EMBO Molecular Medicine
@embomolmed.org
OpenAccess journal dedicated to high quality research at the interface between clinical & basic science.
Tweets from journal editors
Tweets from journal editors
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Our new issue is online! link.springer.com/journal/44321
The cover illustrates the study by B. Stringer, J. Giacomotto & colleagues that introduces a tool for assessing SMN1 pathogenicity in #SpinalMuscularAtrophy using the zebrafish model ➡️ doi.org/10.1038/s443...
The cover illustrates the study by B. Stringer, J. Giacomotto & colleagues that introduces a tool for assessing SMN1 pathogenicity in #SpinalMuscularAtrophy using the zebrafish model ➡️ doi.org/10.1038/s443...
TKI-mediated inhibition of NLRP1 #inflammasome restores #erythropoiesis in Diamond-Blackfan anemia syndrome 👉 doi.org/10.1038/s443...
By J. Lozano-Gil, A. Martínez-López, S. Tyrkalska, V. Mulero & colleagues @ciberisciii.bsky.social & @um.es
By J. Lozano-Gil, A. Martínez-López, S. Tyrkalska, V. Mulero & colleagues @ciberisciii.bsky.social & @um.es
TKI-mediated inhibition of NLRP1 inflammasome restores erythropoiesis in DBA syndrome - EMBO Molecular Medicine
Diamond-Blackfan anemia syndrome (DBAS) is marked by defective erythropoiesis caused by impaired ribosome biogenesis and aberrant signaling. Here, we investigate how ribosomal stress-induced activatio...
doi.org
January 21, 2026 at 7:41 PM
TKI-mediated inhibition of NLRP1 #inflammasome restores #erythropoiesis in Diamond-Blackfan anemia syndrome 👉 doi.org/10.1038/s443...
By J. Lozano-Gil, A. Martínez-López, S. Tyrkalska, V. Mulero & colleagues @ciberisciii.bsky.social & @um.es
By J. Lozano-Gil, A. Martínez-López, S. Tyrkalska, V. Mulero & colleagues @ciberisciii.bsky.social & @um.es
#ExtracellularVesicle -based targeted #ProteinDegradation platform for multiple extracellular proteins
By B. Tong, L. Tan, Z. Liao, C. Yang & colleagues at Huazhong University of Science and Technology
➡️ doi.org/10.1038/s443...
By B. Tong, L. Tan, Z. Liao, C. Yang & colleagues at Huazhong University of Science and Technology
➡️ doi.org/10.1038/s443...
Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins - EMBO Molecular Medicine
Targeted protein degradation (TPD) is an emerging therapeutic approach that enables the degradation of undruggable targets via intracellular degradation systems. Extracellular vesicles (EVs) have show...
doi.org
January 21, 2026 at 7:34 PM
#ExtracellularVesicle -based targeted #ProteinDegradation platform for multiple extracellular proteins
By B. Tong, L. Tan, Z. Liao, C. Yang & colleagues at Huazhong University of Science and Technology
➡️ doi.org/10.1038/s443...
By B. Tong, L. Tan, Z. Liao, C. Yang & colleagues at Huazhong University of Science and Technology
➡️ doi.org/10.1038/s443...
Sarcomeric remodelling in human #HeartFailure unraveled by single molecule #LongReadSequencing
By J. Haas, B. Meder & colleagues @uniheidelberg.bsky.social
By J. Haas, B. Meder & colleagues @uniheidelberg.bsky.social
January 20, 2026 at 3:52 PM
Sarcomeric remodelling in human #HeartFailure unraveled by single molecule #LongReadSequencing
By J. Haas, B. Meder & colleagues @uniheidelberg.bsky.social
By J. Haas, B. Meder & colleagues @uniheidelberg.bsky.social
Online today -> A viral glycoprotein targets IgG+ memory #Bcells to mediate humoral #ImmuneEvasion
by P. Cramer, M. Rizzi, H. Hengel and colleagues @uni-freiburg.de @univie.ac.at
🗞️ doi.org/10.1038/s443...
by P. Cramer, M. Rizzi, H. Hengel and colleagues @uni-freiburg.de @univie.ac.at
🗞️ doi.org/10.1038/s443...
