Lightnews — Scholar-powered news

Reposted by Fernán Agüero

Derek Lowe @dereklowe.bsky.social · 1d

Never assume that you know all about what any drug molecule is doing in the body - where it's going, what it's binding to. A new example:

Rapamycin's Secrets

www.science.org

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Galaxy Project @galaxyproject.bsky.social · 14h

An environment that integrates Jupyter with Galaxy, allowing tools to be added as notebook cells, and providing access to thousands of bioinformatics tools from within a notebook interface.
http://galaxyproject.org/news/2025-04-11-galaxy-to-notebook-g2nb/

##UseGalaxy ##GalaxyProject ##EOSC (1/2)

Genomics to Notebook (g2nb): extending the computational notebook

An environment that integrates Jupyter with Galaxy, allowing tools to be added as notebook cells, and providing access to thousands of bioinformatics tools from within a notebook interface.

galaxyproject.org

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Frances Separovic @francesbiophys.bsky.social · 1d

Maud Menten was born in Canada in 1879 and completed her UG and MD education at University of Toronto. As a research assistant with Leonor Michaelis in 1912, they wrote the classic paper describing the “Michaelis-Menten” model of enzyme kinetics.. #WomenInScience

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Yeast Journal @yeast-journal.bsky.social · 1d

The new issue of #Yeast is out ... with a surprise 😄! This issue marks the 40th anniversary of the creation of our journal, in 1985. To celebrate this achievement, we made a brand new cover with the most beautiful #Yeast front pages 😍

Happy birthday Yeast!!!

onlinelibrary.wiley.com/toc/10970061...

Happy 40th birthday Yeast: Yeast: Vol 42, No 8-10

Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.

onlinelibrary.wiley.com

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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 13h

🧩🔬 1965 → 2025: 60 years of allostery, a concept that transformed molecular biology.

Monod, Wyman & Changeux revealed how proteins regulate themselves—ushering in a new era of biochemistry and inspiring today’s therapeutic innovations.

Dive into the story 👉 www.pasteur.fr/en/research-...

Allostery: a revolution in molecular biology, in 1965

In 1965, the discovery of a mechanism known as allostery revolutionized our understanding of regulation in molecular biology. Sixty years on, we look back at a scientific and human journey that ushere...

www.pasteur.fr

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Richard McElreath 🐈‍⬛ @rmcelreath.bsky.social · 17h

This time of year in central EU, I am reminded that the root meaning of "sky" is cloud. The color of the sky is gray, the heavens unseen are blue, and space is a radioactive void. In March, the Sun may appear once more. Until then, we eat potatoes and dream.

sky(n.)

mid-13c. (c. 1200 as a surname), skie, sci, skei, "a cloud," from Old Norse sky "cloud," from Proto-Germanic *skeujam "cloud, cloud cover" (source also of Old English sceo (Middle English sceu) "the sky, the heavens," Old Saxon scio "cloud, region of the clouds, sky;" Old High German scuwo, Old English scua, Old Norse skuggi "shadow;" Gothic skuggwa "mirror"), from PIE root *(s)keu- "to cover, conceal."

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Richard Sever @richardsever.bsky.social · 13h

Chemists call for ban on generative AI for chemical structures: "serious errors could damag[e] the next generation of scientists"

As ever, the problem seems to be not AI but lazy application of it and lack of checks. Whether _that_ problem is solvable...

www.chemistryworld.com/news/the-che...

The chemistry community should ban drawing chemical structures with generative AI, chemists warn

AIs like Microsoft's Copilot, Google's Gemini and OpenAI's ChatGPT still make serious errors rendering structural formulae

www.chemistryworld.com

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Michael Eisen @mbeisen.bsky.social · 1d

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

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Chemical Biology Services @chembl.bsky.social · 23d

ChEMBL 36 is out!

chembl.blogspot.com/2025/09/chem...

ChEMBL 36 is out!

📊 Database Scale 🆕 New Data Sources Src_ID 72 – Chemical Probe data from Scientific Literature NLP and manual extraction from probe-r...

chembl.blogspot.com

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Marcin Czerwinski @czerwinsmarcin.bsky.social · 16h

Interesting review from Richard Cummings lab about N- and O-glycosylation of brain cell surface glycoproteins. Role in brain development and neuronal functions, spatial distribution, CDG. Must-read!
tinyurl.com/ybbnb4x6

#glycotime

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Gioele La Manno @gioelelamanno.bsky.social · 19h

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...

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Robert Aboukhalil @robert.bio · 7d

Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt

It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.

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STCmicrobeblog @stcmicrobeblog.bsky.social · 1d

#MicroSky "Who is Sali?"

well, for us in the lab, "Sali" has always been the moniker for the restriction enzyme 𝑺𝒂𝒍𝑰 (to remind us that it actually works better with a pinch of salt in the buffer)

from https://www.neb.com/en/products/r0138-sali?srsltid=AfmBOorof2CL0GhMMFfIlXwthq3mbPu0mXmS9ZFiB_P-F8qJdfgHyxem

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paris martineau @paris.nyc · 7d

after the 10th radioactive shrimp recall in 7 weeks, i decided to do some digging

little did i know it would lead me to an underreported industrial accident that may have released an airborne plume of radioactive debris over swaths of indonesia
www.consumerreports.org/health/food-...

