Proud to share our new preprint on improving DNA-damaging cancer therapies through minor spliceosome inhibition. Treatments must be not only effective, but kinder. Grateful for the support. 🤍 www.biorxiv.org/content/10.6...
#minorspliceosome #breastcancer #prostatecancer #U6atac #RNAsplicing
#minorspliceosome #breastcancer #prostatecancer #U6atac #RNAsplicing
December 14, 2025 at 6:25 PM
Proud to share our new preprint on improving DNA-damaging cancer therapies through minor spliceosome inhibition. Treatments must be not only effective, but kinder. Grateful for the support. 🤍 www.biorxiv.org/content/10.6...
#minorspliceosome #breastcancer #prostatecancer #U6atac #RNAsplicing
#minorspliceosome #breastcancer #prostatecancer #U6atac #RNAsplicing
Our new preprint on the limitations of PolyA+ selection vs rRNA-depleted RNA-seq, especially its effects on analysis of splicing and expression of long transcripts (and on findings of diseases linked to these transcripts), is now out: doi.org/10.21203/rs.... #RNAseq #RNASplicing #Bioinformatics
Poly(A) selection limits detection of long and alternatively spliced transcripts compared with rRNA depletion in RNA-Sequencing
The eukaryotic transcriptome diversity arises largely from alternative splicing. One of the widely used high-throughput methods to study this diversity is RNA sequencing. RNA sequencing has become a c...
doi.org
December 11, 2025 at 7:44 AM
Our new preprint on the limitations of PolyA+ selection vs rRNA-depleted RNA-seq, especially its effects on analysis of splicing and expression of long transcripts (and on findings of diseases linked to these transcripts), is now out: doi.org/10.21203/rs.... #RNAseq #RNASplicing #Bioinformatics
🌟...let's meet the next #earlycareerresearcher #ECR #postdoc with a big heart for functional genomics 🧬
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
December 10, 2025 at 9:38 AM
🌟...let's meet the next #earlycareerresearcher #ECR #postdoc with a big heart for functional genomics 🧬
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
🥁 ... Dr RICARDO DE PAOLI-ISEPPI from @unimelb.bsky.social #UniMelb will tell us how he uses #longreadsequencing to understand #RNAsplicing.
Our new preprint on the limitations of PolyA+ selection vs rRNA-depleted RNA-seq, especially its effects on splicing and the expression of long transcripts (and diseases linked to them), is now out: doi.org/10.21203/rs....
#RNAseq #RNASplicing #Bioinformatics
#RNAseq #RNASplicing #Bioinformatics
December 9, 2025 at 11:33 AM
Our new preprint on the limitations of PolyA+ selection vs rRNA-depleted RNA-seq, especially its effects on splicing and the expression of long transcripts (and diseases linked to them), is now out: doi.org/10.21203/rs....
#RNAseq #RNASplicing #Bioinformatics
#RNAseq #RNASplicing #Bioinformatics
Long-read RNA-seq demarcates cis- and trans-directed alternative RNA splicing. #LongRead #RNAseq #Sequencing #RNAsplicing @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 2, 2025 at 10:15 AM
Long-read RNA-seq demarcates cis- and trans-directed alternative RNA splicing. #LongRead #RNAseq #Sequencing #RNAsplicing @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I am happy to share our latest work now posted on @biorxiv-neursci.bsky.social
We report that the #AMPK related kinase #NUAK1 teams up with splicing co-factor SON to regulate #RNAsplicing in developing cortical neurons, supporting axon growth and branching
www.biorxiv.org/content/10.1...
We report that the #AMPK related kinase #NUAK1 teams up with splicing co-factor SON to regulate #RNAsplicing in developing cortical neurons, supporting axon growth and branching
www.biorxiv.org/content/10.1...
The AMPK-related kinase NUAK1 regulates neuronal morphogenesis through the RNA splicing co-factor SON
In recent years, alternative splicing emerged as a major mechanism controlling gene-regulatory networks during brain development, yet how alternative splicing is tuned to the dynamic alterations under...
www.biorxiv.org
October 18, 2025 at 10:36 AM
I am happy to share our latest work now posted on @biorxiv-neursci.bsky.social
We report that the #AMPK related kinase #NUAK1 teams up with splicing co-factor SON to regulate #RNAsplicing in developing cortical neurons, supporting axon growth and branching
www.biorxiv.org/content/10.1...
We report that the #AMPK related kinase #NUAK1 teams up with splicing co-factor SON to regulate #RNAsplicing in developing cortical neurons, supporting axon growth and branching
www.biorxiv.org/content/10.1...