January 20, 2026 at 3:47 PM
Online today -> A viral glycoprotein targets IgG+ memory #Bcells to mediate humoral #ImmuneEvasion
by P. Cramer, M. Rizzi, H. Hengel and colleagues @uni-freiburg.de @univie.ac.at
🗞️ doi.org/10.1038/s443...
by P. Cramer, M. Rizzi, H. Hengel and colleagues @uni-freiburg.de @univie.ac.at
🗞️ doi.org/10.1038/s443...
Our new issue is online! link.springer.com/journal/44321
The cover illustrates the study by B. Stringer, J. Giacomotto & colleagues that introduces a tool for assessing SMN1 pathogenicity in #SpinalMuscularAtrophy using the zebrafish model ➡️ doi.org/10.1038/s443...
The cover illustrates the study by B. Stringer, J. Giacomotto & colleagues that introduces a tool for assessing SMN1 pathogenicity in #SpinalMuscularAtrophy using the zebrafish model ➡️ doi.org/10.1038/s443...
January 20, 2026 at 3:39 PM
Our new issue is online! link.springer.com/journal/44321
The cover illustrates the study by B. Stringer, J. Giacomotto & colleagues that introduces a tool for assessing SMN1 pathogenicity in #SpinalMuscularAtrophy using the zebrafish model ➡️ doi.org/10.1038/s443...
The cover illustrates the study by B. Stringer, J. Giacomotto & colleagues that introduces a tool for assessing SMN1 pathogenicity in #SpinalMuscularAtrophy using the zebrafish model ➡️ doi.org/10.1038/s443...
Reposted by EMBO Molecular Medicine
Molecular profile of human ischemic cardiomyopathy in #diabetes reveals reduced mitochondrial complex I and elevated very long chain acylcarnitines @embomolmed.org
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Left ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathy - EMBO Molecular Medicine
Ischaemic cardiomyopathy is the most common cause of heart failure and often coexists with diabetes mellitus, which worsens patient symptom burden and outcomes. Yet, their combined effects are seldom ...
link.springer.com
January 2, 2026 at 8:34 PM
Molecular profile of human ischemic cardiomyopathy in #diabetes reveals reduced mitochondrial complex I and elevated very long chain acylcarnitines @embomolmed.org
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by EMBO Molecular Medicine
Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with @drjhujh.bsky.social and @profstewartlab.bsky.social alongside @sorenhough.bsky.social and friends in @spjacksongroup.bsky.social.
Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
December 19, 2025 at 10:11 PM
Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with @drjhujh.bsky.social and @profstewartlab.bsky.social alongside @sorenhough.bsky.social and friends in @spjacksongroup.bsky.social.
Mechanisms of resistance to #VHL loss-induced genetic and pharmacological vulnerabilities ➡️ doi.org/10.1038/s443...
By J. Ge, D. Muñoz-Espín, @svanharanta.bsky.social & colleagues @cam.ac.uk @helsinki.fi
By J. Ge, D. Muñoz-Espín, @svanharanta.bsky.social & colleagues @cam.ac.uk @helsinki.fi
December 19, 2025 at 9:15 PM
Mechanisms of resistance to #VHL loss-induced genetic and pharmacological vulnerabilities ➡️ doi.org/10.1038/s443...
By J. Ge, D. Muñoz-Espín, @svanharanta.bsky.social & colleagues @cam.ac.uk @helsinki.fi
By J. Ge, D. Muñoz-Espín, @svanharanta.bsky.social & colleagues @cam.ac.uk @helsinki.fi
Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
December 19, 2025 at 9:09 PM
Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
Online today! Mutant #CHCHD10 disrupts cytochrome c oxidation and activates mitochondrial retrograde signaling
by M. Campos-Ribeiro, T. Wai & colleagues @pasteur.fr
👉 doi.org/10.1038/s443...
by M. Campos-Ribeiro, T. Wai & colleagues @pasteur.fr
👉 doi.org/10.1038/s443...
December 19, 2025 at 9:05 PM
Online today! Mutant #CHCHD10 disrupts cytochrome c oxidation and activates mitochondrial retrograde signaling
by M. Campos-Ribeiro, T. Wai & colleagues @pasteur.fr
👉 doi.org/10.1038/s443...
by M. Campos-Ribeiro, T. Wai & colleagues @pasteur.fr
👉 doi.org/10.1038/s443...
