Vern Dolinsky
@verndolinsky.bsky.social
Co-lead of DREAM, the #Diabetes Theme
@dream-diabetes.bsky.social at the Children's Hospital Research Institute of Manitoba
Professor of Pharmacology & Therapeutics @um-radyfhs.bsky.social @chrimanitoba.bsky.social
@dream-diabetes.bsky.social at the Children's Hospital Research Institute of Manitoba
Professor of Pharmacology & Therapeutics @um-radyfhs.bsky.social @chrimanitoba.bsky.social
Pinned
www.mdpi.com
Our latest REVIEW: Rethinking Childhood-Onset Hypertrophic Cardiomyopathy: A Review of Molecular Mechanisms and Unique Therapy Considerations www.mdpi.com/3512392
Reposted by Vern Dolinsky
🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.
November 17, 2025 at 11:26 PM
🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.
Reposted by Vern Dolinsky
We had a wonderful evening celebrating with our CHRIM community recently at the Child Health Research Days awards dinner. Congratulations to all the winners!
Find a full list of all winners and more photos by visiting our link in bio to see highlights from CHRD 2025.
Find a full list of all winners and more photos by visiting our link in bio to see highlights from CHRD 2025.
November 3, 2025 at 8:26 PM
We had a wonderful evening celebrating with our CHRIM community recently at the Child Health Research Days awards dinner. Congratulations to all the winners!
Find a full list of all winners and more photos by visiting our link in bio to see highlights from CHRD 2025.
Find a full list of all winners and more photos by visiting our link in bio to see highlights from CHRD 2025.
Reposted by Vern Dolinsky
📢🎉New study from our lab on circulating SASP factors suggests a novel senescent cell biomarker across #T1D stages! Congrats🥳Camille Jasmine and @dream-diabetes.bsky.social trainees Grateful to TrialNet @chrimanitoba.bsky.social @cirtn.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Circulating senescence-associated secretory phenotype factors across the stages of type 1 diabetes in a cross-sectional cohort - Scientific Reports
Scientific Reports - Circulating senescence-associated secretory phenotype factors across the stages of type 1 diabetes in a cross-sectional cohort
www.nature.com
November 20, 2025 at 4:28 PM
📢🎉New study from our lab on circulating SASP factors suggests a novel senescent cell biomarker across #T1D stages! Congrats🥳Camille Jasmine and @dream-diabetes.bsky.social trainees Grateful to TrialNet @chrimanitoba.bsky.social @cirtn.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vern Dolinsky
Our team is at the @dream-diabetes.bsky.social workshop in Winnipeg this week! Dr. Lorraine Lipscombe presented about the Network’s progress and our trainees Amrit Thandi and Jashnoor Chhina presented posters. Congrats to Amrit for winning best oral presentation! 🙌
November 14, 2025 at 4:44 PM
Our team is at the @dream-diabetes.bsky.social workshop in Winnipeg this week! Dr. Lorraine Lipscombe presented about the Network’s progress and our trainees Amrit Thandi and Jashnoor Chhina presented posters. Congrats to Amrit for winning best oral presentation! 🙌
Reposted by Vern Dolinsky
This past September, DREAM trainee Khushali Trivedi (PhD student, @verndolinsky.bsky.social lab) was selected to orally present her research at the Canadian Lipid & Vascular Summit in Saskatoon, SK. Way to go, Khushali! 👏
November 20, 2025 at 9:30 PM
This past September, DREAM trainee Khushali Trivedi (PhD student, @verndolinsky.bsky.social lab) was selected to orally present her research at the Canadian Lipid & Vascular Summit in Saskatoon, SK. Way to go, Khushali! 👏
Our latest REVIEW: Rethinking Childhood-Onset Hypertrophic Cardiomyopathy: A Review of Molecular Mechanisms and Unique Therapy Considerations www.mdpi.com/3512392
