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Meghna Gupta

@meghnag27.bsky.social

780 followers 490 following 9 posts

www.mguptalab.com

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Meghna Gupta @meghnag27.bsky.social · May 27

Our latest preprint on peroxisomal fatty-acid transport is live!!

@ohsunews.bsky.social #OHSU @uofcalifornia.bsky.social #UCSF

bioRxivpreprint @biorxivpreprint.bsky.social · May 27

Molecular mechanism of substrate transport by human peroxisomal ABCD3 https://www.biorxiv.org/content/10.1101/2025.05.21.655323v1

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Meghna Gupta @meghnag27.bsky.social · 2d

To the incredible organizers, enthusiastic participants, and sponsors: thank you for creating this space and fostering such a vibrant community!
#cryoEM #wemconference2025 @ohsunews.bsky.social

er-c.org/index.php/co...

Meghna Gupta @meghnag27.bsky.social · 2d

Events celebrating women in electron microscopy are rare, which made my recent experience at the Ernst Ruska-Centre (ER-C), Forschungszentrum Jülich, Germany, truly special. I had the privilege of not only attending but also serving as a young keynote speaker at this inspiring gathering. 🎉

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Reposted by Meghna Gupta

Kara McKinley @karalmckinley.bsky.social · 6d

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

Çağrı Çevrim @cagricevrim.bsky.social · 6d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

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Shanti Gangwar @shantigangwar.bsky.social · Aug 22

Curious to know how does auxiliary subunit Neto2 modulate kainate receptor (KAR) function? Read our latest study describing GluK2-Neto2 complex-captured in both its activated and true apo states.

www.nature.com/articles/s41...

Activation of kainate receptor GluK2–Neto2 complex - Nature Structural & Molecular Biology

Gangwar et al. present cryo-electron microscopy structures of GluK2 kainate receptors with auxiliary subunit Neto2 and reveal the basis of receptor activation.

www.nature.com

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Reposted by Meghna Gupta

Laura Seeholzer @lauraseeholzer.bsky.social · Sep 15

I'm excited to share that I've started my lab @stanford.edu in the Neurobiology Department! neurobiology.stanford.edu/who-we-are/f...

#stanford #newPI #neuroscience

Faculty

neurobiology.stanford.edu

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Reposted by Meghna Gupta

André Nadler @nadlerlab.bsky.social · Aug 21

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

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Reposted by Meghna Gupta

Oli Clarke @olibclarke.bsky.social · Aug 30

Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️

Upper - cryo-EM reconstruction of stomatin AQP1 complex. Lower - reconstruction of stomatin-UT-B complex.

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Meghna Gupta @meghnag27.bsky.social · Aug 30

Thrilled to be heading to Spain next week to speak at the EMBO Workshop on Peroxisomes! 🧫🔬👩‍🔬

Looking forward to sharing our latest research and learning from incredible scientists working on these fascinating organelles.
#peroxisomes #EMBOmeeting #cellbiology
meetings.embo.org/event/25-per...

Reposted by Meghna Gupta

Bronwyn Lucas @bronwynalucas.bsky.social · Aug 30

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

Leopard-EM: An extensible 2DTM package to accelerate in situ structural biology

The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...

www.biorxiv.org

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Reposted by Meghna Gupta

Christina Fitzsimmons @fitzsimmonscm.bsky.social · Aug 25

Excited to announce the opening of the @fitzsimmonslab.bsky.social at @michiganstateu.bsky.social dept. of biochemistry & molecular biology! (1/3)

A photo of a newly renovated science lab with metal cabinets and tile floors. Select pieces of equipment such as test tube racks and chairs are visible.

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Reposted by Meghna Gupta

OHSU Brain Institute @ohsubrain.bsky.social · Aug 13

@ohsunews.bsky.social neuroscientist Dr. Eric Gouaux has earned a rare distinction as a two-time recipient of the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke! news.ohsu.edu/2025/06/23/o...