New review by M. Pepin, X. Gong, A. Schulze and J. Backs @uniheidelberg.bsky.social ➡️Metabo-epigenetic circuits of #HeartFailure: chromatin-modifying enzymes as determinants of metabolic plasticity🫀
🗞️ doi.org/10.1038/s443...
🗞️ doi.org/10.1038/s443...
December 18, 2025 at 9:23 PM
New review by M. Pepin, X. Gong, A. Schulze and J. Backs @uniheidelberg.bsky.social ➡️Metabo-epigenetic circuits of #HeartFailure: chromatin-modifying enzymes as determinants of metabolic plasticity🫀
🗞️ doi.org/10.1038/s443...
🗞️ doi.org/10.1038/s443...
Clinical relevance of #zebrafish for gene variants testing. Proof-of-principle with SMN1/SMA 👉 doi.org/10.1038/s443...
#SpinalMuscularAtrophy
By B. Stringer, J. Giacomotto and colleagues @griffith.edu.au
#SpinalMuscularAtrophy
By B. Stringer, J. Giacomotto and colleagues @griffith.edu.au
December 18, 2025 at 9:16 PM
Clinical relevance of #zebrafish for gene variants testing. Proof-of-principle with SMN1/SMA 👉 doi.org/10.1038/s443...
#SpinalMuscularAtrophy
By B. Stringer, J. Giacomotto and colleagues @griffith.edu.au
#SpinalMuscularAtrophy
By B. Stringer, J. Giacomotto and colleagues @griffith.edu.au
Reposted by EMBO Molecular Medicine
Microplastics reach human lungs, blood, and brain, yet their biological impact is poorly defined. In our new @embomolmed.org review, we connect environmental exposure to inflammation, stress signalling, epigenetic disruption, and cell identity.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Microplastics as environmental modifiers of lung disease - EMBO Molecular Medicine
Human-driven environmental change continues to reshape global patterns of disease, as seen in past pollution-related respiratory crises. Microplastics, persistent synthetic polymer particles, have now...
link.springer.com
December 16, 2025 at 3:14 PM
Microplastics reach human lungs, blood, and brain, yet their biological impact is poorly defined. In our new @embomolmed.org review, we connect environmental exposure to inflammation, stress signalling, epigenetic disruption, and cell identity.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
New Resource Online 👉 Molecular determinants of #CardiacLymphatic dysfunction in a #ChronicPressureOverload model
🗞️ doi.org/10.1038/s443...
by C. Heron, H. Dauchel, @hfpef-diva.bsky.social & colleagues @univrouen.bsky.social @inserm.fr
🗞️ doi.org/10.1038/s443...
by C. Heron, H. Dauchel, @hfpef-diva.bsky.social & colleagues @univrouen.bsky.social @inserm.fr
December 15, 2025 at 9:33 PM
New Resource Online 👉 Molecular determinants of #CardiacLymphatic dysfunction in a #ChronicPressureOverload model
🗞️ doi.org/10.1038/s443...
by C. Heron, H. Dauchel, @hfpef-diva.bsky.social & colleagues @univrouen.bsky.social @inserm.fr
🗞️ doi.org/10.1038/s443...
by C. Heron, H. Dauchel, @hfpef-diva.bsky.social & colleagues @univrouen.bsky.social @inserm.fr
📣 Review on #microplastics as environmental modifiers of #LungDisease 🫁 by E. Epeslidou, @bnmelgert.bsky.social , @stefanprekovic.bsky.social & colleagues @rug.nl & University Medical Center Utrecht
➡️ doi.org/10.1038/s443...
➡️ doi.org/10.1038/s443...
December 15, 2025 at 9:26 PM
📣 Review on #microplastics as environmental modifiers of #LungDisease 🫁 by E. Epeslidou, @bnmelgert.bsky.social , @stefanprekovic.bsky.social & colleagues @rug.nl & University Medical Center Utrecht
➡️ doi.org/10.1038/s443...
➡️ doi.org/10.1038/s443...
Reposted by EMBO Molecular Medicine
New paper out in EMBO Mol Med! We use machine learning to predict Aβ-PET burden from fluid biomarkers. www.embopress.org/doi/full/10....
