#zdenekvrozina
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drinfosec.bsky.social
🚨🚨🚨🧵 by @ZdenekVrozina about "Presence of SARS-CoV-2 in fetal organs via intraamniotic infection"

"And the message is straightforward.
Vertical transmission is real,
and the virus can reach multiple fetal organs - even early in pregnancy..."

Full 21-tweet 🧵
threadreaderapp.com/thread/19919...
This new Nature Communications study is the most comprehensive look we’ve ever had at SARS-CoV-2 inside the human fetus. And the message is straightforward. Vertical transmission is real, and the virus can reach multiple fetal organs - even early in pregnancy
November 22, 2025 at 3:28 AM
thecovidinfoguy.bsky.social
By Zdenek Vrozina:

"A new preprint study shatters the idea that pediatric long COVID is just a mild or different version of the adult form.
It shows that children share the same core immune patterns - and, strikingly, some resemble those seen in chronic infections like HIV"
Alt text: A screenshot from Thread Reader shows the start of a thread by Zdenek Vrozina (@ZdenekVrozina), dated August 24. The text reads: “A new preprint study shatters the idea that pediatric long COVID is just a mild or different version of the adult form. It shows that children share the same core…” On the right side is a small photo of Zdenek wearing sunglasses. The Thread Reader logo is at the top, and a preview link is shown below the text.
November 29, 2025 at 4:56 AM
bassjobsen.mastodon.nl.ap.brid.gy
#zdenekvrozina on X wrote:

A new macaque study looked at how immune memory forms after infections with different SARS-CoV-2 variants.
The main pattern is familiar from other viruses -
immune imprinting tends to stay biased toward earlier variants, even after later infections.🧵 […]
Original post on mastodon.nl
mastodon.nl
February 13, 2026 at 11:24 PM
bassjobsen.mastodon.nl.ap.brid.gy
#zdenekvrozina on X wrote:

New preprint from Harvard & Massachusetts General Hospital -children with Long COVID show markedly increased levels of fibrinaloid microclots in their blood!
The highest levels appear in those with persistent SARS-CoV-2 spike protein in circulation🧵 […]
Original post on mastodon.nl
mastodon.nl
October 11, 2025 at 10:19 PM
bassjobsen.mastodon.nl.ap.brid.gy
#zdenekvrozina on X wrote:

For years, Epstein–Barr virus (EBV) has been linked to multiple sclerosis.
The association was strong.
But the mechanism remained frustratingly abstract - until now.🧵https://threadreaderapp.com/thread/2011400614430007578.html
Thread by @ZdenekVrozina on Thread Reader App
@ZdenekVrozina: For years, Epstein–Barr virus (EBV) has been linked to multiple sclerosis. The association was strong. But the mechanism remained frustratingly abstract - until now.🧵 This new paper in Cell (2026) fi...…
threadreaderapp.com
January 15, 2026 at 11:04 PM
waimiriatroari.bsky.social
via @ZdenekVrozina
COVID can damage memory - even months after recovery.
Not just any memory: the precision of memory, tied to the hippocampus.
A new study shows that it doesn’t recover over time!
It actually gets worse.
A short thread on the hippocampus, neurogenesis and a virus that lingers
June 21, 2025 at 7:09 PM
bassjobsen.mastodon.nl.ap.brid.gy
#zdenekvrozina on X wrote:

This is the strongest evidence yet that ignoring the chronic impacts of COVID in children carries population-level consequences.
A massive Lancet Infect Dis study of >465,000 kids shows:
Reinfections double the risk of long COVID.🧵 […]
Original post on mastodon.nl
mastodon.nl
October 1, 2025 at 10:17 PM
drinfosec.bsky.social
🚨🧵by @ZdenekVrozina by on Twitter about #LongCovid & viral persistence:

"A new study detected a peptide fragment specific to SARS-CoV-2 nsp3 in blood extracellular vesicles (EVs) from Long COVID patients - months to years after infection."

