Lightnews — Scholar-powered news

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 15h

Remember this paper "Low overlap
of transcription factor DNA binding and regulatory targets" ? (www.nature.com/articles/s41...)

well, well, well 🍿

⬇️

www.biorxiv.org/content/10.1...

On the overlap of transcription factor binding and regulatory targets: functional and regulatory coherence of top-bound targets is masked by weakly bound ones

A recent study that systematically mapped genomic bindings and regulatory effects of transcription factors (TFs) reported a surprisingly low overlap between TF binding and regulatory targets in Saccha...

www.biorxiv.org

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The Company of Biologists @biologists.bsky.social · 14h

Looking to get involved in peer review?

Check out the Fast & Fair initiative run by Biology Open.

journals.biologists.com/bio/pages/fa...

#PeerReview #PaidWork #Journals #Academia #Research #Biology #BiologyOpen

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Reposted by preLights

Avezov lab @avezovlab.bsky.social · 5d

New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️

www.biorxiv.org/content/10.1...

#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv

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preLights @prelights.bsky.social · 17h

Daniel Osorno Valencia posted the first preLight drafted as part of a wonderful preprint review initiative @ufrjoficial.bsky.social #brazil

The #preprint discussed uncovers a mechanism underlying snake venom resistance in Neotoma macrotis.

#preLight ⬇️
prelights.biologists.com/highlights/t...

Tandem duplication of serpin genes yields functional variation and snake venom inhibitors - preLights

This study shows coevolutionary adaptation in Neotoma macrotis, where duplicated SERPINA3 genes inhibit Crotalus venom proteases, revealing functional diversification and potential use in antivenom de...

prelights.biologists.com

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Reposted by preLights

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

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preLights @prelights.bsky.social · 1d

CLEC4E as a key driver of damaging inflammation in #influenza.

Did you see the latest post of Charis Qi highlighting work of Christian Forst & team #IcahnMountSinai?

#preLight #SystemsBiology ⬇️👀
prelights.biologists.com/highlights/s...

Single-Cell Network Analysis Identifies CLEC4E as a Key Mediator of Proinflammatory mDC Responses in Influenza Infection - preLights

CLEC4E as a Key Driver of Damaging Inflammation in Influenza

prelights.biologists.com

preLights @prelights.bsky.social · 5d

Extracting the central dogma from a single cancer biopsy.🧬

@mannlab.bsky.social show that clinically meaningful, high-quality data can be obtained from archived protein-rich flowthrough that is usually discarded.

#preLight @philipplange.bsky.social Lab ⬇️
prelights.biologists.com/highlights/i...

In depth profiling of the cancer proteome from the flowthrough of standard RNA- preparation kits for precision oncology - preLights

Extracting the central dogma from a single cancer biopsy

prelights.biologists.com

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Reposted by preLights

Pedro Beltrao @pedrobeltrao.bsky.social · 5d

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

The functional landscape of the human ubiquitinome

Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...

www.biorxiv.org

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preLights @prelights.bsky.social · 6d

Insightful #postLight just uploaded by @vibhasingh.bsky.social 👀

She revisits work from Jonathan Kuhn & team #DevreotesLab, originally posted as a preprint and now published in @natcomms.nature.com

postLight: prelights.biologists.com/highlights/c...

Complementary Cytoskeletal Feedback Loops Control Signal Transduction Excitability and Cell Polarity - preLights

The cytoskeleton talks back and has a bi-directional influence on cell polarity.

prelights.biologists.com

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Reposted by preLights

The Company of Biologists @biologists.bsky.social · 6d

Our first extraordinary biologist featured this week is Katherine Brown, @biologists.bsky.social Publishing Director and former @dev-journal.bsky.social Executive Editor, who has been closely involved with @prelights.bsky.social since its inception. #100biologists

@katherine-brown.bsky.social

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preLights @prelights.bsky.social · 6d

Hsp70 phosphorylation stalls cell cycle, buying time for DNA repair

Ana Sanchez-Molina: “This #preprint provides detailed mechanistic, biochemical, and genetic evidence of a conserved mechanism of cell cycle regulation in response to DNA damage.” #preLight ⬇️
prelights.biologists.com/highlights/a...

A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage - preLights

Hsp70 phosphorylation stalls cell cycle, buying time for DNA repair.

prelights.biologists.com

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preLights @prelights.bsky.social · 7d

Being active when everyone else is asleep 💤

Stefan F. Wirth highlights work from Jona Lopez Pedersen & team (Toxopeus Lab #stfxuniversity) exploring why & how the stonefly Allocapnia pygmaea survives sub-zero temperatures. #preprint

#preLight #Ecology ⬇️👀
prelights.biologists.com/highlights/t...

The cold tolerance of an adult winter-active stonefly: How Allocapnia pygmaea (Plecoptera: Capniidae) avoids freezing in Nova Scotian winters - preLights

Being active when everyone else is asleep: why the stonefly Allocapnia pygmaea survives subzero temperatures

prelights.biologists.com

Reposted by preLights

Nadja M. Hümpfer @nadjahuempf.bsky.social · 7d

Thank you, fellow preLighter @sristi.bsky.social for mentioning our #Atlas 🗺️ on #Cytokinesis ⌛ in the September in #preprints list @prelights.bsky.social 😊

prelights.biologists.com/prelists/sep...