🧬 New in NARMME: RNA splicing tweaks rescue tau toxicity in C. elegans. Modifying tri-snRNP proteins rescues tau-induced deficits in transgenic C. elegans, restoring behaviour, neurodegeneration and extending lifespan.
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
October 16, 2025 at 3:41 PM
🧬 New in NARMME: RNA splicing tweaks rescue tau toxicity in C. elegans. Modifying tri-snRNP proteins rescues tau-induced deficits in transgenic C. elegans, restoring behaviour, neurodegeneration and extending lifespan.
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration
Thank you to the ADAPTAML lab for these incredible years of science, support, and growth! Feeling grateful for everything I’ve learned and excited for what’s next 💫
#PhDDefense #leukemia #RNAsplicing
#PhDDefense #leukemia #RNAsplicing
Congratulations @margauxoberling.bsky.social on your successful PhD defense 🤩! We wish you the best and can't wait to see what you will do next👩🔬!
#leukemia #therapeuticresistance #RNAsplicing
#leukemia #therapeuticresistance #RNAsplicing
October 12, 2025 at 4:18 PM
Thank you to the ADAPTAML lab for these incredible years of science, support, and growth! Feeling grateful for everything I’ve learned and excited for what’s next 💫
#PhDDefense #leukemia #RNAsplicing
#PhDDefense #leukemia #RNAsplicing
Congratulations @margauxoberling.bsky.social on your successful PhD defense 🤩! We wish you the best and can't wait to see what you will do next👩🔬!
#leukemia #therapeuticresistance #RNAsplicing
#leukemia #therapeuticresistance #RNAsplicing
October 10, 2025 at 7:45 AM
Congratulations @margauxoberling.bsky.social on your successful PhD defense 🤩! We wish you the best and can't wait to see what you will do next👩🔬!
#leukemia #therapeuticresistance #RNAsplicing
#leukemia #therapeuticresistance #RNAsplicing
🚨New @biorxivpreprint: We model the splicing factor disease Verheij syndrome using C. elegans. Disruption of methionine and phospholipid metabolism drives growth defects; vitamin #B12 restores metabolic balance and rescues development! #metabolism #Celegans #RNAsplicing
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Vitamin B12 alleviates Verheij syndrome-like defects via phospholipid remodeling in a C. elegans PUF60 spliceosomopathy model
Verheij syndrome (VRJS) is a rare genetic disorder caused by mutations in the poly(U)-binding splicing factor 60 (PUF60), a core component of the spliceosomal complex. VRJS triggers multiple congenita...
doi.org
October 8, 2025 at 2:14 PM
🚨New @biorxivpreprint: We model the splicing factor disease Verheij syndrome using C. elegans. Disruption of methionine and phospholipid metabolism drives growth defects; vitamin #B12 restores metabolic balance and rescues development! #metabolism #Celegans #RNAsplicing
doi.org/10.1101/2025...
doi.org/10.1101/2025...
See also @wojtekgalej.bsky.social and
tinyurl.com/3sfthabb
#MinorSpliceosome #RNAsplicing #snRNP #U12Introns
tinyurl.com/3sfthabb
#MinorSpliceosome #RNAsplicing #snRNP #U12Introns
October 1, 2025 at 8:27 AM
September 16, 2025 at 11:37 AM
Explore how #RNAsplicing Cardiac Diseases are linked, reshaping gene expression and driving innovative therapies in modern medicine to save lives. @harvardmed.bsky.social
#Openaccess: tinyurl.com/22faf2ut
#Openaccess: tinyurl.com/22faf2ut
Alternative RNA Splicing in Cardiac Diseases
Explore how RNA Alternative splicing Cardiac Diseases are linked, reshaping gene expression and driving innovative therapies in modern medicine to save lives.
tinyurl.com
September 15, 2025 at 5:03 AM
Explore how #RNAsplicing Cardiac Diseases are linked, reshaping gene expression and driving innovative therapies in modern medicine to save lives. @harvardmed.bsky.social
#Openaccess: tinyurl.com/22faf2ut
#Openaccess: tinyurl.com/22faf2ut
CETN3 deficiency induces #microcephaly by disrupting neural stem/progenitor cell fate through impaired #CentrosomeAssembly and #RNAsplicing 👉 doi.org/10.1038/s443...
by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University
by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University
September 11, 2025 at 8:42 AM
CETN3 deficiency induces #microcephaly by disrupting neural stem/progenitor cell fate through impaired #CentrosomeAssembly and #RNAsplicing 👉 doi.org/10.1038/s443...
