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Mart Krupovìč

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H-index: 81
Biology 41%
Environmental science 29%
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Reposted by Mart Krupovìč

archaeabio.bsky.social
Live cell imaging of Ca. Nha. antarcticus and Hrr. lacusprofundi using agarose pads. Protocol now live!
www.archaea.bio/protocols/li...
Live Cell Imaging of Ca. Nha. antarcticus and Hrr. lacusprofundi using agarose pads
This protocol is an adapted form of the protocol developed for imaging haloarchaea (Liao et al., 2021) and subsequently applied to co-cultures containing nanohaloarchaea and haloarchaea (Hamm et al., ...
www.archaea.bio
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Reposted by Mart Krupovìč

molbiolgv.bsky.social
The latest preprint from the lab is out!
Here we used structural clustering and immunoprecipitations to uncover some networks in our knowledge of giant virons proteomes. An interesting story by Hela Safi and @ambsch.bsky.social.
www.biorxiv.org/content/10.1...
Elucidating the interaction network of one of the largest icosahedral capsids in the virosphere
Giant viruses challenge traditional boundaries of virology with their large particle sizes, complex genomes, and unique replication strategies. Yet, despite its 750 nm diameter and incorporation of do...
www.biorxiv.org
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Reposted by Mart Krupovìč

vikramalva.bsky.social
Our Pyrodictium cannulae paper is out in its final form! Cannulae assemble into calcium-stabilized tubular filaments stable at 100 °C—a unique archaeal cell–cell connection. Led brilliantly by @mikesleutel.bsky.social & @vinceconticello.bsky.social.

www.nature.com/articles/s41467-025-64120-8
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Reposted by Mart Krupovìč

instruct-eric.bsky.social
We are delighted to be at the FINstruct meeting today in Helsinki - dedicated to the memory of Dennis Bamford

instruct-eric.org/news/in-memo... @helsinki.fi @oulu.fi
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Reposted by Mart Krupovìč

cryoclem.bsky.social
Our work on ribosome hibernation in archaea is out!
We identified Hib, a new hibernation factor broadly distributed across archaea.
Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1
(1/🧵)
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Reposted by Mart Krupovìč

drym.bsky.social
www.biorxiv.org/content/10.1...
A new family of ribosome hibernation factors in Archaea
Ribosome hibernation preserves translation machinery during stress, yet its mechanisms in Archaea remain poorly defined. Here we identify Hib, a previously unrecognized family of archaeal hibernation ...
www.biorxiv.org
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Reposted by Mart Krupovìč, Jesse M. Shapiro, Simon Roux

fredoleroux.bsky.social
Phages evolve fast, or do they?
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
Ecological constraints foster both extreme viral-host lineage stability and mobile element diversity in a marine community
Phages are typically viewed as very rapidly evolving biological entities. Little is known, however, about whether and how phages can establish long-term genetic stability. We addressed this eco-evolut...
www.biorxiv.org
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Reposted by Mart Krupovìč

carmensmp.bsky.social
Pleased to share our latest publication on #adenovirus structure: dx.plos.org/10.1371/jour...
Aviadenovirus structure: A highly thermostable capsid in the absence of stabilizing proteins
Author summary The International Committee for Virus Taxonomy currently recognizes over 120 adenovirus species, grouped in six genera, with host range covering all kinds of vertebrates. Although all a...
dx.plos.org
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Reposted by Mart Krupovìč

evelienadri.bsky.social
For those of you working on tailed #phages, this is the virus realm for you!
#Duplodnaviria #virus #taxonomy

The Profile in #JGenVirol provides the citable reference. More details in the chapter on the ICTV website: ictv.global/report/chapt...
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Reposted by Mart Krupovìč

kawatosatoshi.bsky.social
🚀 Released gbdraw v0.6.0!

- Added dinucleotide skew plotting to linear mode. Fixed the bug where only GC skew could be drawn.

- Added links to relevant sections of the documentation throughout the web app help menu.