www.mdpi.com
November 20, 2025 at 8:34 PM
Our latest REVIEW: Rethinking Childhood-Onset Hypertrophic Cardiomyopathy: A Review of Molecular Mechanisms and Unique Therapy Considerations www.mdpi.com/3512392
Reposted by Vern Dolinsky
Today is #WorldDiabetesDay, an opportunity to raise awareness, foster dialogue, and recognizing and celebrating the role of fundamental science, clinical research, and community in supporting well-being for people living with diabetes. #WDD2025 #DiabetesAwareness #Diabetes
November 14, 2025 at 3:06 PM
Today is #WorldDiabetesDay, an opportunity to raise awareness, foster dialogue, and recognizing and celebrating the role of fundamental science, clinical research, and community in supporting well-being for people living with diabetes. #WDD2025 #DiabetesAwareness #Diabetes
Reposted by Vern Dolinsky
We’re honoured to welcome the Dr. Heather Dean Lectureship speaker Dr. Lindsay Crowshoe from @ucalgary.bsky.social to the DREAM Symposium! The presentation will be hybrid; contact [email protected] for the Zoom link. Deadline to register is Nov 10! tinyurl.com/5d6em33b @chrimanitoba.bsky.social
November 5, 2025 at 5:16 PM
We’re honoured to welcome the Dr. Heather Dean Lectureship speaker Dr. Lindsay Crowshoe from @ucalgary.bsky.social to the DREAM Symposium! The presentation will be hybrid; contact [email protected] for the Zoom link. Deadline to register is Nov 10! tinyurl.com/5d6em33b @chrimanitoba.bsky.social
Reposted by Vern Dolinsky
The 14th Annual DREAM Symposium and DREAM Trainee Day are only days away! We have a great day planned. Don't miss this! Registration closes tonight! tinyurl.com/5d6em33b contact [email protected] #Diabetes #Research #Symposium @chrimanitoba.bsky.social @um-radyfhs.bsky.social
November 11, 2025 at 4:57 AM
The 14th Annual DREAM Symposium and DREAM Trainee Day are only days away! We have a great day planned. Don't miss this! Registration closes tonight! tinyurl.com/5d6em33b contact [email protected] #Diabetes #Research #Symposium @chrimanitoba.bsky.social @um-radyfhs.bsky.social
Maternal #Obesity Programs Transgenerational Glucose Intolerance in Pregnant Female Offspring #DOHaD #diabetes @dream-diabetes.bsky.social diabetesjournals.org/diabetes/art...
Maternal Obesity Programs Glucose Intolerance in Pregnant Female Offspring
Maternal obesity is a known risk factor for metabolic dysfunction in offspring; however, its effect on metabolism during pregnancy in female offspring rema
diabetesjournals.org
November 12, 2025 at 6:47 PM
Maternal #Obesity Programs Transgenerational Glucose Intolerance in Pregnant Female Offspring #DOHaD #diabetes @dream-diabetes.bsky.social diabetesjournals.org/diabetes/art...
Systematic REVIEW: GLP-1 agonist therapy for gestational #diabetes journals.lww.com/md-journal/f...
journals.lww.com
November 10, 2025 at 4:45 PM
Systematic REVIEW: GLP-1 agonist therapy for gestational #diabetes journals.lww.com/md-journal/f...
Cellular acyl-CoA profiling reveals SLC25A42/SLC25A16 in #mitochondria import and #metabolism @natmetabolism.nature.com rdcu.be/eN5N4
Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism
Nature Metabolism - By developing a method that allows detection of transient, low-abundance acyl-CoA species, Liu et al. provide a thorough characterization of coenzyme A dynamics and subcellular...
rdcu.be
November 3, 2025 at 6:08 PM
Cellular acyl-CoA profiling reveals SLC25A42/SLC25A16 in #mitochondria import and #metabolism @natmetabolism.nature.com rdcu.be/eN5N4
From the ECHO Cohort Study (n=13,810) Association of Maternal Pre- #pregnancy BMI With Offspring Cardiometabolic Outcomes in Childhood #DOHaD #obesity @dream-diabetes.bsky.social @dohadcanada.bsky.social onlinelibrary.wiley.com/doi/10.1002/...