Full thread here:
threadreaderapp.com/thread/19550...
Long COVID & viral persistence - new evidence A new study detected a peptide fragment specific to SARS-CoV-2 nsp3 in blood extracellular vesicles (EVs) from Long COVID patients - months to years after infection. Let’s unpack why this matters.🧵
August 12, 2025 at 8:32 PM
bassjobsen.mastodon.nl.ap.brid.gy
#zdenekvrozina on X wrote:

A new study in The Lancet Child & Adolescent Health followed nearly 14 million children in England.
It shows that SARS-CoV-2 infection leaves long-term marks on the vascular and immune system - even in kids.
Not just for weeks, but measurable up to a year later

🧵 […]
Original post on mastodon.nl
mastodon.nl
November 6, 2025 at 11:34 PM
bassjobsen.mastodon.nl.ap.brid.gy
#zdenekvrozina on X wrote: A new important study in Frontiers in Immunology shows that repeated SARS-CoV-2 infections are beginning to display the same patterns seen in chronic viral infections - narrowing of the T-cell repertoire, exhaustion, and loss of immune flexibility (!)🧵 […]
Original post on mastodon.nl
mastodon.nl
October 26, 2025 at 11:25 PM
drinfosec.bsky.social
🚨🧵 by @ZdenekVrozina about Covid's impact on "endothelial progenitor cells - the special cells that normally repair blood vessels after injury..."

"COVID-19 doesn’t just cause inflammation.
It switches off the genes that repair blood vessels - and..."

Full 🧵
threadreaderapp.com/thread/19777...
COVID-19 doesn’t just cause inflammation. It switches off the genes that repair blood vessels - and switches on those that drive inflammation and destruction. And what’s worse - this state lasts for at least six months, long after the infection is gone🧵
October 14, 2025 at 12:37 PM
paulginva.bsky.social
The news here is uniformly disturbing, especially these parts:
• The brain gets sick - even when standard scans look “normal.”
• It’s not just the brain - the body’s autopilot system begins to fail.
• The immune system may start attacking the nervous system itself.
Read the 🧵

x.com/ZdenekVrozin...
Zdenek Vrozina @ZdenekVrozina A major new review from Yale (Moen, Baker, Iwasaki, 2025) offers the most comprehensive picture yet of what SARS-CoV-2 does to the nervous system. The conclusion is stark: Long COVID is a chronic neuroimmune disorder affecting brain, spinal cord, and peripheral nerves. 2:02 PM Jun 19, 2025 317.7K Views
June 21, 2025 at 1:14 PM
drinfosec.bsky.social
🚨🧵 by @ZdenekVrozina on Twitter about post-Covid dysregulated B cell, CD4+ T cell, and treg compartments

"This sustained adaptive immune deficit may represent a important mechanism underlying Long COVID, resembling immunological patterns seen in chronic..."

🧵
threadreaderapp.com/thread/19762...
7-12% of patients recovering from moderate to severe COVID-19 show persistently low counts of B cells, CD4 T cells, and Tregs, even after clinical recovery.🧵 Followed by screenshot of this post: https://x.com/BagaiDr/status/1976253010893287877
October 10, 2025 at 2:10 PM
drinfosec.bsky.social
Interesting🧵by @ZdenekVrozina by on Twitter:

"A short thread on Tat, viroporins, ORF8, and viral neuropathogenesis
[...]
SARS-CoV-2 is not HIV. But some of its proteins - like viroporin E, ORF8, and spike - exhibit functional similarities to Tat, Nef, and gp120."
threadreaderapp.com/thread/19346...
What connects HIV and SARS-CoV-2 in the brain? Not structural homology - but functional parallels between viral proteins that can drive chronic neuroinflammation and immune evasion. A short thread on Tat, viroporins, ORF8, and viral neuropathogenesis. @dbdugger 🧵 COVID-19 (Long COVID) is associated with: microglial activation blood-brain barrier (BBB) disruption persistent viral antigens memory and attention deficits These are also key features of HIV-associated neurocognitive disorder (HAND). What’s the link? In HIV, the Tat protein is central to neuropathology: secreted from infected cells crosses the BBB activates microglia via TLR4 triggers IL-6, TNFa, ROS promotes excitotoxicity in neurons Tat = neurotoxic transcriptional regulator. SARS-CoV-2 doesn’t have Tat. But several of its proteins show comparable effects on inflammatory and neuroimmune pathways, especially: viroporin E (inflammasome activation) ORF8 (MHC-I downregulation) Spike S1 (BBB disruption, NRP1 binding) Viroporin E: small transmembrane viral protein forms ion channels ! activates NLRP3 inflammasome via K+ efflux leads to IL-1β release, pyroptosis Functionally similar to HIV Tat, which induces calcium influx, oxidative stress and inflammation. (Popa et al. 2025) The Molecular Mechanisms of Cognitive Dysfunction in Long COVID: A Narrative Review Cognitive dysfunction represents one of the most persistent and disabling features of Long COVID, yet its molecular underpinnings remain incompletely understood. This narrative review synthesizes curr… https://www.mdpi.com/1422-0067/26/11/5102 Virology 2022. Demonstrates that SARS‑CoV‑2 viroporins (E and ORF3a) directly activate the NLRP3 inflammasome. SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway - PubMed Heightened inflammatory response is a prominent feature of severe COVID-19 disease. We report that the SARS-CoV-2 ORF3a viroporin activates the NLRP3 inflammasome, the most promiscuous of known inflam… https://pubme…
June 16, 2025 at 8:41 PM
bassjobsen.mastodon.nl.ap.brid.gy
#zdenekvrozina on X wrote:

Since 2022, we’ve seen a sharp rise in most types of cancer among working-age adults in England.
The data don’t yet tell us why - but the trend is clear. If confirmed, this could turn out to be one of the most serious public health failures in modern history.

🧵 […]
Original post on mastodon.nl
mastodon.nl
October 6, 2025 at 10:35 PM
drinfosec.bsky.social
🚨🧵 by @ZdenekVrozina on Twitter, about Covid's impact on nerve-muscle comms

"Your nerves remember COVID.
A new study shows the virus can leave a measurable scar in your muscles - electrical, structural, and lasting for over a year..."

Full 🧵
threadreaderapp.com/thread/19756...
Your nerves remember COVID. A new study shows the virus can leave a measurable scar in your muscles - electrical, structural, and lasting for over a year.🧵
October 10, 2025 at 2:52 AM
hanfdampf.bsky.social
nicht nur in Deutschland, der hier geht an die tschechische Regierung
Zdenek Vrozina @ZdenekVrozina 17 Std. It’s almost absurd how public health keeps juggling flu statistics while ignoring the far more profound social impacts of SARS-CoV-2 - which has, in the meantime, fundamentally reshaped how often people get sick and how societies function. @JakubHlavka
October 11, 2025 at 2:58 PM
drinfosec.bsky.social
🚨🧵 by @ZdenekVrozina on Twitter, about Covid's oncogenic potential...

"Severe COVID-19 (or flu) may leave a hidden scar in the lungs - one that quietly fuels lung cancer growth.

A new preprint - Qian et al., 2025 - shows the first direct evidence of..."