by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University
by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University
Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state. #SingleCellProfiling #RNAsplicing #Chromatin #Transcriptome @natbiotech.nature.com 🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 29, 2025 at 10:30 AM
Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state. #SingleCellProfiling #RNAsplicing #Chromatin #Transcriptome @natbiotech.nature.com 🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
📣 New NAR Breakthrough article! 📣
🧬 Cells resist starvation through a nutrient stress splice switch 🧬
👉 Read the free full text here: lnkd.in/eeE8KM8i
#NARBreakthrough #RNAsplicing #YeastGenetics #Introns #Spliceosome
🧬 Cells resist starvation through a nutrient stress splice switch 🧬
👉 Read the free full text here: lnkd.in/eeE8KM8i
#NARBreakthrough #RNAsplicing #YeastGenetics #Introns #Spliceosome
June 24, 2025 at 4:46 PM
📣 New NAR Breakthrough article! 📣
🧬 Cells resist starvation through a nutrient stress splice switch 🧬
👉 Read the free full text here: lnkd.in/eeE8KM8i
#NARBreakthrough #RNAsplicing #YeastGenetics #Introns #Spliceosome
🧬 Cells resist starvation through a nutrient stress splice switch 🧬
👉 Read the free full text here: lnkd.in/eeE8KM8i
#NARBreakthrough #RNAsplicing #YeastGenetics #Introns #Spliceosome
RNA splicing is entering a new era. From long-read transcriptomics to cryo-electron microscopy and beyond, we’re finally mapping the real transcriptome. The latest @NaturePortfolio collection dives deep:
🔗 www.nature.com/collections/...
#LongReads #RNAsplicing
🔗 www.nature.com/collections/...
#LongReads #RNAsplicing
RNA splicing
Technological and computational advances in recent years, from cryo-electron microscopy to sequencing technologies and machine learning
www.nature.com
May 23, 2025 at 11:14 AM
RNA splicing is entering a new era. From long-read transcriptomics to cryo-electron microscopy and beyond, we’re finally mapping the real transcriptome. The latest @NaturePortfolio collection dives deep:
🔗 www.nature.com/collections/...
#LongReads #RNAsplicing
🔗 www.nature.com/collections/...
#LongReads #RNAsplicing
Wonderful attendance for Student Research Conference 2025 at St. John's U! My lab presented a poster on #RNAsplicing of voltage-gated #potassium channels Kv7.2 #KCNQ2 and Kv7.3 #KCNC3. Students Amatun Noor Prapty and Chris Beauvil presented the poster. Thank you NIH and NIGMS for funding our work!
April 9, 2025 at 4:50 PM
Wonderful attendance for Student Research Conference 2025 at St. John's U! My lab presented a poster on #RNAsplicing of voltage-gated #potassium channels Kv7.2 #KCNQ2 and Kv7.3 #KCNC3. Students Amatun Noor Prapty and Chris Beauvil presented the poster. Thank you NIH and NIGMS for funding our work!
Biochemists Uncover How Cells Eliminate RNA Splicing Errors #Science #Biology #MolecularBiology #RNAsplicing #CellBiology #BiochemistryResearch
Biochemists Uncover How Cells Eliminate RNA Splicing Errors
Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA splicing. Two molecular control factors play a key role in splicing, the process...
purescience.news
April 5, 2025 at 10:42 PM
Biochemists Uncover How Cells Eliminate RNA Splicing Errors #Science #Biology #MolecularBiology #RNAsplicing #CellBiology #BiochemistryResearch
Our manuscript got highlighted with a beautiful infographic!
#TDP43 #PerrySyndrome #Neurodegeneration #RNAsplicing #Biomarkers #Neuroscience #FTLD #ALS #PrudencioLab
DOI: lnkd.in/eXr8te8A
#TDP43 #PerrySyndrome #Neurodegeneration #RNAsplicing #Biomarkers #Neuroscience #FTLD #ALS #PrudencioLab
DOI: lnkd.in/eXr8te8A
April 3, 2025 at 4:17 PM
Our manuscript got highlighted with a beautiful infographic!
