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shantigangwar.bsky.social
Shanti Gangwar
@shantigangwar.bsky.social
20 followers 32 following 1 posts
Cryo-EM, Ion Channels, iGluRs, Synapse, Columbia Univeristy
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olibclarke.bsky.social
Oli Clarke @olibclarke.bsky.social · Sep 13
This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x
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shantigangwar.bsky.social
Shanti Gangwar @shantigangwar.bsky.social · Aug 22
Curious to know how does auxiliary subunit Neto2 modulate kainate receptor (KAR) function? Read our latest study describing GluK2-Neto2 complex-captured in both its activated and true apo states.

www.nature.com/articles/s41...
Activation of kainate receptor GluK2–Neto2 complex - Nature Structural & Molecular Biology
Gangwar et al. present cryo-electron microscopy structures of GluK2 kainate receptors with auxiliary subunit Neto2 and reveal the basis of receptor activation.
www.nature.com
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