#cerebralperfusion
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rhyothemis.bsky.social
interesting
#physiology #microgravity #CerebralPerfusion
screenshot of Google results page on search terms 'carotid body head down tilt' showing AI Overview - Head-down tilt (HDT) typically induces a cephalad fluid shift, increasing intracranial pressure and altering hemodynamics in the carotid arteries. While HDT can increase cerebral perfusion, studies indicate it often causes a decrease in carotid artery blood flow velocity, despite increasing vessel diameter, as the body adapts to fluid redistribution.  Key Findings on Carotid Body/Artery and Head-Down Tilt:  Carotid Blood Flow Changes: Research on older adults suggests total blood flow in the carotid artery decreases during HDT compared to supine positions. Velocity and Diameter: Studies show that when moving from a supine to a -30 degree head-down tilt, blood flow velocities in the common carotid (CCA), internal carotid (ICA), and internal jugular vein (IJV) significantly decrease, while diameters increase. Brain Perfusion: Despite reduced carotid blood flow velocity, HDT (e.g., -15 degree to -30 degree) can increase overall cerebral blood flow (CBF) and is sometimes used to improve cerebral perfusion in ischemic stroke patients. Carotid Sinus/Body Interaction: The increased pressure in the neck vessels (carotid sinus) during HDT acts as a stimulant for cardiovascular regulation, potentially reducing heart rate and blood pressure to manage increased blood volume in the head. Short-term vs. Long-term: While acute, short-term HDT (-10 degree to -30 degree) might preserve steady-state CBF due to robust cerebral regulation, long-term exposure can lead to complex changes in hemodynamics.  These effects are often studied to simulate the cardiovascular adaptations to microgravity (spaceflight) or to evaluate therapeutic positions for improved brain oxygenation. 
February 8, 2026 at 8:15 PM
izzynchristie.bsky.social
If you are in Oxford on Friday 23rd, I will be presenting my work:
With much thanks to the funders: @physoc.bsky.social and @wellcometrust.bsky.social

#hypoxia #neuroscience #cerebralperfusion #collaborations #networking
January 18, 2026 at 9:34 PM