Try out:👉 gbdraw.streamlit.app
A grid of 12 circular E. coli genome maps showing dinucleotide skew plots for GC, CG, AG, GA, CT, TC, TG, GT, CA, AC, AT, and TA. Each circle displays color-coded genome annotations (CDS, rRNA, tRNA, etc.) around the outer ring, with inner line plots showing positive and negative dinucleotide skew values. Below the grid, a linear representation of two E. coli genomes shows annotated tracks, GC content, and GC skew plots, with two genomes linked with ribbons representing BLASTN hits. Note that the lower track (pathogenic strain O157:H7 Sakai) has multiple prophage insertions (shaded with orange) that are absent from the upper track (the laboratory strain K-12). Further below are five linear genome comparison diagrams of Hepatoplasmataceae mollicutes, each with colored gene annotations, GC content and GC skew plots, and gray ribbons indicating TBLASTX hits across genomes.
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Reposted by Mart Krupovìč, Curtis A. Suttle

asherleeks.bsky.social
I gave a talk last year at TEDxNewEngland aimed at introducing the idea of viral sociality to a general audience, including implications for evolution & virology. Video now available online below.

#socialviruses #evosky #virosky 🧪
The social lives of viruses | Asher Leeks | TEDxNewEngland
YouTube video by TEDx Talks
www.youtube.com
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Reposted by Mart Krupovìč, Simon Roux

daumlab.bsky.social
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail
This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.
www.science.org
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Reposted by Mart Krupovìč, Jean-Yves Tinévez

thibautbrunet.bsky.social
Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
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Reposted by Mart Krupovìč

jinoceanvir.bsky.social
(1/9) Latest preprint from our lab at
@uwaterloo.ca conceived predominantly by our very talented #PhD #student Isaac Meza-Padilla:

www.biorxiv.org/content/10.1...
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Reposted by Mart Krupovìč

lucas.farnunglab.com
New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com
Protein Domain Designer tool for the generation of publication-ready protein domain diagrams
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Reposted by Mart Krupovìč

evgenii-protasov.bsky.social
“Paraxenoviridae”, a putative family of globally distributed marine bacteriophages with double-stranded RNA genomes
#viruses #bacteriophages #phages
@isme-microbes.bsky.social
academic.oup.com/ismej/articl...
“Paraxenoviridae”, a putative family of globally distributed marine bacteriophages with double-stranded RNA genomes
Abstract. Metatranscriptome sequencing dramatically expanded the known diversity of the global RNA virome and, in particular, suggested several new candida
academic.oup.com
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Reposted by Mart Krupovìč

steffffff.bsky.social
It is now on air.
Please look it up and join us!
Great science and wonderful venue👍🏻

www.isdv2026.com
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Reposted by Mart Krupovìč

mmarbout.bsky.social
You like phages ? In this publication, we use metaHiC and our new version of the MetaTOR pipeline to challenge the traditional view of phages with a narrow host range.
@rkoszul.bsky.social @natmicrobiol.nature.com @cnrs.fr @institutpasteur.bsky.social

www.nature.com/articles/s41...
Phages with a broad host range are common across ecosystems - Nature Microbiology
Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.
www.nature.com
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Reposted by Mart Krupovìč, Alan McNally

enningalab.bsky.social
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫

Thread coming soon!
biorxiv-microbiol.bsky.social
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 27d
Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1
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Reposted by Mart Krupovìč

archaellum.bsky.social
Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...

Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
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Reposted by Mart Krupovìč, Mya Breitbart

adi-gajigan.bsky.social
Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail
nature.com/articles/s41467-025-63463-6
Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail - Nature Communications
Rodrigues and Queiroz et al. report the discovery of Naiavirus, the largest enveloped virus, isolated from a Brazil biome. With an oval capsid and flexible tail, its giant genome holds many novel gene...
nature.com
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Reposted by Mart Krupovìč

