice via Adrenocortical Carcinoma and the Mitotane Morass: A Physician/Patient Perspective #endosky www.endocrinepractice.org/article/S153...

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Reposted by Adhithya Sankar

Sarah Finer @sarahfiner.bsky.social · Nov 26

It’s a big day for @genesandhealth.bsky.social @samcbhodgson.bsky.social @moneeza-ks.bsky.social Genes & Health, with @ Sam Hodgson, Moneeza Kalhan Siddiqui and I, as we publish our paper rdcu.be/d1vj0 on the genetic basis of #type2diabetes & #gestationaldiabetes (#T2D and #GDM) in south Asians. A🧵

Genetic basis of early onset and progression of type 2 diabetes in South Asians

Nature Medicine - In a cohort of 50,556 South Asian individuals, partitioned polygenic scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key...

rdcu.be

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Reposted by Adhithya Sankar

AMEND UK @amenduk.bsky.social · Nov 20

Presentation and management of patients with adrenal masses: a large tertiary centre experience by Onnicha Suntornlohanakul et al @Bham_AT doi.org/10.1093/ejen... #adrenal #phaeochromocytoma #ACC

Presentation and management of patients with adrenal masses: a large tertiary centre experience

AbstractBackground. Adrenal masses are found in up to 5%-7% of adults. The 2016 European guidelines on the management of adrenal incidentalomas have standa

doi.org

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Reposted by Adhithya Sankar

Current Biology @currentbiology.bsky.social · Nov 25

How the #brain talks to the #gut and vice versa!
🧪🧠💩

Check out the great primer on gut-brain communication and #interoception by @amberalhadeff.bsky.social and Nilay Yapici

👇👇👇
www.cell.com/current-biol...

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Reposted by Adhithya Sankar

Joel Topf @kidneyboy.bsky.social · Nov 19

Honey, stop what you're doing, new hyponatremia research just dropped!

What's it say?

It looks like slow correction is associated with worse outcomes, like death and length of stay!

Was it just a small study?

No, it was a meta-analysis of almost 12,000 patients!

jamanetwork.com/journals/jam...

Correction Rates and Clinical Outcomes in Hospitalized Adults With Severe Hyponatremia

This systematic review and meta-analysis evaluates the association of sodium correction rates with mortality among hospitalized adults with severe hyponatremia.

jamanetwork.com

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Reposted by Adhithya Sankar

GoggleDocs @goggledocs.bsky.social · Nov 16

Expert statement on Diagnosis & Mx of peripheral neuropathy in #diabetes & pre-diabetes (Gulf region)

🔸suggest routine screening (patient questionnaire & clinical assessment)

🔹Universal B12 Rx

🔸Check B 1&6 levels

🔹Use of CGM

🔸Use of GLP1

🔗 link.springer.com/article/10.1...

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