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Reposted by EMBO Molecular Medicine

Christos Karampelias @ckarampelias.bsky.social · 3d

Interesting knockout phenotype on intestinal stem cell regeneration.
@embomolmed.org

www.embopress.org/doi/full/10....

Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2 | EMBO Molecular Medicine

imageimageHyaline Fibromatosis Syndrome (HFS) is caused by mutations in the CMG2 gene. Full loss of function mutations lead to death around 18 months due to recurrent diarrhea of unknown origin. We us...

www.embopress.org

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EMBO Molecular Medicine @embomolmed.org · 5d

📣 Our October issue is online! www.embopress.org/toc/17574684...

This month's cover highlights the article by C. Zhu, M. Kong et al (www.embopress.org/doi/full/10....) that uncovers a new mechanism underlying #MyocardialFibrosis with druggable targets.

Scientific illustration by the authors

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EMBO Molecular Medicine @embomolmed.org · 6d

Brown remodeling of #WhiteAdiposeTissue protects against #AbdominalAorticAneurysm via batokine FSTL1

By C. Huang, Y. Huang, B. Huang, L. Yao, J. Wang, Y. Chen, Z. Liu and colleagues at Sun Yat-Sen University

➡️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · 9d

#AI -identified #CD133 -targeting natural compounds demonstrate differential anti-tumor effects and mechanisms in pan-cancer models

By Y. Hou, Z. Wang, W. Wang, Y. Zhang, X. Dai, S. Ma & colleagues

🗞️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · 9d

A neuroprotective tetrapeptide for treatment of #AcuteTraumaticBrainInjury

By A. Mann, S. Hussain, E. Ruoslahti & colleagues @sbpdiscovery.bsky.social

➡️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · 16d

Complete attenuation of #PlasmodiumFalciparum sporozoites by atovaquone–proguanil 👉 doi.org/10.1038/s443...

By S Borrmann, Z Sulyok, K Müller, R Fendel, S Hoffman, P Kremsner, K Matuschewski, B Mordmüller & colleagues

Read also related N&V by G Rochfort Peters & J Baum 👉 doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · 16d

New method ➡️ Domain-substituted IGF2 tag modulates targeting of lentiviral #GeneTherapy for #HunterSyndrome

By F. Catalano, WWMP Pijnappel & colleagues @erasmusmc.bsky.social

🗞️ doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · 22d

📣 Metabolic #cardiomyopathies: untangling clinical heterogeneity with human #StemCell derived models

By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam

➡️ doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · 26d

Impaired migration and #LungInvasion of human #melanoma by a novel small molecule targeting the transmembrane domain of death receptor #p75NTR

by V. Lopes-Rodrigues, C. Ibanez & colleagues

doi.org/10.1038/s443...

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Reposted by EMBO Molecular Medicine

EMBO Molecular Medicine @embomolmed.org · 29d

Bead-based plasma #proteomics workflows boost proteome coverage but are vulnerable to cellular contamination, highlighting the need for contamination-aware quality control in #biomarker discovery.

K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social

🗞️ doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · 26d

Glycans on non-structural protein 1 prevent premature #Tcell mediated #DengueVirus clearance

By F. Idris, S. Alonso & colleagues at National Centre for Infectious Diseases Singapore

🗞️ doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · 29d

Dietary supplementation of #ArachidonicAcid promotes #HumoralImmunity

By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University

➡️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · 29d

Bead-based plasma #proteomics workflows boost proteome coverage but are vulnerable to cellular contamination, highlighting the need for contamination-aware quality control in #biomarker discovery.

K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social

🗞️ doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · Sep 11

Anti-M1R/B6R antibody characterization & bispecific design for enhanced #orthopoxvirus protection.

🗞 doi.org/10.1038/s443...

by R. Zhao, L. Wu, Y. Zhang, J. Ma, J. Xue, Q. Wang & colleagues at Chinese Academy of Medical Sciences

EMBO Molecular Medicine @embomolmed.org · Sep 11

CETN3 deficiency induces #microcephaly by disrupting neural stem/progenitor cell fate through impaired #CentrosomeAssembly and #RNAsplicing 👉 doi.org/10.1038/s443...

by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University

EMBO Molecular Medicine @embomolmed.org · Sep 11

Our September issue is online! www.embopress.org/toc/17574684...

On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...

Scientific image: R. Hahn & K. Avraham, at Tel Aviv University

EMBO Molecular Medicine: Vol 17, No 9

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org

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EMBO Molecular Medicine @embomolmed.org · Sep 10

Identification of #p38 MAPK inhibition as a neuroprotective strategy for combinatorial #SpinalMuscularAtrophy therapy

By M. Carlini, L. Pellizzoni & colleagues @columbiauniversity.bsky.social

➡️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · Sep 10

Novel #Zika vaccine platform designed by disrupting viral #RNATertiaryStructure achieves tissue-specific attenuation & protection, reducing vertical transmission in animal models.

X. Chen, ML Cheng, XY Huang, MX Sun, RT Li, CF Qin at Chinese Academy of Medical Sciences

doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · Sep 10

#TET3 is a regulator and can be targeted for the intervention of #MyocardialFibrosis

By C. Zhu, W. Hong, Y. Zhu, D. Jiang, Y. Xu, M. Kong and colleagues at Nanjing Medical University

🗞️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · Sep 8

New study by K. Avraham & colleagues ➡️ AAV #GeneTherapy rescues #hearing and #balance in a model of CLIC5 deafness

🗞️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · Sep 8

EMT-ciliary signaling in quasi-mesenchymal-stem-like cells drives #TherapeuticResistance & is a druggable vulnerability in #TNBC

By C Tessier, J Derrien, V Guen & al @inserm.fr @cnrs.fr

🗞️ doi.org/10.1038/s443...

👉N&V by AP Morel and @mariaouzounova.bsky.social
doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · Sep 8

Pyrin #inflammasome -driven #ErosiveArthritis caused by unprenylated RHO GTPase signaling

By M. Akula, G. van Loo & colleagues at VIB Ghent

🗞️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · Sep 3

🎉Congratulations to Yibing Wang at Inst Genet Dev Biol, Beijing, for winning the @embomolmed.org poster award at #OsakaMito2025!

Reposted by EMBO Molecular Medicine

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · Sep 2

CMG2 (alias the anthrax toxin receptor) on gut cells is vital for replenishing intestinal stem cells – insights into genetic disorder hyaline fibromatosis syndrome

📷 Lucie Bracq et al EPFL (Swiss Federal Technology Institute of Lausanne) in @embomolmed.org

➡️ bpod.org.uk/archive/2025...

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