What Is Really Going on With All This Radioactive Shrimp? - Consumer Reports

Here’s the latest on how shrimp and spices got contaminated with cesium-137, how the FDA has responded, and why consumers should not panic.

www.consumerreports.org

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Marcel Dickmanns | 🌿❄️🔬 @madic.bsky.social · 9d

You can get MSAs directly from AlphaFold DB now (alphafold.ebi.ac.uk). I also missed the FoldSeek implementation, which lets you search for structurally similar proteins direktly.

This saves some clicking around. Neat!

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Stephan Hacker @stephanhacker2.bsky.social · 9d

Amazing news that the 5th Virtual @chembiotalks.bsky.social attracted 450 participants from 50 countries.

If you are as excited as we are, already mark next year's date (29th of September, 2026) in your calendars and make sure to suggest your favorite speakers!

#ChemSky #ChemBio #DrugDiscovery

Virtual ChemBioTalks @chembiotalks.bsky.social · 9d

We are excited that the 5th Virtual #ChemBioTalks attracted 450 participants from 50 different countries world-wide. Thank you all for making this such an engaging event!

If you want to suggest speakers and keynotes for 2026, please do so by October 31st at [email protected]

#ChemBio #ChemSky

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Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 14d

Test the activity of 300+ natural enzymes against 100+ substrates, discover 200+ new enzymatic reactions, and train machine learning models to predict which enzymes can do which reactions.

@aepaton.bsky.social @gabegomes.bsky.social @alisonnarayan.bsky.social

www.nature.com/articles/s41...

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Michael Clarke @mtclarke.bsky.social · 14d

Yes, yes, Europe has its benefits. Walkable cities. Cultural heritage. Amazing food. Little gun violence. Healthcare. Governments that are not shut down. But the number of website pop-ups asking one to accept cookies renders the continent pretty much unlivable.

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Magdalena Skipper @magdalenaskipper.bsky.social · 15d

The obsession with economic output as a measure of human development puts sustainability on the back burner

Time to end the GDP mania

Our editorial inspired by a @nature.com paper that looks at how the world should really measure prosperity
🧪 #SGDs #doughnuteconomics
www.nature.com/articles/d41...

End GDP mania: how the world should really measure prosperity

The obsession with economic output as a measure of human development puts sustainability on the back burner. Researchers can now help to devise better indicators.

www.nature.com

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Kate Cavanaugh @katecavanaugh.bsky.social · 15d

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

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EMBL-EBI @ebi.embl.org · 15d

💊Did you know that ChEMBL @chembl.bsky.social isn’t just for bioactivity data?

It also curates open-access info on approved drugs and clinical candidates.

Explore why ChEMBL should be a go-to resource if you work in pharma, biotech & AI drug discovery.

📖 pubs.acs.org/doi/10.1021/...

#PharmSky

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Simon Dürr @simonduerr.eu · 15d

Cool work to design phospho-tyrosine binder by the Baker lab. They show it works but success rate is low (<0.1%) and binders are not super strong (>500nM, likely related to cost of desolvating the phosphate) .
www.biorxiv.org/content/10.1...

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EMBL-EBI @ebi.embl.org · 16d

There are millions of openly available microbial genomes, but searching them can be slow.

Until now 🥁

Introducing LexicMap, a new alignment tool that lets scientists search these data in minutes, helping track antibiotic resistance, trace outbreaks, and more.

www.ebi.ac.uk/about/news/r...
🦠

How to rapidly search the world’s microbial DNA

By making the world’s microbial DNA easier to explore, LexicMap helps researchers track outbreaks, study antibiotic resistance, and understand microbial diversity.

www.ebi.ac.uk

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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 19d

So for >30y, it was thought that #MAPK cascade in #fission #yeast lacked a scaffold ! Like in #animals, or #budding yeast.

Well this changes today !

All hail #Sms1

Congrats @borissieber.bsky.social @sophiemartinlab.bsky.social and Team !!

Boris Sieber @borissieber.bsky.social · 21d

Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!

Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1

doi.org/10.1101/2025...

Schematic of MAPK signalling in fission yeast, budding yeast and Metazoa. No MAPK scaffold was known for ERK-like MAPK in fission yeast, as opposed to budding yeast Ste5 and metazoan KSR1/2.

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Ghostly Bree @mostlybree.kitrocha.com · Sep 4

my stand mixer is older than most of gen z and I think about that A LOT every time something I bought in the last 5 years breaks after 6 months.

Dr. Damien P. Williams Wants A Better Sociotechnical Paradigm @wolvendamien.bsky.social · Sep 3

Reminder that things are in fact worse quality for more money, that no, Elder Gen Z/millennials/gen x, you're not imagining it, nor should you accept it as "the way things are."

Shirts I've had 30 fucking yrs are still wearable, but a shirt I've had 2 months & worn MAYBE twice is already unraveling

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