Key findings:
- Performance R² = 0.79
- CSF Aβ42/Aβ40 most predictive of Aβ plaque presence
- Plasma p-tau217 best for tracking increasing amyloid plaque burden
Key findings:
- Performance R² = 0.79
- CSF Aβ42/Aβ40 most predictive of Aβ plaque presence
- Plasma p-tau217 best for tracking increasing amyloid plaque burden
Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and β-amyloid | EMBO Molecular Medicine
imageimageMachine-learning models using CSF and plasma biomarkers accurately predicted quantitative
Aβ-PET burden. Distinct contributions of soluble Aβ42/Aβ40 and plasma P-tau217 reveal
their role in ...
www.embopress.org
December 2, 2025 at 12:13 PM
New paper out in EMBO Mol Med! We use machine learning to predict Aβ-PET burden from fluid biomarkers. www.embopress.org/doi/full/10....
Key findings:
- Performance R² = 0.79
- CSF Aβ42/Aβ40 most predictive of Aβ plaque presence
- Plasma p-tau217 best for tracking increasing amyloid plaque burden
Key findings:
- Performance R² = 0.79
- CSF Aβ42/Aβ40 most predictive of Aβ plaque presence
- Plasma p-tau217 best for tracking increasing amyloid plaque burden
Reposted by EMBO Molecular Medicine
One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org
www.embo.org/people/revie...
www.embo.org/people/revie...
Review Commons: rethinking peer review – Features – EMBO
A conversation with Thomas Lemberger, lead of the Review Commons initiative and Head of Open Science Implementation at EMBO.
www.embo.org
December 11, 2025 at 8:52 AM
One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org
www.embo.org/people/revie...
www.embo.org/people/revie...
Loss of #EHMT2 enhances #NKcell -driven #AntiTumorImmunity through #TGFβ1 suppression
by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social
doi.org/10.1038/s443...
by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social
doi.org/10.1038/s443...
December 10, 2025 at 4:10 PM
Loss of #EHMT2 enhances #NKcell -driven #AntiTumorImmunity through #TGFβ1 suppression
by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social
doi.org/10.1038/s443...
by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social
doi.org/10.1038/s443...
Development of blue light activated, kinetically balanced ChR variants optimized for high-frequency #optogenetic stimulation of SGNs at low light intensities
#cochlearimplants
By L. Roos, T. Moser, T. Mager & colleagues at University Medical Center Göttingen
🗞️ doi.org/10.1038/s44321-025-00350-z
#cochlearimplants
By L. Roos, T. Moser, T. Mager & colleagues at University Medical Center Göttingen
🗞️ doi.org/10.1038/s44321-025-00350-z
December 10, 2025 at 4:07 PM
Development of blue light activated, kinetically balanced ChR variants optimized for high-frequency #optogenetic stimulation of SGNs at low light intensities
#cochlearimplants
By L. Roos, T. Moser, T. Mager & colleagues at University Medical Center Göttingen
🗞️ doi.org/10.1038/s44321-025-00350-z
#cochlearimplants
By L. Roos, T. Moser, T. Mager & colleagues at University Medical Center Göttingen
🗞️ doi.org/10.1038/s44321-025-00350-z
Micrometastasis-derived models enable drug testing for early-stage, high-risk #melanoma patients
By K. Weidele, C. A. Klein & colleagues @uniregensburg.bsky.social
➡️ doi.org/10.1038/s44321-025-00339-8
By K. Weidele, C. A. Klein & colleagues @uniregensburg.bsky.social
➡️ doi.org/10.1038/s44321-025-00339-8
December 10, 2025 at 4:05 PM
Micrometastasis-derived models enable drug testing for early-stage, high-risk #melanoma patients
By K. Weidele, C. A. Klein & colleagues @uniregensburg.bsky.social
➡️ doi.org/10.1038/s44321-025-00339-8
By K. Weidele, C. A. Klein & colleagues @uniregensburg.bsky.social
➡️ doi.org/10.1038/s44321-025-00339-8
New issue online! ➡️ link.springer.com/journal/4432...
The cover highlights the article by S Hirschberger, S Kreth, M Hübner & al 👉 #MitochondrialDamage drives #Tcell immunometabolic paralysis after major surgery: link.springer.com/article/10.1...