September in preprints – Cell biology edition - preLights

prelights.biologists.com

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preLights @prelights.bsky.social · 7d

Lot of new preLights this week! 🙌

Ruoheng Li discusses a #preprint from the #ExtavourLab @harvard.edu studying an extraordinary case of epithelial morphogenesis.

How shrimp embryos set up an epithelial checkerboard: down and across.
#preLight #DevBio ⬇️👀 prelights.biologists.com/highlights/l...

Lineage domains and cytoskeletal cables organize a cellular square grid in a crustacean - preLights

How shrimp embryos set up an epithelial checkerboard: down and across

prelights.biologists.com

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preLights @prelights.bsky.social · 8d

Excellent #postLight uploaded by @fadelvalle.bsky.social!

He revisits work from Werner van der Meer & colleagues originally posted as a preprint and now published in @cp-cellreports.bsky.social

postLight: prelights.biologists.com/highlights/l...

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preLights @prelights.bsky.social · 8d

Stopping norovirus at the gate. 🚧

In her first preLight, Leonie Brüne explores work from Maryna Chaika & team (@uniluebeck.bsky.social) highlighting polyamines as a possible new lead for therapeutics against norovirus. #preprint

#preLight #Immunology ⬇️👀
prelights.biologists.com/highlights/p...

Polyamine depletion inhibits norovirus infection by blocking virus-induced apoptosis - preLights

Stopping norovirus at the gate: Polyamines as a possible new lead for therapeutics against norovirus

prelights.biologists.com

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Reposted by preLights

Dan Portik @dportik.bsky.social · 13d

New pre-print from the Banfield lab, highlighting an interesting case of 1.5Mb megaplasmids found in human gut.

Plasmid genomes were resolved using #PacBio HiFi sequencing with hifiasm-meta for #metagenome assembly. Host association was detected using epigenetic signals.

doi.org/10.1101/2025...

Megaplasmids associate with Escherichia coli and other Enterobacteriaceae

Humans and animals are ubiquitously colonized by Enterobacteriaceae , a bacterial family that contains both commensals and clinically significant pathogens. Here, we report Enterobacteriaceae megaplas...

doi.org

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preLights @prelights.bsky.social · 13d

Happy October 1st!

A good time to share another #CellBio #preprint reading list put together by a team of preLighters: @sristi.bsky.social, Matthew Davies, @vibhasingh.bsky.social, @fadelvalle.bsky.social & Barbora Knotkova.

Check out their picks ⬇️👀
prelights.biologists.com/prelists/sep...

September in preprints – Cell biology edition - preLights

prelights.biologists.com

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preLights @prelights.bsky.social · 14d

Our latest ‘call for preLighters’ closes tonight!

Interested, but didn’t find the time to write an application? Expressions of interest are also welcome – just email us at [email protected]

Why join? See what other preLighters have to say…⬇️👀

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preLights @prelights.bsky.social · 14d

Turning back the clock on stem cells. 🕒

Did you see the preLight @vibhasingh.bsky.social posted last week highlighting the #preprint of Eva Mejía-Ramírez & team?

#preLight: prelights.biologists.com/highlights/t...

This work was also discussed in a recent webinar ⬇️👀

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Reposted by preLights

Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · Aug 11

🔥my latest paper from @odedrechavi.bsky.social lab🔥
we found small RNAs act across tissues to regulate fertlity in C. elegans 🪱. Surprisingly, we also found that O2-sensing neurons inhibit germline maintenance. Follow along our journey👇https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1

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Nadja M. Hümpfer @nadjahuempf.bsky.social · 16d

Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF

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Reposted by preLights

Denis Wirtz @deniswirtz.bsky.social · 16d

Multimodal SRS imaging reveals metabolic remodeling in ovarian precancerous lesions.

In collaboration with Prof. Lingyan Shi (UCSD), we integrated spatial metabolomics into a new 3D tissue mapping workflow at single-cell resolution

More here: www.biorxiv.org/content/10.1...

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The Company of Biologists @biologists.bsky.social · 16d

Calling early-career developmental biologists!

Apply for a funded place at our #Workshop, Novelty, Co-option and Divergence During Gene Network Evolution.

Application deadline: 5 December

www.biologists.com/workshops/ju...

#DevBio #BiologistsWorkshops #Collaboration #Networking

Workshop: Novelty, Co-option and Divergence During Gene Network Evolution. Organisers: James Hombría and Antónia Monteiro. 14-17 June 2026, Buxted Park, East Sussex, UK. Early-career researchers apply for funded places.

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Reposted by preLights

FocalPlane @focalplane.bsky.social · 18d

ICYMI – the recording from FocalPlane features… @prelights.bsky.social LIVE is up!
preLighters @fadelvalle.bsky.social & @vibhasingh.bsky.social present their live preLights & share research talks from @probablycarmen.bsky.social & Eva Mejía-Ramírez.
#preprints #cellbio #microscopy

FocalPlane features... preLights recording - FocalPlane

FocalPlane features... preLights recording - News

focalplane.biologists.com

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