#TDP43 #PerrySyndrome #Neurodegeneration #RNAsplicing #Biomarkers #Neuroscience #FTLD #ALS #PrudencioLab
DOI: lnkd.in/eXr8te8A
#TDP43 #PerrySyndrome #Neurodegeneration #RNAsplicing #Biomarkers #Neuroscience #FTLD #ALS #PrudencioLab
DOI: lnkd.in/eXr8te8A
Fragile X syndrome (FXS) is caused by CGG repeat expansion in FMR1, leading to DNA methylation and loss of FMRP. This #RNASpecialIssue paper explores how splice-switching ASOs and kinase inhibition can restore FMR1 expression, offering new therapeutic potential: bit.ly/4i2UpF2 #FragileX #RNAsplicing
March 19, 2025 at 2:59 PM
Fragile X syndrome (FXS) is caused by CGG repeat expansion in FMR1, leading to DNA methylation and loss of FMRP. This #RNASpecialIssue paper explores how splice-switching ASOs and kinase inhibition can restore FMR1 expression, offering new therapeutic potential: bit.ly/4i2UpF2 #FragileX #RNAsplicing
Explore how #RNAsplicing #CardiacDiseases are linked, reshaping gene expression and driving innovative therapies in modern medicine to #savelives.
Read More: tinyurl.com/bdenfu7z
#CVIAJournal #CVIA #Cardiology #CardioEd @scienceopen.bsky.social
@harvardmed.bsky.social
Read More: tinyurl.com/bdenfu7z
#CVIAJournal #CVIA #Cardiology #CardioEd @scienceopen.bsky.social
@harvardmed.bsky.social
Alternative RNA Splicing in Cardiac Diseases
Explore how RNA Alternative splicing Cardiac Diseases are linked, reshaping gene expression and driving innovative therapies in modern medicine to save lives.
cvia-journal.org
February 14, 2025 at 7:45 AM
Explore how #RNAsplicing #CardiacDiseases are linked, reshaping gene expression and driving innovative therapies in modern medicine to #savelives.
Read More: tinyurl.com/bdenfu7z
#CVIAJournal #CVIA #Cardiology #CardioEd @scienceopen.bsky.social
@harvardmed.bsky.social
Read More: tinyurl.com/bdenfu7z
#CVIAJournal #CVIA #Cardiology #CardioEd @scienceopen.bsky.social
@harvardmed.bsky.social
📣 Our 2nd Blog post on improving #sQTL modeling and why it matters #RNASplicing #Genetics #Statistics #QTL biociphers.wordpress.com/2025/01/28/a...
A Deep Dive into sQTL Modeling – Part 2
In my previous post, I described how, in our recent sQTL preprint, we broke current sQTL pipelines into their basic elements. This led to identifying potential issues/areas we may be able to improv…
biociphers.wordpress.com
January 29, 2025 at 4:05 AM
📣 Our 2nd Blog post on improving #sQTL modeling and why it matters #RNASplicing #Genetics #Statistics #QTL biociphers.wordpress.com/2025/01/28/a...
🌟 Inverna is heading to JPM Week in SF! 🌟
Our CEO, Poul Sørensen, will share our vision for disease-modifying therapies for Huntington’s disease, powered by our RNA splicing platform.
📅 Attending too? Let’s connect to discuss partnerships and innovation!
#jpm2025 #biotech #huntington #rnasplicing
Our CEO, Poul Sørensen, will share our vision for disease-modifying therapies for Huntington’s disease, powered by our RNA splicing platform.
📅 Attending too? Let’s connect to discuss partnerships and innovation!
#jpm2025 #biotech #huntington #rnasplicing
January 8, 2025 at 8:57 AM
🌟 Inverna is heading to JPM Week in SF! 🌟
Our CEO, Poul Sørensen, will share our vision for disease-modifying therapies for Huntington’s disease, powered by our RNA splicing platform.
📅 Attending too? Let’s connect to discuss partnerships and innovation!
#jpm2025 #biotech #huntington #rnasplicing
Our CEO, Poul Sørensen, will share our vision for disease-modifying therapies for Huntington’s disease, powered by our RNA splicing platform.
📅 Attending too? Let’s connect to discuss partnerships and innovation!
#jpm2025 #biotech #huntington #rnasplicing
Among so many amazing starter packs, but none focused on RNA splicing - so we made one!
Check out the accounts we’ve included so far, and let us know if you’d like to be added or have suggestions!
go.bsky.app/TigRnmC
#rnasplicing
Check out the accounts we’ve included so far, and let us know if you’d like to be added or have suggestions!
go.bsky.app/TigRnmC
#rnasplicing
November 17, 2024 at 10:13 AM
Among so many amazing starter packs, but none focused on RNA splicing - so we made one!
Check out the accounts we’ve included so far, and let us know if you’d like to be added or have suggestions!
go.bsky.app/TigRnmC
#rnasplicing
Check out the accounts we’ve included so far, and let us know if you’d like to be added or have suggestions!
go.bsky.app/TigRnmC
#rnasplicing