An individual in a blue shirt and sweatshirt stands in front of a machine with the words "Titan Krios" on the side.

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Reposted by Meghna Gupta

tafesselab.bsky.social @tafesselab.bsky.social · Aug 12

Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.

Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.

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Reposted by Meghna Gupta

OHSU Brain Institute @ohsubrain.bsky.social · Aug 11

Take charge of your #brain health!

Join us for a community conference on brain health, #aging and Alzheimer's science. Each event features Alzheimer's and dementia resources in Oregon and Southwest Washington.

Learn more and find an event near you: bit.ly/brainhealth25

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Reposted by Meghna Gupta

Kimberly Beatty @beattylab.bsky.social · Aug 5

Registration for the 2025 Chemical Biology and Physiology meeting is open! This biennial symposium features the latest and most impactful work in chemical biology. Dec. 11-13 2025 in Portland, Oregon (USA). Register here: www.ohsu.edu/school-of-me...
Pls share

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Reposted by Meghna Gupta

Debnath Ghosal @debnathghosal.bsky.social · Aug 2

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬

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OHSU Knight Cancer Institute @ohsuknight.bsky.social · Jul 25

Congratulations to Dr. Shivaani Kummar on being honored with the prestigious 2024 National Cancer Institute Director’s Award!

The award is one of the NCI’s highest accolades and is bestowed upon those who demonstrate excellence, innovation, and commitment throughout their organization.

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Reposted by Meghna Gupta

bioRxivpreprint @biorxivpreprint.bsky.social · Jul 24

DNA Methylation Ageing Atlas Across 17 Human Tissues https://www.biorxiv.org/content/10.1101/2025.07.21.665830v1

Reposted by Meghna Gupta

Kimberly Beatty @beattylab.bsky.social · Jul 21

Thank you to the organizers for inviting me to speak at the 2025 FASEB: Optical Probes meeting. Stunning desert location. #OPTSRC

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Reposted by Meghna Gupta

Nitesh Khandelwal @nkhandelwal.bsky.social · Jul 20

Check out our new study revealing how yeast cells regulate oxidative stress.

cryoEM papers @cryoempapers.bsky.social · Jul 19

Structural Basis for Oxidized Glutathione Recognition by Yeast Cadmium Factor 1 pubmed.ncbi.nlm.nih.gov/40679299/ #cryoem

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Hiten Madhani @hitenmadhani.bsky.social · Jul 12

Bill Rutter passed away at age 97 yesterday. He chaired our Department through the 1970s and was instrumental in the development of UCSF basic science. He hired Christine Guthrie, Keith Yamamoto, Bruce Alberts, Marc Kirschner, Pat O’Farrell, Peter Walter, Ira Herskowitz among others.

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Meghna Gupta @meghnag27.bsky.social · Jul 3

Congratulations!! 🎉🎊

Reposted by Meghna Gupta

Alexey Amunts @amunts.bsky.social · Jun 30

Excited to contribute to the Mitoribosome collaborative study led by @wredenberglab.bsky.social in @natcomms.nature.com🎉 "The mitochondrial methylation potential gates mitoribosome assembly"
The assembly starts before the completion of the rRNA gene cluster processing🧵
www.nature.com/articles/s41...

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Reposted by Meghna Gupta

Misha Kudryashev @mishakudryashev.bsky.social · Jun 8

We have a preprint for you

EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer

By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...

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tafesselab.bsky.social @tafesselab.bsky.social · Jun 4

Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social

www.biorxiv.org/content/10.1...

Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection

The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanis...

www.biorxiv.org

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Del Mármol lab @delmarmollab.bsky.social · Jun 3

New preprint in the lab combining what we like best: insects, love, chemistry and the olfactory system! 1/8
www.biorxiv.org/content/10.1...

A covalent recognition strategy enables conspecific mate identification

The olfactory system can detect an uncountable number of volatile molecules while retaining the ability to discriminate amongst very similar ones. We identified a unique mechanism employed by insect o...

www.biorxiv.org

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