Discovery of a novel double-stranded DNA virus associated with ant labial gland disease reveals its long-term interaction with ants journals.asm.org/doi/10.1128/...
Discovery of a novel double-stranded DNA virus associated with ant labial gland disease reveals its long-term interaction with ants | Journal of Virology
Ants, as highly eusocial insects, play vital roles in ecosystems worldwide. While numerous RNA viruses have been documented in ants, no double-stranded DNA (dsDNA) virus has previously been confirmed to infect them. Labial gland disease, reported for decades, lacks a clearly defined cause until now. Here, we identify and characterize a large filamentous dsDNA virus, Camponotus japonicus labial gland disease virus (CjLGDV), from the swollen labial gland of C. japonicus, and a closely related Anoplolepis gracilipes labial gland disease virus in A. gracilipes. Phylogenetic and genomic analyses of the two viruses support the establishment of a new viral family within the order Lefavirales, class Naldaviricetes. The discovery of endogenous viral elements related to CjLGDV in multiple ant genomes suggests the historical infection of CjLGDV-like viruses in ants. These findings broaden the known host range of naldaviricetes and shed new light on the diversity, evolution, and host interaction of large dsDNA viruses in arthropods.
journals.asm.org
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Reposted by Mart Krupovìč

garushyants.bsky.social
Sanasar has been digging into how bacterial defense systems shift under different phage attack modes – from long-term infections by similar phages to constantly changing phage assaults. Glad to be part of that story, out today
Evolution of antivirus defense in prokaryotes, depending on the environmental virus prevalence and virome dynamics | mBio
The virus-host arms race is a major component of the evolutionary process in all organisms that drove the evolution of a broad variety of immune mechanisms. In the last few years, over 200 distinct an...
journals.asm.org
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Reposted by Mart Krupovìč

fnobrega.bsky.social
Three new kids on the block. ARMADA, BRIGADE, and TALON. Impressive how multiple labs all come together to contribute to discovery. Great collaboration with Simon, Chase, and Eugene. From the very talented Ryan Bell, together with Thomas Gaudin and our own Yi Wu.

www.biorxiv.org/content/10.1...
YprA family helicases provide the missing link between diverse prokaryotic immune systems
Bacteria and archaea possess an enormous variety of antivirus immune systems that often share homologous proteins and domains, some of which contribute to diverse defense strategies. YprA family helic...
www.biorxiv.org
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Reposted by Mart Krupovìč

gerovac.bsky.social
No Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com
Programmable antisense oligomers for phage functional genomics - Nature
Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...
www.nature.com
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Reposted by Mart Krupovìč

evelienadri.bsky.social
Today, I'm excited to announce the publication of the Duplodnaviria realm Profile and Chapter.
The realm includes viruses of archaea, bacteria and eukaryotes and is best known for its inclusion of herpesviruses and tailed phages.

www.microbiologyresearch.org/content/jour...
ICTV Virus Taxonomy Profile: Duplodnaviria 2025
The realm Duplodnaviria includes viruses of archaea, bacteria and eukaryotes, with linear dsDNA genomes. Duplodnavirians share a distinct morphogenetic module of four hallmark genes encoding the HK97-...
www.microbiologyresearch.org
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Reposted by Mart Krupovìč

evelienadri.bsky.social
The ICTV Report chapters, which are linked to the profiles and get updated when the taxonomy changes, can be found on the ICTV website:
ictv.global/report
ICTV Report Chapters | ICTV
ictv.global
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Reposted by Mart Krupovìč, Alan McNally

evelienadri.bsky.social
We have expanded our ICTV Virus Taxonomy profiles and chapters to include higher ranks, which have been recently introduced and may not be familiar to all virologists.

You can find our 2-page Profiles (citable record) in JGV @microbiologysociety.org
www.microbiologyresearch.org/content/ictv...
ICTV Virus Taxonomy Profiles | Microbiology Society
Journal of General Virology ICTV Virus Taxonomy Profiles are a freely available series of concise, review-type articles that provide overviews of the classification, structure and properties of indivi...
www.microbiologyresearch.org
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Reposted by Mart Krupovìč, Nicole Dubilier

soreklab.bsky.social
Preprint: De-novo design of proteins that inhibit bacterial defenses

Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications

Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection
Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...
www.biorxiv.org
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by Mart Krupovìč

mkrupovic.bsky.social
Many interesting PhD projects, including ours. Consider applying!
pasteur.fr
Institut Pasteur | 130 years of biomedical research @pasteur.fr · Sep 1
🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry.

Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, [email protected], PPU-EID @upcite.bsky.social & more 🧬

Register now ✍️ www.pasteur.fr/en/education...
Pasteur-Paris University International Doctoral Programme, The call for enrollment of students in October 2026 will be open from September 1st to October 20th, 2025
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