Eric J. Topol

Eric Topol

@erictopol.bsky.social

A new world record for ultra rapid whole genome sequencing and interpretation for critically ill individuals less than 4hrs! www.nejm.org/doi/full/10....

Toward Same-Day Genome Sequencing in the Critical Care Setting | NEJM

Decisions about critical care are almost always made without access to genetic information. The authors report the application of a new method of DNA sequencing in infants in a neonatal intensive c...

www.nejm.org

1 18 87

by Eric J. Topol

Eric Topol

@erictopol.bsky.social

What does the naked mole rat’s extreme healthspan have to do with ongoing clinical trials?

open.substack.com/pub/erictopo...

A Long-Awaited Longevity Mystery Solved

Spotlighting an essential human biologic pathway targeted by drugs in clinical trials

open.substack.com

2 30 100

by Eric J. Topol

by Eric J. Topol — Reposted by Siegfried Hekimi

Eric Topol

@erictopol.bsky.social

New @nejm.org
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521

DB-OTO Gene Therapy for Inherited Deafness | NEJM

Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; children...

www.nejm.org

9 87 340

by Eric J. Topol — Reposted by John De Vos

Reposted by Eric J. Topol

by Eric J. Topol

Eric Topol

@erictopol.bsky.social

When 2 life science discoveries converge: solving a ~3 decade mystery of extraordinary longevity and healthspan + an essential cell danger sensor
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...

A Long-Awaited Longevity Mystery Solved

Spotlighting an essential human biologic pathway targeted by drugs in clinical trials

erictopol.substack.com

3 40 150

by Eric J. Topol — Reposted by John De Vos

by Eric J. Topol

Substack

A Long-Awaited Longevity Mystery Solved

Spotlighting an essential human biologic pathway targeted by drugs in clinical trials Spotlighting an essential human biologic pathway targeted by drugs in clinical trials

Reposts 0 3d

by Eric J. Topol

Eric Topol

@erictopol.bsky.social

What happens in England is unlikely to stay in England

6 17 130

by Eric J. Topol

by Eric J. Topol — Reposted by Robert M. Califf, Ruairidh Milne, Christina Pagel

Eric Topol

@erictopol.bsky.social

Waning immunity. A significant Covid wave in England. No new variant.
Thanks Prof Pagel for highlighting and contextualizing

16 230 500

Reposted by Eric J. Topol

by Eric J. Topol

Eric Topol

@erictopol.bsky.social

Reclaiming care of patients in the age of A.I.
"A.I. will not replace care, rather, it could help us rediscover it."
This week's @thelancet.com editorial
www.thelancet.com/journals/lan...

6 15 71

by Eric J. Topol

Eric Topol

@erictopol.bsky.social

Hormone replacement therapy helps restore immune function in menopausal women, reducing inflammaging and preserving monocyte function. open-access
onlinelibrary.wiley.com/doi/10.1111/...

Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...

11 73 280

by Eric J. Topol

by Eric J. Topol — Reposted by Brendan Nyhan

Eric Topol

@erictopol.bsky.social

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...

12 95 330

by Eric J. Topol — Reposted by Philippe Froguel, Demis Hassabis, John De Vos

by Eric J. Topol

A Long-Awaited Longevity Mystery Solved

References

Fields & subjects