Association of Maternal Prepregnancy BMI With Offspring Cardiometabolic Outcomes in Childhood
Objective This study aimed to evaluate associations of maternal prepregnancy BMI with offspring BMI and blood pressure in childhood, specifically for infants born preterm. Methods In this observat...
onlinelibrary.wiley.com
October 31, 2025 at 2:01 AM
From the ECHO Cohort Study (n=13,810) Association of Maternal Pre- #pregnancy BMI With Offspring Cardiometabolic Outcomes in Childhood #DOHaD #obesity @dream-diabetes.bsky.social @dohadcanada.bsky.social onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Vern Dolinsky
Discover MyRoad, a platform supported by CIHR, offering research training & mentorship in #obesity, #diabetes & #cardiometabolic #diseases. New opportunities this fall include cohort training, travel awards & more. 🎓✈️
Learn more: www.myroadplatform.ca/en
Contact: [email protected]
Learn more: www.myroadplatform.ca/en
Contact: [email protected]
September 2, 2025 at 6:46 PM
Discover MyRoad, a platform supported by CIHR, offering research training & mentorship in #obesity, #diabetes & #cardiometabolic #diseases. New opportunities this fall include cohort training, travel awards & more. 🎓✈️
Learn more: www.myroadplatform.ca/en
Contact: [email protected]
Learn more: www.myroadplatform.ca/en
Contact: [email protected]
Looking forward to the 14th Annual DREAM Symposium will be on Nov 13, 2025, and the DREAM Trainee Day will be Nov 12. Free to Register Here! tinyurl.com/5d6em33b #Diabetes #Research #Symposium @chrimanitoba.bsky.social @um-radyfhs.bsky.social
October 30, 2025 at 1:01 AM
Looking forward to the 14th Annual DREAM Symposium will be on Nov 13, 2025, and the DREAM Trainee Day will be Nov 12. Free to Register Here! tinyurl.com/5d6em33b #Diabetes #Research #Symposium @chrimanitoba.bsky.social @um-radyfhs.bsky.social
Reposted by Vern Dolinsky
Introducing the second keynote speaker of the DREAM #Symposium: Making Connections for Innovation, Dr. Lorraine Lipscombe from @utoronto.ca! Mark your calendars for Nov 13📅 Register here: tinyurl.com/5d6em33b @chrimanitoba.bsky.social @um-radyfhs.bsky.social @nhp-uoft.bsky.social #Diabetes #Research
October 3, 2025 at 8:24 PM
Introducing the second keynote speaker of the DREAM #Symposium: Making Connections for Innovation, Dr. Lorraine Lipscombe from @utoronto.ca! Mark your calendars for Nov 13📅 Register here: tinyurl.com/5d6em33b @chrimanitoba.bsky.social @um-radyfhs.bsky.social @nhp-uoft.bsky.social #Diabetes #Research
Reposted by Vern Dolinsky
We’re excited to announce our third keynote speaker for the 2025 DREAM #Symposium: Dr. Barry Lavallee, Chief Executive Officer of Keewatinohk Inniniw Minoayawin Inc.! Don't miss this event! Register here: tinyurl.com/5d6em33b @chrimanitoba.bsky.social @um-radyfhs.bsky.social #Diabetes #Research
October 15, 2025 at 3:37 PM
We’re excited to announce our third keynote speaker for the 2025 DREAM #Symposium: Dr. Barry Lavallee, Chief Executive Officer of Keewatinohk Inniniw Minoayawin Inc.! Don't miss this event! Register here: tinyurl.com/5d6em33b @chrimanitoba.bsky.social @um-radyfhs.bsky.social #Diabetes #Research
Reposted by Vern Dolinsky
I recently had the opportunity to chat with Dr. Shazhan Amed about how she is using data in innovative ways to improve outcomes for children and youth living with type 1 diabetes. Thanks to the T2D Network (part of IHSTS) for hosting this conversation. www.youtube.com/watch?v=Eazx...
Empowering Diabetes Care Integrating Health Information
YouTube video by T2D Network
www.youtube.com
October 20, 2025 at 9:47 PM
I recently had the opportunity to chat with Dr. Shazhan Amed about how she is using data in innovative ways to improve outcomes for children and youth living with type 1 diabetes. Thanks to the T2D Network (part of IHSTS) for hosting this conversation. www.youtube.com/watch?v=Eazx...
Functional recovery of islet β cells in human type 2 #diabetes: Transcriptome signatures unveil therapeutic approaches @dream-diabetes.bsky.social @chrisadoucette.bsky.social www.science.org/doi/10.1126/...
Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches
Human T2D beta cell function was restored, the rescuing mechanisms disentangled, and hits identified to promote T2D remission.
www.science.org
October 21, 2025 at 7:08 PM
Functional recovery of islet β cells in human type 2 #diabetes: Transcriptome signatures unveil therapeutic approaches @dream-diabetes.bsky.social @chrisadoucette.bsky.social www.science.org/doi/10.1126/...
