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Reposted by Nitesh Khandelwal

Meghna Gupta @meghnag27.bsky.social · 2d

Events celebrating women in electron microscopy are rare, which made my recent experience at the Ernst Ruska-Centre (ER-C), Forschungszentrum Jülich, Germany, truly special. I had the privilege of not only attending but also serving as a young keynote speaker at this inspiring gathering. 🎉

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Shanti Gangwar @shantigangwar.bsky.social · Aug 22

Curious to know how does auxiliary subunit Neto2 modulate kainate receptor (KAR) function? Read our latest study describing GluK2-Neto2 complex-captured in both its activated and true apo states.

www.nature.com/articles/s41...

Activation of kainate receptor GluK2–Neto2 complex - Nature Structural & Molecular Biology

Gangwar et al. present cryo-electron microscopy structures of GluK2 kainate receptors with auxiliary subunit Neto2 and reveal the basis of receptor activation.

www.nature.com

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Nitesh Khandelwal @nkhandelwal.bsky.social · Jul 20

Check out our new study revealing how yeast cells regulate oxidative stress.

cryoEM papers @cryoempapers.bsky.social · Jul 19

Structural Basis for Oxidized Glutathione Recognition by Yeast Cadmium Factor 1 pubmed.ncbi.nlm.nih.gov/40679299/ #cryoem

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Nitesh Khandelwal @nkhandelwal.bsky.social · Jul 3

Could you add me please?

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Meghna Gupta @meghnag27.bsky.social · May 27

Our latest preprint on peroxisomal fatty-acid transport is live!!

@ohsunews.bsky.social #OHSU @uofcalifornia.bsky.social #UCSF

bioRxivpreprint @biorxivpreprint.bsky.social · May 27

Molecular mechanism of substrate transport by human peroxisomal ABCD3 https://www.biorxiv.org/content/10.1101/2025.05.21.655323v1

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Meghna Gupta @meghnag27.bsky.social · May 27

Congratulations to all the co-authors-
🙌 🎉 🥳
@nkhandelwal.bsky.social, Devin J Seka, Sree G Balasubramani, Miles S Dickinson, Alexander Myasnikov, @igech.bsky.social, Robert M Stroud.

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Nitesh Khandelwal @nkhandelwal.bsky.social · Apr 26

Congratulations to you and your team.

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Cornelius Gati @gati.bsky.social · Apr 23

I'm excited to share our lab's newest publication on the structure and pharmacology of human GABA transporter 3 @natcomms.nature.com. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. 💊 🧪 #CryoEM #OpenAccess rdcu.be/ei2KY

Molecular basis of human GABA transporter 3 inhibition

Nature Communications - GABA transporters maintain GABA homeostasis and regulate synaptic signaling. Here, the authors determined the cryoEM structures of GABA transporter 3 (GAT3) in its apo form...

urldefense.com

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Lorenz Lamm @lorenzlamm.bsky.social · Apr 25

🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo

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Krista Freeman @kfreeman.bsky.social · Apr 16

Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection.

www.sciencedirect.com/science/arti...

Structure and infection dynamics of mycobacteriophage Bxb1

Mycobacteriophage Bxb1 is a well-characterized virus of Mycobacterium smegmatis with double-stranded DNA and a long, flexible tail. Mycobacteriophages…

www.sciencedirect.com

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Structura Biotechnology @structurabio.bsky.social · Apr 9

#CryoSPARC v4.7 is out! 🚀
Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more!
Full changelog: cryosparc.com/updates

#cryoEM

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Nitesh Khandelwal @nkhandelwal.bsky.social · Apr 3

@naturecomms.bsky.social @ucsfhealth.bsky.social @ohsunews.bsky.social @broadinstitute.org

Nitesh Khandelwal @nkhandelwal.bsky.social · Apr 3

Congratulations to all the co-authors- @meghnag27.bsky.social, Jim Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Eng, Tomohiko Kawate, Sree Ganesh Balasubramani, Andrej Sali, Deborah Hung, Robert M Stroud

Huge thanks to the funding agencies !
The National Institutes of Health

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Nitesh Khandelwal @nkhandelwal.bsky.social · Apr 3

Our paper on " Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A" is published in Nature Communications 🥂 🎊

www.nature.com/articles/s41...

Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A - Nature Communications

A chemical genetic screen identified inhibitors of an essential transporter from Mycobacterium tuberculosis. Here authors determine atomic structures of EfpA that indicate that it is a lipid transport...

www.nature.com

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Nitesh Khandelwal @nkhandelwal.bsky.social · Mar 27

You are welcome.
Good luck with your job hunt. Indeed it’s a tough year.

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Wooyoung Choi @wooyoungchoi.bsky.social · Mar 2

I am super excited to share that my work at @yifan_ucsf has just been published in Nature🎉 From developing pYC KI system, it was a long journey to understand endogenous protein dynamics. I appreciate the support from FASN team! 🕺Let's dive into the endogenous & dynamic protein world🏊🏄🚣

Nature @nature.com.web.brid.gy · Feb 21

Structural dynamics of human fatty acid synthase in the condensing cycle

Nature, Published online: 20 February 2025; doi:10.1038/s41586-025-08782-w Structural dynamics of human fatty acid synthase in the condensing cycle

www.nature.com

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Nitesh Khandelwal @nkhandelwal.bsky.social · Mar 22

Congratulations !!

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Cooty McCootFace @cootymccootface.bsky.social · Mar 17

Coot 1.1.14 has been released!

Coming to homebrew and flatpak soon!

- Clark & Labute comes to Coot 1, Moorhen & chapi!
(svg, 2D ligand environment view)
- Solid Symmetry (symmetry that you can see!)
- PAE plot for AlphaFold models
#coot
#molmatinf

Screenshot of 2d ligand environment view, 1x8b 4dfr, 2vtq, 2p4y

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ChimeraX @chimerax.ucsf.edu · Mar 17

ChimeraX can be used to find pockets and cavities in protein structures using the Find Cavities tool or kvfinder command. This feature is available in daily builds from 10 March 2025 or later.

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Reichow Lab @reichowlab.bsky.social · Feb 21

#NIHFundedDiscovery

How do cells avoid the "kiss of death"?

Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage.

#CryoEM reveals the molecular switches behind this process!

www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...

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Nitesh Khandelwal @nkhandelwal.bsky.social · Feb 21

In this article, we established how fiducial marker can be used for small membrane protein structure determination and impact of their position on the protein. We established how urate interacts with SLC2A9 transporter, and we provide the mechanistic details of disease-causing mutations.

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Nitesh Khandelwal @nkhandelwal.bsky.social · Feb 21

I am thankful to the wonderful team @meghnag27.bsky.social , Paras Kumar , Sree Ganesh Balasubramani, Ignacia Echeverria, and Robert M Stroud , whose contribution and help made it possible.
Huge thanks to the funding agencies The National Institutes of Health.

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Nitesh Khandelwal @nkhandelwal.bsky.social · Feb 21

I am happy to share my new publication in PNAS entitled “Structural basis of disease mutation and substrate recognition by the human SLC2A9 transporter” (www.pnas.org/doi/full/10....).

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Meghna Gupta @meghnag27.bsky.social · Feb 21

Our paper "Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica" is published in Science Advances today 🥂 🎊

tinyurl.com/MGuptaSA

Huge congratulations to the team- @nkhandelwal.bsky.social, Andrew Nelson, Peter Hwang, Sergei Pourmal, Jeffrey Bennett, ROBERT M STROUD!

Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica

Pathogenic autoantibodies in neuromyelitis optica bind three multiply presented loops on arrays of human aquaporin-4.

tinyurl.com

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