Full 🧵:
threadreaderapp.com/thread/19654...
Severe COVID-19 (or flu) may leave a hidden scar in the lungs - one that quietly fuels lung cancer growth. A new preprint - Qian et al., 2025 - shows the first direct evidence of this link. The key points🧵
September 10, 2025 at 3:07 AM
charitychicken.bsky.social
For the precious few zero COVID peeps out there, if you need a transfusion or transplant for some reason down the line, could this be an issue? We discussed this years ago with our poor testing protocols/record keeping and the dropping of protective measures.
threadreaderapp.com/thread/20197...
Screenshot from linked Thread reader site: By Zdenek Vrozina @ZdenekVrozina Feb 6 • 9 tweets • 2 min read • Read on X If normal population plasma truly carries more low-grade inflammation, this study hints at a fork in the road. Either we lower the bar and call it a new normal, or this is a hidden population burden that will surface later as comorbidities🧵 A new study on the cytokine IL-32 after COVID-19 points directly at this uncomfortable question. The authors analyzed nearly 1,000 healthy blood donors sampled before and during the pandemic, plus 212 hospitalized COVID-19 patients. The result is consistent - plasma collected after 2020 shows systematically higher IL-32 levels compared to pre-pandemic plasma. Importantly - this is seen even in people without severe COVID, the authors interpret it as a consequence of mass exposure to SARS-CoV-2, suggesting a persistent, low-grade inflammatory imprint at the population level. What this does not mean? No contamination, no acute inflammation or infectious risk, no loss of transfusion safety. What it does mean? The reference normal of plasma may have shifted since 2019, some cytokines (here IL-32) behave like long-term memory of immune activation, in simple words - plasma is no longer immunologically identical to the pre-pandemic era, even in clinically healthy people. A key detail. IL-32 is not a cytokine storm marker. It reflects chronic, silent inflammation/immune reprogramming. That’s exactly why this finding matters. The question isn’t whether this matters. If population baseline inflammation has shifted, this affects how we interpret biomarkers, controls, reference ranges, and biobank data going forward. Miano et al., Frontiers in Immunology, 2026. Association of SARS-CoV-2 infection with long-lasting increase in circulating IL-32 levels.
February 9, 2026 at 4:45 AM
drinfosec.bsky.social
Another 🚨🧵 by @ZdenekVrozina on Twitter, this time about pediatric #LongCovid...

Full thread:
threadreaderapp.com/thread/19594...

#Kids #Covid #LongCovid
A new preprint study shatters the idea that pediatric long COVID is just a mild or different version of the adult form. It shows that children share the same core immune patterns - and, strikingly, some resemble those seen in chronic infections like HIV.🧵
August 25, 2025 at 1:41 AM
njbbari3.bsky.social
There are many things that can kill your brain cells… infections… multiply exponentially.

So it’s nothing like taking a sip of alcohol.
Zdenek Vrozina & @ZdenekVrozina X.com A new preprint study shows that the SARS-CoV-2 protein ORF6 directly kills human neurons. Not by accident, but through necroptosis - a kind of cell death where neurons burst and fuel inflammation. This may underlie the long-term brain symptoms of Long COVID.:
September 10, 2025 at 9:48 PM
bassjobsen.mastodon.nl.ap.brid.gy
#zdenekvrozina on X wrote:

New mega–meta-analysis on #LongCovid ever prevalence.
Long COVID has affected 36% of people after a COVID-19 infection worldwide.
South America: 51%
Europe: 39%
Asia: 35%
USA: 29%🧵

https://threadreaderapp.com/thread/1967157631262593066.html
September 14, 2025 at 10:25 PM
bassjobsen.mastodon.nl.ap.brid.gy
#zdenekvrozina on X wrote:

Children after mild or ordinary COVID-19 show measurable brain changes. Some improve, others persist.
This is a peer-reviewed MRI study in Brain and Behavior, 2025.
MRI data in children are still scarce - every study counts.🧵 […]
Original post on mastodon.nl
mastodon.nl
September 23, 2025 at 10:22 PM
drinfosec.bsky.social
🚨🧵 by @ZdenekVrozina (from Nov 28) on Covid's impact on the brain...

"SARS-CoV-2 causes long-lasting structural changes in the brain - even in people without symptoms.
Recovered ≠ normal. In this study, every single recovered participant..."

21-tweet 🧵
threadreaderapp.com/thread/19944...
SARS-CoV-2 causes long-lasting structural changes in the brain - even in people without symptoms. Recovered ≠ normal. In this study, every single recovered participant still showed measurable abnormalities. And this is 6-12 months after infection🧵
December 6, 2025 at 11:13 PM
bassjobsen.mastodon.nl.ap.brid.gy
#zdenekvrozina on X wrote:

New study: Omicron ≠ harmless for kids
We often hear - Omicron is just a mild flu, harmless for children.
A new study in Pediatric Neurology shows otherwise - even mild infections can leave measurable marks on the brain and cognition.

🧵 […]
Original post on mastodon.nl
mastodon.nl
September 6, 2025 at 10:07 PM