From the HAPO study (n=112) : From Mothers With Hyperglycemia in Pregnancy 19 cord blood DNA Methylation CpG Predict Offspring beta cell dysfunction at ages 7, 11 and 18 #DOHaD @dohadcanada.bsky.social @dream-diabetes.bsky.social @adapubs.bsky.social diabetesjournals.org/diabetes/art...
August 29, 2025 at 4:58 PM
From the HAPO study (n=112) : From Mothers With Hyperglycemia in Pregnancy 19 cord blood DNA Methylation CpG Predict Offspring beta cell dysfunction at ages 7, 11 and 18 #DOHaD @dohadcanada.bsky.social @dream-diabetes.bsky.social @adapubs.bsky.social diabetesjournals.org/diabetes/art...
Reposted by Vern Dolinsky
🚨New in JAMA Pediatrics: Edmondson, Shah & Gregory discuss the promise & challenges of using GLP-1 receptor agonists for youth obesity. From safety concerns to access barriers, the piece highlights key unanswered questions for care & policy. 📖👇
jamanetwork.com/journals/jam... #obesity #youth #GLP1
jamanetwork.com/journals/jam... #obesity #youth #GLP1
Glucagon-Like Peptide-1 Receptor Agonists and Youth Obesity
This Viewpoint discusses the use of glucagon-like peptide-1 receptor agonist treatments for weight management in youth.
jamanetwork.com
August 26, 2025 at 4:38 PM
🚨New in JAMA Pediatrics: Edmondson, Shah & Gregory discuss the promise & challenges of using GLP-1 receptor agonists for youth obesity. From safety concerns to access barriers, the piece highlights key unanswered questions for care & policy. 📖👇
jamanetwork.com/journals/jam... #obesity #youth #GLP1
jamanetwork.com/journals/jam... #obesity #youth #GLP1
Transcriptomics reveals that Maternal western diet has a lasting impact of dysregulated #metabolism and RNA processing #genes in the skeletal muscles of Japanese Macaque offspring #DOHaD @dohadcanada.bsky.social @dream-diabetes.bsky.social
rdcu.be/eCbj2
rdcu.be/eCbj2
Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques
Scientific Reports - Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques
rdcu.be
August 25, 2025 at 12:32 AM
Transcriptomics reveals that Maternal western diet has a lasting impact of dysregulated #metabolism and RNA processing #genes in the skeletal muscles of Japanese Macaque offspring #DOHaD @dohadcanada.bsky.social @dream-diabetes.bsky.social
rdcu.be/eCbj2
rdcu.be/eCbj2
Metabolomic and transcriptomic remodeling of bone marrow myeloid cells in response to maternal #obesity #DOHaD @dream-diabetes.bsky.social @dohadcanada.bsky.social journals.physiology.org/doi/full/10....
August 21, 2025 at 7:15 PM
Metabolomic and transcriptomic remodeling of bone marrow myeloid cells in response to maternal #obesity #DOHaD @dream-diabetes.bsky.social @dohadcanada.bsky.social journals.physiology.org/doi/full/10....
Parental #obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction #DOHaD @dohadcanada.bsky.social @dream-diabetes.bsky.social journals.physiology.org/doi/full/10....
Parental obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction | American Journal of Physiology-Heart and Circulatory Phy...
Acute myocardial infarction (MI) is a leading cause of death worldwide, accounting for >1 million deaths/year in the United States alone. Although parental obesity is a risk factor for offspring cardi...
journals.physiology.org
August 12, 2025 at 6:21 PM
Parental #obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction #DOHaD @dohadcanada.bsky.social @dream-diabetes.bsky.social journals.physiology.org/doi/full/10....
Wow! check this out: #Proteomic profiling from pregnant human islets donors reveals the adaptations of the human endocrine pancreas to #pregnancy @nature.com pmc.ncbi.nlm.nih.gov/articles/PMC...
August 12, 2025 at 6:14 PM
Wow! check this out: #Proteomic profiling from pregnant human islets donors reveals the adaptations of the human endocrine pancreas to #pregnancy @nature.com pmc.ncbi.nlm.nih.gov/articles/PMC...