Scientific illustration by M Hübner; S Hirschberger
The cover highlights the article by S Hirschberger, S Kreth, M Hübner & al 👉 #MitochondrialDamage drives #Tcell immunometabolic paralysis after major surgery: link.springer.com/article/10.1...
Scientific illustration by M Hübner; S Hirschberger
December 10, 2025 at 3:48 PM
New issue online! ➡️ link.springer.com/journal/4432...
The cover highlights the article by S Hirschberger, S Kreth, M Hübner & al 👉 #MitochondrialDamage drives #Tcell immunometabolic paralysis after major surgery: link.springer.com/article/10.1...
Scientific illustration by M Hübner; S Hirschberger
The cover highlights the article by S Hirschberger, S Kreth, M Hübner & al 👉 #MitochondrialDamage drives #Tcell immunometabolic paralysis after major surgery: link.springer.com/article/10.1...
Scientific illustration by M Hübner; S Hirschberger
Reposted by EMBO Molecular Medicine
Exciting to know that a main finding from our recent publication with @embomolmed.org (link.springer.com/article/10.1...) is taken up in a clinical trial that started a few days ago here in Tübingen and which may revolutionise chemoprophylaxis of malaria: euclinicaltrials.eu/search-for-c....
Complete attenuation of Plasmodium falciparum sporozoites by atovaquone–proguanil - EMBO Molecular Medicine
To develop a Plasmodium falciparum (Pf) vaccine that precludes replication inside the host for improved vaccine safety, we tested chemo-attenuation (CVac) of sporozoites (SPZ) with atovaquone–proguani...
link.springer.com
December 5, 2025 at 4:26 PM
Exciting to know that a main finding from our recent publication with @embomolmed.org (link.springer.com/article/10.1...) is taken up in a clinical trial that started a few days ago here in Tübingen and which may revolutionise chemoprophylaxis of malaria: euclinicaltrials.eu/search-for-c....
#TyphoidToxin of Salmonella Typhi elicits host antimicrobial response during acute #TyphoidFever
By S. Srour, D. Humphreys & colleagues @sheffielduni.bsky.social
🗞️ doi.org/10.1038/s443...
By S. Srour, D. Humphreys & colleagues @sheffielduni.bsky.social
🗞️ doi.org/10.1038/s443...
December 2, 2025 at 8:41 AM
#TyphoidToxin of Salmonella Typhi elicits host antimicrobial response during acute #TyphoidFever
By S. Srour, D. Humphreys & colleagues @sheffielduni.bsky.social
🗞️ doi.org/10.1038/s443...
By S. Srour, D. Humphreys & colleagues @sheffielduni.bsky.social
🗞️ doi.org/10.1038/s443...
Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated #tau and #βamyloid 👉 doi.org/10.1038/s443...
By N. Mattsson-Carlgren, L. Karlsson, O. Hansson & colleagues @lund-university.bsky.social
By N. Mattsson-Carlgren, L. Karlsson, O. Hansson & colleagues @lund-university.bsky.social
December 2, 2025 at 8:37 AM
Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated #tau and #βamyloid 👉 doi.org/10.1038/s443...
By N. Mattsson-Carlgren, L. Karlsson, O. Hansson & colleagues @lund-university.bsky.social
By N. Mattsson-Carlgren, L. Karlsson, O. Hansson & colleagues @lund-university.bsky.social
📣This timely review by Chin Lin and colleagues discusses advances in #ArtificialIntelligence -enabled #electrocardiography (AI-ECG) including emerging roles in early disease detection, improved risk stratification, and clinical decision-making.
#TaipeiMedicalUniversity
👉 doi.org/10.1038/s443...
#TaipeiMedicalUniversity
👉 doi.org/10.1038/s443...
December 2, 2025 at 8:32 AM
📣This timely review by Chin Lin and colleagues discusses advances in #ArtificialIntelligence -enabled #electrocardiography (AI-ECG) including emerging roles in early disease detection, improved risk stratification, and clinical decision-making.
#TaipeiMedicalUniversity
👉 doi.org/10.1038/s443...
#TaipeiMedicalUniversity
👉 doi.org/10.1038/s443...