VAD is a Viral AlphaFold Database of protein monomers and homodimers from viruses infecting hosts across the tree of life.

In a surprising twist, UNC scientists discovered that SETD2, a tumor suppressor best known for modifying DNA-packaging proteins, also preserves nuclear structure during cell division—a hidden role tha...

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

Our current carbon economy relies on fossil fuels, from which we isolate small organic molecules to produce medicines, plastics, cosmetic, or other chemicals that we use everyday. However, sustainability requires a more biomass-based carbon economy, where we engineer plants to produce precursor molecules, which can then be assembled to desired chemicals that we use daily. Plants have evolved an amazing diversity of metabolites, but these metabolites are not produced in every cell of the plant. Therefore, it is essential to understand how plants can express different metabolic pathways across different organs, tissues, and even cell types. We are interested in the following questions: How are metabolic pathways (especially specialized metabolism) controlled by cell fate? How can we reprogram plant cell fates for biomanufacturing? How can we toggle between differentiated cell states for metabolic engineering and totipotent cell state for genetic engineering?